Investigation of pathogenesis of hematological malignancies by analyzing balanced and unbalanced chromosomal translocations

• Project/Area Number: 22591037
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Kobe University
• Principal Investigator: YAMAMOTO Katsuya 神戸大学, 医学部, 非常勤講師 (60306199)
• Co-Investigator(Kenkyū-buntansha): MATSUI Toshimitsu 神戸大学, 医学研究科, 准教授 (10219371)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 染色体転座 / 悪性リンパ腫 / TFL 遺伝子 / 骨髄異形成症候群 / 造血器腫瘍 / TFL遺伝子

Research Abstract

A novel gene TFL was cloned at the 6q25 breakpoint of a balanced translocation t(2;6)(p12;q25) appearing during transformation from follicular lymphoma to diffuse large B-cell lymphoma. In this study, we establishedTFL knockout mice and analyzed TFL function. We also examined the expression and structural abnormality of TFL in malignant lymphomas. Next, we characterized clinical and hematological features of myelodysplastic syndromes with a novel unbalanced translocationder(5;19)(p10;q10). Furthermore, we identified several rare balanced or unbalanced translocations from newly diagnosed cases of hematological malignancies.

Research Products

• [Journal Article] A novel TRB@/NOTCH1fusion gene in T-cell lymphoblastic lymphoma with t (2013)
  • Author(s): Yamamoto K, Nakamachi Y, Yakushijin K, Miyata Y, Okamura A, Kawano S, Matsuoka H, Minami H.
  • Journal Title: Eur. J. Haematol. Volume: 90巻 Issue: 1 Pages: 68-75
  • DOI: 10.1111/ejh.12019
  • Peer Reviewed
• [Journal Article] IGH@/BCL6rearrangement on the der(3)t(3;14) (q27;q32) in primary mediastinal large B-cell lymphoma (2012)
  • Author(s): Yamamoto K, Okamura A, Inui Y, Yakushijin K, Kawakami F, Itoh T, Matsuoka H, Minami H
  • Journal Title: Leuk. Res. Volume: 36巻 Issue: 12 Pages: e218-e221
  • DOI: 10.1016/j.leukres.2012.07.011
  • Peer Reviewed
• [Journal Article] Cryptic insertion of BCL2gene into immunoglobulin heavy locus in follicular lymphoma witht(6;9)(p23;p13) (2012)
  • Author(s): Yamamoto K, Okamura A, Inui Y, Yakushijin K, Murayama T, Matsuoka H, Minami H
  • Journal Title: Leuk. Res Volume: 36巻 Issue: 9 Pages: e202-e205
  • DOI: 10.1016/j.leukres.2012.05.002
  • Peer Reviewed
• [Journal Article] A novel recurrent translocation t(7;17)(q22;p13) and a late-appearing t(2;3)(p13;q26.2) with dysmegakaryopoiesis in acute myeloid leukemia (2012)
  • Author(s): Yamamoto K, Okamura A, Inui Y, Yakushijin K, Matsuoka H, Minami H.
  • Journal Title: Leuk. Res Volume: 36巻 Issue: 4 Pages: e84-e86
  • DOI: 10.1016/j.leukres.2011.12.007
  • Peer Reviewed
• [Journal Article] Expression of the novel NUP98/PSIP1fusion transcripts in myelodysplastic syndrome with t(9;11)(p22;p15) (2012)
  • Author(s): Yamamoto K, Nakamachi Y, Yakushijin K, Funakoshi Y, Okamura A, Kawano S, Matsuoka H, Minami H
  • Journal Title: Eur. J. Haematol Volume: 88巻 Issue: 3 Pages: 244-248
  • DOI: 10.1111/j.1600-0609.2011.01736.x
  • Peer Reviewed
• [Journal Article] Mycophenolate mofetil: fully utilize its benefits for GvHD prophylaxis (2012)
  • Author(s): Minagawa K, Yamamori M, Katayama Y, Matsui T
  • Journal Title: Int. J. Hematol Volume: 96巻 Issue: 1 Pages: 10-25
  • DOI: 10.1007/s12185-012-1086-x
  • NAID: 10030954340
  • Peer Reviewed
