The role of chemerin in the development of diabetes

• Project/Area Number: 22591012
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Kobe University
• Principal Investigator: TAKAHASHI Michiko 神戸大学, 医学研究科, 医学研究員 (70570274)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Yutaka 神戸大学, 医学研究科, 講師 (70301281)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 糖尿病 / アディポカイン / ケマリン / Chemerin / 糖代謝 / インスリン分泌 / MafA

Research Abstract

We identified chemerin as a novel adipokine (FEBS letters2008 582: 573-578). We further analyzed the physiological function of chemerin using chemeirn-deficient mice. We have shown that chemerin regulates ・-cell function and plays an important role in glucose homeostasis in a tissue-dependent manner （ Scientific Reports2011 1 123 DOI:10.1038/srep00123 . We have also demonstrated that serum chemerin concentrations are associated with the development of diabetes in humans (Endocrine J2012 60 37).

Research Products

• [Journal Article] Efficacy of combined octreotide and cabergoline treatment in patients with acromegaly: a retrospective clinical study and review of the literature (2013)
  • Author(s): SudaK, Inoshita N, Iguchi G, Fukuoka H, Takahashi M, Nishizawa H, Yamamoto M, Yamada S, Takahashi Y
  • Journal Title: Endocrine J Volume: 60 Pages: 507-515
  • NAID: 10031170640
  • Peer Reviewed
• [Journal Article] Efficacy of combined octreotide and cabergoline treatment in patients with acromegaly: a retrospective clinical study and review of the literature. (2013)
  • Author(s): Suda K, Inoshita N, Iguchi G, Fukuoka H, Takahashi M, Nishizawa H, Yamamoto M, Yamada S, Takahashi Y
  • Journal Title: Endocrine J Volume: 60 Pages: 507-515
  • NAID: 10031170640
  • Peer Reviewed
• [Journal Article] IGF-I enhances cellular senescence via the reactive oxygen species-p53 pathway (2012)
  • Author(s): Handayaningshi AE, Takahashi M,Fukuoka H, Iguchi G, Nishizawa H, Yamamoto M, Suda K, Takahashi Y
  • Journal Title: Biochem Biophys Res Commun Volume: 425 Pages: 478-84
  • Peer Reviewed
• [Journal Article] Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism (2012)
  • Author(s): Takahashi M, Inomata S, Okimura Y, IguchiG, FukuokaH, Miyake K, Koga D, Akamatsu S, Kasuga M, Takahashi Y
  • Journal Title: Endocrine J Volume: 60 Pages: 37-44
  • NAID: 10031156720
  • Peer Reviewed
• [Journal Article] GH-independent IGF-I action is essential to prevent the development of nonalcoholic steatohepatitis in a GH-deficient rat model. (2012)
  • Author(s): Nishizawa H, Takahashi M, Fukuoka H, Iguchi G, Kitazawa R, Takahashi Y
  • Journal Title: Biochem Biophys Res Commun. Volume: 423 Pages: 295-300
  • Peer Reviewed
• [Journal Article] Nonalcoholic fatty liver disease in adult hypopituitary patients with growth hormone deficiency and the impact of growth hormone replacement therapy (2012)
  • Author(s): Nishizawa H, Iguchi G, Murawaki A, Fukuoka H, Hayashi Y, Kaji H, Yamamoto M, Suda K, Takahashi M, Seo Y, Yano Y, Kitazawa R, Kitazawa S, Koga M, Okimura Y, Chihara K, Takahashi Y
  • Journal Title: Eur J Endocrinol Volume: 167 Pages: 67-74
  • Peer Reviewed
• [Journal Article] Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans (2012)
  • Author(s): Nishizawa H, Handayaningsih AE, Iguchi G, Cho Y, Takahashi M, Yamamoto M, Suda K, Kasahara K, Hakuno F, Yamanouchi K, Nishihara M, Seino S, Takahashi S, Takahashi Y
  • Journal Title: Growth Horm IGF Res Volume: 22(2) Pages: 64-8
  • Peer Reviewed
• [Journal Article] Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism. (2012)
  • Author(s): Takahashi M, Inomata S, Okimura Y, Iguchi G, Fukuoka H, Miyake K, Koga D, Akamatsu S, Kasuga M, Takahashi Y.
