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Basic stydies of suppression to expansion of PNH colne by new methods

Research Project

Project/Area Number 22591044
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionFukushima Medical University

Principal Investigator

SHICHISHIMA Tsutomu  福島県立医科大学, 医学部, 研究員 (10192105)

Co-Investigator(Kenkyū-buntansha) SHIKAMA Yayoi  福島県立医科大学, 医学部, 准教授 (40291562)
NOJI Hideyoshi  福島県立医科大学, 医学部, 講師 (20347214)
Co-Investigator(Renkei-kenkyūsha) IKEDA Kazuhiko  福島県立医科大学, 医学部, 助教 (90381392)
NASHIMOTO Masayuki  新潟薬科大学, 応用生物科学, 教授 (30228069)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords血液内科学 / 発作性夜間ヘモグロビン尿症 / テロメア長 / テロメラーゼ / 造血動態 / WT-1 / HMGA2 / TRUE法 / sgRNA
Research Abstract

We investigated telomere length, activity of teilmerase, and the regulation mechanisms in GPI+/GPI- cells from patients with paroxysmal nocturnal hemogolbinuria(PNH), so that the differences of hematopoietics in hemolytic PNH and bone-marrow-failure-type PNH are clarified. In addition, the mechanisms of expansion of PNH clones are also unclear, but WT1 and HMGA2 are thought to be associating with that. Then we also incestigated suppress effects for the sxpansions fo PNH clones by those genes, due to development of molecularly targeted therapy for PNH.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (104 results)

All 2012 2011 2010 Other

All Journal Article (18 results) (of which Peer Reviewed: 12 results) Presentation (82 results) (of which Invited: 3 results) Book (4 results)

  • [Journal Article] Deregulated expression of HMGA2 is implicated in clonal expansion of PIGA deficient cells in paroxysmal nocturnal haemoglobinuria2012

    • Author(s)
      Murakami, Y., N. Inoue, T. Shichishima, R. Ohta, H. Noji, Y. Maeda, J. Nishimura, Y. Kanakura and T. Kinoshita
    • Journal Title

      Br. J. Haematol

      Volume: 156 Issue: 3 Pages: 383-387

    • DOI

      10.1111/j.1365-2141.2011.08914.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maturity-dependent fractionation of neutrophil progenitors: A new method to examine in vivo expression profiles of differentiation-regulating genes2012

    • Author(s)
      Hu H, Shikama Y, Shichishima T, Ikeda K, Akutsu K, Ono T, Kimura H, Ogawa K, Noji H, Takeishi Y, Kimura J
    • Journal Title

      ExpHematol

      Volume: 40(8) Issue: 8 Pages: 675-681

    • DOI

      10.1016/j.exphem.2012.03.003

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Safety and feasibility of high-dose ranimustine (MCNU), carboplatin, etoposide, and cyclophosphamide (MCVC) therapy followed by autologous stem cell transplantation for malignant lymphoma2012

    • Author(s)
      Kameoka Y, Takahashi N, Ishizawa K, Kato Y, Ito J, Sasaki O, Murai K, Noji H, Hirokawa M, Tajima K, Shichishima T, Ishida Y, Harigae H, Sawada K
    • Journal Title

      Int J Hematol

      Volume: 96(5) Issue: 5 Pages: 624-630

    • DOI

      10.1007/s12185-012-1186-7

    • NAID

      10031126760

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] T-cell prolymphocytic leukemia in Japan: is it a variant2012

    • Author(s)
      Kameoka J, Takahashi N, Noji H, Murai K, Tajima K, Kameoka Y, Sato S, Shichishima T, Ishida Y, Harigae H, Sawada K
    • Journal Title

      Int J Hematol

      Volume: 96(5) Issue: 6 Pages: 660-667

    • DOI

      10.1007/s12185-012-1077-y

    • NAID

      10030793639

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A patient with acute lymphoblastic leukaemia presenting with an extremely high level (21.0%) of HbA1c2011

    • Author(s)
      Suzuki Y, Shichishima T, Yamashiro Y, Kimura H, Ishii R, Miyazaki K, Horie R, Moriya T, Hattori Y
    • Journal Title

      Ann Clin Biochem

      Volume: 48(5) Issue: 5 Pages: 474-477

    • DOI

      10.1258/acb.2011.010121

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Long-Term Clinical Outcomes of CHOP Chemotherapy between Japanese Patients with Nodal Peripheral T-Cell Lymphomas and Those with Diffuse Large B-Cell Lymphoma in the Study Group of the Tohoku Hematology Forum2011

