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The role of chemerin in the development of diabetes

Research Project

Project/Area Number 22591012
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionKobe University

Principal Investigator

TAKAHASHI Michiko  神戸大学, 医学研究科, 医学研究員 (70570274)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Yutaka  神戸大学, 医学研究科, 講師 (70301281)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords糖尿病 / アディポカイン / ケマリン / Chemerin / 糖代謝 / インスリン分泌 / MafA
Research Abstract

We identified chemerin as a novel adipokine (FEBS letters2008 582: 573-578). We further analyzed the physiological function of chemerin using chemeirn-deficient mice. We have shown that chemerin regulates ・-cell function and plays an important role in glucose homeostasis in a tissue-dependent manner ( Scientific Reports2011 1 123 DOI:10.1038/srep00123 . We have also demonstrated that serum chemerin concentrations are associated with the development of diabetes in humans (Endocrine J2012 60 37).

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (106 results)

All 2013 2012 2011 2010 2008 Other

All Journal Article (34 results) (of which Peer Reviewed: 21 results) Presentation (36 results) (of which Invited: 2 results) Book (31 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Efficacy of combined octreotide and cabergoline treatment in patients with acromegaly: a retrospective clinical study and review of the literature2013

    • Author(s)
      SudaK, Inoshita N, Iguchi G, Fukuoka H, Takahashi M, Nishizawa H, Yamamoto M, Yamada S, Takahashi Y
    • Journal Title

      Endocrine J

      Volume: 60 Pages: 507-515

    • NAID

      10031170640

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of combined octreotide and cabergoline treatment in patients with acromegaly: a retrospective clinical study and review of the literature.2013

    • Author(s)
      Suda K, Inoshita N, Iguchi G, Fukuoka H, Takahashi M, Nishizawa H, Yamamoto M, Yamada S, Takahashi Y
    • Journal Title

      Endocrine J

      Volume: 60 Pages: 507-515

    • NAID

      10031170640

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IGF-I enhances cellular senescence via the reactive oxygen species-p53 pathway2012

    • Author(s)
      Handayaningshi AE, Takahashi M,Fukuoka H, Iguchi G, Nishizawa H, Yamamoto M, Suda K, Takahashi Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 425 Pages: 478-84

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism2012

    • Author(s)
      Takahashi M, Inomata S, Okimura Y, IguchiG, FukuokaH, Miyake K, Koga D, Akamatsu S, Kasuga M, Takahashi Y
    • Journal Title

      Endocrine J

      Volume: 60 Pages: 37-44

    • NAID

      10031156720

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] GH-independent IGF-I action is essential to prevent the development of nonalcoholic steatohepatitis in a GH-deficient rat model.2012

    • Author(s)
      Nishizawa H, Takahashi M, Fukuoka H, Iguchi G, Kitazawa R, Takahashi Y
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 423 Pages: 295-300

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nonalcoholic fatty liver disease in adult hypopituitary patients with growth hormone deficiency and the impact of growth hormone replacement therapy2012

    • Author(s)
      Nishizawa H, Iguchi G, Murawaki A, Fukuoka H, Hayashi Y, Kaji H, Yamamoto M, Suda K, Takahashi M, Seo Y, Yano Y, Kitazawa R, Kitazawa S, Koga M, Okimura Y, Chihara K, Takahashi Y
    • Journal Title

      Eur J Endocrinol

      Volume: 167 Pages: 67-74

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans2012

    • Author(s)
      Nishizawa H, Handayaningsih AE, Iguchi G, Cho Y, Takahashi M, Yamamoto M, Suda K, Kasahara K, Hakuno F, Yamanouchi K, Nishihara M, Seino S, Takahashi S, Takahashi Y
    • Journal Title

      Growth Horm IGF Res

      Volume: 22(2) Pages: 64-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism.2012

    • Author(s)
      Takahashi M, Inomata S, Okimura Y, Iguchi G, Fukuoka H, Miyake K, Koga D, Akamatsu S, Kasuga M, Takahashi Y.
    • Journal Title