  • Journal Title: Endocrine J Volume: 60 Pages: 37-44
  • NAID: 10031156720
  • Peer Reviewed
• [Journal Article] AIP mutation identified in a patient with acromegaly caused by pituitary somatotroph adenoma with neuronal choristoma. (2012)
  • Author(s): Nishizawa H, Fukuoka H, Iguchi G, Inoshita N, Yamada S, Takahashi Y.
  • Journal Title: Experimental and Clinical Endocrinology & Diabetes Volume: 120 Pages: 1-5
  • Peer Reviewed
• [Journal Article] IGF-I enhances cellular senescence via the reactive oxygen species-p53 pathway. (2012)
  • Author(s): Handayaningshi AE, Takahashi M, Fukuoka H, Iguchi G, Nishizawa H, Yamamoto M, Suda K, Takahashi Y.
  • Journal Title: Biochem Biophys Res Commun Volume: 425 Pages: 478-84
  • Peer Reviewed
• [Journal Article] GH-independent IGF-I action is essential to prevent the development of nonalcoholic steatohepatitis in a GH-deficient rat model. (2012)
  • Author(s): Nishizawa H, Takahashi M, Fukuoka H, Iguchi G, Kitazawa R, Takahashi Y.
  • Journal Title: Biochem Biophys Res Commun Volume: 423 Pages: 295-300
  • Peer Reviewed
• [Journal Article] Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans. (2012)
  • Author(s): Nishizawa S, Handayanings ih AE, Iguchi G, Cho Y, Takahashi M, Yamamoto M, Suda K, Kasahara K, Fumihiko H, Yamanouchi K, Nishihara M, Seino S, Takahashi SI, Takahashi Y.
  • Journal Title: Growth Hormone and IGF-I Research Volume: 22 Pages: 64-68
  • Peer Reviewed
• [Journal Article] Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans (2012)
  • Author(s): Nishizawa M, et al
  • Journal Title: Growth Hormone and IGF-I Research Volume: (In press)(掲載確定)
  • Peer Reviewed
• [Journal Article] 先端巨大症 (2012)
  • Author(s): 高橋裕
  • Journal Title: 今日の臨床サポート Volume: (総説)(In press)(掲載確定)
• [Journal Article] 小児内分泌疾患のトランジション (2012)
  • Author(s): 高橋裕
  • Journal Title: 小児科診療 Volume: (総説)(In press)(掲載確定)
• [Journal Article] 症例に学ぶNASH/NAFLDの診断と治療:成人成長ホルモン分泌不全症にNASHが合併し成長ホルモンが著効した症例 (2012)
  • Author(s): 高橋裕
  • Journal Title: 診断と治療別冊 Volume: (In press)(掲載確定)
• [Journal Article] 自己抗体研究の新展開:内分泌領域の自己抗体研究の進歩 (2012)
  • Author(s): 高橋裕
  • Journal Title: 臨床化学 Volume: (総説)(In press)(掲載確定)
• [Journal Article] 内分泌疾患-疑うヒントと専門医へ紹介するポイント-先端巨大症 (2012)
  • Author(s): 高橋裕
  • Journal Title: 診断と治療 Volume: (総説)(In press)(掲載確定)
• [Journal Article] 知っておきたい内科症候群、抗PIT-1抗体症候群 (2012)
  • Author(s): 高橋裕
  • Journal Title: 内科別冊 Volume: (総説)(In press)(掲載確定)
• [Journal Article] 下垂体機能低下症を呈する新たな疾患概念、抗PIT-1抗体症候群 (2012)
  • Author(s): 高橋裕、井口元三
  • Journal Title: 成長・代謝 Volume: (総説)(In press)(掲載確定)
• [Journal Article] 新たな疾患概念「抗PIT-1抗体症候群」 (2012)
  • Author(s): 高橋裕
  • Journal Title: バイオクリニカ Volume: (In press)(掲載確定)
• [Journal Article] Chemerin regulates β-cell function in mice. (2011)
  • Author(s): Takahashi M, Okimura Y, Iguchi G, Nishizawa H, Yamamoto M, Suda K, Kitazawa R, Fujimoto W, Takahashi K, Zolotaryov FN, Hong KS, Kiyonari H, Abe T, Kaji H, Kitazawa S, Kasuga M, Chihara K, Takahashi Y.
