The Role of the Lyn-PI 3-kinase signaling pathways and PKM2 in the myeloma cell proliferation
Project/Area Number |
22591039
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Senri Kinran University (2012) Yamaguchi University (2010-2011) |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
小幡 雅則 山口大学, 大学院・医学系研究科, 講師 (80158831)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 骨髄腫 / IL-6 / Lyn / PI 3-kinase / Akt / FoxO1 / NF-kB / 解糖系 / Fox01 / PI3-kinase / PKM2 |
Research Abstract |
In addition to the activation of both signal transducer and activator of transcription (STAT) 3 and extracellular signal-regulated kinase (ERK)1/2, the CD45-Lyn-mediating activation of the phosphoinositide (PI) 3-kinase-Akt signaling pathways appear to be important for the IL-6 induced proliferation of myeloma cells.
|
Report
(4 results)
Research Products
(18 results)