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Analysis of adult T-cell leukemia cells using multi-color flow cytometry can detect high risk asymptomatic HTLV-1 carriers to progress into adult T-cell leukemia.

Research Project

Project/Area Number 22591028
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionThe University of Tokyo

Principal Investigator

UCHIMARU Kaoru  東京大学, 医科学研究所, 准教授 (60251203)

Co-Investigator(Kenkyū-buntansha) WATANABE Nobukazu  東京大学, 医科学研究所, 特任准教授 (10334278)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsHTLV-1 / ATL / FACS / TSLC1 / CADM1 / CD7 / HTLV-1 / ATL / FACS / TSLC1 / CADM1 / CD7 / CCR4 / TSLC-1 / HTLV-1キャリア / リスクファター
Research Abstract

ATL cells can be detected as CADM1+/CD7- cells using multi-color fllow cytometry and this analysis is helpful for monitoring therapeutic effect for ATL. This technique can purify the cells in intermediate state of oncogensis of HTLV-1 infected cells to ATL as CADM1+/CD7dim cells. These CADM1+/CD7dim cells is detected in the peripheral blood of a part of asymptomatic carriers at high risk to develop ATL.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (42 results)

All 2013 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 11 results) Presentation (27 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Development of peripheral T-cell lymphoma not otherwise specified in an HTLV-1 carrier.2013

    • Author(s)
      Ishigaki T, Isobe M, Kobayashi S, Yuji K, Ohno N, Watanabe N, Tojo A and Uchimaru K.
    • Journal Title

      Int J Heamtol.

      Volume: prepublished online Issue: 5 Pages: 667-672

    • DOI

      10.1007/s12185-013-1314-z

    • NAID

      10031176497

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The CD3 versus CD7 plot in multicolor flow cytometry reflects progression of disease stage in patients infected with HTLV-I.2013

    • Author(s)
      Kobayashi S, Tian Y, Ohno N, Yuji K, Ishigaki T, Isobe M, Ohfuchi-Tsuda M, Oyaizu N, Watanabe E, Watanabe N, Tani K, Tojo A and Uchimaru K.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 1 Pages: e53728-e53728

    • DOI

      10.1371/journal.pone.0053728

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adult T-cell leukemia cells are characterized by abnormalities of Helios expression that promote T-cell growth.2013

    • Author(s)
      Asanuma S, Uchimaru K, et al.
    • Journal Title

      Cancer Sci

      Volume: - Issue: 8 Pages: 1097-1106

    • DOI

      10.1111/cas.12181

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polycomb-Mediated Loss of miR-31 Activates NIK-dependent NF-κB Pathway in Adult T-cell Leukemia and Other Cancers2012

    • Author(s)
      Yamagishi M, Uchimaru K, et al.
    • Journal Title

      Cancer cell

      Volume: 21 Issue: 1 Pages: 121-135

    • DOI

      10.1016/j.ccr.2011.12.015

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arinobu Tojo and Kaoru Uchimaru Leukemic T cells are specifically enriched in aunique CD3dimCD7low subpopulation of CD4+ T cells in acute-type adult T-cell leukemia.2011

    • Author(s)
      Yamin Tian, Seiichro Kobayashi, Nobuhiro Ohno, Masamichi Isobe, Mayuko Tsuda, Yuji Zaike, Nobukazu Watanabe, Kenzaburo Tani
    • Journal Title

      Cancer Sci.

      Volume: 102(3) Pages: 569-577

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polycomb-Mediated Loss of miR-31Activates NIK-dependent NF-κ B Pathway in Adult T-cell Leukemia and Other Cancers.2011

    • Author(s)
      Makoto Yamagishi, Kazumi Nakano, Ariko Miyake, Tadanori Yamochi, Yayoi Kagami, Akihisa, Tsutsumi, Yuka Matsuda, Aiko Sato-Otsubo, Satsuki Muto, Atae Utsunomiya, Kazunari Yamaguchi, Kaoru Uchimaru, Seishi Ogawa, and Toshiki Watanabe.
    • Journal Title

      Cancer cell.

