Exposure to Artificial Sweetener in Juvenile Mice Intensifies Addictionto High-Fat Diet and Exaggerates Leptin Resistance in Adulthood

• Project/Area Number: 22591014
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: University of the Ryukyus
• Principal Investigator: YABIKU Kouichi 琉球大学, 医学部附属病院, 講師 (70545748)
• Co-Investigator(Kenkyū-buntansha): MASUZAKI Hiroaki 琉球大学, 医学研究科, 教授 (00291899) ; TAKAYAMA Chitoshi 琉球大学, 医学研究科, 教授 (60197217) ; SHIMABUKURO Michio 琉球大学, 医学部附属病院, 講師 (60271144) ; KOUKI Tsuyoshi 琉球大学, 医学部附属病院, 講師 (80273415)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 肥満 / レプチン抵抗性 / 視床下部 / 視床下部小胞体ストレス / 分子シャペロン

Research Abstract

Artificial sweeteners during the juvenile period may increase susceptibility to diet-induced obesity in adulthood through the augmentation of ER stress in the hypothalamus. This was confirmed by co-administration of a chemical chaperone with artificial sweeteners, which attenuated hypothalamic ER stress and HFD preference in adulthood. In murine primary neuronal cells, artificial sweeteners substantially augmented the expression of ER stress-related genes, suggesting direct contribution of artificial sweeteners to hypothalamic ER stress.

Research Products

• [Journal Article] J Metab Synd (2010)
  • Author(s): Yabiku K, Ohshiro Y, Sunagawa S, Kozuka C, Taira S, Ueda R, Nakamoto K, Iwabuchi K, Yonaha M, Yamakawa K, Higa M, Shimabukuro M, Masuzaki H
  • Journal Title: J Metab Synd Volume: 7 Pages: 26-30
• [Presentation] 若齢期に対する人工甘味料曝露給餌によるレプチン抵抗性獲得と高尿酸血症の誘導高尿酸血症 (2010)
  • Author(s): 屋比久浩市(代表者)、大城譲、砂川澄人、小塚智沙代、平良伸一郎、植田玲、仲本桂子、岩渕敬子、與那覇恵、山川研、比嘉盛丈、島袋充生、高山千利、益崎裕章
  • Organizer: メタボリックシンドロームリサーチフォーラム第6回研究集会
  • Place of Presentation: 大阪府大阪市ホテルグランヴィア大阪
  • Year and Date: 2010-08-06
• [Presentation] 若齢期の人工甘味料曝露によるレプチン抵抗性獲得機構の解明 (2010)
  • Author(s): 屋比久浩市(代表者)、大城譲、砂川澄人、小塚智沙代、 幸喜毅、平良伸一郎、植田玲、仲本桂子、岩渕敬子、山川研、比嘉盛丈、島袋充生、高山千利、益崎裕章
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山県岡山市デジタルミュージアム
  • Year and Date: 2010-05-29
• [Presentation] 若齢期の人工甘味料曝露によるレプチン抵抗性獲得機構の解明 (2010)
  • Author(s): 屋比久浩市
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山市デジタルミュージアム4F
  • Year and Date: 2010-05-29