| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In order to study the effect of NMU on cholesterol metabolism and development of atherosclerosis, double knockout mice of NMU and Apolipoprotein E was synthesized. Apo E and NMU double knockout mice showed severe hypercholesterolemia, the development of atherosclerosis and survival curve showed almost the same. NMU was shown to have significant roles in cholesterol metabolism and development of atherosclerosis.
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