  • Journal Title: Scientific Reports Volume: 1 Issue: 1 Pages: 123-123
  • DOI: 10.1038/srep00123
  • Peer Reviewed
• [Journal Article] Reactive oxygen species play an essential role in IGF-I signaling and IGF-I-induced myocyte hypertrophy in C2C12 myocytes (2011)
  • Author(s): Handayaningshi AE, Iguchi G, Fukuoka H, Nishizawa H, Takahashi M, Yamamoto M, Herningtyas HE, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y
  • Journal Title: Endocrinology Volume: 152 Pages: 912-21
  • Peer Reviewed
• [Journal Article] Adult combined GH, prolactin and TSH deficiency associated with circulating PIT-1 antibody in humans (2011)
  • Author(s): Yamamoto M, Iguchi G, Takeno R, Okimura Y, Sano S, Takahashi M, Nishizawa H, Handayaningshi AE, Fukuoka H, Tobita M, Saitoh T, Tojo T, Mokubo A, Morinobu A, Iida K, Kaji H, Seino S, Chihara K, Takahashi Y
  • Journal Title: J Clin Invest Volume: 121 Pages: 113-9
  • NAID: 120004754212
  • Peer Reviewed
• [Journal Article] A Case of Primary Aldosteronism Caused by Multiple Adrenocortical Macronodules (2011)
  • Author(s): Hashimoto N, et al
  • Journal Title: Internal Medicine Volume: 50 Issue: 6 Pages: 585-590
  • DOI: 10.2169/internalmedicine.50.4280
  • NAID: 130000649890
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] CKDと成長ホルモン (2011)
  • Author(s): 高橋裕
  • Journal Title: ホルモンと臨床 Volume: 58(総説) Pages: 1-4
• [Journal Article] 視床下部腫瘍 (2011)
  • Author(s): 高橋裕
  • Journal Title: 日本臨床増刊号 Volume: 69(総説) Pages: 142-145
• [Journal Article] 成人GH分泌不全症の成人期管理 (2011)
  • Author(s): 高橋裕
  • Journal Title: ホルモンと臨床 Volume: 58(総説) Pages: 41-45
• [Journal Article] 遺伝学的解析から明らかになる内分泌代謝系と寿命調節 (2011)
  • Author(s): 高橋裕
  • Journal Title: 成長・代謝 Volume: 2(総説) Pages: 3-4
• [Journal Article] 抗PIT-1抗体症候群 (2011)
  • Author(s): 井口元三、山本雅昭、高橋裕
  • Journal Title: 内分泌・糖尿病科 Volume: 33(総説) Pages: 240-246
• [Journal Article] Circulating level of chemerin is upregulated in psoriasis. (2010)
  • Author(s): Nakajima H, Nakajima K, Nagano Y, Yamamoto M, Tarutani M, Takahashi M, Takahashi Y, Sano S
  • Journal Title: J Dermatol Sci Volume: 60 Pages: 45-47
  • NAID: 10027473682
  • Peer Reviewed
• [Journal Article] IGF-I stimulates reactive oxygen species (ROS) production and inhibits insulin-dependent glucose uptake via ROS in 3T3-L1 adipocytes (2010)
  • Author(s): Fukuoka H, Iida K, Nishizawa H, Imanaka M, Takeno R, Iguchi G, Takahashi M, Okimura Y, Kaji H, Chihara K, Takahashi Y
  • Journal Title: Growth Horm IGF Res Volume: 20 Pages: 212-219
  • Peer Reviewed