• [Journal Article] A novel feedback mechanism by Ephrin-B1/B2 in T-cell activation involves a concentration-dependent switch from co-stimulation to inhibition. (2012)
  • Author(s): Kawano H, Katayama Y, Minagawa K, Shimoyama M, Henkemeyer M, Matsui T
  • Journal Title: Eur. J. Immunol Volume: 42巻 Issue: 6 Pages: 1562-1572
  • DOI: 10.1002/eji.201142175
  • Peer Reviewed
• [Journal Article] The putative tumor suppressor Zc3h12d modulates toll-like receptor signaling in macrophages (2012)
  • Author(s): Huang S, Qi D, Liang J, Miao R, Minagawa K, Quinn T, Matsui T, Fan D, Liu J, Fu M.
  • Journal Title: Cell Signal Volume: 24巻 Issue: 2 Pages: 569-76
  • DOI: 10.1016/j.cellsig.2011.10.011
  • Peer Reviewed
• [Journal Article] Reed-Sternberg-like cells of ALK-positive anaplastic large cell lymphoma with near-tetraploidy (2012)
  • Author(s): 山本克也
  • Journal Title: European Journal of Haematology Volume: 88 Issue: 6 Pages: 553-554
  • DOI: 10.1111/j.1600-0609.2012.01756.x
  • Peer Reviewed
• [Journal Article] A novel five-way translocation, t(3;9;13;8;14)(q27;p13;q32;q24;q32), with concurrent MYCand BCL6rearrangements in a primary bone marrow B-cell lymphoma (2011)
  • Author(s): Yamamoto K, Matsuoka H, Yakushijin K, Funakoshi Y, Hayashi Y, Minami H.
  • Journal Title: Cancer Genet Volume: 204巻 Issue: 9 Pages: 501-506
  • DOI: 10.1016/j.cancergen.2011.08.017
  • Peer Reviewed
• [Journal Article] Biallelic ETV6rearrangements by recurrent translocations t(7;12)(p15;p13) and t(3;12)(q26.2;p13) in acute myeloid leukemia (2011)
  • Author(s): Yamamoto K, Yakushijin K, Funakoshi Y, Inui Y, Okamura A, Matsuoka H, Minami H.
  • Journal Title: Leuk. Res Volume: 35巻 Issue: 11 Pages: e212-e214
  • DOI: 10.1016/j.leukres.2011.07.012
  • Peer Reviewed
• [Journal Article] Pharmacokinetics-based optimal dose prediction of mycophenolate mofetil in unrelated hematopoietic cell transplantation depending on donor source (2011)
  • Author(s): Wakahashi K, Yamamori M, Minagawa K, Ishii S, Nishikawa S, Shimoyama M, Kawano H, Kawano H, Kawamori Y, Sada A, Matsui T, Katayama Y.
  • Journal Title: Int. J. Hematol Volume: 94巻 Issue: 2 Pages: 193-202
  • DOI: 10.1007/s12185-011-0888-6
  • Peer Reviewed
• [Journal Article] A novel dicentric chromosome, dic(9;9 )(p13;q34), leading to trisomy 9 in follicular lymphoma without t(14;18) (2011)
  • Author(s): Katsuya Yamamoto
  • Journal Title: Leukemia Research Volume: 35 Issue: 7 Pages: e100-e103
  • DOI: 10.1016/j.leukres.2011.02.017
  • Peer Reviewed
• [Journal Article] Therapy-Related Pure Erythroid Leukemia with Hepatic Infiltration and Hemophagocytic Syndrome (2011)
  • Author(s): Yohei Funakoshi
  • Journal Title: Internal Medicine Volume: 50 Issue: 24 Pages: 3031-3035
  • DOI: 10.2169/internalmedicine.50.6168
  • NAID: 130002062729
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Unbalanced whole-arm translocation der(18;21) (q10;q10) is a recurrent cytogenetic aberration appearing disease progression in myeloid leukemias (2010)
  • Author(s): Yamamoto K, Shimoyama M, Katayama Y, Matsui T.
  • Journal Title: Leuk. Res Volume: 34巻 Issue: 12 Pages: e339-e341
  • DOI: 10.1016/j.leukres.2010.08.016
  • Peer Reviewed