      Endocrine J

      Volume: 60 Pages: 37-44

    • NAID

      10031156720

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AIP mutation identified in a patient with acromegaly caused by pituitary somatotroph adenoma with neuronal choristoma.2012

    • Author(s)
      Nishizawa H, Fukuoka H, Iguchi G, Inoshita N, Yamada S, Takahashi Y.
    • Journal Title

      Experimental and Clinical Endocrinology & Diabetes

      Volume: 120 Pages: 1-5

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IGF-I enhances cellular senescence via the reactive oxygen species-p53 pathway.2012

    • Author(s)
      Handayaningshi AE, Takahashi M, Fukuoka H, Iguchi G, Nishizawa H, Yamamoto M, Suda K, Takahashi Y.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 425 Pages: 478-84

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GH-independent IGF-I action is essential to prevent the development of nonalcoholic steatohepatitis in a GH-deficient rat model.2012

    • Author(s)
      Nishizawa H, Takahashi M, Fukuoka H, Iguchi G, Kitazawa R, Takahashi Y.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 423 Pages: 295-300

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans.2012

    • Author(s)
      Nishizawa S, Handayanings ih AE, Iguchi G, Cho Y, Takahashi M, Yamamoto M, Suda K, Kasahara K, Fumihiko H, Yamanouchi K, Nishihara M, Seino S, Takahashi SI, Takahashi Y.
    • Journal Title

      Growth Hormone and IGF-I Research

      Volume: 22 Pages: 64-68

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced oxidative stress in GH-transgenic rat and acromegaly in humans2012

    • Author(s)
      Nishizawa M, et al
    • Journal Title

      Growth Hormone and IGF-I Research

      Volume: (In press)(掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 先端巨大症2012

    • Author(s)
      高橋裕
    • Journal Title

      今日の臨床サポート

      Volume: (総説)(In press)(掲載確定)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 小児内分泌疾患のトランジション2012

    • Author(s)
      高橋裕
    • Journal Title

      小児科診療

      Volume: (総説)(In press)(掲載確定)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 症例に学ぶNASH/NAFLDの診断と治療:成人成長ホルモン分泌不全症にNASHが合併し成長ホルモンが著効した症例2012

    • Author(s)
      高橋裕
    • Journal Title

      診断と治療別冊

      Volume: (In press)(掲載確定)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 自己抗体研究の新展開:内分泌領域の自己抗体研究の進歩2012

    • Author(s)
      高橋裕
    • Journal Title

      臨床化学

      Volume: (総説)(In press)(掲載確定)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 内分泌疾患-疑うヒントと専門医へ紹介するポイント-先端巨大症2012

    • Author(s)
      高橋裕
    • Journal Title

      診断と治療

      Volume: (総説)(In press)(掲載確定)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 知っておきたい内科症候群、抗PIT-1抗体症候群2012

    • Author(s)
      高橋裕
    • Journal Title

      内科別冊

      Volume: (総説)(In press)(掲載確定)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 下垂体機能低下症を呈する新たな疾患概念、抗PIT-1抗体症候群2012

    • Author(s)
      高橋裕、井口元三
    • Journal Title

      成長・代謝

      Volume: (総説)(In press)(掲載確定)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 新たな疾患概念「抗PIT-1抗体症候群」2012

    • Author(s)
      高橋裕
    • Journal Title

      バイオクリニカ

      Volume: (In press)(掲載確定)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Chemerin regulates β-cell function in mice.2011

    • Author(s)
      Takahashi M, Okimura Y, Iguchi G, Nishizawa H, Yamamoto M, Suda K, Kitazawa R, Fujimoto W, Takahashi K, Zolotaryov FN, Hong KS, Kiyonari H, Abe T, Kaji H, Kitazawa S, Kasuga M, Chihara K, Takahashi Y.
    • Journal Title

      Scientific Reports

      Volume: 1 Issue: 1 Pages: 123-123

    • DOI

      10.1038/srep00123

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactive oxygen species play an essential role in IGF-I signaling and IGF-I-induced myocyte hypertrophy in C2C12 myocytes2011

