Innovation of a novel anti-hypertensive therapy due to the inhibitionof aldosterone synthase (CYP11B2) gene expression
| Project/Area Number |
22591006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Tohoku University |
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Principal Investigator |
SUGAWARA Akira 東北大学, 大学院・医学系研究科, 教授 (90270834)
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| Co-Investigator(Kenkyū-buntansha) |
KUDO Masataka 東北大学, 病院, 講師 (20509583)
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| Co-Investigator(Renkei-kenkyūsha) |
NOGUCHI Naoya 仙台市立病院, 耳鼻咽喉科, 医長 (20333792)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 内分泌学 / 分子高血圧学 / アルドステロン / CYB11B2遺伝子 / 治療抵抗性高血圧 / 新規降圧療法 / PPARγ / ATF-2 / 新規圧療法 |
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| Research Abstract |
In the present study, we elucidated that both PPARγ and RXR agonists suppressed aldosterone synthase (CYP11B2) expression at the gene transcription level, while the supernatant of adipocytes induced CYP11B2 transcription activation. Additionally, we generated a stable H295R cell line expressing CYP11B2 promoter/luciferase chimeric reporter construct. Based on these observations, we are going to develop novel anti-hypertensive drugs.
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Report
(4 results)
Research Products
(121 results)
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[Journal Article] The effects of GLP-1 receptor agonists on endothelial function: do they function directly or indirectly?2013
Author(s)
Kudo M, Saito-Hakoda A, Matsuda K, Shimizu K, Sato I, Uruno A, Yoshikawa T, Iki Y, Sugawara K, Kogure N, Saito-Ito T, Ito S, Sugawara A
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Journal Title
J Autacoids
Volume: 2
Issue: 01
DOI
Related Report
Peer Reviewed
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[Journal Article] Assisting the diagnosis of overt hypothyroidism with pattern recognition methods making use of a set of routine tests, and their multiple correlation with total T42012
Author(s)
Aoki S, Hoshi K, Kawakami J, Sato K, Sato W, Satoh H, Mori K, Sugawara A, Nakagawa Y, Yoshida K
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Journal Title
Biomed Pharmacother
Volume: (Epub ahead of print)
Issue: 3
Pages: 195-205
DOI
Related Report
Peer Reviewed
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[Journal Article] All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells: possible involvement of protein kinase C-{delta}2011
Author(s)
Uruno A, Noguchi N, Matsuda K, Nata K, Yoshikawa T, Chikamatsu Y, Kagechika H, Harigae H, Ito S, Okamoto H, Sugawara A.
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Journal Title
J Leukoc Biol
Volume: 90
Issue: 2
Pages: 235-247
DOI
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Peer Reviewed
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[Journal Article] Retinoid receptors in human esophageal squamous cell carcinoma : Retinoid X receptor as a potent prognostic factor2011
Author(s)
Fujishima F, Suzuki T, Nakamura Y, Taniyama Y, Ono K, Sugawara A, Miyazaki S, Moriya T, Sato A, Satomi S, Sasano H
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Journal Title
Pathol Int
Volume: 61
Issue: 7
Pages: 401-408
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] All-trans retinoic acid and a novel synthetic retinoid tamibarotene (Am80) differentially regulate CD38 expression in human leukemia HL-60 cells : possible involvement of protein kinase C-{delta}2011
Author(s)
Uruno A, Noguchi N, Matsuda K, Nata K, Yoshikawa T, Chikamatsu Y, Kagechika H, Harigae H, Ito S, Okamoto H, Sugawara A.
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Journal Title
J Leukoc Biol
Volume: Epub ahead of print
Related Report
Peer Reviewed
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[Journal Article] Up-regulation of REG Iα accelerates tumor progression in pancreatic cancer with diabetes2010
Author(s)
Zhou L, Zhang R, Wang L, Shen S, Okamoto H, Sugawara A, Xia L, Wang X, Noguchi N, Yoshikawa T, Uruno A, Yao W, Yuan Y
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Journal Title
Int J Cancer
Volume: 127
Pages: 1795-1803
Related Report
Peer Reviewed
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[Presentation] Retinoid X receptor agonists differentially affect proliferation, apoptosis, and ACTH secretion/POMC gene expression in AtT20 corticotroph cells2012
Author(s)
Saito-Hakoda A, Uruno A, Shimizu K, Kudo M, Saito-Ito T, Yoshikawa T, Matsuda K, Fujiwara I, Kagechika H, Iwasaki Y, Ito S, Sugawara A
Organizer
The Endocrine Society 94th Annual Meeting.
Place of Presentation
Houston, USA
Related Report
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[Presentation] Telmisartan stimulates aldosterone synthase gene (CYP11B2) expression via the CaMK-mediated induction of NURR12012
Author(s)
Matsuda K, Uruno A, Saito-Ito T, Shimizu K, Kudo M, Satoh F, Yoshikawa T, Saito-Hakoda A, Ito S, Sugawara A
Organizer
The Endocrine Society 94th Annual Meeting.
Place of Presentation
Houston, USA
Related Report
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[Presentation] High-glucose stimulates aldosterone synthase gene (CYP11B2) expression in human adrenal H295R cells2012
Author(s)
Saito-Ito T, Matsuda K, Uruno A, Shimizu K, Nakamura M, Takahashi R, Yoshikawa T, Kudo M, Saito-Hakoda A, Ito S, Sugawara A
Organizer
The Endocrine Society 94th Annual Meeting.
Place of Presentation
Houston, USA
Related Report
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[Presentation] Relationship between silent brain infarction and primary aldosteronism2011
Author(s)
Kudo M, Satoh F, Morimoto R, Iwakura Y, Ono Y, Murakami O, Matsuda K, Sugawara A, Uruno A, Takase K, Ito S
Organizer
The Endocrine Society 93rd Annual Meeting
Place of Presentation
Boston
Year and Date
2011-06-05
Related Report
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[Presentation] Clinical significance of silent brain infarction in the patients with primary aldosteronism2011
Author(s)
Kudo M, Satoh F, Morimoto R, Iwakura Y, Ono Y, Murakami O, Matsuda K, Sugawara A, Uruno A, Takase K, Ito S
Organizer
The 37th International Aldosterone Conference
Place of Presentation
Boston
Year and Date
2011-06-02
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