| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
In the present study, we elucidated that both PPARγ and RXR agonists suppressed aldosterone synthase (CYP11B2) expression at the gene transcription level, while the supernatant of adipocytes induced CYP11B2 transcription activation. Additionally, we generated a stable H295R cell line expressing CYP11B2 promoter/luciferase chimeric reporter construct. Based on these observations, we are going to develop novel anti-hypertensive drugs.
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