Studying the CBF leukemogenesis and developing anti-cancer agents
| Project/Area Number |
22591026
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University (2012)
The University of Tokyo (2010-2011) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 動物 / 癌 / 遺伝子 / RUNX1コンプレックス / HAT / 白血病マウス / CBF白血病 / AML1/RUNX1 / ノックアウトマウス |
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| Research Abstract |
RUNX1 Dominant Inhibition has been proposed as a central dogma of CBF leukemogenesis. The project has clarified that RUNX1 is required for CBF leukememogenesis and RUNX1 and HATs maybe good therapeutic targets.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Primary gastrointestinal follicular lymphoma with histological transformation.2012
Author(s)
Hangai S, Nakamura F, Kamikubo Y, Ichikawa M, Suzuki H, Yoshida S, Yamada A, Takazawa Y,Fukayama M, Koike K, Kurokawa M
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Journal Title
Related Report
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[Journal Article] Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples2012
Author(s)
Keiki Kumano, Shunya Arai, Masataka Hosoi, Kazuki Taoka , Naoya Takayama, Makoto Otsu, Genta Nagae, Koki Ueda, Kumi Nakazaki, Yasuhiko Kamikubo, Koji Eto, Hiroyuki Aburatani, Hiromitsu Nakauchi and Mineo Kurokawa
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Related Report
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[Journal Article] Crk-associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/Abl.2011
Author(s)
Sachiko Seo, Tetsuya Nakamoto, Masataka Takeshita, Jun Lu, Tomohiko Sato, Takahiro Suzuki, Yasuhiko Kamikubo, Motoshi Ichikawa, Masaki Noda, Seishi Ogawa, Hiroaki Honda, Hideaki Oda and Mineo Kurokawa
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Journal Title
NAID
Related Report
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[Journal Article] Composite diffuse large B-cell lymphoma and CD20-positive peripheral T-cell lymphoma.2011
Author(s)
Sho Yamazaki, Yosei Fujioka, Fumihiko Nakamura, Satoshi Ota, Aya Shinozaki, Go Yamamoto, Yasuhiko Kamikubo, Yasuhito Nannya, Motoshi Ichikawa, Masashi Fukayama, Mineo Kurokawa
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Journal Title
Pathol Int
Volume: 61
Pages: 662-6
NAID
Related Report
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[Journal Article] Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity bindingwith RUNX12010
Author(s)
Kamikubo Y, Zhao L, Wunderlich M, Corpora T, Hyde RK, Paul TA, Kundu M, Garrett L, Compton S,Huang G, Wolff L, Ito Y, Bushweller J, Mulloy JC, Liu PP
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Journal Title
Cancer Cell
Volume: 17
Pages: 455-68
Related Report
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