Molecular mechanism of the therapy-related myeloid neoplasms
| Project/Area Number |
22591038
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Hiroshima University |
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Principal Investigator |
HARADA Yuka 広島大学, 原爆放射線医科学研究所, 助教 (50379848)
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| Co-Investigator(Kenkyū-buntansha) |
HARADA Hironori 広島大学, 原爆放射線医科学研究所, 講師 (10314775)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 治療関連造血器腫瘍 / 遺伝子異常 / 急性前骨髄球性白血病 / RUNX1 / 骨髄異形成症候群 / MLL / エトポシド / BMI1 / 遺伝子変異 / ヒト造血幹細胞 / キメラ遺伝子 / 転写因子 / AML1/RUNX1遺伝子 / 急性骨髄性白血病 / ATRA |
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| Research Abstract |
We analyzed genetic abnormalities in the patients with therapy-related myeloid neoplasms (t-MN), and found that gene abnormalities of RUNX1 orMLL gene were the most common molecular abnormalities in t-MN after acute promyelocytic leukemia treated with VP16. VP16-treated cells showed rearrangement bands in both RUNX1 and MLL genes, suggesting that it may result in subsequent development of t-MN. Furthermore, we verified that RUNX1 mutant collaborates with BMI1 overexpression in the development of t-MDS/AML.
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Report
(4 results)
Research Products
(92 results)
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[Journal Article] RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes2013
Author(s)
Harada Y, Inoue D, Ding Y, Imagawa J, Doki N, Matsui H, Yahata T, Matsushita H, Ando K, Sashida G, Iwama A, Kitamura T, Harada H
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Journal Title
Related Report
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[Journal Article] Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis2012
Author(s)
Oki T, Kitaura J, Watanabe-Okochi N, Nishimura K, Maehara A, Uchida T, Komeno Y, Nakahara F, Harada Y, Sonoki T, Harada H, Kitamura T
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Journal Title
Leukemia
Volume: (in press)
Issue: 5
Pages: 1038-1045
DOI
Related Report
Peer Reviewed
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[Journal Article] Morphologic analysis in myelodysplastic syndromes with del(5q) treated with lenalidomide. A Japanese multiinstitutional study2012
Author(s)
Matsuda A, Taniwaki M, Jinnai I, Harada H, Watanabe M, Suzuki K, Yanagita S, Suzuki T, Yoshida Y, Kimura A, Tsudo M, Tohyama K, Takatoku M, Ozawa K
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Journal Title
Leuk Res
Volume: (in press)
Issue: 5
Pages: 575-580
DOI
Related Report
Peer Reviewed
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[Journal Article] Fyn is not essential for Bcr-Ab1-induced leukemogenesis in mouse bone marrow transplantation models2012
Author(s)
Doki N, Kitaura J, Inoue D, Kato N, Kagiyama Y, Uchida T, Togami K, Isobe M, Ito S, Maehara A, Izawa K, Oki T, Harada Y, Nakahara F, Harada H, Kitamura T
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Journal Title
Int J Hematol
Volume: 95(2)
Issue: 2
Pages: 167-175
DOI
Related Report
Peer Reviewed
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[Journal Article] 骨髄異形成症候群(MDS)と慢性骨髄性白血病(CML)における白血病移行の分子機構.第73回日本血液学会学術集会シンポジウム 112012
Author(s)
北村俊雄,大河内直子,井上大地,戸上勝仁,内田智之,鍵山侑希,川畑公人,千葉 滋,原田結花,原田浩徳,北浦次郎,中原史雄
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Journal Title
臨床血液
Volume: 53(8)
Pages: 734-739
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[Journal Article] AID-induced T-lymphoma or B-leukemia/lymphoma in a mouse BMT model2010
Author(s)
Komeno Y, Kitaura J, Watanabe-Okochi N, Kato N, Oki T, Nakahara F, Harada Y, Harada H, Shinkura R, Nagaoka H, Hayashi Y, Honjo T, Kitamura T.
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Journal Title
Leukemia
Volume: 24
Issue: 5
Pages: 1018-1024
DOI
Related Report
Peer Reviewed
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[Presentation] Deferasirox improved cytopenia in patients with bone marrow failure2011
Author(s)
Harada Y, Okikawa Y, Kimura A, Ito T, Niimi H, Noda M, Tanaka H, Shimomura T, Kuroda Y, Katsutani S, Kimura A, Harada H
Organizer
第73回日本血液学会学術集会
Place of Presentation
名古屋市
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