Elucidation of chemoresistance in hypoxic condition and a developmentof radical treatment in AML cells by hypoxia specific inhibitory drugs

Research Project

Project/Area Number	22591042
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Hematology
Research Institution	Kagawa University (2011-2012) University of Miyazaki (2010)
Principal Investigator	MATSUNAGA Takuya 香川大学, 医学部, 教授 (70260768)
Co-Investigator(Kenkyū-buntansha)	SHIMODA Kazuya 宮崎大学, 医学部, 教授 (90311844)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	血液腫瘍学 / 抗癌剤耐性 / AML / 低酸素環境 / 低酸素選択性薬剤 / HIF-1alpha / HIF-1α
Research Abstract	It was demonstrated that the chemoresistance in hypoxic condition might be a cause of minimal residual disease in bone marrow after chemotherapy in AML.We developed a radical treatment of AML with (i)combination of anticancer drugs and hypoxia specific inhibitory drug, or (ii)combination of anticancer drugs, hypoxia specific inhibitory drug and CAM-DR inhibitory drugs.

Report

(4 results)