• [Journal Article] Two further cases of myelodysplastic syndrome and acute myeloid leukemia with der(5;19)(p10;q10): association with abnormalities involving chromosomes 12 and 21. (2010)
  • Author(s): Yamamoto K, Wakahashi K, Okamura A, Katayama Y, Shimoyama M, Matsui T
  • Journal Title: Leuk. Res Volume: 34巻
  • NAID: 120003307581
  • Peer Reviewed
• [Journal Article] Role for vitamin D receptor in the neuronal control of the hematopoietic stem cell niche (2010)
  • Author(s): Kawamori Y, Katayama Y, Asada N, Minagawa K, Sato M, Okamura A, Shimoyama M, Nakagawa K, Okano T, Tanimoto M, Kato S, Matsui T
  • Journal Title: Blood Volume: 116巻 Issue: 25 Pages: 5528-5535
  • DOI: 10.1182/blood-2010-04-279216
  • Peer Reviewed
• [Journal Article] Unbalanced whole-arm translocation der(18;21)(q10;q10)is a recurrent cytogenetic aberration appearing during progression in myeloid leukemias (2010)
  • Author(s): Katsuya Yamamoto
  • Journal Title: Leukemia Research Volume: 34
  • NAID: 120003307579
  • Peer Reviewed
• [Journal Article] Therapy-related, mixed phenotype acute leukemia with t(1;21)(p36;q22)and RUNX1 rearrangement (2010)
  • Author(s): Katsuya Yamamoto
  • Journal Title: Cancer Genetics and Cytogenetics Volume: 201 Pages: 122-127
  • NAID: 120003307582
  • Peer Reviewed
• [Journal Article] A novel unbalanced whole-arm translocation der(3;10)(q10;q10)in acute monocytic leukemia (2010)
  • Author(s): Katsuya Yamamoto
  • Journal Title: Cancer Genetics and Cytogenetics Volume: 199 Pages: 134-138
  • NAID: 120003307583
  • Peer Reviewed
• [Presentation] A novel TRB@/NOTCH1fusion gene in T-cell lymphoblastic lymphoma with t(7;9)(q34;q34) (2012)
  • Author(s): 山本克也, 他
  • Organizer: 第74回日本血液学会
  • Place of Presentation: 京都.
  • Year and Date: 2012-10-20
• [Presentation] A novel zinc finger protein TFL suppresses IL-17 dependent T-cell-mediated autoimmune disease (2012)
  • Author(s): 皆川健太郎, 松井利充, 他
  • Organizer: 第74回日本血液学会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-20
• [Presentation] t(9;11)(p22;p15)転座と新たなNUP98/PSIP1融合遺伝子発現を認めた骨髄異形成症候群. (2011)
  • Author(s): 山本克也, 他
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-14
• [Presentation] A novel activated lymphocyte marker TFL is highly expressed in follicular lymphoma but less in DLBCL (2011)
  • Author(s): 皆川健太郎, 松井利充, 他
  • Organizer: 第73回日本血液学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-14
• [Presentation] 新たなNUP98/PSIP1融合遺伝子発現とt(9;11)(p22;p15)転座を認めた骨髄異形成症候群 (2011)
  • Author(s): 山本克也
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋市・名古屋国際会議場
  • Year and Date: 2011-10-14
• [Presentation] 新たな dicentric chromosomedic(9;9)(p12;q34)を認めたt(14;18)陰性濾胞性リンパ腫 (2010)
  • Author(s): 山本克也, 他:
  • Organizer: 第72回日本血液学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] 新たなdicentric chromosome dic(9;9)(p12;q34)を認めたt(14;18)陰性濾胞性リンパ腫 (2010)
  • Author(s): 山本克也
  • Organizer: 第72回日本血液学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2010-09-25
• [Presentation] 悪性リンパ腫より見出された新規リンパ腫活性化マーカーTFL の発現変化の検討 (2010)
  • Author(s): 皆川健太郎, 松井利充, 他
  • Organizer: 第72回日本血液学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-24
• [Presentation] A novel TRB@/NOTCH1 fusion gene in T-cell lymphoblastic lymphoma with t(7;9)(q34;q34)
  • Author(s): 山本克也
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 国立京都国際会館