    • Author(s)
      Handayaningshi AE, Iguchi G, Fukuoka H, Nishizawa H, Takahashi M, Yamamoto M, Herningtyas HE, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y
    • Journal Title

      Endocrinology

      Volume: 152 Pages: 912-21

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adult combined GH, prolactin and TSH deficiency associated with circulating PIT-1 antibody in humans2011

    • Author(s)
      Yamamoto M, Iguchi G, Takeno R, Okimura Y, Sano S, Takahashi M, Nishizawa H, Handayaningshi AE, Fukuoka H, Tobita M, Saitoh T, Tojo T, Mokubo A, Morinobu A, Iida K, Kaji H, Seino S, Chihara K, Takahashi Y
    • Journal Title

      J Clin Invest

      Volume: 121 Pages: 113-9

    • NAID

      120004754212

    • Related Report
      2012 Final Research Report 2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Case of Primary Aldosteronism Caused by Multiple Adrenocortical Macronodules2011

    • Author(s)
      Hashimoto N, et al
    • Journal Title

      Internal Medicine

      Volume: 50 Issue: 6 Pages: 585-590

    • DOI

      10.2169/internalmedicine.50.4280

    • NAID

      130000649890

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CKDと成長ホルモン2011

    • Author(s)
      高橋裕
    • Journal Title

      ホルモンと臨床

      Volume: 58(総説) Pages: 1-4

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 視床下部腫瘍2011

    • Author(s)
      高橋裕
    • Journal Title

      日本臨床増刊号

      Volume: 69(総説) Pages: 142-145

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 成人GH分泌不全症の成人期管理2011

    • Author(s)
      高橋裕
    • Journal Title

      ホルモンと臨床

      Volume: 58(総説) Pages: 41-45

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 遺伝学的解析から明らかになる内分泌代謝系と寿命調節2011

    • Author(s)
      高橋裕
    • Journal Title

      成長・代謝

      Volume: 2(総説) Pages: 3-4

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 抗PIT-1抗体症候群2011

    • Author(s)
      井口元三、山本雅昭、高橋裕
    • Journal Title

      内分泌・糖尿病科

      Volume: 33(総説) Pages: 240-246

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Circulating level of chemerin is upregulated in psoriasis.2010

    • Author(s)
      Nakajima H, Nakajima K, Nagano Y, Yamamoto M, Tarutani M, Takahashi M, Takahashi Y, Sano S
    • Journal Title

      J Dermatol Sci

      Volume: 60 Pages: 45-47

    • NAID

      10027473682

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IGF-I stimulates reactive oxygen species (ROS) production and inhibits insulin-dependent glucose uptake via ROS in 3T3-L1 adipocytes2010

    • Author(s)
      Fukuoka H, Iida K, Nishizawa H, Imanaka M, Takeno R, Iguchi G, Takahashi M, Okimura Y, Kaji H, Chihara K, Takahashi Y
    • Journal Title

      Growth Horm IGF Res

      Volume: 20 Pages: 212-219

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IGF-I stimulates reactive oxygen species (ROS) production and inhibits insulin-dependent glucose uptake via ROS in 3T3-L1 adipocytes.2010

    • Author(s)
      Fukuoka H, et al
    • Journal Title

      Growth Horm IGF Res

      Volume: 20 Pages: 212-219

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactive oxygen species play an essential role in IGF-I signaling and IGF-I-induced myocyte hypertrophy in C2C12 myocytes

    • Author(s)
      Handayaningshi AE, et al
    • Journal Title

      Endocrinology

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] サブクリニカル機能性下垂体腺腫の病態2013

    • Author(s)
      高橋 裕
    • Organizer
      第23回日本間脳下垂体腫瘍学
    • Place of Presentation
      鹿児島 県民交流センター
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 新規アディポカイン、ケマリンの発見と病態生理学的意義の解明(基調講演)2012

