Studying the CBF leukemogenesis and developing anti-cancer agents

• Project/Area Number: 22591026
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Osaka University (2012); The University of Tokyo (2010-2011)
• Principal Investigator: KAMIKUBO Yasuhiko 大阪大学, 医学系研究科, 助教 (60548527)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 動物 / 癌 / 遺伝子 / RUNX1コンプレックス / HAT / 白血病マウス / CBF白血病 / AML1/RUNX1 / ノックアウトマウス

Research Abstract

RUNX1 Dominant Inhibition has been proposed as a central dogma of CBF leukemogenesis. The project has clarified that RUNX1 is required for CBF leukememogenesis and RUNX1 and HATs maybe good therapeutic targets.

Research Products

• [Journal Article] A case of CD20-positive peripheral T-cell lymphoma treated with rituximab and multiagent chemotherapy (2013)
  • Author(s): Kamata M, Sugaya M, Miyagaki T, Sonoda K, Ichimura Y, Mitsui H, Sato S, Kamikubo Y, Kurokawa M.
  • Journal Title: Int J Dermatol 2013 Volume: 53 Issue: 1 Pages: 1365-1366
  • DOI: 10.1111/j.1365-4632.2012.05483.x
  • URL: http://www.med.osaka-u.ac.jp/pub/gts/research_d.html
  • Peer Reviewed
• [Journal Article] The C-terminus of CBFβ-SMMHC is required to induce embryonic hematopoietic defects andleukemogenesis. (2013)
  • Author(s): Kamikubo Y, Hyde RK, Zhao L, Alemu L, Rivas C, Garrett LJ, Liu PP.
  • Journal Title: Blood 2013 Volume: 24 Issue: 4 Pages: 638-42
  • DOI: 10.1182/blood-2012-06-434688
  • Peer Reviewed
• [Journal Article] Acute myeloid leukemia with cryptic CBFB-MYH11 type D. (2013)
  • Author(s): Kobayashi T, Ichikawa M, Kamikubo Y, Kurokawa M.
  • Journal Title: Int J Clin Exp Pathol. Volume: 6 Pages: 110-2
  • Peer Reviewed
• [Journal Article] Acute myeloid leukemia with cryptic CBFB-MYH11 type D (2013)
  • Author(s): Takashi Kobayashi
  • Journal Title: Int J Clin Exp Pathol Volume: 6(1) Pages: 110-112
  • Peer Reviewed
• [Journal Article] Erythroleukemia showing early erythroid and cytogenetic responses to azacitidine therapy (2013)
  • Author(s): Sho Hangai
  • Journal Title: Annals of Hematology Volume: 92 Issue: 5 Pages: 707-709
  • DOI: 10.1007/s00277-012-1603-2
  • Peer Reviewed
• [Journal Article] Primary gastrointestinal follicular lymphoma with histological transformation. (2012)
  • Author(s): Hangai S, Nakamura F, Kamikubo Y, Ichikawa M, Suzuki H, Yoshida S, Yamada A, Takazawa Y,Fukayama M, Koike K, Kurokawa M
  • Journal Title: Ann Hematol
• [Journal Article] Erythroleukemia showing early erythroid and cytogenetic responses to azacitidine therapy. (2012)
  • Author(s): Hangai S, Nakamura F, Kamikubo Y, Honda A, Arai S, Nakagawa M, Ichikawa M, Kurokawa M.
  • Journal Title: Ann Hematol.
• [Journal Article] Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples (2012)
  • Author(s): Keiki Kumano, Shunya Arai, Masataka Hosoi, Kazuki Taoka , Naoya Takayama, Makoto Otsu, Genta Nagae, Koki Ueda, Kumi Nakazaki, Yasuhiko Kamikubo, Koji Eto, Hiroyuki Aburatani, Hiromitsu Nakauchi and Mineo Kurokawa
  • Journal Title: Blood.
• [Journal Article] Pituitary lymphoma developing within pituitary adenoma (2012)
  • Author(s): Ken Morita, Fumihiko Nakamura, Yasuhiko Kamikubo, Naoaki Mizuno, Masashi Miyauchi, Yasuhito Nannya, Motoshi Ichikawa, Mineo Kurokawa
  • Journal Title: Int J Hematol Volume: 96 Pages: 721-4
  • NAID: 10030793836
• [Journal Article] C-KIT with D816Y/V Mutations Cooperate with CBFB-MYH11 to Accelerate Leukemogenesis in Mice. (2012)
  • Author(s): Martha Kirby, Stacie Anderson, Shelly H Miller, Yasuhiko Kamikubo, Gary Gilliland, and Pu Paul Liu