• [Journal Article] IGF-I stimulates reactive oxygen species (ROS) production and inhibits insulin-dependent glucose uptake via ROS in 3T3-L1 adipocytes. (2010)
  • Author(s): Fukuoka H, et al
  • Journal Title: Growth Horm IGF Res Volume: 20 Pages: 212-219
  • Peer Reviewed
• [Journal Article] Reactive oxygen species play an essential role in IGF-I signaling and IGF-I-induced myocyte hypertrophy in C2C12 myocytes
  • Author(s): Handayaningshi AE, et al
  • Journal Title: Endocrinology Volume: (In press)
  • Peer Reviewed
• [Presentation] サブクリニカル機能性下垂体腺腫の病態 (2013)
  • Author(s): 高橋 裕
  • Organizer: 第23回日本間脳下垂体腫瘍学
  • Place of Presentation: 鹿児島 県民交流センター
  • Invited
• [Presentation] 新規アディポカイン、ケマリンの発見と病態生理学的意義の解明(基調講演) (2012)
  • Author(s): 高橋 裕
  • Organizer: 第9回 GPCR 研究会
  • Place of Presentation: 東京、日本科学未来館
  • Year and Date: 2012-05-12
• [Presentation] 新たな疾患概念の提唱とホルモンの発見-抗 PIT-1 抗体症候群と新規アディポカイン、ケマリン-(特別講演) (2012)
  • Author(s): 高橋 裕
  • Organizer: 第6回四国先端糖尿病研究会
  • Place of Presentation: 香川、ロイヤルパークホテル高松
  • Year and Date: 2012-03-10
• [Presentation] 成長ホルモン、IGF-Iの肝臓における生理的意義と治療応用 (2012)
  • Author(s): 高橋裕
  • Organizer: 第4回Pacific pituitary forum
  • Place of Presentation: ロイヤルパークホテル高松(香川県)(特別講演)(招待講演)
  • Year and Date: 2012-03-10
• [Presentation] 成長ホルモン、IGF-Iの肝臓における生理的意義と治療応用 (2012)
  • Author(s): 高橋裕
  • Organizer: 第4回Pacific pituitary forum
  • Place of Presentation: 新横浜プリンスホテル(神奈川県)(特別講演)(招待講演)
  • Year and Date: 2012-03-03
• [Presentation] 成人GH分泌不全症におけるNAFLD/NASH発症を防止するためのGH補充療法 (2012)
  • Author(s): 高橋裕
  • Organizer: 第22回日本間脳下垂体腫瘍学会
  • Place of Presentation: 東京ステーションコンファレンス(東京都)(シンポジウム)(招待講演)
  • Year and Date: 2012-02-25
• [Presentation] 成長ホルモン、IGF-Iの肝臓における新たな作用と治療応用 (2012)
  • Author(s): 高橋裕
  • Organizer: 第21回臨床内分泌代謝:Update
  • Place of Presentation: 浜松アクトシティ(静岡県)(イブニングセミナー)(招待講演)
  • Year and Date: 2012-01-27
• [Presentation] GH、IGF-Iの肝臓における新たな作用の解明 (2012)
  • Author(s): 高橋裕、福岡秀規、井口元三
  • Organizer: 間脳下垂体機能障害に関する調査研究(難治性疾患克服研究事業班会議)
  • Place of Presentation: 東京アステラス製薬本社(東京都)(招待講演)
  • Year and Date: 2012-01-06
• [Presentation] A novel missense mutation of AIPgene in a patient with octreotide-resistant non-familial gigantism. (2012)
  • Author(s): Fukuoka H, IguchiG, Suda K, Yamamoto M, Nishizawa H, Takahashi M, Seino S, Yamada S, Takahashi Y
  • Organizer: The 94th Annual Meeting of the Endocrine Society
  • Place of Presentation: Houston, USA
• [Presentation] SOCS2 missense mutation identified in a patient with gigantism without GH producing pituitary tumor. (2012)
  • Author(s): Suda K, Iguchi G, Fukuoka H, Yamamoto M, Nishizawa H, Takahashi M, Seino S, Takahashi Y.