    • Author(s)
      高橋 裕
    • Organizer
      第9回 GPCR 研究会
    • Place of Presentation
      東京、日本科学未来館
    • Year and Date
      2012-05-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 新たな疾患概念の提唱とホルモンの発見-抗 PIT-1 抗体症候群と新規アディポカイン、ケマリン-(特別講演)2012

    • Author(s)
      高橋 裕
    • Organizer
      第6回四国先端糖尿病研究会
    • Place of Presentation
      香川、ロイヤルパークホテル高松
    • Year and Date
      2012-03-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 成長ホルモン、IGF-Iの肝臓における生理的意義と治療応用2012

    • Author(s)
      高橋裕
    • Organizer
      第4回Pacific pituitary forum
    • Place of Presentation
      ロイヤルパークホテル高松(香川県)(特別講演)(招待講演)
    • Year and Date
      2012-03-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 成長ホルモン、IGF-Iの肝臓における生理的意義と治療応用2012

    • Author(s)
      高橋裕
    • Organizer
      第4回Pacific pituitary forum
    • Place of Presentation
      新横浜プリンスホテル(神奈川県)(特別講演)(招待講演)
    • Year and Date
      2012-03-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 成人GH分泌不全症におけるNAFLD/NASH発症を防止するためのGH補充療法2012

    • Author(s)
      高橋裕
    • Organizer
      第22回日本間脳下垂体腫瘍学会
    • Place of Presentation
      東京ステーションコンファレンス(東京都)(シンポジウム)(招待講演)
    • Year and Date
      2012-02-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 成長ホルモン、IGF-Iの肝臓における新たな作用と治療応用2012

    • Author(s)
      高橋裕
    • Organizer
      第21回臨床内分泌代謝:Update
    • Place of Presentation
      浜松アクトシティ(静岡県)(イブニングセミナー)(招待講演)
    • Year and Date
      2012-01-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] GH、IGF-Iの肝臓における新たな作用の解明2012

    • Author(s)
      高橋裕、福岡秀規、井口元三
    • Organizer
      間脳下垂体機能障害に関する調査研究(難治性疾患克服研究事業班会議)
    • Place of Presentation
      東京アステラス製薬本社(東京都)(招待講演)
    • Year and Date
      2012-01-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] A novel missense mutation of AIPgene in a patient with octreotide-resistant non-familial gigantism.2012

    • Author(s)
      Fukuoka H, IguchiG, Suda K, Yamamoto M, Nishizawa H, Takahashi M, Seino S, Yamada S, Takahashi Y
    • Organizer
      The 94th Annual Meeting of the Endocrine Society
    • Place of Presentation
      Houston, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] SOCS2 missense mutation identified in a patient with gigantism without GH producing pituitary tumor.2012

    • Author(s)
      Suda K, Iguchi G, Fukuoka H, Yamamoto M, Nishizawa H, Takahashi M, Seino S, Takahashi Y.
    • Organizer
      The 6th international congress of the GRS and the IGF society
    • Place of Presentation
      Houston, USA (Travel grant)
    • Related Report
      2012 Final Research Report
  • [Presentation] IGF-I prevents the development of hepatic fibrosis in nonalcoholic steatohepatitis via regulating oxidative stress and inactivating the hepatic stellate cells.2012

    • Author(s)
      Nishizawa H, Iguchi G, Fukuoka H, Suda K, Yamamoto M, Takahashi M, Seino S, Takahashi Y
    • Organizer
      The 6thinternational congress of the GRS and the IGF society
    • Place of Presentation
      Houston, USA (Travel grant)
    • Related Report
      2012 Final Research Report
  • [Presentation] Sirt1 negatively regulates IGF-I production by growth hormone via deacetylation of Stat5 in liver2012

    • Author(s)
      Yamamoto M, Iguchi G, Fukuoka H, Takahashi M, Nishizawa H, Suda K, Seino S, Takahashi Y.
    • Organizer
      The 6thinternational congress of the GRS and the IGF society
    • Place of Presentation
      Houston, USA (Travel grant, poster prize)
    • Related Report
      2012 Final Research Report
  • [Presentation] The essential role of GH/IGF-I in liver. (plenary lecture)2012

