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Mineralocorticoid receptor-associated hypertension: molecular mechanisms and novel therapies

Research Project

Project/Area Number 22591018
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Endocrinology
Research InstitutionKeio University

Principal Investigator

SHIBATA Hirotaka  慶應義塾大学, 医学部, 講師 (20245484)

Co-Investigator(Kenkyū-buntansha) ITOH Hiroshi  慶應義塾大学, 医学部, 教授 (40252457)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords内分泌学 / アルドステロン / ミネラルコルチコイド受容体 / PKC
Research Abstract

The present study investigated mechanisms for improvement of renal dysfunction and resistant hypertensionby administration of mineralocorticoid receptor antagonist in diabetes. The results showed that high glucose conditions activate protein kinase C (PKC

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (29 results)

All 2012 2011 2010

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (16 results) (of which Invited: 5 results) Book (2 results)

  • [Journal Article] Mineralocorticoid receptor-associated hypertension and its end-organ damage:clinical relevance for resistant hypertension.2012

    • Author(s)
      H.Shibata, H.Itoh.
    • Journal Title

      Am J Hypertension

      Volume: 25 Issue: 5 Pages: 514-523

    • DOI

      10.1038/ajh.2011.245

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells.2012

    • Author(s)
      S.Monticone, H.Shibata, et al.
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 97 Issue: 8 Pages: 1567-1572

    • DOI

      10.1210/jc.2011-3132

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress-induced glomerular mineralocorticoid receptor activation olimits the benefit of salt reduction in Dahl salt-sensitive rats2012

    • Author(s)
      K.Kitada, H.Shibata, et al.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 7 Pages: e41896-e41896

    • DOI

      10.1371/journal.pone.0041896

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for perioperative complications of laparoscopic adrenalectomy including single-site surgery.2012

    • Author(s)
      S.Hattori, H.Shibata, et al.
    • Journal Title

      J Endourol

      Volume: 26 Issue: 11 Pages: 1463-1467

    • DOI

      10.1089/end.2012.0274

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells2012

    • Author(s)
      S.Monticone
    • Journal Title

      Journal of Clinical Endocrinology and Metabolism

      Volume: 97 Pages: 1567-1572

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress-induced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats.2012

    • Author(s)
      K.Kitada
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for perioperative complications of laparoscopic adrenalectomy including single-site surgery2012

    • Author(s)
      S.Hattori
    • Journal Title

      Journal of Endourology

      Volume: 26 Pages: 1463-1467

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Free cortisol/cortisone ratio in pooled urine was increased after rapid-ACTH stimulation test under dexamethasone suppression.2011

    • Author(s)
      Y.Koyama, H.Shibata, H.Itoh, et al.
    • Journal Title

      Endocr J

      Volume: 58 Pages: 1099-1103

    • NAID

      10030392658

    • URL

      http://dx.doi.org/10.1507/endocrj.EJ11-0021

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Guideline for the diagnosis and treatment of primary aldosteronism-The Japan Endocrine Society 2009-2011

    • Author(s)
      T.Nishikawa, H.Shibata, et al.
    • Journal Title

      Endocr J

      Volume: 58 Pages: 711-721

    • NAID

      10029862542

    • URL

      http://dx.doi.org/10.1507/endocrj.EJ11-0133

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS12011

    • Author(s)
      N.Suda, H.Shibata, et al.
    • Journal Title

      Endocrinology

      Volume: 152 Issue: 6 Pages: 2266-2277

    • DOI

      10.1210/en.2010-1232

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guidelines for the diagnosis and treatment of primary aldosteronism -The Japan Endocrine Society 2009-2011

    • Author(s)
      Tetsuo Nishikawa
    • Journal Title

      Endocrine Journal

      Volume: 58 Issue: 9 Pages: 711-721

    • DOI

      10.1507/endocrj.EJ11-0133

    • NAID

      130004443739

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Clinical relevance of mineralocorticoid receptor-associated hypertension: a subtype of resistant hypertension2012