  • Organizer: The 6th international congress of the GRS and the IGF society
  • Place of Presentation: Houston, USA (Travel grant)
• [Presentation] IGF-I prevents the development of hepatic fibrosis in nonalcoholic steatohepatitis via regulating oxidative stress and inactivating the hepatic stellate cells. (2012)
  • Author(s): Nishizawa H, Iguchi G, Fukuoka H, Suda K, Yamamoto M, Takahashi M, Seino S, Takahashi Y
  • Organizer: The 6thinternational congress of the GRS and the IGF society
  • Place of Presentation: Houston, USA (Travel grant)
• [Presentation] Sirt1 negatively regulates IGF-I production by growth hormone via deacetylation of Stat5 in liver (2012)
  • Author(s): Yamamoto M, Iguchi G, Fukuoka H, Takahashi M, Nishizawa H, Suda K, Seino S, Takahashi Y.
  • Organizer: The 6thinternational congress of the GRS and the IGF society
  • Place of Presentation: Houston, USA (Travel grant, poster prize)
• [Presentation] The essential role of GH/IGF-I in liver. (plenary lecture) (2012)
  • Author(s): Yutaka Takahashi
  • Organizer: The 5th international congress of the GRS and the IGF society
  • Place of Presentation: Gasteig, Munich
  • Invited
• [Presentation] A novel missense mutation of AIP gene in a patient with octreotide-resistant non-familial gigantism. (2012)
  • Author(s): Fukuoka H, Iguchi G, Suda K, Yamamoto M, Nishizawa H, Takahashi M, Seino S, Yamada S, Takahashi Y.
  • Organizer: The 94th Annual Meeting of the Endocrine Society
  • Place of Presentation: Houston convention center
• [Presentation] IGF-I prevents the development of hepatic fibrosis in nonalcoholic steatohepatitis via regulating oxidative stress and inactivating the hepatic stellate cells. (2012)
  • Author(s): Nishizawa H, Iguchi G, Fukuoka H, Suda K, Yamamoto M, Takahashi M, Seino S, Takahashi Y.
  • Organizer: The 94th Annual Meeting of the Endocrine Society
  • Place of Presentation: Houston convention center
• [Presentation] 新しい下垂体の病気の発見とその意義 (2011)
  • Author(s): 高橋裕
  • Organizer: 間脳下垂体機能障害に関する調査研究(難治性疾患克服研究事業班会議)
  • Place of Presentation: 名古屋大学医学部(愛知県)(市民公開講座)(招待講演)
  • Year and Date: 2011-12-06
• [Presentation] 下垂体機能低下症をきたす新たな疾患概念後天性GH,PEL,TSH欠損症 (2011)
  • Author(s): 高橋裕
  • Organizer: 第38回日本神経内分泌学会学術集会
  • Place of Presentation: 東京都道府県会館(東京都)(ランチョンセミナー)(招待講演)
  • Year and Date: 2011-11-25
• [Presentation] 先端巨大症update基礎 (2011)
  • Author(s): 高橋裕
  • Organizer: アクロメガリーフォーラム
  • Place of Presentation: 東京プリンスホテル(東京都)(シンポジウム)(招待講演)
  • Year and Date: 2011-11-05
• [Presentation] 下垂体機能低下症をきたす新たな疾患概念後天性GH,PRL,TSH欠損症 (2011)
  • Author(s): 高橋裕
  • Organizer: 第11回日本内分泌学会九州地方会
  • Place of Presentation: 福岡大学医学部(福岡県)(特別講演)(招待講演)
  • Year and Date: 2011-08-27
• [Presentation] GH-IGF-I系、Sirt1による寿命調節機構とその意義について考える (2011)
  • Author(s): 高橋裕
  • Organizer: GH/IGF-I & Longevity Meeting 2011
  • Place of Presentation: アキバホール(東京都)(招待講演)
  • Year and Date: 2011-07-02
• [Presentation] GH and IGF-I ameliorate liver steatosis and fibrosis in nonal coholic steatohepatitis mouse model (2011)
  • Author(s): Nishizawa H, et al
  • Organizer: The 93th Annual Meeting of the Endocrine Society
  • Place of Presentation: Boston convention center (USA)
  • Year and Date: 2011-06-04
• [Presentation] A case of gigantism associated with a missense mutation in SOCS2 gene (2011)
  • Author(s): Suda K, et al
  • Organizer: The 93th Annual Meeting of the Endocrine Society
  • Place of Presentation: Boston convention center (USA)
  • Year and Date: 2011-06-04
• [Presentation] Novel autoimmune polyendocrine syndrome : Adult combined GH, prolactin and TSH deficiency associated with circulating PIT-1 antibody (2011)
  • Author(s): Takahashi Y, et al
  • Organizer: The 93th Annual Meeting of the Endocrine Society
  • Place of Presentation: Boston convention center (USA)
  • Year and Date: 2011-06-04
• [Presentation] 寿命、代謝を制御する成長ホルモン/IGF-IとNAFLD/NASHの密接な関係 (2011)
  • Author(s): 高橋裕
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 京都国際会館(京都府)(シンポジウム)(招待講演)
  • Year and Date: 2011-05-28
• [Presentation] 成人GHDの合併症としてのNAFLD/NASH-臨床的意義、メカニズムと臨床応用 (2011)
  • Author(s): 高橋裕
  • Organizer: 第83回日本内分泌学会学術総会
  • Place of Presentation: 神戸国際会議場(兵庫県)(シンポジウム)(招待講演)
  • Year and Date: 2011-04-22
• [Presentation] GH産生腫瘍を合併したPANCHの一例 (2011)
  • Author(s): 西沢衝, ら
  • Organizer: 第20回臨床内分泌代謝Update
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2011-01-28
• [Presentation] 先端巨大症におけるOctreotide LARとPegvisomant併用療法の検討 (2011)
  • Author(s): 山本雅昭, ら
  • Organizer: 第20回臨床内分泌代謝Update
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2011-01-28
• [Presentation] 先端巨大症におけるOctreotide LARとカベルゴリン併用療法の検討 (2011)
  • Author(s): 隅田健太郎, ら
  • Organizer: 第20回臨床内分泌代謝Update
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2011-01-28
• [Presentation] GH and IGF-I ameliorate liver steatosis and fibrosis in nonalcoholic steatohepatitis mouse model. (2011)
  • Author(s): Nishizawa H, Iguchi G, Takahashi M, Yamamoto M, Suda S, Okimura Y, Kaji K, Chihara K, Takahashi Y.
  • Organizer: The 93th Annual Meeting of the Endocrine Society
  • Place of Presentation: Boston, USA
• [Presentation] A case of gigantism associated with a missense mutation in SOCS2gene (2011)
  • Author(s): Suda K, Iguchi G, Yamamoto M, Handayaningsih AE, Nishizawa H, Takahashi M, Okimura Y, Kaji K, Chihara K, Takahashi Y.
