| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
PGRN KO mice exhibited lipid abnormality such as higher plasma triglyceride and lower ability of HDL to take up cholesterol. In addition, we crossed PGRN KO mice with ApoE KO mice to generate PGRN-/-ApoE-/- (double KO, DKO) mice. DKO mice showed much more pronounced atherosclerosis compared with ApoE KO mice. Moreover, PGRN concentration in the blood collected from the culprit lesion in the acute phase of ACS was lower than that in the peripheral blood and in chronic phase of ACS, suggesting that PGRN might be associated with the plaque stability.
|
