Regulatory mechanisms of hepcidin, the central regulator of body iron homeostasis
| Project/Area Number |
22591033
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TOMOSUGI Naohisa 金沢医科大学, 総合医学研究所, 教授 (80155580)
MORI Kiyoshi 京都大学, 医学研究科, 准教授 (60343232)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 鉄代謝 / ヘプシジン / フェリチン / 造血幹細胞移植 / GVHD / 鉄過剰症 / 血液内科学 |
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| Research Abstract |
The purpose of this study was to clarify the pathogenesis of iron disorders through basic and clinical studies of iron metabolism-associated molecules such as hepcidin and ferritin. We identified that hepcidin expression by hepatoma cells was affected by microenvironmental pH. We also found that iron storage protein H-ferritin was selectively taken up by erythroid cells through transferrin receptor 1. Furthermore, we demonstrated that pre-transplant hyperferritinemia was a risk factor for bacterial infection and disease relapse after allogenic stem cell transplantation.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Differing impacts of pretransplant serum ferritin and c-reactive protein levels on the incidence of chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation2013
Author(s)
Sakamoto S, Kawabata H, Kanda J, Uchiyama T, Mizumoto C, Kondo T, Yamashita K, Ichinohe T, Ishikawa T, Kadowaki N, Takaori-Kondo A
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Journal Title
Int J Hematol
Volume: 97
Issue: 1
Pages: 109-116
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] A case of congenital dyserythropoietic anemia type 1 in a japanese adult with a cdan1 gene mutation and an inappropriately low serum hepcidin-25 level2012
Author(s)
Kawabata H, Doisaki S, Okamoto A, Uchiyama T, Sakamoto S, Hama A, Hosoda K, Fujikura J, Kanno H, Fujii H, Tomosugi N, Nakao K, Kojima S, Takaori-Kondo A
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Journal Title
Intern Med
Volume: 51
Pages: 917-920
NAID
Related Report
Peer Reviewed
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[Journal Article] A case of congenital dyserythropoietic anemia type 1 in a japanese adult with a cdan1 gene mutation and an inappropriately low serum hepcidin-25 level.2012
Author(s)
Kawabata H, Doisaki S, Okamoto A, Uchiyama T, Sakamoto S, Hama A, Hosoda K, Fujikura J, Kanno H, Fujii H, Tomosugi N, Nakao K, Kojima S, Takaori-Kondo A
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Journal Title
Intern Med
Volume: 51
Pages: 917-920
NAID
Related Report
Peer Reviewed
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[Journal Article] Pretransplant serum ferritin and c-reactive protein as predictive factors for early bacterial infection after allogeneic hematopoietic cell transplantation2011
Author(s)
Kanda J, Mizumoto C, Ichinohe T, Kawabata H, Saito T, Yamashita K, Kondo T, Takakura S, Ichiyama S, Uchiyama T, Ishikawa T
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Journal Title
Bone Marrow Transplant
Volume: 46
Issue: 2
Pages: 208-216
DOI
Related Report
Peer Reviewed
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[Journal Article] Pretransplant serum ferritin and c-reactive protein as predictive factors for early bacterial infection after allogeneic hematopoietic cell transplantation.2011
Author(s)
Kanda J, Mizumoto C, Ichinohe T, Kawabata H, Saito T, Yamashita K, Kondo T., Takakura S, Ichiyama S, Uchiyama T, Ishikawa T
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Journal Title
Bone Marrow Transplant.
Volume: 46
Pages: 208-216
Related Report
Peer Reviewed
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[Journal Article] Clinical features and treatments of multicentric castleman's disease: A retrospective study of 21 japanese cases in a single institute
Author(s)
Kawabata H, Kadowaki N, Nishikori M, Kitawaki T, Kondo T, Ishikawa T, Yoshifuji H, Yamakawa N, Imura Y, Mimori T, Matsumura Y, Miyachi Y, Matsubara T, Haga H, Takaori-Kondo A
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Journal Title
J Clin Exp Hematopathol in press
Related Report
Peer Reviewed
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[Presentation] Impact of pre-transplant hepcidin-25 in patients undergoing allo-SCT for hematologic malignancies(造血器腫瘍に対する同種造血幹細胞移植における移植前ヘプシジン値の影響)2011
Author(s)
Soichiro Sakamoto, Hiroshi Kawabata, Junya Kanda, Tatsuki Uchiyama, Chisaki Mizumoto, Tadakazu Kondo, Kouhei Yamashita, Tatsuo Ichinohe, Takayuki Ishikawa, Norimitsu Kadowaki, Naohisa Tomosugiand Akifumi Takaori-Kondo
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋国際会議場・名古屋市・愛知県
Related Report
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[Presentation] PROGNOSTIC IMPACT OF PRE-TRANSPLANT SERUM HEPCIDIN LEVELS ON CLINICAL OUTCOMES AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION2011
Author(s)
Soichiro Sakamoto, Hiroshi Kawabata, Junya Kanda, Tatsuki Uchiyama, Chisaki Mizumoto, Tadakazu Kondo, Kouhei Yamashita, Tatsuo Ichinohe, Takayuki Ishikawa, Norimitsu Kadowaki, Naohisa Tomosugi and Akifumi Takaori-Kondo
Organizer
16th Congress of the European Hematology Association
Place of Presentation
Excel, London, United Kingdom
Related Report
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[Presentation] Impact of pre-transplant hepcidin-25 in patients undergoing allo-SCT for hematologic malignancies造血器腫瘍に対する同種造血幹細胞移植における移植前ヘプシジン値の影響2011
Author(s)
Soichiro Sakamoto, Hiroshi Kawabata, Junya Kanda, Tatsuki Uchiyama, Chisaki Mizumoto, Tadakazu Kondo, Kouhei Yamashita, Tatsuo Ichinohe, Takayuki Ishikawa, Norimitsu Kadowaki, Naohisa Tomosugi, Akifumi Takaori-Kondo
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋国際会議場・名古屋市・愛知県
Related Report
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[Presentation] Impact of Serum Ferritin Levels on the Incidence of Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation2010
Author(s)
Sakamoto S, Kawabata H, Kanda J, Uchiyama T, Mizumoto C, Kondo T, Ichinohe T, Ishikawa T, Takaori-Kondo A
Organizer
The American Society of Hematology 52nd Annual Meeting
Place of Presentation
Orland, FL, USA
Related Report
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[Presentation] Impact of Serum Ferritin Levels on the Incidence of Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation.2010
Author(s)
Sakamoto S, Kawabata H, Kanda J, Uchiyama T, Mizumoto C, Kondo T, Ichinohe T, Ishikawa T, Takaori-Kondo A.
Organizer
The American Society of Hematology 52nd Annual Meeting
Place of Presentation
Orland, FL, USA.
Related Report
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