Identification of hybrid Treg in type 1 diabetes

• Project/Area Number: 22590994
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Keio University
• Principal Investigator: SHIMADA Akira 慶應義塾大学, 医学部, 講師(非常勤) (60206167)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 1型糖尿病 / 免疫制御性T細胞 / ケモカイン / 抗原特異的T細胞 / インスリン

Research Abstract

In order to cure type 1 diabetes, we need to obtain both beta cell proliferation and regulation of autoimmunity. We found the unique regulatory T cell which expresses CXCR3 on the surface called hybrid Treg regulates type 1 diabetes effectively. Moreover

Research Products

• [Journal Article] Acceleration of diabetes development in CXC chemokine receptor 3 (CXCR3)-deficient NOD mice. (2012)
  • Author(s): Yamada Y, Okubo Y, Shimada A, Oikawa Y, Yamada S,Narumi S, Matsushima K, Itoh H.
  • Journal Title: Diabetologia Volume: 55(8) Issue: 8 Pages: 2238-45
  • DOI: 10.1007/s00125-012-2547-8
  • Peer Reviewed
• [Journal Article] Analysis of the HLA and non-HLA susceptibility loci in Japanese type 1 diabetes. (2011)
  • Author(s): Yamashita H, Awata T, Kawasaki E, Ikegami H, Tanaka S, Maruyama T, Shimada A, Nakanishi K, Takahashi K, Kobayashi T, Kawabata Y, Miyashita Y, Kurihara S, Morita-Ohkubo T, Katayama S
  • Journal Title: Japanese Study Group on Type 1 Diabetes Genetics.DiabetesMetab Res Rev Volume: 27(8) Issue: 8 Pages: 844-8
  • DOI: 10.1002/dmrr.1234
  • Peer Reviewed
• [Journal Article] A mimic of viral double-stranded RNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouse. (2011)
  • Author(s): Tada A, Shimada A, Yamada T, Oikawa Y, Yamada Y, Okubo Y, Irie J, Bluestone JA, Itoh H
  • Journal Title: J Immunol Volume: 187(10) Issue: 10 Pages: 4947-53
  • DOI: 10.4049/jimmunol.1000837
  • Peer Reviewed
• [Journal Article] RIG-I- and MDA5-initiated innate immunity linked with adaptive immunity accelerates beta-cell death in fulminant type 1 diabetes. (2011)
  • Author(s): Aida K, Nishida Y, Tanaka S, Maruyama T, Shimada A, Awata T, Suzuki M, Shimura H, Takizawa S, Ichijo M, Akiyama D, Furuya F, Kawaguchi A, Kaneshige M, Itakura J, Fujii H, Endo T, Kobayashi T
  • Journal Title: Diabetes Volume: 60(3) Issue: 3 Pages: 884-9
  • DOI: 10.2337/db10-0795
  • Peer Reviewed
• [Journal Article] CXC chemokine ligand 10 DNA vaccination plus Complete Freund's Adjuvant reverses hyperglycemia in non-obese diabetic mice. (2010)
  • Author(s): Oikawa Y, Shimada A,Yamada Y, Okubo Y, Katsuki T, Shigihara T, Miyazaki J, Narumi S
  • Journal Title: Itoh H.Rev Diabet Stud Volume: 7(3) Pages: 209-24
  • Peer Reviewed
• [Presentation] 1型糖尿病患者における末梢血CXCR3陽性制御性T細胞分画の検討 (2011)
  • Author(s): 及川洋一ほか
  • Organizer: 第54回日本糖尿病学会
  • Place of Presentation: 札幌
• [Presentation] 劇症1型糖尿病膵(FT1D)における自然免疫/獲得免疫関連分子の発現 (2011)
  • Author(s): 西田頼子ほか
  • Organizer: 第54回日本糖尿病学会
  • Place of Presentation: 札幌
• [Presentation] 1型糖尿病の成因と予防 新しい展開と洞察 1型糖尿病の「治癒」は可能か (2011)
  • Author(s): 島田朗ほか
  • Organizer: 第54回日本糖尿病学会
  • Place of Presentation: 札幌
• [Presentation] 1型糖尿病の成因と予防 新しい展開と洞察 劇症1型糖尿病と緩徐進行1型糖尿病の膵 その異質性 (2011)
  • Author(s): 会田薫ほか
  • Organizer: 第54回日本糖尿病学会
  • Place of Presentation: 札幌
• [Presentation] 1型糖尿病の「治癒」は可能か (2011)
  • Author(s): 島田朗
  • Organizer: 第54回日本糖尿病学会
  • Place of Presentation: ロイトン札幌(札幌市)
• [Presentation] CXCR3ノックアウトNODマウスにおける膵β細胞増殖と糖尿病発症との関連 (2010)
  • Author(s): 山田善史、島田朗, ほか
  • Organizer: 第53回日本糖尿病学会
  • Place of Presentation: 岡山県岡山市
  • Year and Date: 2010-05-28
• [Presentation] DNAワクチンによる自己免疫性糖尿病の寛解過程におけるHybrid Tregの関与 (2010)
  • Author(s): 及川洋一、島田朗, ほか
  • Organizer: 第53回日本糖尿病学会
  • Place of Presentation: 岡山県岡山市
  • Year and Date: 2010-05-27
• [Presentation] 型糖尿病の新しい展開 1型糖尿病の膵病変 劇症1型糖尿病と緩徐進行1型糖尿病の対比から (2010)
  • Author(s): 会田薫ほか
  • Organizer: 第53回日本糖尿病学会
  • Place of Presentation: 岡山
• [Presentation] Pathogenesis of Type 1 Diabetes The Role of CXCL10/CXCR3 System in the Disease Process and the Potential Therapy Approaches of Type 1 Diabetes
  • Author(s): 及川洋一
  • Organizer: 第55回日本糖尿病学会
  • Place of Presentation: 横浜
  • Invited