  • Organizer: The 93th Annual Meeting of the Endocrine Society
  • Place of Presentation: Boston, USA (Abstract award)
• [Presentation] Novel autoimmune polyendocrine syndrome: Adult combined GH,prolactin and TSH deficiency associated with circulating PIT-1 antibody. (2011)
  • Author(s): Takahashi Y, Yamamoto M, Iguchi G, Takeno R, Okimura Y, Sano T, Takahashi M, Nishizawa H, Handayaningsih AE, Tojo K, Mokubo A, Iida K, Kaji K, Chihara K
  • Organizer: The 93th Annual Meeting of the Endocrine Society
  • Place of Presentation: Boston, USA
• [Presentation] Sirtl negatively regulates IGF-I production by growth hormone in hepatocytes (2010)
  • Author(s): Yamamoto M, et al
  • Organizer: The 5^<th> international congress of the GRS and the IGF society
  • Place of Presentation: ニューヨーク(アメリカ)
  • Year and Date: 2010-10-05
• [Presentation] Sirt1 negatively regulates IGF-I production by growth hormone in hepatocytes (2010)
  • Author(s): Yamamoto M, IguchiG, Fukuoka H, Takahashi M, Nishizawa H, Handayaningsih AE, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y
  • Organizer: The 5thinternational congress of the GRS and the IGF society
  • Place of Presentation: New York, USA
• [Presentation] Sirt1 negatively regulates IGF-I production by growth hormone in hepatocytes (2010)
  • Author(s): Yamamoto M, IguchiG, Fukuoka H, Takahashi M, Nishizawa H, Handayaningsih AE, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y
  • Organizer: The 14th International Congress of Endocrinology
  • Place of Presentation: Japan, Kyoto
• [Presentation] IGF-1 induces cellular senescence via reactive oxygen species in vascular smooth muscle cells. (2010)
  • Author(s): Handayaningsih AE, IguchiG, Fukuoka H, Nishizawa H, Yamamoto M, Herningtyas H, Takahashi M, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y.
  • Organizer: The 14th International Congress of Endocrinology
  • Place of Presentation: Japan, Kyoto
• [Presentation] GH and IGF-Iameliorate inflammation and fibrosis in nonalcoholic steatohepatitis mouse model (2010)
  • Author(s): Nishizawa H, IguchiG, Takahashi M, Yamamoto M, Handayaningsih AE, Kitazawa R, Okimura Y, Kaji H, Kitazawa S, Hayashi Y, Chihara K, Seino S, Takahashi Y.
  • Organizer: The 14th International Congress of Endocrinology
  • Place of Presentation: Japan, Kyoto
• [Book] 代謝・内分泌疾患診療最新ガイドライン成人 GH 分泌不全症 (2012)
  • Author(s): 高橋 裕
  • Publisher: 総合医学社
• [Book] 下垂体診療マニュアル 成長ホルモン (2012)
  • Author(s): 高橋 裕
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 先端巨大症 (2012)
  • Author(s): 高橋 裕
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 成人 GH 分泌不全症 (2012)
  • Author(s): 高橋 裕
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル ドーパミンアゴニストと心臓弁膜症 (2012)
  • Author(s): 高橋 裕
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 抗 PIT-1 抗体症候群 (2012)
  • Author(s): 井口元三、高橋 裕
  • Total Pages: 185
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 下垂体の転写因子 (2012)
