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Studying the CBF leukemogenesis and developing anti-cancer agents

Research Project

Project/Area Number 22591026
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionOsaka University (2012)
The University of Tokyo (2010-2011)

Principal Investigator

KAMIKUBO Yasuhiko  大阪大学, 医学系研究科, 助教 (60548527)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords動物 / 癌 / 遺伝子 / RUNX1コンプレックス / HAT / 白血病マウス / CBF白血病 / AML1/RUNX1 / ノックアウトマウス
Research Abstract

RUNX1 Dominant Inhibition has been proposed as a central dogma of CBF leukemogenesis. The project has clarified that RUNX1 is required for CBF leukememogenesis and RUNX1 and HATs maybe good therapeutic targets.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (45 results)

All 2013 2012 2011 2010 Other

All Journal Article (27 results) (of which Peer Reviewed: 16 results) Presentation (13 results) (of which Invited: 3 results) Book (2 results) Remarks (3 results)

  • [Journal Article] A case of CD20-positive peripheral T-cell lymphoma treated with rituximab and multiagent chemotherapy2013

    • Author(s)
      Kamata M, Sugaya M, Miyagaki T, Sonoda K, Ichimura Y, Mitsui H, Sato S, Kamikubo Y, Kurokawa M.
    • Journal Title

      Int J Dermatol 2013

      Volume: 53 Issue: 1 Pages: 1365-1366

    • DOI

      10.1111/j.1365-4632.2012.05483.x

    • URL

      http://www.med.osaka-u.ac.jp/pub/gts/research_d.html

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The C-terminus of CBFβ-SMMHC is required to induce embryonic hematopoietic defects andleukemogenesis.2013

    • Author(s)
      Kamikubo Y, Hyde RK, Zhao L, Alemu L, Rivas C, Garrett LJ, Liu PP.
    • Journal Title

      Blood 2013

      Volume: 24 Issue: 4 Pages: 638-42

    • DOI

      10.1182/blood-2012-06-434688

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute myeloid leukemia with cryptic CBFB-MYH11 type D.2013

    • Author(s)
      Kobayashi T, Ichikawa M, Kamikubo Y, Kurokawa M.
    • Journal Title

      Int J Clin Exp Pathol.

      Volume: 6 Pages: 110-2

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute myeloid leukemia with cryptic CBFB-MYH11 type D2013

    • Author(s)
      Takashi Kobayashi
    • Journal Title

      Int J Clin Exp Pathol

      Volume: 6(1) Pages: 110-112

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erythroleukemia showing early erythroid and cytogenetic responses to azacitidine therapy2013

    • Author(s)
      Sho Hangai
    • Journal Title

      Annals of Hematology

      Volume: 92 Issue: 5 Pages: 707-709

    • DOI

      10.1007/s00277-012-1603-2

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary gastrointestinal follicular lymphoma with histological transformation.2012

    • Author(s)
      Hangai S, Nakamura F, Kamikubo Y, Ichikawa M, Suzuki H, Yoshida S, Yamada A, Takazawa Y,Fukayama M, Koike K, Kurokawa M
    • Journal Title

      Ann Hematol

    • Related Report
      2012 Final Research Report
  • [Journal Article] Erythroleukemia showing early erythroid and cytogenetic responses to azacitidine therapy.2012

    • Author(s)
      Hangai S, Nakamura F, Kamikubo Y, Honda A, Arai S, Nakagawa M, Ichikawa M, Kurokawa M.
    • Journal Title

      Ann Hematol.

    • Related Report
      2012 Final Research Report
  • [Journal Article] Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples2012

    • Author(s)
      Keiki Kumano, Shunya Arai, Masataka Hosoi, Kazuki Taoka , Naoya Takayama, Makoto Otsu, Genta Nagae, Koki Ueda, Kumi Nakazaki, Yasuhiko Kamikubo, Koji Eto, Hiroyuki Aburatani, Hiromitsu Nakauchi and Mineo Kurokawa
    • Journal Title

      Blood.

    • Related Report
      2012 Final Research Report
  • [Journal Article] Pituitary lymphoma developing within pituitary adenoma2012

    • Author(s)
      Ken Morita, Fumihiko Nakamura, Yasuhiko Kamikubo, Naoaki Mizuno, Masashi Miyauchi, Yasuhito Nannya, Motoshi Ichikawa, Mineo Kurokawa
    • Journal Title

      Int J Hematol

      Volume: 96 Pages: 721-4

    • NAID

      10030793836

    • Related Report
      2012 Final Research Report
  • [Journal Article] C-KIT with D816Y/V Mutations Cooperate with CBFB-MYH11 to Accelerate Leukemogenesis in Mice.2012

    • Author(s)
      Martha Kirby, Stacie Anderson, Shelly H Miller, Yasuhiko Kamikubo, Gary Gilliland, and Pu Paul Liu
    • Journal Title

      Blood.

