| Project/Area Number |
22591044
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIKAMA Yayoi 福島県立医科大学, 医学部, 准教授 (40291562)
NOJI Hideyoshi 福島県立医科大学, 医学部, 講師 (20347214)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Kazuhiko 福島県立医科大学, 医学部, 助教 (90381392)
NASHIMOTO Masayuki 新潟薬科大学, 応用生物科学, 教授 (30228069)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 血液内科学 / 発作性夜間ヘモグロビン尿症 / テロメア長 / テロメラーゼ / 造血動態 / WT-1 / HMGA2 / TRUE法 / sgRNA |
|---|
| Research Abstract |
We investigated telomere length, activity of teilmerase, and the regulation mechanisms in GPI+/GPI- cells from patients with paroxysmal nocturnal hemogolbinuria(PNH), so that the differences of hematopoietics in hemolytic PNH and bone-marrow-failure-type PNH are clarified. In addition, the mechanisms of expansion of PNH clones are also unclear, but WT1 and HMGA2 are thought to be associating with that. Then we also incestigated suppress effects for the sxpansions fo PNH clones by those genes, due to development of molecularly targeted therapy for PNH.
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