Analysis of adult T-cell leukemia cells using multi-color flow cytometry can detect high risk asymptomatic HTLV-1 carriers to progress into adult T-cell leukemia.
| Project/Area Number | 22591028 |
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
UCHIMARU Kaoru 東京大学, 医科学研究所, 准教授 (60251203)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Nobukazu 東京大学, 医科学研究所, 特任准教授 (10334278)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed(Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost : ¥2,800,000、Indirect Cost : ¥840,000)
Fiscal Year 2012 : ¥780,000 (Direct Cost : ¥600,000、Indirect Cost : ¥180,000)
Fiscal Year 2011 : ¥780,000 (Direct Cost : ¥600,000、Indirect Cost : ¥180,000)
Fiscal Year 2010 : ¥2,080,000 (Direct Cost : ¥1,600,000、Indirect Cost : ¥480,000)
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| Keywords | HTLV-1 / ATL / FACS / TSLC1 / CADM1 / CD7 / ＨＴＬＶ－１ / ＡＴＬ / ＦＡＣＳ / ＴＳＬＣ１ / ＣＡＤＭ１ / ＣＤ７ / ＣＣＲ４ / TSLC-1 / HTLV-1キャリア / リスクファター |
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| Research Abstract |
ATL cells can be detected as CADM1+/CD7- cells using multi-color fllow cytometry and this analysis is helpful for monitoring therapeutic effect for ATL. This technique can purify the cells in intermediate state of oncogensis of HTLV-1 infected cells to ATL as CADM1+/CD7dim cells. These CADM1+/CD7dim cells is detected in the peripheral blood of a part of asymptomatic carriers at high risk to develop ATL.
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Report
(4results)
Research Products
(42results)
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[Journal Article] The CD3 versus CD7 plot in multicolor flow cytometry reflects progression of disease stage in patients infected with HTLV-I.2013
Author(s)
Kobayashi S, Tian Y, Ohno N, Yuji K, Ishigaki T, Isobe M, Ohfuchi-Tsuda M, Oyaizu N, Watanabe E, Watanabe N, Tani K, Tojo A and Uchimaru K.
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Journal Title
DOI
Related Report
Peer Reviewed
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[Journal Article] Polycomb-Mediated Loss of miR-31Activates NIK-dependent NF-κ B Pathway in Adult T-cell Leukemia and Other Cancers.2011
Author(s)
Makoto Yamagishi, Kazumi Nakano, Ariko Miyake, Tadanori Yamochi, Yayoi Kagami, Akihisa, Tsutsumi, Yuka Matsuda, Aiko Sato-Otsubo, Satsuki Muto, Atae Utsunomiya, Kazunari Yamaguchi, Kaoru Uchimaru, Seishi Ogawa, and Toshiki Watanabe.
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Journal Title
Cancer cell.
Volume : 21(1)
Pages : 121-135
Related Report
Peer Reviewed
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[Journal Article] Human T-cell leukemiavirus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan.2010
Author(s)
Masako Iwanaga, Toshiki Watanabe, Atae Utsunomiya, Akihiko Okayama,Kaoru Uchimaru, Ki-Ryang Koh, Masao Ogata, Hiroshi Kikuchi, Yasuko Sagara, Kimiharu Uozumi, Manabu Mochizuki, Kunihiro Tsukasaki, Yoshio Saburi, Masaomi Yamamura, Junji Tanaka, Yukiyoshi Moriuchi, Shigeo Hino, Shimeru Kamihira, and Kazunari Yamaguchi.
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Journal Title
Blood
Volume : 116(8)
Pages : 1211-9
Related Report
Peer Reviewed
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[Journal Article] Adult T-cell leukemia cells are characterized by abnormalities of Helios expression that promote T-cell growth.
Author(s)
Asanuma S, Yamagishi M, Kawanami Ka, Nakano K, Sato-Otsubo A, Muto S, Sanada M, Yamochi T, Kobayashi S, Utsunomiya A, Iwanaga M, Yamaguchi K, Uchimaru K, Ogawa S and Watanabe T.
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Journal Title
Cancer Sci.
Volume : in press.
Related Report
Peer Reviewed
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