    • Author(s)
      Akagi T, Takahashi N, Yamaguchi K, Ishizawa K, Murai K, Tajima K, Ikeda K, Kameoka Y, Kameoka J, Ito S, Kato Y, Noji H, Shichishima T, Itoh J, Ichinohasama R, Harigae H, Ishida Y, Sawada K
    • Journal Title

      Journal of Clinical and Experimental Hematopathology

      Volume: 51 Issue: 1 Pages: 29-35

    • DOI

      10.3960/jslrt.51.29

    • NAID

      10028239022

    • ISSN
      1346-4280, 1880-9952
    • Related Report
      2012 Final Research Report
  • [Journal Article] Impairment of FOS mRNA induction by a translation inhibitor puromycin in granulocytes from myelodysplastic syndrome patients2011

    • Author(s)
      Shikama Y, XiaoMin F, Shichishima T, Ono T, Noji H, Ikeda K, Ogawa K, Takeishi Y, Kimura J
    • Journal Title

      Br J haematol

      Volume: 154(4) Issue: 4 Pages: 525-527

    • DOI

      10.1111/j.1365-2141.2010.08504.x

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS Clinical Trial2011

    • Author(s)
      Kanakura Y, Ohyashiki K, Shichishima T, Shinichiro O, Ando K, Ninomiya H, Kawaguchi T, Nakao S, Nakakuma H, Nishimura J, Kinoshita T, Bedrosian C, Valentine M, Khursigara G, Ozawa K, Omine M
    • Journal Title

      Int J hematol

      Volume: 93(1) Issue: 1 Pages: 36-46

    • DOI

      10.1007/s12185-010-0748-9

    • NAID

      10029532438

    • Related Report
      2012 Final Research Report
  • [Journal Article] 特集骨髄不全症診療の新しい展開PNHの病態解析と治療の進歩2011

    • Author(s)
      七島勉
    • Journal Title

      血液内科

      Volume: 63(2) Pages: 208-215

    • Related Report
      2012 Final Research Report
  • [Journal Article] Comparison of long-term clinical outcomes of CHOP chemotherapy between Japanese patients with nodal peripheral T-cell lymphomas and those with diffuse large B-cell lymphoma in the study group of the Tohoku Hematology Forum2011

    • Author(s)
      Akagi T, Takahashi N, Shichishima T, et al
    • Journal Title

      Journal of Clinical and Experimental Hematopathology

      Volume: 51 Pages: 29-35

    • NAID

      10028239022

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A patient with acute lymphoblastic leukaemia presenting with an extremely high level (21.0%)of HbAlc2011

    • Author(s)
      Suzuki Y, Shichishima T, Yamashiro Y, et al
    • Journal Title

      Annals of Clinical Biochemistry

      Volume: 48 Pages: 474-477

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria : the AEGIS Clinical Trial2011

    • Author(s)
      Kanakura Y, Ohyashiki K, Shichishima T, et al
    • Journal Title

      International Journal of Hematology

      Volume: 93 Pages: 36-46

    • NAID

      10029532438

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria : the AEGIS Clinicai Trial2011

    • Author(s)
      Kanakura Y, Shichishima T, et al.
    • Journal Title

      International Journal of Hematology

      Volume: 93 Pages: 36-46

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low concentration of serum haptoglobin has impact on understanding complex pathophysiology in patients with acquired bone marrow failure syndromes2010

    • Author(s)
      Shichishima T, Ikeda K, Takahashi N, Kameoka J, Tajima K, Murai K, Tamai Y, Shichishima-Nakamura A, Akutsu K, Noji H, Okamoto M, Kimura H, Harigae H, Oyamada T, Kamesaki T, Takeishi Y, Sawada K
    • Journal Title

      Int J Hematol

      Volume: 91(4) Issue: 4 Pages: 602-610

    • DOI

      10.1007/s12185-010-0559-z

    • NAID

      10026401926

    • Related Report
      2012 Final Research Report
  • [Journal Article] Transcripts expressed using a bicistronic vector pIREShyg2 are sensitized to nonsense-mediated mRNA decay2010

    • Author(s)
      Shikama Y, Hu H, Ohno M, Matsuoka I, Shichishima T, Kimura J
    • Journal Title

      BMC Mol Biol

      Volume: 11 Issue: 1 Pages: 42-42

    • DOI

      10.1186/1471-2199-11-42

    • Related Report
      2012 Final Research Report
  • [Journal Article] 解説:発作性夜間ヘモグロビン尿症の診断・治療の実際2010

    • Author(s)
      七島勉
    • Journal Title

      血液・腫瘍科

      Volume: 60(6) Pages: 777-786

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] Low concentration of serum haptoglobin has impact on understanding complex pathophysiology in patients with acquired bone marrow failure syndromes2010

