Comprehensive analysis of hematopoietic stem cell-specific genes
| Project/Area Number |
22591035
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
MAEDA Tetsuo 大阪大学, 医学系研究科, 助教 (00403064)
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| Co-Investigator(Kenkyū-buntansha) |
KANAKURA Yuzuru 大阪大学, 医学系研究科, 教授 (20177489)
ORITANI Kenji 大阪大学, 医学系研究科, 准教授 (70324762)
YOKOTA Takafumi 大阪大学, 医学系研究科, 助教 (60403200)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 造血幹細胞 / 赤血球 / 膜蛋白 / ESAM-1 / 細胞周期 / 自己複製 / 初期分化 / 血管内皮細胞 / 目己複製 |
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| Research Abstract |
The aim of this study is to clarify meanings of endothelial cell-specific adhesion molecule-1 (ESAM-1) in hematopoietic stem cell biology. Expression of ESAM-1 was up-regulated when hematopoietic stem cells went into proliferation state. In ESAM-1-deficient mice, they died after 5-FU treatment by severe anemia. We found that ESAM-1 was required for early differentiation of red blood cells.Although human hematopoietic stem cells expressed ESAM-1, we found a highly ESAM-1-expressing population in cord blood cells. They had an ability to differentiate into endotherial cells, thereby indicating as a new source of cell-based therapy.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal2012
Author(s)
Sudo T, Yokota T, Oritani K, Satoh Y, Sugiyama T, Ishida T, Shibayama H, Ezoe S, Fujita N, Tanaka H, Maeda T, Nagasawa T, Kanakura Y
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Journal Title
J Immunol
Volume: 189
Pages: 200-210
Related Report
Peer Reviewed
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[Journal Article] Peripheral T-cell lymphoma of Lennert type complicated by monoclonal proliferation of large B-cells2010
Author(s)
Chihara T, Wada N, Kohara M, Matsui T, Masaya H, Maeda T, Shibayama H, Kanakura Y, Tani M, Morii E, Aozasa K
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Journal Title
Pathol Res Pract
Volume: 206
Pages: 185-190
Related Report
Peer Reviewed
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[Journal Article] Pulmonary hypertension associated with bone marrow transplantaion2010
Author(s)
Nakaoka H, Sakata Y, Yamamoto M, Maeda T, Arita Y, Shioyama W, Nakaoka Y, Kanakura Y, Yamashita S, Komuro I, Yamauchi-Takihara K.
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Journal Title
J Cardiol cases
Volume: 2
Pages: 23-27
Related Report
Peer Reviewed
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[Journal Article] The efficacy of tocilizumab in a patient with pulmonary arterial hypertension associated with Castleman's disease2010
Author(s)
Arita Y, Sakata Y, Sudo T, Maeda T, Matsuoka K, Tamai K, Higuchi K, Shioyama W, Nakaoka Y, Kanakura Y, Yamauchi-Takihara K.
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Journal Title
Heart Vessels
Volume: 25
Pages: 444-447
Related Report
Peer Reviewed
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