| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
The receptor for AGEs (RAGE) is implicated in the progression of diabetic complications. We were interested in determining the influence of RAGE on bone metabolism. In the experiments using pre-osteoclastic RAW264.7 cells and pre-osteoblastic MC3T3-E1 cells, ligand-induced activation of RAGE-stimulates osteoclastogenesis through factors secreted from osteoblasts. Each NFATc1-downstream gene has a different timing of its peak expression, suggesting stage-specific regulation of the each NFATc1 target genes.
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