Investigation of molecular mechanism for energy metabolism of diet resistant rats
| Project/Area Number |
22591013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
DATE Yukari 宮崎大学, フロンティア科学実験総合センター, 教授 (70381100)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAZATO Mikiya 独立行政法人国立循環器病研究センター, 生化学部, 部長 (50291183)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | マクロファージ / メタボリック症候群 / 肥満 / 脂肪細胞 / 高脂肪食耐性動物 |
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| Research Abstract |
We investigated the characteristics of energy metabolism of diet resistant (DR) rats. There were no significant differences in energy intake and energy expenditure between DR and diet-induced obese (DIO) rats, whereas the body weights of DR rats were significantly lower than those of DIO rats. We analyzed gene expressions of mesenteric fat of DR rats and found high expressions of guanylin and its receptor; guanylyl cyclase C (GC-C) inthe macrophages of mesenteric fat of DR rats. Therefore, we developed guanylin/GC-C double transgenic (Tg) rats and showed that Tg rats also have diet-resistance. Our data indicate that guanylin/GC-C system in the macrophage may contribute to the regulation of lipid accumulation.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to high-fat diet2013
Author(s)
Akieda-Asai S, Sugiyama M, Miyazawa T, Koda S, Okano I, Senba K, Poleni PE, Hizukuri Y, Okamoto A, Yamahara K, Mutoh E, Aoyama F, Sawaguchi A, Furuya M, Miyazato M, Kangawa K, Date Y
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Journal Title
Journal of Lipid Research
Volume: 54
Pages: 85-96
Related Report
Peer Reviewed
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[Journal Article] Neuropeptide W : an anorectic peptide regulated by leptin and metabolicstate2010
Author(s)
Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F, Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S, Cone RD, Nakazato M.
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Journal Title
Endocrinology
Volume: 151
Pages: 2200-2210
Related Report
Peer Reviewed
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[Presentation] A new bioactive peptide and its receptor cascades prevent the accumulation of lipid droplets2011
Author(s)
Akieda-Asai S, Sugiyama M, Miyazawa T, Koda S, Okano I, Senba K, Poleni PE, Hizukuri Y, Okamoto A, Mutoh E, Furuya M, Miyazato M, Kangawa K, Date Y
Organizer
Keystone Symposia (Lipid Biology and Lipotoxicity)
Place of Presentation
アメリカ
Year and Date
2011-05-18
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