    • Author(s)
      Yutaka Takahashi
    • Organizer
      The 5th international congress of the GRS and the IGF society
    • Place of Presentation
      Gasteig, Munich
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] A novel missense mutation of AIP gene in a patient with octreotide-resistant non-familial gigantism.2012

    • Author(s)
      Fukuoka H, Iguchi G, Suda K, Yamamoto M, Nishizawa H, Takahashi M, Seino S, Yamada S, Takahashi Y.
    • Organizer
      The 94th Annual Meeting of the Endocrine Society
    • Place of Presentation
      Houston convention center
    • Related Report
      2012 Annual Research Report
  • [Presentation] IGF-I prevents the development of hepatic fibrosis in nonalcoholic steatohepatitis via regulating oxidative stress and inactivating the hepatic stellate cells.2012

    • Author(s)
      Nishizawa H, Iguchi G, Fukuoka H, Suda K, Yamamoto M, Takahashi M, Seino S, Takahashi Y.
    • Organizer
      The 94th Annual Meeting of the Endocrine Society
    • Place of Presentation
      Houston convention center
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新しい下垂体の病気の発見とその意義2011

    • Author(s)
      高橋裕
    • Organizer
      間脳下垂体機能障害に関する調査研究(難治性疾患克服研究事業班会議)
    • Place of Presentation
      名古屋大学医学部(愛知県)(市民公開講座)(招待講演)
    • Year and Date
      2011-12-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 下垂体機能低下症をきたす新たな疾患概念後天性GH,PEL,TSH欠損症2011

    • Author(s)
      高橋裕
    • Organizer
      第38回日本神経内分泌学会学術集会
    • Place of Presentation
      東京都道府県会館(東京都)(ランチョンセミナー)(招待講演)
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 先端巨大症update基礎2011

    • Author(s)
      高橋裕
    • Organizer
      アクロメガリーフォーラム
    • Place of Presentation
      東京プリンスホテル(東京都)(シンポジウム)(招待講演)
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 下垂体機能低下症をきたす新たな疾患概念後天性GH,PRL,TSH欠損症2011

    • Author(s)
      高橋裕
    • Organizer
      第11回日本内分泌学会九州地方会
    • Place of Presentation
      福岡大学医学部(福岡県)(特別講演)(招待講演)
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] GH-IGF-I系、Sirt1による寿命調節機構とその意義について考える2011

    • Author(s)
      高橋裕
    • Organizer
      GH/IGF-I & Longevity Meeting 2011
    • Place of Presentation
      アキバホール(東京都)(招待講演)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] GH and IGF-I ameliorate liver steatosis and fibrosis in nonal coholic steatohepatitis mouse model2011

    • Author(s)
      Nishizawa H, et al
    • Organizer
      The 93th Annual Meeting of the Endocrine Society
    • Place of Presentation
      Boston convention center (USA)
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] A case of gigantism associated with a missense mutation in SOCS2 gene2011

    • Author(s)
      Suda K, et al
    • Organizer
      The 93th Annual Meeting of the Endocrine Society
    • Place of Presentation
      Boston convention center (USA)
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel autoimmune polyendocrine syndrome : Adult combined GH, prolactin and TSH deficiency associated with circulating PIT-1 antibody2011

    • Author(s)
      Takahashi Y, et al
    • Organizer
      The 93th Annual Meeting of the Endocrine Society
    • Place of Presentation
      Boston convention center (USA)
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 寿命、代謝を制御する成長ホルモン/IGF-IとNAFLD/NASHの密接な関係2011

    • Author(s)
      高橋裕
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都国際会館(京都府)(シンポジウム)(招待講演)
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 成人GHDの合併症としてのNAFLD/NASH-臨床的意義、メカニズムと臨床応用2011

    • Author(s)
      高橋裕
    • Organizer
      第83回日本内分泌学会学術総会
    • Place of Presentation
      神戸国際会議場(兵庫県)(シンポジウム)(招待講演)
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] GH産生腫瘍を合併したPANCHの一例2011

