• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The effect of progranulin, a novel ApoA1-binding protein, on the plaque rapture and the mechanism of dementia onset

Research Project

Project/Area Number 22591000
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Metabolomics
Research InstitutionOsaka University

Principal Investigator

OHAMA Tohru  大阪大学, 保健センター, 助教 (20467583)

Co-Investigator(Kenkyū-buntansha) YAMASHITA Shizuya  大阪大学, 大学院・医学系研究科, 准教授 (60243242)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsプログラニュリン / HDL / 動脈硬化 / 急性冠症候群 / 痴呆 / 耐糖能異常
Research Abstract

PGRN KO mice exhibited lipid abnormality such as higher plasma triglyceride and lower ability of HDL to take up cholesterol. In addition, we crossed PGRN KO mice with ApoE KO mice to generate PGRN-/-ApoE-/- (double KO, DKO) mice. DKO mice showed much more pronounced atherosclerosis compared with ApoE KO mice. Moreover, PGRN concentration in the blood collected from the culprit lesion in the acute phase of ACS was lower than that in the peripheral blood and in chronic phase of ACS, suggesting that PGRN might be associated with the plaque stability.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2013 2012 2011 2010 Other

All Presentation (9 results)

  • [Presentation] Deletion of Progranulin Exacerbates Atherosclerosis by changing HDL-associated proteins and altering ApoE KO DKODKOeNOSApoE KOp-eNOSβ-actinSRA CD36## cholesterol homeostasis2013

    • Author(s)
      大〓透、山下静也
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2013-03-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Deletion of Progranulin Results In Various Metabolic Dysfunctions2012

    • Author(s)
      大〓透、山下静也
    • Organizer
      第44回日本動脈硬化学会総会
    • Place of Presentation
      ヒルトン福岡シーホーク
    • Year and Date
      2012-07-19
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel HDL-associated protein, Progranulin, May Play An Atheroprotective Role by Enhancing Reverse Cholesterol Transport2011

    • Author(s)
      大 濱 透 , 山 下 静 也
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-08-04
    • Related Report
      2012 Final Research Report
  • [Presentation] A Novel HDL-associated Protein, Progranulin, May Play An Atheroprotective Role By Enhancing Reverse Cholesterol Transport2011

    • Author(s)
      大濱透
    • Organizer
      第75回日本循環器学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜会議センター
    • Year and Date
      2011-08-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Defiency of Progranulin (PGRN) Alters Lipid Metabolism Including HDL Functions2011

    • Author(s)
      川瀬良太
    • Organizer
      第43回動脈硬化学会総会・学術集会
    • Place of Presentation
      ロイトン札幌
    • Year and Date
      2011-07-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] A Novel HDL-associated Protein, Progranulin, May Play An Atheroprotective Role By Enhancing Reverse Cholesterol Transport2010

    • Author(s)
      大濱透
    • Organizer
      日本動脈硬化学会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Novel HDL-associated Protein, Progranulin, Might Play An Atheroprotective Role By Enhancing Reverse Chelesterol Transport2010

    • Author(s)
      大濱透
    • Organizer
      ヨーロッパ動脈硬化学会
    • Place of Presentation
      Congress Center Hamburg(ドイツ)
    • Year and Date
      2010-06-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Deletion of Progranulin Results in Various Metabolic Dysfunctions

    • Author(s)
      大濵 透
    • Organizer
      第44回日本動脈硬化学会総会
    • Place of Presentation
      ヒルトン福岡シーホーク
    • Related Report
      2012 Annual Research Report
  • [Presentation] Deletion of Progranulin Exacerbates Atherosclerosis by Changing HDL-associated Antiatherogenic Proteins and Altering Cholesterol Homeostasis

    • Author(s)
      大濵 透
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi