The Role of the Lyn-PI 3-kinase signaling pathways and PKM2 in the myeloma cell proliferation

• Project/Area Number: 22591039
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Senri Kinran University (2012); Yamaguchi University (2010-2011)
• Principal Investigator: ISHIKAWA Hideaki 千里金蘭大学, 生活科学部, 教授 (40294623)
• Co-Investigator(Kenkyū-buntansha): 小幡 雅則 山口大学, 大学院・医学系研究科, 講師 (80158831)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 骨髄腫 / IL-6 / Lyn / PI 3-kinase / Akt / FoxO1 / NF-kB / 解糖系 / Fox01 / PI3-kinase / PKM2

Research Abstract

In addition to the activation of both signal transducer and activator of transcription (STAT) 3 and extracellular signal-regulated kinase (ERK)1/2, the CD45-Lyn-mediating activation of the phosphoinositide (PI) 3-kinase-Akt signaling pathways appear to be important for the IL-6 induced proliferation of myeloma cells.

Research Products

• [Journal Article] 骨髄腫細胞のシグナル伝達 (2012)
  • Author(s): 石川秀明
  • Journal Title: 医学のあゆみ Volume: Vol. 242, No. 13 Pages: 1027-1032
  • URL: http://www.ishiyaku.co.jp/
• [Journal Article] A novel signaling pathway associated with Lyn,PI3-kinase and Akt supports the proliferation of myeloma cells (2010)
  • Author(s): Mohd S. Iqbal, Naohiro Tsuyama , Masanori Obata and Hideaki Ishikawa
  • Journal Title: Biochemical and Biophysical Research Communications Volume: Vol. 392, No. 3 Issue: 3 Pages: 415-420
  • DOI: 10.1016/j.bbrc.2010.01.038
  • Peer Reviewed
• [Journal Article] A novel signaling pathway associated with Lyn, PI 3-kinase and Akt supports the proliferation of myeloma cells (2010)
  • Author(s): Mohd S.Iqbal
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 392 Pages: 415-420
  • Peer Reviewed
• [Presentation] IL-6-induced phosphorylation of FoxO1 as a target of the PI-3-kinase-Akt pathway in myeloma cells(骨髄腫細胞における IL-6 刺激後 PI3-kinase-Akt 刺激伝達系標的分子 FoxO1 の リン酸化) (2011)
  • Author(s): 石川秀明、小幡雅則
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-16
• [Presentation] 骨髄腫細胞におけるIL-6刺激後PI 3-kinase-Akt刺激伝達系標的分子Fox01のリン酸化 (2011)
  • Author(s): 石川秀明
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2011-10-16
• [Presentation] IL-6-induced phosphorylation ofAkt and FoxO1 in human myeloma cell lines(IL-6 刺激後の骨髄腫細胞における Akt と FoxO1 のリン酸化) (2011)
  • Author(s): 石川秀明
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] IL-6刺激後の骨髄腫細胞におけるAktとFox01の・リン酸化 (2011)
  • Author(s): 石川秀明
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2011-10-04
• [Presentation] Lyn-PI 3-kinase-Akt 刺激伝達系によ る骨髄腫細胞の増殖機構 (2010)
  • Author(s): 石川秀明 、Mohd S. Iqbal、津山尚宏、小幡雅則
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] Lyn-PI 3-kinase-Akt刺激伝達系による骨髄腫細胞の増殖機構 (2010)
  • Author(s): 石川秀明
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
  • Place of Presentation: 兵庫県・神戸国際展示場
  • Year and Date: 2010-12-08
• [Presentation] The Lyn,PI 3-kinase and Akt signaling pathway supports the proliferation of humanmyeloma cells(Lyn-PI3 kinase-Akt 刺激伝達系はヒト骨髄腫細胞の増殖を促進する) (2010)
  • Author(s): 石川秀明、Mohd S. Iqbal,、津山尚宏、小幡雅則
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25
• [Presentation] The Lyn, PI 3-kinase and Akt signaling pathway supports the proliferation of human myeloma cells (2010)
  • Author(s): 石川秀明
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: 神奈川県・パシフィコ横浜
  • Year and Date: 2010-09-25
• [Presentation] The IL-6-mediated signaling pathway associated with Lyn,PI 3-kinase and Akt supports the proliferation of human myeloma cells (2010)
  • Author(s): Hideaki Ishikawa, Mohd S. Iqbal, Naohiro Tsuyama and Masanori Obata
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-24
• [Presentation] The IL-6-mediated signaling pathway associated with Lyn, PI 3-kinase and Akt supports the proliferation of human myeloma cells (2010)
  • Author(s): Hideaki Ishikawa
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 兵庫県・神戸国際展示場
  • Year and Date: 2010-08-24
• [Book] 別冊日本臨牀血液症候群III-その他の血液疾患を含めて-第2版 (2013)
  • Author(s): 石川秀明
  • Publisher: 日本臨牀社
• [Book] 別冊日本臨牀 血液症候群III (2013)
  • Author(s): 石川秀明
  • Publisher: 日本臨牀社
• [Book] 多発性骨髄腫治療マニュアル (2012)
  • Author(s): 石川秀明
  • Publisher: 南江堂
• [Remarks]
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~plasma/
• [Remarks]
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~plasma/cellularsignalanalysis.html