    • Author(s)
      西沢衝, ら
    • Organizer
      第20回臨床内分泌代謝Update
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-01-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 先端巨大症におけるOctreotide LARとPegvisomant併用療法の検討2011

    • Author(s)
      山本雅昭, ら
    • Organizer
      第20回臨床内分泌代謝Update
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-01-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 先端巨大症におけるOctreotide LARとカベルゴリン併用療法の検討2011

    • Author(s)
      隅田健太郎, ら
    • Organizer
      第20回臨床内分泌代謝Update
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-01-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] GH and IGF-I ameliorate liver steatosis and fibrosis in nonalcoholic steatohepatitis mouse model.2011

    • Author(s)
      Nishizawa H, Iguchi G, Takahashi M, Yamamoto M, Suda S, Okimura Y, Kaji K, Chihara K, Takahashi Y.
    • Organizer
      The 93th Annual Meeting of the Endocrine Society
    • Place of Presentation
      Boston, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] A case of gigantism associated with a missense mutation in SOCS2gene2011

    • Author(s)
      Suda K, Iguchi G, Yamamoto M, Handayaningsih AE, Nishizawa H, Takahashi M, Okimura Y, Kaji K, Chihara K, Takahashi Y.
    • Organizer
      The 93th Annual Meeting of the Endocrine Society
    • Place of Presentation
      Boston, USA (Abstract award)
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel autoimmune polyendocrine syndrome: Adult combined GH,prolactin and TSH deficiency associated with circulating PIT-1 antibody.2011

    • Author(s)
      Takahashi Y, Yamamoto M, Iguchi G, Takeno R, Okimura Y, Sano T, Takahashi M, Nishizawa H, Handayaningsih AE, Tojo K, Mokubo A, Iida K, Kaji K, Chihara K
    • Organizer
      The 93th Annual Meeting of the Endocrine Society
    • Place of Presentation
      Boston, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Sirtl negatively regulates IGF-I production by growth hormone in hepatocytes2010

    • Author(s)
      Yamamoto M, et al
    • Organizer
      The 5^<th> international congress of the GRS and the IGF society
    • Place of Presentation
      ニューヨーク(アメリカ)
    • Year and Date
      2010-10-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sirt1 negatively regulates IGF-I production by growth hormone in hepatocytes2010

    • Author(s)
      Yamamoto M, IguchiG, Fukuoka H, Takahashi M, Nishizawa H, Handayaningsih AE, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y
    • Organizer
      The 5thinternational congress of the GRS and the IGF society
    • Place of Presentation
      New York, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Sirt1 negatively regulates IGF-I production by growth hormone in hepatocytes2010

    • Author(s)
      Yamamoto M, IguchiG, Fukuoka H, Takahashi M, Nishizawa H, Handayaningsih AE, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y
    • Organizer
      The 14th International Congress of Endocrinology
    • Place of Presentation
      Japan, Kyoto
    • Related Report
      2012 Final Research Report
  • [Presentation] IGF-1 induces cellular senescence via reactive oxygen species in vascular smooth muscle cells.2010

    • Author(s)
      Handayaningsih AE, IguchiG, Fukuoka H, Nishizawa H, Yamamoto M, Herningtyas H, Takahashi M, Okimura Y, Kaji H, Chihara K, Seino S, Takahashi Y.
    • Organizer
      The 14th International Congress of Endocrinology
    • Place of Presentation
      Japan, Kyoto
    • Related Report
      2012 Final Research Report
  • [Presentation] GH and IGF-Iameliorate inflammation and fibrosis in nonalcoholic steatohepatitis mouse model2010

    • Author(s)
      Nishizawa H, IguchiG, Takahashi M, Yamamoto M, Handayaningsih AE, Kitazawa R, Okimura Y, Kaji H, Kitazawa S, Hayashi Y, Chihara K, Seino S, Takahashi Y.
    • Organizer
      The 14th International Congress of Endocrinology
    • Place of Presentation
      Japan, Kyoto
    • Related Report
      2012 Final Research Report
  • [Book] 代謝・内分泌疾患診療最新ガイドライン成人 GH 分泌不全症2012

