Mineralocorticoid receptor-associated hypertension: molecular mechanisms and novel therapies

• Project/Area Number: 22591018
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Keio University
• Principal Investigator: SHIBATA Hirotaka 慶應義塾大学, 医学部, 講師 (20245484)
• Co-Investigator(Kenkyū-buntansha): ITOH Hiroshi 慶應義塾大学, 医学部, 教授 (40252457)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 内分泌学 / アルドステロン / ミネラルコルチコイド受容体 / ＰＫＣ

Research Abstract

The present study investigated mechanisms for improvement of renal dysfunction and resistant hypertensionby administration of mineralocorticoid receptor antagonist in diabetes. The results showed that high glucose conditions activate protein kinase C (PKC

Research Products

• [Journal Article] Mineralocorticoid receptor-associated hypertension and its end-organ damage:clinical relevance for resistant hypertension. (2012)
  • Author(s): H.Shibata, H.Itoh.
  • Journal Title: Am J Hypertension Volume: 25 Issue: 5 Pages: 514-523
  • DOI: 10.1038/ajh.2011.245
  • Peer Reviewed
• [Journal Article] Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells. (2012)
  • Author(s): S.Monticone, H.Shibata, et al.
  • Journal Title: J Clin Endocrinol Metab Volume: 97 Issue: 8 Pages: 1567-1572
  • DOI: 10.1210/jc.2011-3132
  • Peer Reviewed
• [Journal Article] Oxidative stress-induced glomerular mineralocorticoid receptor activation olimits the benefit of salt reduction in Dahl salt-sensitive rats (2012)
  • Author(s): K.Kitada, H.Shibata, et al.
  • Journal Title: PLoS One Volume: 7 Issue: 7 Pages: e41896-e41896
  • DOI: 10.1371/journal.pone.0041896
  • Peer Reviewed
• [Journal Article] Risk factors for perioperative complications of laparoscopic adrenalectomy including single-site surgery. (2012)
  • Author(s): S.Hattori, H.Shibata, et al.
  • Journal Title: J Endourol Volume: 26 Issue: 11 Pages: 1463-1467
  • DOI: 10.1089/end.2012.0274
  • Peer Reviewed
• [Journal Article] Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells (2012)
  • Author(s): S.Monticone
  • Journal Title: Journal of Clinical Endocrinology and Metabolism Volume: 97 Pages: 1567-1572
  • Peer Reviewed
• [Journal Article] Oxidative stress-induced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats. (2012)
  • Author(s): K.Kitada
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] Risk factors for perioperative complications of laparoscopic adrenalectomy including single-site surgery (2012)
  • Author(s): S.Hattori
  • Journal Title: Journal of Endourology Volume: 26 Pages: 1463-1467
  • Peer Reviewed
• [Journal Article] Free cortisol/cortisone ratio in pooled urine was increased after rapid-ACTH stimulation test under dexamethasone suppression. (2011)
  • Author(s): Y.Koyama, H.Shibata, H.Itoh, et al.
  • Journal Title: Endocr J Volume: 58 Pages: 1099-1103
  • NAID: 10030392658
  • URL: http://dx.doi.org/10.1507/endocrj.EJ11-0021
  • Peer Reviewed
• [Journal Article] Guideline for the diagnosis and treatment of primary aldosteronism-The Japan Endocrine Society 2009- (2011)
  • Author(s): T.Nishikawa, H.Shibata, et al.
  • Journal Title: Endocr J Volume: 58 Pages: 711-721
  • NAID: 10029862542
  • URL: http://dx.doi.org/10.1507/endocrj.EJ11-0133
  • Peer Reviewed
• [Journal Article] Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1 (2011)
  • Author(s): N.Suda, H.Shibata, et al.
  • Journal Title: Endocrinology Volume: 152 Issue: 6 Pages: 2266-2277
  • DOI: 10.1210/en.2010-1232
  • Peer Reviewed
• [Journal Article] Guidelines for the diagnosis and treatment of primary aldosteronism -The Japan Endocrine Society 2009- (2011)
