| Project/Area Number |
22591035
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
MAEDA Tetsuo 大阪大学, 医学系研究科, 助教 (00403064)
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| Co-Investigator(Kenkyū-buntansha) |
KANAKURA Yuzuru 大阪大学, 医学系研究科, 教授 (20177489)
ORITANI Kenji 大阪大学, 医学系研究科, 准教授 (70324762)
YOKOTA Takafumi 大阪大学, 医学系研究科, 助教 (60403200)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 造血幹細胞 / 赤血球 / 膜蛋白 / ESAM-1 / 細胞周期 / 自己複製 / 初期分化 / 血管内皮細胞 / 目己複製 |
|---|
| Research Abstract |
The aim of this study is to clarify meanings of endothelial cell-specific adhesion molecule-1 (ESAM-1) in hematopoietic stem cell biology. Expression of ESAM-1 was up-regulated when hematopoietic stem cells went into proliferation state. In ESAM-1-deficient mice, they died after 5-FU treatment by severe anemia. We found that ESAM-1 was required for early differentiation of red blood cells.Although human hematopoietic stem cells expressed ESAM-1, we found a highly ESAM-1-expressing population in cord blood cells. They had an ability to differentiate into endotherial cells, thereby indicating as a new source of cell-based therapy.
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