The role of stretch signal induced by the adipocytes hypertrophy and activation of Rho/Rho kinase pathway in the pathogenesis of obesity
| Project/Area Number |
22591017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Keio University |
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Principal Investigator |
WAKINO Shu 慶應義塾大学, 医学部, 講師 (50265823)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Hiroshi 慶應義塾大学, 医学部, 教授 (40252457)
TANABE Yoshiyuki 岩手医科大学, 薬学部, 准教授 (10275109)
SAITO Maki 岩手医科大学, 薬学部, 助教 (40365185)
TOKUYAMA Hiroumi 慶應義塾大学, 医学部, 講師 (50276250)
HARA Yoshikazu 慶應義塾大学, 医学部, 助教 (30383863)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 内科 / シグナル伝達 / 肥満 / Rhoキナーゼ / 脂肪組織 |
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| Research Abstract |
The development of obesity involves multiple mechanisms. Here we demonstrate adipocyte Rho/Rho-kinase as a culprit in obesity. In high fat diet (HFD)-fed mice, Rho-kinase inhibitor treatment prevented body weight gain and insulin resistance. Transgenic mi
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Role of mineralocorticoid receptor/Rho/Rho-kinase pathway in obesity-related renal injury2012
Author(s)
Tokuyama H, Wakino S, Hara Y, Washida N, Fujimura K, Hosoya K, Yoshioka K, Hasegawa K, Minakuchi H, Homma K, Hayashi K, Itoh H.
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Journal Title
Int J Obes
Volume: 36(8)
Pages: 1062-71
Related Report
Peer Reviewed
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[Journal Article] Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch.2011
Author(s)
Hara Y, Wakino S, Tanabe Y, Saito M, Tokuyama H, Washida N, Tatematsu S, Yoshioka K, Homma K, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Nakayama K, Itoh H.
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Journal Title
Science Signaling
Volume: 4(157)
Pages: 1-10
Related Report
Peer Reviewed
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[Journal Article] Itoh H Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch.2010
Author(s)
Hara Y, Wakino S, Tanabe Y, Saito M, Tokuyama H, Washida N, Tatematsu S, Yoshioka K, Homma K, Hasegawa K, Minakuchi H, Fujimura K, Hosoya K, Hayashi K, Nakayama K
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Journal Title
Science Signaling
Volume: 4(157)
Pages: 1-10
Related Report
Peer Reviewed
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[Presentation] 肥満関連腎症における腹部脂肪組織除去の有用性2011
Author(s)
徳山博文, 脇野修, 神田武志, 原義和, 鷲田直輝, 長谷川一宏, 水口斎, 藤村慶子, 本間康一郎, 林晃一, 伊藤裕
Organizer
第54回日本腎臓学会
Place of Presentation
パシフィコ横浜(神奈川)
Year and Date
2011-06-15
Related Report
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