      Volume: 9 Pages: 1511-21

    • Related Report
      2012 Final Research Report
  • [Journal Article] Primary gastrointestinal follicular lymphoma with histological transformation2012

    • Author(s)
      Sho Hangai
    • Journal Title

      Annals of Hematology

      Volume: December12 Issue: 7 Pages: 1654-1655

    • DOI

      10.1007/s00277-012-1654-4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia2012

    • Author(s)
      Keiki Kumano
    • Journal Title

      BLOOD

      Volume: 119 Issue: 26 Pages: 6234-6242

    • DOI

      10.1182/blood-2011-07-367441

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pituitary lymphoma developing within pituitary adenoma2012

    • Author(s)
      Ken Morita
    • Journal Title

      Int J Hematol.

      Volume: 95(6) Issue: 6 Pages: 721-724

    • DOI

      10.1007/s12185-012-1075-0

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-KIT with D816Y/V Mutations Cooperate with CBFB-MYH11 to Accelerate Leukemogenesis2012

    • Author(s)
      Ling Zhao
    • Journal Title

      BLOOD

      Volume: 119(6) Issue: 6 Pages: 1511-1521

    • DOI

      10.1182/blood-2011-02-338210

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of Induced Pluripotent Stem Cells From Primary Chronic Myelogenous Leukemia Patient Sample2012

    • Author(s)
      熊野恵城
    • Journal Title

      Blood

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymphoma with specific affinity to endocrine organs.2011

    • Author(s)
      Morita K, Nakamura F, Nannya Y, Kamikubo Y, Ichikawa M, and Kurokawa M.
    • Journal Title

      Ann Hematol

    • Related Report
      2012 Final Research Report
  • [Journal Article] Crk-associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/Abl.2011

    • Author(s)
      Sachiko Seo, Tetsuya Nakamoto, Masataka Takeshita, Jun Lu, Tomohiko Sato, Takahiro Suzuki, Yasuhiko Kamikubo, Motoshi Ichikawa, Masaki Noda, Seishi Ogawa, Hiroaki Honda, Hideaki Oda and Mineo Kurokawa
    • Journal Title

      Cancer Science

    • NAID

      10030245544

    • Related Report
      2012 Final Research Report
  • [Journal Article] Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia throughdownregulation of p19AR2011

    • Author(s)
      Nahoko Nishimoto, Shunya Arai, Motoshi Ichikawa, Masahiro Nakagawa, Susumu Goyama, Keiki Kumano,Tsuyoshi Takahashi, Yasuhiko Kamikubo, Yoichi Imai, and Mineo Kurokawa
    • Journal Title

      Blood.

      Volume: 118 Pages: 2541-50

    • Related Report
      2012 Final Research Report
  • [Journal Article] Composite diffuse large B-cell lymphoma and CD20-positive peripheral T-cell lymphoma.2011

    • Author(s)
      Sho Yamazaki, Yosei Fujioka, Fumihiko Nakamura, Satoshi Ota, Aya Shinozaki, Go Yamamoto, Yasuhiko Kamikubo, Yasuhito Nannya, Motoshi Ichikawa, Masashi Fukayama, Mineo Kurokawa
    • Journal Title

      Pathol Int

      Volume: 61 Pages: 662-6

    • NAID

      10031185137

    • Related Report
      2012 Final Research Report
  • [Journal Article] Lymphoma with specific affinity to endocrine organs2011

    • Author(s)
      森田剣
    • Journal Title

      Ann Hematol.

      Volume: Nov 22 Issue: 7 Pages: 1149-1150

    • DOI

      10.1007/s00277-011-1372-3

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-KIT with D816Y/V Mutations Cooperate with CBFB-MYH11 to Accele rate Leukemogenesis in Mice2011

    • Author(s)
      Ling Zhao
    • Journal Title

      Blood

      Volume: 119(6) Pages: 1511-21

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cas-L regulates myeloid cell motility and suppresses progression of leukemia induced by p210Bcr/Abl2011

    • Author(s)
      黒川峰夫, 他
    • Journal Title

      Cancer Science

      Volume: 102 Issue: 12 Pages: 2109-2117

    • DOI

      10.1111/j.1349-7006.2011.02066.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Composite diffuse large B-cell lymphoma and CD20-positive peripheral T-cell lymphoma2011

    • Author(s)
      山崎翔
    • Journal Title

      Pathol Int

      Volume: 61(11) Issue: 11 Pages: 662-666

    • DOI

      10.1111/j.1440-1827.2011.02713.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through downregulation of p19ARF2011

    • Author(s)
      西本菜穂子
    • Journal Title

      Blood

      Volume: 118(9) Pages: 2541-50

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity bindingwith RUNX12010

    • Author(s)
      Kamikubo Y, Zhao L, Wunderlich M, Corpora T, Hyde RK, Paul TA, Kundu M, Garrett L, Compton S,Huang G, Wolff L, Ito Y, Bushweller J, Mulloy JC, Liu PP
    • Journal Title

