Elucidation of the roles of Neuromedin U on development of atherosclerosis and its therapeutic application
Project/Area Number |
22591004
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
SHIBA Mariko 独立行政法人国立循環器病研究センター, 研究所, 部長 (70271575)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | ニューロメジンU / 動脈硬化 / モデル動物 / 脂質異常症 / ニューロメジンU / マクロファージ / 動脈硬化症硬 / アポEノックアウトマウス / コレステロール |
Research Abstract |
In order to study the effect of NMU on cholesterol metabolism and development of atherosclerosis, double knockout mice of NMU and Apolipoprotein E was synthesized. Apo E and NMU double knockout mice showed severe hypercholesterolemia, the development of atherosclerosis and survival curve showed almost the same. NMU was shown to have significant roles in cholesterol metabolism and development of atherosclerosis.
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Report
(4 results)
Research Products
(121 results)
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[Journal Article] Multicenter study to determine the diagnosis criteria of heterozygous familial hypercholesterolemia in Japan2012
Author(s)
Harada-Shiba M, Arai H, Okamura T, Yokote K, Oikawa S, Nohara A, Okada T, Ohta T, Bujo H, Watanabe M, Wakatsuki A, Yamashita S
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Journal Title
J Atheroscler Thromb
Volume: 19(11)
Pages: 1019-1026
Related Report
Peer Reviewed
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[Journal Article] Defining Patients at Extremely High Risk for Coronary Artery Disease in Heterozygous Familial Hypercholesterolemia2012
Author(s)
Sugisawa T, Okamura T, Makino H, Watanabe M, Kishimoto I, Miyamoto Y, Iwamoto N, Yamamoto A, Yokoyama S, Harada-Shiba M
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 19
Issue: 4
Pages: 369-375
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed
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[Journal Article] Background to Discuss Guidelines for Control of Plasma HDL-Cholesterol in Japan*2012
Author(s)
Yokoyama S, Yamashita S, Ishibashi S, Sone H, Oikawa S, Shirai K, Ohta T, Bujo H, Kobayashi J, Arai H, Harada-Shiba M, Eto M, Hayashi T, Gotoda T, Suzuki H, Yamada N
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 19
Issue: 3
Pages: 207-212
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed
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[Journal Article] Diagnosis and Management of Type I and Type V Hyperlipoproteinemia2012
Author(s)
Gotoda T, Shirai K, Ohta T, Kobayashi J, Yokoyama S, Oikawa S, Bujo H, Ishibashi S, Arai H, Ya mashita S, Harada-Shiba M, Eto M, Hayashi T, Sone H, Suzuki H, Yamada N
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 19
Issue: 1
Pages: 1-12
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed
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[Journal Article] Management of Type IIb Dyslipidemia2012
Author(s)
Arai H, Ishibashi S, Bujo H, Hayashi T, Yokoyama S, Oikawa S, Kobayashi J, Shirai K, Ota T, Yamashita S, Gotoda T, Harada-Shiba M, Sone H, Eto M, Suzuki H, Yamada N.
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 19
Issue: 2
Pages: 105-114
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed
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