      Volume: 21(1) Pages: 121-135

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced dose chemotherapy for acute promyelocytic leukaemia with adult Down syndrome2011

    • Author(s)
      Tsuda, M., Ebihara, Y., Mochizuki, S., et al.(6名2番目)
    • Journal Title

      Br J Haematol

      Volume: 155 Issue: 1 Pages: 130-132

    • DOI

      10.1111/j.1365-2141.2011.08655.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HTLV-1キャリア対応・ATL診療の問題点2011

    • Author(s)
      内丸薫
    • Journal Title

      臨床血液

      Volume: 52 Pages: 1432-1438

    • NAID

      10029768420

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 高齢者の成人T細胞白血病・リンパ腫のマネジメント2011

    • Author(s)
      内丸薫
    • Journal Title

      血液内科

      Volume: 62 Pages: 713-720

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Human T-cell leukemiavirus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan.2010

    • Author(s)
      Masako Iwanaga, Toshiki Watanabe, Atae Utsunomiya, Akihiko Okayama,Kaoru Uchimaru, Ki-Ryang Koh, Masao Ogata, Hiroshi Kikuchi, Yasuko Sagara, Kimiharu Uozumi, Manabu Mochizuki, Kunihiro Tsukasaki, Yoshio Saburi, Masaomi Yamamura, Junji Tanaka, Yukiyoshi Moriuchi, Shigeo Hino, Shimeru Kamihira, and Kazunari Yamaguchi.
    • Journal Title

      Blood

      Volume: 116(8) Pages: 1211-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leukemic T cells are specifically enriched in a unique CD3^<dim>CD7^<low> subpopulation of CD4^+ T cells in acute-type adult T cell leukemia.2010

    • Author(s)
      Tian A, et al.
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 569-577

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human T-cell leukemia virus type I(HTLV-1)proviral load and disease progression in asy mptomatic HTLV-1 carriers : a nationwide prospective study in Japan.2010

    • Author(s)
      Iwanaga M, et al.
    • Journal Title

      Blood

      Volume: 116 Pages: 1211-1219

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adult T-cell leukemia cells are characterized by abnormalities of Helios expression that promote T-cell growth.

    • Author(s)
      Asanuma S, Yamagishi M, Kawanami Ka, Nakano K, Sato-Otsubo A, Muto S, Sanada M, Yamochi T, Kobayashi S, Utsunomiya A, Iwanaga M, Yamaguchi K, Uchimaru K, Ogawa S and Watanabe T.
    • Journal Title

      Cancer Sci.

      Volume: in press.

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] CD7 vs CADM1 in FACS reflects multi-step oncogenesis of ATL and discriminates HTLV-1 infected cells.2012

    • Author(s)
      Seiichro Kobayashi et al.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2012-10-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 患者検体を用いた CD7と TSLC1/CADM1 の FACS 解析は ATL の多 段階発癌を反映する2012

    • Author(s)
      小林誠一郎ほか
    • Organizer
      第1回 ATLシン ポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-08-25
    • Related Report
      2012 Final Research Report
  • [Presentation] CD3とCD7の展開によるATL細胞の同定:急性型ATLの治療反応性のモニタリングとして2011

    • Author(s)
      大野伸広、内丸薫, 他.名古屋2011
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] CD3 vs CD7 plot in multi-colour FACS reflects progression of disease stage of HTLV-1 infected patients2011

    • Author(s)
      Kobayashi S, Uchimaru K, et al.
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Nation-wide survey of the management of adult T-cell leukemia and HTLV-1 carrier2011

    • Author(s)
      Uchimaru K, et al.
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Polycomb-Mediated Epigenetic Silencing of miR-31 Activates NF-κB Signaling in Adult T-cell Leukemia2011

    • Author(s)
      Yamagishi M, Uchimaru K, et al.
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] HTLV-1キャリア対応・ATL診療の問題点2011

    • Author(s)
      内丸薫
    • Organizer
      第73回日本血液学会総会
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Multi-color FACS用いたCD3/7展開による急性型ATLの治療反応性のモニタリング2011

    • Author(s)
      大野伸広、内丸薫, 他
    • Organizer
      第4回HTLV-1研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] マルチカラーFACSにおけるCD3とCD7の展開はHTLV-1感染患者 の病期の進行を反映する2011

    • Author(s)
      小林誠一郎ほか
    • Organizer
      第4回HTLV-1 研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] フローサイトメトリーによるフェノタイプ解析を用いた、急性型ATLの末梢血腫瘍細胞数の評価2011

    • Author(s)
      石垣知寛、内丸薫, 他東京2011 Yamagishi M, Uchimaru K, et al.
    • Organizer
      第4回HTLV-1研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] マルチカラーFACSにおけるCD3とCD7の展開はHTLV-1感染患者の病期の進行を反映する2011