    • Author(s)
      高橋 裕
    • Publisher
      総合医学社
    • Related Report
      2012 Final Research Report
  • [Book] 下垂体診療マニュアル 成長ホルモン2012

    • Author(s)
      高橋 裕
    • Publisher
      診断と治療社
    • Related Report
      2012 Final Research Report
  • [Book] 下垂体診療マニュアル 先端巨大症2012

    • Author(s)
      高橋 裕
    • Publisher
      診断と治療社
    • Related Report
      2012 Final Research Report
  • [Book] 下垂体診療マニュアル 成人 GH 分泌不全症2012

    • Author(s)
      高橋 裕
    • Publisher
      診断と治療社
    • Related Report
      2012 Final Research Report
  • [Book] 下垂体診療マニュアル ドーパミンアゴニストと心臓弁膜症2012

    • Author(s)
      高橋 裕
    • Publisher
      診断と治療社
    • Related Report
      2012 Final Research Report
  • [Book] 下垂体診療マニュアル 抗 PIT-1 抗体症候群2012

    • Author(s)
      井口元三、高橋 裕
    • Total Pages
      185
    • Publisher
      診断と治療社
    • Related Report
      2012 Final Research Report
  • [Book] 下垂体診療マニュアル 下垂体の転写因子2012

    • Author(s)
      井口元三、高橋 裕
    • Publisher
      診断と治療社
    • Related Report
      2012 Final Research Report
  • [Book] 下垂体診療マニュアル 下垂体茎断裂症候群2012

    • Author(s)
      井口元三、高橋 裕
    • Publisher
      診断と治療社
    • Related Report
      2012 Final Research Report
  • [Book] 下垂体診療マニュアル 特定疾患治療研究事業の対象7疾患の概略2012

    • Author(s)
      高橋 裕
    • Total Pages
      41
    • Publisher
      診断と治療社
    • Related Report
      2012 Final Research Report
  • [Book] 小児内分泌疾患のトランジション(総説)2012

    • Author(s)
      高橋 裕
    • Publisher
      小児科診療
    • Related Report
      2012 Final Research Report
  • [Book] 症例に学ぶ NASH/NAFLD の診断と治療:成人成長ホルモン分泌不全症に NASH が合併し成長ホルモンが著効した症例2012

    • Author(s)
      高橋 裕
    • Publisher
      診断と治療
    • Related Report
      2012 Final Research Report
  • [Book] 自己抗体研究の新展開:内分泌領域の自己抗体研究の進歩(総説)2012

    • Author(s)
      高橋 裕
    • Publisher
      臨床化学
    • Related Report
      2012 Final Research Report
  • [Book] 内分泌疾患-疑うヒントと専門医へ紹介するポイント-先端巨大症(総説)2012

    • Author(s)
      高橋 裕
    • Publisher
      診断と治療
    • Related Report
      2012 Final Research Report
  • [Book] 知っておきたい内科症候群、抗 PIT-1 抗体症候群(総説)2012

    • Author(s)
      高橋 裕、井口元三
    • Publisher
      内科6
    • Related Report
      2012 Final Research Report
  • [Book] 新たな疾患概念「抗 PIT-1 抗体症候群」2012

    • Author(s)
      高橋 裕、山本雅昭、井口元三
    • Publisher
      バイオクリニカ
    • Related Report
      2012 Final Research Report
  • [Book] 美和小児期から成人期へ:GH 分泌不全症の移行期診療を考える2012

    • Author(s)
      島津 章、香川 二郎、都 研一、高橋 裕、堀川 玲子、高野 幸路、中村 明枝、沼倉 周彦、北中 幸子、長崎 啓祐、河野 斉
    • Publisher
      内分泌・糖尿病・代謝内科
    • Related Report
      2012 Final Research Report
  • [Book] 成人 GH 分泌不全症2012