  • Author(s): Tetsuo Nishikawa
  • Journal Title: Endocrine Journal Volume: 58 Issue: 9 Pages: 711-721
  • DOI: 10.1507/endocrj.EJ11-0133
  • NAID: 130004443739
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed
• [Presentation] Clinical relevance of mineralocorticoid receptor-associated hypertension: a subtype of resistant hypertension (2012)
  • Author(s): H.Shibata
  • Organizer: A Satellite symposium of the 24thScientific Meeting of the International Society of Hypertension, Aldosterone & Salt: Heart and Kidney
  • Place of Presentation: Palm Cove, Australia
• [Presentation] ミネラルコルチコイド受容体関連高血圧におけるアルドステロン拮抗薬の使い分け (2012)
  • Author(s): 柴田洋孝
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: 名古屋
• [Presentation] 睡眠時無呼吸症候群とアルドステロン (2012)
  • Author(s): 柴田洋孝
  • Organizer: 第35回日本高血圧学会総会
  • Place of Presentation: 名古屋
• [Presentation] 治療抵抗性高血圧のサブタイプとしてのミネラルコルチコイド受容体関連高血圧の重要性 (2012)
  • Author(s): 柴田洋孝
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 糖尿病におけるミネラルコルチコイド受容体の活性化機構 (2012)
  • Author(s): 柴田洋孝
  • Organizer: 第85回日本内分泌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] ミネラルコルチコイド受容体関連高血圧におけるアルドステロン拮抗薬の使い分け (2012)
  • Author(s): 柴田洋孝
  • Organizer: 第３５回日本高血圧学会総会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 睡眠時無呼吸症候群とアルドステロン (2012)
  • Author(s): 柴田洋孝
  • Organizer: 第３５回日本高血圧学会総会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] Clinical relevance of mineralocorticoid receptor-associated hypertension: a subtype of resistant hypertension (2012)
  • Author(s): H.Shibata
  • Organizer: A satellite symposium of the 24th Scientific Meeting of the International Society of Hypertension, Aldosterone & Salt: Heart and Kidney
  • Place of Presentation: Palm Cove, Australia
  • Invited
• [Presentation] 治療抵抗性高血圧のサブタイプとしてのミネラルコルチコイド受容体関連高血圧の重要性 (2012)
  • Author(s): 柴田洋孝
  • Organizer: 第８５回日本内分泌学会学術総会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] 糖尿病におけるミネラルコルチコイド受容体の活性化機構 (2012)
  • Author(s): 柴田洋孝
  • Organizer: 第８５回日本内分泌学会学術総会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] High glucose treatment enhances mineralocorticoid receptor expression and its transcriptional activity through the PKCbeta activation (2011)
  • Author(s): T.Hayashi
  • Organizer: The 37^<th>International Aldosterone Conference
  • Place of Presentation: ボストン(米国)
• [Presentation] High glucose treatment enhances mineralocorticoid receptor expression and its transcriptional activity through the PKCbeta activation (2011)
  • Author(s): Takeshi Hayashi
  • Organizer: The 37^<th> International Aldosterone Conference 2011
  • Place of Presentation: Boston, U.S.A.
• [Presentation] 副腎静脈血中18-水酸化ステロイド測定は原発性アルドステロン症の病型診断に有用である (2010)
  • Author(s): 栗原 勲
  • Organizer: 第33回日本高血圧学会総会
  • Place of Presentation: 福岡国際会議場
• [Presentation] ミネラルコルチコイド受容体は栄養センサーとして高血圧の増悪因子となる:慢性高血糖状態における細胞内O-linked β-N-acetylglucosamine レベルの上昇との関連 (2010)
  • Author(s): 城 理絵
  • Organizer: 第33回日本高血圧学会総会
  • Place of Presentation: 福岡国際会議場
• [Presentation] マクロファージはミネラルコルチコイド受容体活性亢進因子を分泌してアルドステロン作用を増強する (2010)
  • Author(s): 林 毅
  • Organizer: 第33回日本高血圧学会総会
  • Place of Presentation: 福岡国際会議場
• [Presentation] ミネラルコルチコイド受容体は栄養センターとして高血圧の増悪因子となる:慢性高血糖状態における細胞内O-linked β-N-acetylglucosamineレベルの上昇との関連 (2010)
  • Author(s): 城理絵
  • Organizer: 第33回日本高血圧学会総会
  • Place of Presentation: 福岡国際会議場
• [Book] Annual Review糖尿病・代謝・内分泌2012 (2012)
  • Author(s): 柴田洋孝
  • Total Pages: 240
  • Publisher: 中外医学社
• [Book] 心血管内分泌検査から読み解く降圧薬俺流処方 (2012)
  • Author(s): 柴田洋孝
  • Total Pages: 160
  • Publisher: 南山堂