| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We investigated the characteristics of energy metabolism of diet resistant (DR) rats. There were no significant differences in energy intake and energy expenditure between DR and diet-induced obese (DIO) rats, whereas the body weights of DR rats were significantly lower than those of DIO rats. We analyzed gene expressions of mesenteric fat of DR rats and found high expressions of guanylin and its receptor; guanylyl cyclase C (GC-C) inthe macrophages of mesenteric fat of DR rats. Therefore, we developed guanylin/GC-C double transgenic (Tg) rats and showed that Tg rats also have diet-resistance. Our data indicate that guanylin/GC-C system in the macrophage may contribute to the regulation of lipid accumulation.
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