    • Author(s)
      Shichishima T, et. al.
    • Journal Title

      International Journal of Hematology

      Volume: 91 Pages: 602-610

    • NAID

      10026401926

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcripts expressed using a bicistronic vector pIREShyg2 are sensitized to nonsense-mediated mRNA decay2010

    • Author(s)
      Shikama T, Shichishima T, et. al
    • Journal Title

      BMC Molecular Biology

      Volume: 11 Pages: 42-42

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 特別講演:PNHの治療戦略とエクリズマブ.NPO法人2012

    • Author(s)
      七島勉
    • Organizer
      PNH倶楽部設立1周年記念医療講演会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 特別講演:最新のPNH治療2012

    • Author(s)
      七島勉
    • Organizer
      山形PNH講演会
    • Place of Presentation
      山形
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 特別講演:PNH治療の最新治験2012

    • Author(s)
      七島勉
    • Organizer
      秋田PNH講演会
    • Place of Presentation
      秋田
    • Year and Date
      2012-08-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 東北PNH 研究会: Paroxysmal nocturnal hemoglobinuria (PNH)症例におけるEculizumab治療の赤血球結合IgGおよびC3に対する影響2012

    • Author(s)
      野地秀義, 亀崎豊実, 濱中純子, 山口公平, 神林裕行, 竹石恭知, 七島勉
    • Organizer
      第4回造血器腫瘍免疫療法研究会
    • Place of Presentation
      金沢
    • Year and Date
      2012-08-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨髄低形成を伴うPNH 症例に対するEculizmab 使用経験.2012

    • Author(s)
      野地秀義, 七島 勉, 竹石恭知
    • Organizer
      2012 Japan PNH Masters
    • Place of Presentation
      東京
    • Year and Date
      2012-07-28
    • Related Report
      2012 Final Research Report
  • [Presentation] T-PIG研究の中間報告.2012

    • Author(s)
      野地秀義, 七島 勉
    • Organizer
      第3回 東北PNH 研究会
    • Place of Presentation
      仙台
    • Year and Date
      2012-06-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 講演:PNH患者におけるエクリズマブ投与の実際 -自験例からの知見-2012

    • Author(s)
      七島 勉
    • Organizer
      北海道PNH研究会
    • Place of Presentation
      札幌
    • Year and Date
      2012-01-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Impairment of HuR-mediated FOS mRNA stabilization in granulocytes from myelodysplastic syndrome patients2012

    • Author(s)
      Xiaomin F, Yayoi S, Shichishima T, Noji H, Ikeda K, Ogawa K, Takeishi Y, Kimura J
    • Organizer
      2012 American Society of Hematology (ASH) Annual Meeting and Exposition
    • Place of Presentation
      Atlanta, Georgia, USA
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Morphologic and cytogenetic examinations with bone marrow cells in PNH patients2012

    • Author(s)
      Noji H, Hamanaka S, Yamaguchi K, Ogawa K, Murai K, Kimura H, Mita M, Suzuki I, Kohno K, Kimura S, Saitoh Y, Hatta S, Michishita Y, Kanbayashi H, Ishida Y, Harigae H, Sawada K, Takeishi Y, Shichishima T
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Detection of PNH-type cells using high-resolution flow cytometry: Interim analysis of OPTIMA study2012

    • Author(s)
      Hosokawa K, Sugimori C, Yamamoto M, Nishimura J, Yonemura Y, Obara N, Noji H, Nakamura Y, Ando K, Shichishima T, Ninomiya H, Chiba S, Kawaguchi T, Nakao S, Kanakura Y
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Mechanism of impaired FOS mRNA induction by emetine in myelodysplastic syndrome granulocytes.2012

    • Author(s)
      Feng X, Shikama Y, Noji H, Shichishima T, Ikeda K, Ogawa K, Takeishi Y, Kimura J
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] A preliminary study on telomere length of granulocytes and mononuclear cells in PNH patients2012

    • Author(s)
      Takahashi H, Noji H, Takeishi Y, Shichishima T
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Erythema annulare centrifugum in a patient with paroxysmal nocturnal hemoglobinuria2012

    • Author(s)
      Noji H, Usuki K, Otsuka M, Horiuchi H, Yamamoto T, Takahashi H, Takeishi Y, Shichishima T
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Paroxysmal nocturnal hemoglobinuria in a patient with del(5q)(q23q32) myelodysplastic syndromes2012

    • Author(s)
      Mita M, Nakamura K, Takahashi H, Noji H, Takeishi Y, Shichishima T
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Del(13q) myelodysplastic syndromes in a patient with paroxysmal nocturnal hemoglobinuria (PNH)2012

