The establishment of the system to evaluate the effect of CNP on skeletal dysplasia by using iPS cells
| Project/Area Number |
22591009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kyoto University |
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Principal Investigator |
MIURA Masako 京都大学, 医学研究科, 特定講師 (80437235)
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| Co-Investigator(Renkei-kenkyūsha) |
YASODA Akihiro 京都大学, 医学研究科, 講師 (50378642)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 内分泌学 / 骨代謝 / 低身長 / 軟骨 / 再生医療 / iPS細胞 / C型ナトリウム利尿ペプチド |
|---|
| Research Abstract |
In this study, we have tried to establish the system to evaluate the effects of CNP on iPS cells derived from skeletal dysplasia patients with dwarfism. First, we developed the culture method to induce chondrocytes from undifferentiated iPS cells in vitro. Second, we succeeded in generating iPS cells from the patient of achondroplasia. In our induction system, CNP promoted the chondrogenic differentiation of iPS cells from healthy donors. Now we are investigating the effects of CNP on the iPS cells derived from achondroplasia patient.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Human induced pluripotent stem cells differentiated into chondrogenic lineage via generation of mesenchymal progenitor cells2013
Author(s)
Koyama, N., Miura, M., Nakao, K., Kondo, E., Fujii, T., Taura, D., Kanamoto, N., Sone, M., Yasoda, A., Arai, H., Bessho, K., Nakao, K.
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Journal Title
Stem Cells and Development
Volume: 22(1)
Issue: 1
Pages: 102-113
DOI
Related Report
Peer Reviewed
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[Journal Article] The effects of C-type natriuretic peptide on craniofacial skeletogenesis2013
Author(s)
Nakao K, Okubo Y, Yasoda A, Koyama N, Osawa K, Isobe Y, Kondo E, Fujii T, Miura M, Nakao K, Bessho K
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Journal Title
J Dent Res
Volume: 92(1)
Issue: 1
Pages: 58-64
DOI
Related Report
Peer Reviewed
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[Journal Article] Human induced pluripotent stem cells differentiated into chondrogenic lineage via generation of mesenchymal progenitor cells.2013
Author(s)
Koyama N, Miura M, Nakao K, Kondo E, Fujii T, Taura D, Kanamoto N, Sone M, Yasoda A, Arai H, Bessho K, Nakao K.
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Journal Title
Stem Cells Dev.
Volume: 22(1)
Pages: 102-113
Related Report
Peer Reviewed
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[Journal Article] The Effects of C-type Natriuretic Peptide on Craniofacial Skeletogenesis.2013
Author(s)
Nakao K, Okubo Y, Yasoda A, Koyama N, Osawa K, Isobe Y, Kondo E, Fujii T, Miura M, Nakao K, Bessho K.
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Journal Title
J Dent Res.
Volume: 92(1)
Pages: 58-64
Related Report
Peer Reviewed
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[Journal Article] A case of myelolipoma with bilateral adrenal hyperaldosteronism cured after unilateral adrenalectomy2012
Author(s)
Inuzuka M, Tamura N, Sone M, Taura D, Sonoyama T, Honda K, Kojima K, Fukuda Y, Ueda Y, Yamashita Y, Kondo E, Yamada G, Fujii T, Miura M, Kanamoto N, Yasoda A, Arai H, Mikami Y, Sasano H, Nakao K
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Journal Title
Intern Med
Volume: 51(5)
Pages: 479-85
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] Skeletal Analysis of the Long Bone Abnormality (lbab/lbab)Mouse, A Novel Chondrodysplastic C-Type Natriuretic Peptide Mutant2012
Author(s)
Kondo E, Yasoda A, Tsuji T, Fujii T, Miura M, Kanamoto N, Tamura N, Arai H, Kunieda T, Nakao K
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Journal Title
Calcif Tissue Int
Volume: 90(4)
Pages: 307-318
NAID
Related Report
Peer Reviewed
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[Journal Article] A case of myelolipoma with bilateral adrenal hyperaldosteronism cured after unilateral adrenalectomy2012
Author(s)
Inuzuka M, Tamura N, Sone M, Taura D, Sonoyama T, Honda K, Kojima K, Fukuda Y, Ueda Y, Yamashita Y, Kondo E, Yamada G, Fujii T, Miura_M, Kanamoto N, Yasoda A, Arai H, Mikami Y, Sasano H, Nakao K
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Journal Title
Intern Med
Volume: 51(5)
Pages: 479-485
NAID
Related Report
Peer Reviewed
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[Journal Article] Skeletal Analysis of the Long Bone Abnormality (lbab/lbab) Mouse, A Novel Chondrodysplastic C-Type Natriuretic Peptide Mutant2012
Author(s)
Nambu T, Mori K, Shinoto Y, Izumi R, Matsuo K, Kanai Y, Kanamoto N, Miura M, Yonemitsu S, Yasoda A, Muro S, Arai H, Oki S, Nakao K
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Significance of adrenocorticotropin stimulation test in the diagnosis of an aldosterone-producing adenoma2011
Author(s)
Sonoyama T, Sone M, Miyashita K, Tamura N, Yamahara K, Park K, Oyamada N, Taura D, Inuzuka M, Kojima K, Honda K, Fukunaga Y, Kanamoto N, Miura M, Yasoda A, Arai H, Itoh H, Nakao K
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Journal Title
J Clin Endocrinol Metab
Volume: 96(9)
Issue: 9
Pages: 2771-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Significance of adrenocorticotropin stimulation test in the diagnosis of an aldosterone-producing adenoma2011
Author(s)
Sonoyama T, Sone M, Miyashita K, Tamura N, Yamahara K Park K, Oyamada N, Taura D, Inuzuka M, Kojima K, Honda K, Fukunaga Y, Kanamoto N, Miura M, Yasoda A, Arai H, Itoh H, Nakao K
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Journal Title
J Clin Endocrinol Metab
Volume: 96(9)
Pages: 2771-2778
Related Report
Peer Reviewed
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[Journal Article] Molecular characterization of tumors from a transgenic mouse adrenal tumor model: comparison with human pheochromocytoma2010
Author(s)
Hattori Y, Kanamoto N, Kawano K, Iwakura H, Sone M, Miura M, Yasoda A, Tamura N, Arai H, Akamizu T, Nakao K, Maitani Y
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Journal Title
Int J Oncol
Volume: 37(3)
Pages: 695-705
URL
Related Report
Peer Reviewed
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