      Cancer Cell

      Volume: 17 Pages: 455-68

    • Related Report
      2012 Final Research Report
  • [Journal Article] Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX12010

    • Author(s)
      上久保靖彦
    • Journal Title

      Cancer Cell

      Volume: 17(5) Pages: 455-468

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Case of splenic abscess due to Propionibacterium acnes

    • Author(s)
      Kiriya S, Sugimoto M, Kamikubo Y, Kurokawa M, Norihiro Kokudo
    • Journal Title

      CLINCIAL GASTROENTEROLOGY AND HEPATOLOGY

    • Related Report
      2012 Final Research Report
  • [Presentation] 米国におけるunmet population を対象とした開発治験の動向とわが国の取り組み2012

    • Author(s)
      上久保靖彦
    • Organizer
      第33回日本臨床薬理学会学術集会
    • Place of Presentation
      沖縄
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 遥かなるワシントンDC:私のNIH 研究留学活用法2012

    • Author(s)
      上久保靖彦
    • Organizer
      日米医学医療交流セミナー
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 新規白血病発症機構解明とNIH MLP/HTS による抗癌剤開発について2012

    • Author(s)
      上久保靖彦
    • Organizer
      独立行政法人医薬基盤研究所研究振興部セミナー
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] KIT with D816 Mutations Cooperates with CBFB-MYH11 for Leukemogenesis in Mice2011

    • Author(s)
      Ling Zhao
    • Organizer
      ASH
    • Place of Presentation
      米国(San Diego, California)
    • Year and Date
      2011-12-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] コアバインディングファクター(CBF)白血病新規発症機構:RUNX1 Dominant Inhibition Independent Leukemogenesis2011

    • Author(s)
      上久保靖彦
    • Organizer
      JACLS(小児白血病研究会)総会
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] CBF白血病新規発症機構:RUNX1 Dominant Inhibition Independent Leukemogenesis2011

    • Author(s)
      上久保靖彦
    • Organizer
      Kyoto Hematology Forum
    • Place of Presentation
      京都
    • Year and Date
      2011-03-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] CBF 白血病新規発症機構及び造血器悪性腫瘍共通発症機構解明の試み

    • Organizer
      2013 年第32回南大阪血液疾患・幹細胞移植研究会特別講演
    • Related Report
      2012 Final Research Report
  • [Presentation] 米国における unmet population を対象とした開発治験の動向とわが国の取り組み

    • Organizer
      2012 年第33回日本臨床薬理学会学術総会シンポジウム「Unfit population に対するがん化学療法の現状とエビデンス構築のための臨床試験」
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規白血病発症機構解明と NIH MLP/HTS による抗癌剤開発について

    • Organizer
      2012 年独立行政法人医薬基盤研究所研究振興部セミナー招待講演
    • Related Report
      2012 Final Research Report
  • [Presentation] コアバインディングファクター(CBF)白血病新規発症機構:RUNX1 DominantInhibition Independent Leukemogenesis

    • Organizer
      2012 年大阪大学大学院医学研究科セミナー招待講演
    • Related Report
      2012 Final Research Report
  • [Presentation] コアバインディングファクター(CBF)白血病新規発症機構:RUNX1 DominantInhibition Independent Leukemogenesis

    • Organizer
      2011 年 JACLS(日本小児白血病研究会)総会招待講演
    • Related Report
      2012 Final Research Report
  • [Presentation] コアバインディングファクター(CBF)白血病新規発症機構:RUNX1 DominantInhibition Independent Leukemogenesis

    • Organizer
      2011 年 Kyoto Hematology Forum 特別招待講演
    • Related Report
      2012 Final Research Report
  • [Presentation] コアバインディングファクター(CBF)白血病新規発症機構:RUNX1 DominantInhibition Independent Leukemogenesis

    • Organizer
      2011 年 Kyoto Hematology Forum 特別招待講演
    • Related Report
      2012 Final Research Report
  • [Book] 平成 23 年度造血器疾患治療マニュアル平成2011

    • Author(s)
      上久保担当一般事項、付録、HLA 項目
    • Publisher
      コアバインディングファクター(CBF)白血病新規発症機構:RUNX1 DominantInhibition Independent Leukemogenesis
    • Related Report
      2012 Final Research Report
  • [Book] 上久保担当急性リンパ性白血病、慢性リンパ性白血病、特発性血小板減少性紫斑病

    • Author(s)
      平成 22 年度東京大学医学部 M2PBL チュートリアル資料分担
    • Publisher
      東京大学医学部企画情報部出版
    • Related Report
      2012 Final Research Report
  • [Remarks] 平成 22 年度東京大学医学部 M2PBL チュートリアル資料分担

    • Related Report
      2012 Final Research Report
  • [Remarks] 大阪大学大学院医学系研究科|遺伝子治療学

    • URL

      http://www.med.osaka-u.ac.jp/pub/gts/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.h.u-tokyo.ac.jp/hematology/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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