    • Author(s)
      Kimura S, Saitou Y, Kanbayashi H, Matuda S, Odajima H, Takahashi H, Noji H, Takeishi Y, Shichishima T
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] OPTIMA試験:高精度フローサイトメトリー法によるGPIアンカー膜蛋白欠損血球の検出2012

    • Author(s)
      山本正樹,西村純一,細川晃平,杉盛千春,米村雄士,小原直,中村嘉彦,野地秀義,七島勉,安藤潔,二宮治彦,千葉滋,川口辰哉,中尾眞二,金倉譲
    • Organizer
      第49回補体シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] OPTIMA試験:高精度フローサイトメトリー法によるGPIアンカー型蛋白欠損血球の検出2012

    • Author(s)
      山本正樹, 西村純一, 細川晃平, 杉盛千春, 米村雄士, 小原 直, 野地秀義, 中村嘉彦, 安藤 潔, 七島 勉, 二宮治彦, 千葉 滋, 川口辰哉, 中尾眞二, 金倉 譲
    • Organizer
      第22回 サイトメトリー学会
    • Place of Presentation
      豊中
    • Related Report
      2012 Final Research Report
  • [Presentation] Morphologic and cytogenetic examinations with bone marrow cells in PNH patients2012

    • Author(s)
      Noji H, Hamanaka S, Yamaguchi K, Ogawa K, Murai K, Kimura H, Mita M, Suzuki I, Kohno K, Kimura S, Saitoh Y, Hatta S, Michishita Y, Takeishi Y, Shichishima T, et al
    • Organizer
      第74回 日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Detection of PNH-type cells using high-resolution flow cytometry: Interim analysis of OPTIMA study2012

    • Author(s)
      Hosokawa K, Sugimori C, Yamamoto M, Nishimura J, Yonemura Y, Obara N, Noji H, Nakamura Y, Ando K, Shichishima T, Ninomiya H, Chiba S, Kawaguchi T, Nakao S, Kanakura Y
    • Organizer
      第74回 日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mechanism of impaired FOS mRNA induction by emetine in myelodysplastic syndrome granulocytes2012

    • Author(s)
      Feng X, Shikama Y, Noji H, Shichishima T, Ikeda K, Ogawa K, Takeishi Y, Kimura J
    • Organizer
      第74回 日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] A preliminary study on telomere length of granulocytes and mononuclear cells in PNH patients2012

    • Author(s)
      Takahashi H, Noji H, Takeishi Y, Shichishima T
    • Organizer
      第74回 日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Erythema annulare centrifugum in a patient with paroxysmal nocturnal hemoglobinuria2012

    • Author(s)
      Noji H, Usuki K, Otsuka M, Horiuchi H, Yamamoto T, Takahashi H, Takeishi Y, Shichishima T
    • Organizer
      第74回 日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Paroxysmal nocturnal hemoglobinuria in a patient with del(5q)(q23q32) myelodysplastic syndromes2012

    • Author(s)
      Mita M, Nakamura K, Takahashi H, Noji H, Takeishi Y, Shichishima T
    • Organizer
      第74回 日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Del(13q) myelodysplastic syndromes in a patient with paroxysmal nocturnal hemoglobinuria (PNH)2012

    • Author(s)
      Kimura S, Saitou Y, Kanbayashi H, Matuda S, Odajima H, Takahashi H, Noji H, Takeishi Y, Shichishima T
    • Organizer
      第74回 日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] 特別講演:PNHの多様性と治療戦略. NPO法人PNH倶楽部2011

    • Author(s)
      七島 勉
    • Organizer
      設立報告会・記念講演会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-23
    • Related Report
      2012 Final Research Report
  • [Presentation] PNHの多様性と治療戦略2011

    • Author(s)
      七島勉
    • Organizer
      NPO法人PNH倶楽部設立報告会・記念講演会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 溶血を伴う骨髄不全型PNHに対するアプローチ:骨髄不全型PNHの自験例(パネルディスカッション)2011

    • Author(s)
      七島 勉
    • Organizer
      第2回 北陸PNH研究会
    • Place of Presentation
      金沢
    • Year and Date
      2011-10-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 溶血を伴う骨髄不全型PNHに対するアプローチ:骨髄不全型PNHの自験例2011

    • Author(s)
      七島勉
    • Organizer
      第2回北陸PMH研究会
    • Place of Presentation
      金沢
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Safety and feasibility of MEAM therapy fllowed by auto-HSCT for malignant lymphoma2011