  • Author(s): 井口元三、高橋 裕
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 下垂体茎断裂症候群 (2012)
  • Author(s): 井口元三、高橋 裕
  • Publisher: 診断と治療社
• [Book] 下垂体診療マニュアル 特定疾患治療研究事業の対象7疾患の概略 (2012)
  • Author(s): 高橋 裕
  • Total Pages: 41
  • Publisher: 診断と治療社
• [Book] 小児内分泌疾患のトランジション(総説) (2012)
  • Author(s): 高橋 裕
  • Publisher: 小児科診療
• [Book] 症例に学ぶ NASH/NAFLD の診断と治療:成人成長ホルモン分泌不全症に NASH が合併し成長ホルモンが著効した症例 (2012)
  • Author(s): 高橋 裕
  • Publisher: 診断と治療
• [Book] 自己抗体研究の新展開:内分泌領域の自己抗体研究の進歩(総説) (2012)
  • Author(s): 高橋 裕
  • Publisher: 臨床化学
• [Book] 内分泌疾患-疑うヒントと専門医へ紹介するポイント-先端巨大症(総説) (2012)
  • Author(s): 高橋 裕
  • Publisher: 診断と治療
• [Book] 知っておきたい内科症候群、抗 PIT-1 抗体症候群(総説) (2012)
  • Author(s): 高橋 裕、井口元三
  • Publisher: 内科6
• [Book] 新たな疾患概念「抗 PIT-1 抗体症候群」 (2012)
  • Author(s): 高橋 裕、山本雅昭、井口元三
  • Publisher: バイオクリニカ
• [Book] 美和小児期から成人期へ:GH 分泌不全症の移行期診療を考える (2012)
  • Author(s): 島津 章、香川 二郎、都 研一、高橋 裕、堀川 玲子、高野 幸路、中村 明枝、沼倉 周彦、北中 幸子、長崎 啓祐、河野 斉
  • Publisher: 内分泌・糖尿病・代謝内科
• [Book] 成人 GH 分泌不全症 (2012)
  • Author(s): 高橋 裕
  • Total Pages: 275
  • Publisher: からだの科学
• [Book] 代謝・内分泌疾患診療最新ガイドライン、成人GH分泌不全症 (2012)
  • Author(s): 高橋裕
  • Publisher: 総合医学社(In press)
• [Book] 下垂体診療マニュアル、成長ホルモン (2012)
  • Author(s): 高橋裕
  • Publisher: 診断と治療社(In press)
• [Book] 下垂体診療マニュアル、先端巨大症 (2012)
  • Author(s): 高橋裕
  • Publisher: 診断と治療社(In press)
• [Book] 下垂体診療マニュアル、成人GH分泌不全症 (2012)
  • Author(s): 高橋裕
  • Publisher: 診断と治療社(In press)
• [Book] 下垂体診療マニュアル、ドーパミンアゴニストと心臓弁膜症 (2012)
  • Author(s): 高橋裕
  • Publisher: 診断と治療社(In press)
• [Book] 下垂体診療マニュアル、特定疾患治療研究事業の対象7疾患の概略 (2012)
  • Author(s): 高橋裕
  • Publisher: 診断と治療社(In press)
• [Book] 下垂体診療マニュアル、抗PIT-1抗体症候群 (2012)
  • Author(s): 井口元三、高橋裕
  • Publisher: 診断と治療社(In press)
• [Book] 下垂体診療マニュアル、下垂体の転写因子 (2012)
  • Author(s): 井口元三、高橋裕
  • Publisher: 診断と治療社(In press)
• [Book] 下垂体診療マニュアル、下垂体茎断裂症候群 (2012)
  • Author(s): 井口元三、高橋裕
  • Publisher: 診断と治療社(In press)
• [Book] CKD と成長ホルモン(総説) (2011)
  • Author(s): 高橋 裕
  • Publisher: ホルモンと臨床
• [Book] 視床下部腫瘍(総説) (2011)
  • Author(s): 高橋 裕
  • Publisher: 日本臨床
• [Book] ホルモンと臨床 (2011)
  • Author(s): 高橋 裕
  • Publisher: 成人 GH 分泌不全症の成人期管理(総説)
• [Book] 抗 PIT-1抗体症候群(総説) (2011)
  • Author(s): 井口元三、山本雅昭、高橋 裕
  • Publisher: 内分 泌・糖尿 病科
• [Book] 成人 GH 分泌不全症と GH 補充療法(総説) (2010)
  • Author(s): 高橋 裕
  • Publisher: Annual Review:糖尿病・代謝・内分泌
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/im2/doctor/activity/acti-04.html
• [Remarks] 神戸大学大学院医学研究科糖尿病内分泌内科学 神経内分泌グループ
  • URL: http://www.med.kobe-u.ac.jp/im2/doctor/activity/acti-04.html
• [Remarks]
  • URL: http://mdl.oops.jp/kobe-diabetes/doctor/activity/acti-04.html
• [Patent(Industrial Property Rights)] 糖尿病治療剤 (2013)
  • Inventor(s): 高橋裕、千原和夫
  • Industrial Property Rights Holder: 神戸大学、日本ケミカルリサーチ株式会社
  • Acquisition Date: 2013-03-01
• [Patent(Industrial Property Rights)] 糖尿病の診断方法 (2008)
  • Inventor(s): 高橋裕、千原和夫、古賀大輔
  • Industrial Property Rights Holder: 神戸大学、大塚製薬株式会社
  • Filing Date: 2008-01-17