    • Author(s)
      高橋 裕
    • Total Pages
      275
    • Publisher
      からだの科学
    • Related Report
      2012 Final Research Report
  • [Book] 代謝・内分泌疾患診療最新ガイドライン、成人GH分泌不全症2012

    • Author(s)
      高橋裕
    • Publisher
      総合医学社(In press)
    • Related Report
      2011 Annual Research Report
  • [Book] 下垂体診療マニュアル、成長ホルモン2012

    • Author(s)
      高橋裕
    • Publisher
      診断と治療社(In press)
    • Related Report
      2011 Annual Research Report
  • [Book] 下垂体診療マニュアル、先端巨大症2012

    • Author(s)
      高橋裕
    • Publisher
      診断と治療社(In press)
    • Related Report
      2011 Annual Research Report
  • [Book] 下垂体診療マニュアル、成人GH分泌不全症2012

    • Author(s)
      高橋裕
    • Publisher
      診断と治療社(In press)
    • Related Report
      2011 Annual Research Report
  • [Book] 下垂体診療マニュアル、ドーパミンアゴニストと心臓弁膜症2012

    • Author(s)
      高橋裕
    • Publisher
      診断と治療社(In press)
    • Related Report
      2011 Annual Research Report
  • [Book] 下垂体診療マニュアル、特定疾患治療研究事業の対象7疾患の概略2012

    • Author(s)
      高橋裕
    • Publisher
      診断と治療社(In press)
    • Related Report
      2011 Annual Research Report
  • [Book] 下垂体診療マニュアル、抗PIT-1抗体症候群2012

    • Author(s)
      井口元三、高橋裕
    • Publisher
      診断と治療社(In press)
    • Related Report
      2011 Annual Research Report
  • [Book] 下垂体診療マニュアル、下垂体の転写因子2012

    • Author(s)
      井口元三、高橋裕
    • Publisher
      診断と治療社(In press)
    • Related Report
      2011 Annual Research Report
  • [Book] 下垂体診療マニュアル、下垂体茎断裂症候群2012

    • Author(s)
      井口元三、高橋裕
    • Publisher
      診断と治療社(In press)
    • Related Report
      2011 Annual Research Report
  • [Book] CKD と成長ホルモン(総説)2011

    • Author(s)
      高橋 裕
    • Publisher
      ホルモンと臨床
    • Related Report
      2012 Final Research Report
  • [Book] 視床下部腫瘍(総説)2011

    • Author(s)
      高橋 裕
    • Publisher
      日本臨床
    • Related Report
      2012 Final Research Report
  • [Book] ホルモンと臨床2011

    • Author(s)
      高橋 裕
    • Publisher
      成人 GH 分泌不全症の成人期管理(総説)
    • Related Report
      2012 Final Research Report
  • [Book] 抗 PIT-1抗体症候群(総説)2011

    • Author(s)
      井口元三、山本雅昭、高橋 裕
    • Publisher
      内分 泌・糖尿 病科
    • Related Report
      2012 Final Research Report
  • [Book] 成人 GH 分泌不全症と GH 補充療法(総説)2010

    • Author(s)
      高橋 裕
    • Publisher
      Annual Review:糖尿病・代謝・内分泌
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kobe-u.ac.jp/im2/doctor/activity/acti-04.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 神戸大学大学院医学研究科糖尿病内分泌内科学 神経内分泌グループ

    • URL

      http://www.med.kobe-u.ac.jp/im2/doctor/activity/acti-04.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://mdl.oops.jp/kobe-diabetes/doctor/activity/acti-04.html

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 糖尿病治療剤2013

    • Inventor(s)
      高橋裕、千原和夫
    • Industrial Property Rights Holder
      神戸大学、日本ケミカルリサーチ株式会社
    • Acquisition Date
      2013-03-01
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 糖尿病の診断方法2008

    • Inventor(s)
      高橋裕、千原和夫、古賀大輔
    • Industrial Property Rights Holder
      神戸大学、大塚製薬株式会社
    • Filing Date
      2008-01-17
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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