    • Author(s)
      小林誠一郎、内丸薫, 他大野伸広、内丸薫, 他
    • Organizer
      第4回HTLV-1研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Leukemic T cells are specifically enriched in a unique CD3dimCD7low Subpopulation of CD4+ T cells in acute-type adult Tcell leuk emia.2010

    • Author(s)
      Tian Y et al.
    • Organizer
      ASH annual meeting.
    • Place of Presentation
      Orland, USA
    • Year and Date
      2010-12-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Leukemic T cells are specifically enriched in a unique CD3^<dim>CD7^<low> subpopulation of CD4^+ T cells in acute-type adult T cell leukemia.2010

    • Author(s)
      Tian Y, et al.
    • Organizer
      ASH annual meeting
    • Place of Presentation
      Orland, USA
    • Year and Date
      2010-12-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Combination of CD3 and CD7 in multi-color FACS discriminates malignant cells in ATL patients.2010

    • Author(s)
      Tian Y, et al.
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      横浜パシフィコ
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] HTLV-1キャリアにおけるMulti-color FACS : CD3とCD7の展開によるクローン増殖性リンパ球同定の試み2010

    • Author(s)
      大野伸広, ほか
    • Organizer
      第72回日本血液学会総会
    • Place of Presentation
      横浜パシフィコ
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] HTLV-1キャリア末梢血におけるMulti-color FACS : CD3とCD7の展開による異常リンパ球と発症高危険群の選別の試み2010

    • Author(s)
      大野伸広, ほか
    • Organizer
      第3回HTLV-1研究会
    • Place of Presentation
      東京大学医科学研究所
    • Year and Date
      2010-08-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Multi-color FACS for efficient discrimination of ATL cells.2010

    • Author(s)
      Tian Y, et al.
    • Organizer
      等3回HTLV-1研究会
    • Place of Presentation
      東京大学医科学研究所
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] ATLとの鑑別を要したATLA^+PTCL-NOSの一例.2010

    • Author(s)
      磯部優理, ほか
    • Organizer
      第3回HTLV-1研究会
    • Place of Presentation
      東京大学医科学研究所
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 患者血液検体を用いたCD7とTSLC1/CADM1のFACS解析はATLの多段階発癌を反映する

    • Author(s)
      小林誠一郎、内丸 薫 他.
    • Organizer
      第1回ATL シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] TSLC1/CD7を用いた造血細胞移植後のATL細胞のモニタリング

    • Author(s)
      石垣知寛、内丸 薫 他.
    • Organizer
      第5回HTLV-1研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 成人T細胞白血病におけるtumor initiating cell の探索の試み

    • Author(s)
      矢持忠徳、内丸 薫 他.
    • Organizer
      第5回HTLV-1研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 同種造血幹細胞移植を見据えたATLの治療戦略:その後方視的解析

    • Author(s)
      大野伸広、内丸 薫 他.
    • Organizer
      第5回HTLV-1研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 成人T細胞白血病(ATL)における新規TIAM2変異体の同定と遺伝子発現の解析

    • Author(s)
      笹島悟史、内丸 薫 他.
    • Organizer
      第5回HTLV-1研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular Hallmarks of Adult T cell Leukemia: miRNA, Epigenetics, and Emerging Signaling Abnormalities

    • Author(s)
      Makoto Yamagishi, Kaoru Uchimaru, et al.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] CD7 vs CADM1 in FACS reflects multi-step oncogenesis of ATL and discriminates HTLV-1 infected cells.

    • Author(s)
      Seiichro Kobayashi, Kaoru Uchimaru, et al.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Monitoring ATL cells after allogeneic hematopoietic stem cell transplantation with CADM1 and CD7.

    • Author(s)
      石垣 知寛、内丸 薫 他.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] CD3とCD7の展開による急性型ATL細胞の同定:治療後のCD3dimCD7(-)分画のクローナリティ解析

    • Author(s)
      大野伸広、内丸 薫 他.
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 患者検体を用いた HTLV-1 キャリア、成人 T 細胞白血病の発癌過程進行度又 は悪性度の評価法2013

    • Inventor(s)
      内丸 薫、小林誠一郎、渡辺信和
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2013-034326
    • Filing Date
      2013-02-25
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 患者検体を用いたHTLV-1キャリア、成人T細胞白血病の発癌過程進行度又は悪性度の評価法2013

    • Inventor(s)
      内丸 薫、小林誠一郎、渡辺信和
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-02-25
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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