| Project/Area Number |
22590987
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMURA Takeshi 熊本大学, 医学部附属病院, 講師 (20398192)
NISHIKAWA Takeshi 熊本大学, 生命科学研究部, 准教授 (70336212)
KONDO Tatsuya 熊本大学, 生命科学研究部, 助教 (70398204)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 肥満 / 糖尿病 / インスリン抵抗性 / TNFa 変換酵素(TACE) / ストレスキナーゼ / インスリンシグナル伝達 / TNFa産生 / 発現制御 / 細胞・組織 / シグナル伝達 / 蛋白質 |
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| Research Abstract |
T umor necrosis factor (TNF) converting enzyme (TACE)cleaves the transmembrane precursor of TNF and produces mature TNF , which is aproinflammatory cytokine and one of the major mediators of obesity- and diabetes-inducedinsulin resistance. However , the regulation of TACE activity and expression ininsulin-sensitive tissues in obesity has not been fully determined. In the presentinvestigation, we found the adipose tissue-specific upregulation of TACE activity andexpression induced by obesity and the downregulation by caloric restriction in KKAy mice.In addition, we found that the activation of several stress-kinases may involve in theupreglation of TACE function in adipose tissue of obese mice.
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