  • Journal Title: Blood. Volume: 9 Pages: 1511-21
• [Journal Article] Primary gastrointestinal follicular lymphoma with histological transformation (2012)
  • Author(s): Sho Hangai
  • Journal Title: Annals of Hematology Volume: December12 Issue: 7 Pages: 1654-1655
  • DOI: 10.1007/s00277-012-1654-4
  • Peer Reviewed
• [Journal Article] Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia (2012)
  • Author(s): Keiki Kumano
  • Journal Title: BLOOD Volume: 119 Issue: 26 Pages: 6234-6242
  • DOI: 10.1182/blood-2011-07-367441
  • Peer Reviewed
• [Journal Article] Pituitary lymphoma developing within pituitary adenoma (2012)
  • Author(s): Ken Morita
  • Journal Title: Int J Hematol. Volume: 95(6) Issue: 6 Pages: 721-724
  • DOI: 10.1007/s12185-012-1075-0
  • Peer Reviewed
• [Journal Article] C-KIT with D816Y/V Mutations Cooperate with CBFB-MYH11 to Accelerate Leukemogenesis (2012)
  • Author(s): Ling Zhao
  • Journal Title: BLOOD Volume: 119(6) Issue: 6 Pages: 1511-1521
  • DOI: 10.1182/blood-2011-02-338210
  • Peer Reviewed
• [Journal Article] Generation of Induced Pluripotent Stem Cells From Primary Chronic Myelogenous Leukemia Patient Sample (2012)
  • Author(s): 熊野恵城
  • Journal Title: Blood Volume: (In press)
  • Peer Reviewed
• [Journal Article] Lymphoma with specific affinity to endocrine organs. (2011)
  • Author(s): Morita K, Nakamura F, Nannya Y, Kamikubo Y, Ichikawa M, and Kurokawa M.
  • Journal Title: Ann Hematol
• [Journal Article] Crk-associated substrate lymphocyte type regulates myeloid cell motility and suppresses the progression of leukemia induced by p210Bcr/Abl. (2011)
  • Author(s): Sachiko Seo, Tetsuya Nakamoto, Masataka Takeshita, Jun Lu, Tomohiko Sato, Takahiro Suzuki, Yasuhiko Kamikubo, Motoshi Ichikawa, Masaki Noda, Seishi Ogawa, Hiroaki Honda, Hideaki Oda and Mineo Kurokawa
  • Journal Title: Cancer Science
  • NAID: 10030245544
• [Journal Article] Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia throughdownregulation of p19AR (2011)
  • Author(s): Nahoko Nishimoto, Shunya Arai, Motoshi Ichikawa, Masahiro Nakagawa, Susumu Goyama, Keiki Kumano,Tsuyoshi Takahashi, Yasuhiko Kamikubo, Yoichi Imai, and Mineo Kurokawa
  • Journal Title: Blood. Volume: 118 Pages: 2541-50
• [Journal Article] Composite diffuse large B-cell lymphoma and CD20-positive peripheral T-cell lymphoma. (2011)
  • Author(s): Sho Yamazaki, Yosei Fujioka, Fumihiko Nakamura, Satoshi Ota, Aya Shinozaki, Go Yamamoto, Yasuhiko Kamikubo, Yasuhito Nannya, Motoshi Ichikawa, Masashi Fukayama, Mineo Kurokawa
  • Journal Title: Pathol Int Volume: 61 Pages: 662-6
  • NAID: 10031185137
• [Journal Article] Lymphoma with specific affinity to endocrine organs (2011)
  • Author(s): 森田剣
  • Journal Title: Ann Hematol. Volume: Nov 22 Issue: 7 Pages: 1149-1150
  • DOI: 10.1007/s00277-011-1372-3
  • Peer Reviewed
• [Journal Article] C-KIT with D816Y/V Mutations Cooperate with CBFB-MYH11 to Accele rate Leukemogenesis in Mice (2011)
  • Author(s): Ling Zhao
  • Journal Title: Blood Volume: 119(6) Pages: 1511-21
  • Peer Reviewed
• [Journal Article] Cas-L regulates myeloid cell motility and suppresses progression of leukemia induced by p210Bcr/Abl (2011)
  • Author(s): 黒川峰夫, 他
  • Journal Title: Cancer Science Volume: 102 Issue: 12 Pages: 2109-2117
  • DOI: 10.1111/j.1349-7006.2011.02066.x
  • Peer Reviewed
• [Journal Article] Composite diffuse large B-cell lymphoma and CD20-positive peripheral T-cell lymphoma (2011)
  • Author(s): 山崎翔
  • Journal Title: Pathol Int Volume: 61(11) Issue: 11 Pages: 662-666