    • Author(s)
      H.Shibata
    • Organizer
      A Satellite symposium of the 24thScientific Meeting of the International Society of Hypertension, Aldosterone & Salt: Heart and Kidney
    • Place of Presentation
      Palm Cove, Australia
    • Related Report
      2012 Final Research Report
  • [Presentation] ミネラルコルチコイド受容体関連高血圧におけるアルドステロン拮抗薬の使い分け2012

    • Author(s)
      柴田洋孝
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 睡眠時無呼吸症候群とアルドステロン2012

    • Author(s)
      柴田洋孝
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 治療抵抗性高血圧のサブタイプとしてのミネラルコルチコイド受容体関連高血圧の重要性2012

    • Author(s)
      柴田洋孝
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 糖尿病におけるミネラルコルチコイド受容体の活性化機構2012

    • Author(s)
      柴田洋孝
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] ミネラルコルチコイド受容体関連高血圧におけるアルドステロン拮抗薬の使い分け2012

    • Author(s)
      柴田洋孝
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 睡眠時無呼吸症候群とアルドステロン2012

    • Author(s)
      柴田洋孝
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Clinical relevance of mineralocorticoid receptor-associated hypertension: a subtype of resistant hypertension2012

    • Author(s)
      H.Shibata
    • Organizer
      A satellite symposium of the 24th Scientific Meeting of the International Society of Hypertension, Aldosterone & Salt: Heart and Kidney
    • Place of Presentation
      Palm Cove, Australia
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 治療抵抗性高血圧のサブタイプとしてのミネラルコルチコイド受容体関連高血圧の重要性2012

    • Author(s)
      柴田洋孝
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 糖尿病におけるミネラルコルチコイド受容体の活性化機構2012

    • Author(s)
      柴田洋孝
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] High glucose treatment enhances mineralocorticoid receptor expression and its transcriptional activity through the PKCbeta activation2011

    • Author(s)
      T.Hayashi
    • Organizer
      The 37^<th>International Aldosterone Conference
    • Place of Presentation
      ボストン(米国)
    • Related Report
      2012 Final Research Report
  • [Presentation] High glucose treatment enhances mineralocorticoid receptor expression and its transcriptional activity through the PKCbeta activation2011

    • Author(s)
      Takeshi Hayashi
    • Organizer
      The 37^<th> International Aldosterone Conference 2011
    • Place of Presentation
      Boston, U.S.A.
    • Related Report
      2011 Annual Research Report
  • [Presentation] 副腎静脈血中18-水酸化ステロイド測定は原発性アルドステロン症の病型診断に有用である2010

    • Author(s)
      栗原 勲
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] ミネラルコルチコイド受容体は栄養センサーとして高血圧の増悪因子となる:慢性高血糖状態における細胞内O-linked β-N-acetylglucosamine レベルの上昇との関連2010

    • Author(s)
      城 理絵
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Final Research Report
  • [Presentation] マクロファージはミネラルコルチコイド受容体活性亢進因子を分泌してアルドステロン作用を増強する2010

    • Author(s)
      林 毅
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] ミネラルコルチコイド受容体は栄養センターとして高血圧の増悪因子となる:慢性高血糖状態における細胞内O-linked β-N-acetylglucosamineレベルの上昇との関連2010

    • Author(s)
      城理絵
    • Organizer
      第33回日本高血圧学会総会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2010 Annual Research Report
  • [Book] Annual Review糖尿病・代謝・内分泌20122012

    • Author(s)
      柴田洋孝
    • Total Pages
      240
    • Publisher
      中外医学社
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Book] 心血管内分泌検査から読み解く降圧薬俺流処方2012

    • Author(s)
      柴田洋孝
    • Total Pages
      160
    • Publisher
      南山堂
    • Related Report
      2012 Annual Research Report 2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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