Mineralocorticoid receptor-associated hypertension: molecular mechanisms and novel therapies
| Project/Area Number |
22591018
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Hiroshi 慶應義塾大学, 医学部, 教授 (40252457)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 内分泌学 / アルドステロン / ミネラルコルチコイド受容体 / ＰＫＣ |
|---|
| Research Abstract |
The present study investigated mechanisms for improvement of renal dysfunction and resistant hypertensionby administration of mineralocorticoid receptor antagonist in diabetes. The results showed that high glucose conditions activate protein kinase C (PKC
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Report
(4 results)
Research Products
(29 results)