  • DOI: 10.1111/j.1440-1827.2011.02713.x
  • Peer Reviewed
• [Journal Article] Loss of AML1/Runx1 accelerates the development of MLL-ENL leukemia through downregulation of p19ARF (2011)
  • Author(s): 西本菜穂子
  • Journal Title: Blood Volume: 118(9) Pages: 2541-50
  • Peer Reviewed
• [Journal Article] Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity bindingwith RUNX1 (2010)
  • Author(s): Kamikubo Y, Zhao L, Wunderlich M, Corpora T, Hyde RK, Paul TA, Kundu M, Garrett L, Compton S,Huang G, Wolff L, Ito Y, Bushweller J, Mulloy JC, Liu PP
  • Journal Title: Cancer Cell Volume: 17 Pages: 455-68
• [Journal Article] Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1 (2010)
  • Author(s): 上久保靖彦
  • Journal Title: Cancer Cell Volume: 17(5) Pages: 455-468
  • Peer Reviewed
• [Journal Article] A Case of splenic abscess due to Propionibacterium acnes
  • Author(s): Kiriya S, Sugimoto M, Kamikubo Y, Kurokawa M, Norihiro Kokudo
  • Journal Title: CLINCIAL GASTROENTEROLOGY AND HEPATOLOGY
• [Presentation] 米国におけるunmet population を対象とした開発治験の動向とわが国の取り組み (2012)
  • Author(s): 上久保靖彦
  • Organizer: 第33回日本臨床薬理学会学術集会
  • Place of Presentation: 沖縄
  • Invited
• [Presentation] 遥かなるワシントンDC：私のNIH 研究留学活用法 (2012)
  • Author(s): 上久保靖彦
  • Organizer: 日米医学医療交流セミナー
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 新規白血病発症機構解明とNIH MLP/HTS による抗癌剤開発について (2012)
  • Author(s): 上久保靖彦
  • Organizer: 独立行政法人医薬基盤研究所研究振興部セミナー
  • Place of Presentation: 大阪
  • Invited
• [Presentation] KIT with D816 Mutations Cooperates with CBFB-MYH11 for Leukemogenesis in Mice (2011)
  • Author(s): Ling Zhao
  • Organizer: ASH
  • Place of Presentation: 米国(San Diego, California)
  • Year and Date: 2011-12-12
• [Presentation] コアバインディングファクター(CBF)白血病新規発症機構:RUNX1 Dominant Inhibition Independent Leukemogenesis (2011)
  • Author(s): 上久保靖彦
  • Organizer: JACLS(小児白血病研究会)総会
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2011-05-14
• [Presentation] CBF白血病新規発症機構:RUNX1 Dominant Inhibition Independent Leukemogenesis (2011)
  • Author(s): 上久保靖彦
  • Organizer: Kyoto Hematology Forum
  • Place of Presentation: 京都
  • Year and Date: 2011-03-05
• [Presentation] CBF 白血病新規発症機構及び造血器悪性腫瘍共通発症機構解明の試み
  • Organizer: 2013 年第32回南大阪血液疾患・幹細胞移植研究会特別講演
• [Presentation] 米国における unmet population を対象とした開発治験の動向とわが国の取り組み
  • Organizer: 2012 年第33回日本臨床薬理学会学術総会シンポジウム「Unfit population に対するがん化学療法の現状とエビデンス構築のための臨床試験」
• [Presentation] 新規白血病発症機構解明と NIH MLP/HTS による抗癌剤開発について
  • Organizer: 2012 年独立行政法人医薬基盤研究所研究振興部セミナー招待講演
• [Presentation] コアバインディングファクター(CBF)白血病新規発症機構:RUNX1 DominantInhibition Independent Leukemogenesis
  • Organizer: 2012 年大阪大学大学院医学研究科セミナー招待講演
• [Presentation] コアバインディングファクター(CBF)白血病新規発症機構:RUNX1 DominantInhibition Independent Leukemogenesis
  • Organizer: 2011 年 JACLS(日本小児白血病研究会)総会招待講演
• [Presentation] コアバインディングファクター(CBF)白血病新規発症機構:RUNX1 DominantInhibition Independent Leukemogenesis
  • Organizer: 2011 年 Kyoto Hematology Forum 特別招待講演
• [Presentation] コアバインディングファクター(CBF)白血病新規発症機構:RUNX1 DominantInhibition Independent Leukemogenesis
  • Organizer: 2011 年 Kyoto Hematology Forum 特別招待講演
• [Book] 平成 23 年度造血器疾患治療マニュアル平成 (2011)
  • Author(s): 上久保担当一般事項、付録、HLA 項目
  • Publisher: コアバインディングファクター(CBF)白血病新規発症機構:RUNX1 DominantInhibition Independent Leukemogenesis
• [Book] 上久保担当急性リンパ性白血病、慢性リンパ性白血病、特発性血小板減少性紫斑病
  • Author(s): 平成 22 年度東京大学医学部 M2PBL チュートリアル資料分担
  • Publisher: 東京大学医学部企画情報部出版
• [Remarks] 平成 22 年度東京大学医学部 M2PBL チュートリアル資料分担
• [Remarks] 大阪大学大学院医学系研究科｜遺伝子治療学
  • URL: http://www.med.osaka-u.ac.jp/pub/gts/
• [Remarks]
  • URL: http://www.h.u-tokyo.ac.jp/hematology/