| Project/Area Number |
22591014
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | University of the Ryukyus |
|---|
Principal Investigator |
YABIKU Kouichi 琉球大学, 医学部附属病院, 講師 (70545748)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
MASUZAKI Hiroaki 琉球大学, 医学研究科, 教授 (00291899)
TAKAYAMA Chitoshi 琉球大学, 医学研究科, 教授 (60197217)
SHIMABUKURO Michio 琉球大学, 医学部附属病院, 講師 (60271144)
KOUKI Tsuyoshi 琉球大学, 医学部附属病院, 講師 (80273415)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肥満 / レプチン抵抗性 / 視床下部 / 視床下部小胞体ストレス / 分子シャペロン |
|---|
| Research Abstract |
Artificial sweeteners during the juvenile period may increase susceptibility to diet-induced obesity in adulthood through the augmentation of ER stress in the hypothalamus. This was confirmed by co-administration of a chemical chaperone with artificial sweeteners, which attenuated hypothalamic ER stress and HFD preference in adulthood. In murine primary neuronal cells, artificial sweeteners substantially augmented the expression of ER stress-related genes, suggesting direct contribution of artificial sweeteners to hypothalamic ER stress.
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