Effects of statin on apolipoprotein metabolism in patients with hemodialysis
| Project/Area Number |
22591002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | National Defense Medical College |
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Principal Investigator |
IKEWAKI Katsunori 防衛医科大学校, 医学教育部医学科専門課程, 教授 (40287199)
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| Co-Investigator(Kenkyū-buntansha) |
AYAORI Makoto 防衛医科大学校, 病院, 助教 (70532464)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脂質代謝異常 / 透析 / 安定同位体 / アポ蛋白 / リポ蛋白 / スタチン / アポ蛋白B / 血液透析 / トレーサー |
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| Research Abstract |
Dyslipidemia in hemodialysis (HD) patients are responsible for the increased risk for cardiovascular disease (CVD). Previously, we demonstrated that various metabolic abnormaltities in HD patients including delayed catabolism of remnant and LDL apoB. In the present study, we assessed effects of statin (atorvastatin) on the impaired LDL apoB metabolism in HD patients using in vivo metabolic study using stable isotopically-labeled amino acid and found that atorvastatin substantially improved delayed catabolism of LDL apoB.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] In vivo stable-isotope kinetic study suggests intracellular assembly of lipoprotein(a)2012
Author(s)
Frischmann ME, Ikewaki K, Trenkwalder E, Lamina C, Dieplinger B, SoufiM, Schweer H, Schaefer JR, Konig P, Kronenberg F, Dieplinger H
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Journal Title
Atherosclerosis
Volume: 225(2)
Pages: 322-7
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