    • Author(s)
      Kameoka Y, Takahashi N, Shichishima T, et al
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Efficacy of Eculizumab for nontransfused Japanese patients with PNH : case report from AEGIS study2011

    • Author(s)
      Shirasugi Y, Ando K, Shichishima T, et al
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Long-term efficacy of Eculizumab in Japanese patients with PNH : AEGIS Trial2011

    • Author(s)
      Gotoh A, Ohyashiki K, Shichishima T, et al
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] PNH-type cells by flow cytometric methods with a monoclonal antibody and FLAER in BMFS patients2011

    • Author(s)
      Takahashi H, Shichishima T, Noji H, et al
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 補体研究:基礎から臨床へ:発作性夜間血色素尿症をはじめとするGPI損症について2011

    • Author(s)
      村上良子, 井上徳光, 七島勉, et al
    • Organizer
      第48回補体シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Paroxysmal nocturnal hemoglobinuria(PNH)8症例におけるEculizumabの効果および安全性2011

    • Author(s)
      野地秀義, 七島勉, 高橋裕志, et al
    • Organizer
      第3回造血器腫瘍免疫療法研究会学術集会
    • Place of Presentation
      別府
    • Year and Date
      2011-08-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 種々のPNH症例とその治療経験 (Hemorrhagic diathesis in PNH: A case of PNH complicating acquired von Willebrand disease (vWD) during clinical course)2011

    • Author(s)
      七島 勉
    • Organizer
      Japan PNH Masters Program
    • Place of Presentation
      東京
    • Year and Date
      2011-07-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 種々のPNH症例とその治療経験(Hemarrhagic diathesis in PNH : A case of PNH complicating acquired von Willebrand disease (vWD) during clinical course)2011

    • Author(s)
      七島勉
    • Organizer
      Japan PNH Masters Program
    • Place of Presentation
      東京
    • Year and Date
      2011-07-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Long-term efficacy of Eculizumab in Japanese patients with PNH: AEGIS Trial.2011

    • Author(s)
      Gotoh A, Ohyashiki K, Kanakura Y, Okamoto S, Shichishima T, Ando K, Ninomiya H, Kawaguchi T, Nakao S, Nakakuma H, Nishimura J, Kinoshita T, Bedrosian C, Valentine M, Ozawa K, Omine M
    • Organizer
      第73回 日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] Safety and feasibility of MEAM therapy followed by auto-HSCT for malignant lymphoma2011

    • Author(s)
      Kameoka Y, Takahashi N, Akagi T, Hiroshima Y, Yokoyama H, Murai K, Tajima K, Shichishima T, Ishida Y, Harigae H, Sawada K
    • Organizer
      第73回 日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] PNH-type cells by flow cytometric methods with a monoclonal antibody and FLAER in BMFS patients2011

    • Author(s)
      Takahashi H, Shichishima T, Noji H, Ogawa K, Takeishi Y
    • Organizer
      第73回 日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] Efficacy of Eculizumab for nontransfused Japanese patients with PNH: case report from AEGIS study2011

    • Author(s)
      Shirasugi Y, Ando K, Kanakura Y, Okamoto S, Ohyashiki K, Shichishima T, Ninomiya H, Kawaguchi T, Nakao S, Nakakuma H, Nishimura J, Kinoshita T, Bedrosian C, Valentine M, Ozawa K, Omine M
    • Organizer
      第73回 日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] 補体研究:基礎から臨床へ:発作性夜間血色素尿症をはじめとするGPI欠損症について(シンポジウム)2011

    • Author(s)
      村上良子, 井上徳光, 七島 勉, 太田里永子, 野地秀義, 前田裕輔, 西村純一, 木下タロウ
    • Organizer
      第48回 補体シンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2012 Final Research Report
  • [Presentation] Paroxysmal nocturnal hemoglobinuria (PNH) 8症例におけるEculizumabの効果および安全性2011

    • Author(s)
      野地秀義, 七島 勉, 高橋裕志, 小川一英, 竹石恭知
    • Organizer
      第3回 造血器腫瘍免疫療法研究会学術集会
    • Place of Presentation
      別府
    • Related Report
      2012 Final Research Report
  • [Presentation] PNH 診断と治療について(パネルディスカッション)2010

    • Author(s)
      金倉 護, 西村純一, 中熊秀樹, 七島 勉, 二宮治彦, 川口辰哉
    • Organizer
      日本PNH研究会・関西キックオフミーティング
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-09
    • Related Report
      2012 Final Research Report
  • [Presentation] PNH診断と治療について(パネルディスカッション)2010

    • Author(s)
      七島勉
    • Organizer
      日本PNH研究会・関西キックオフミーティング
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 急性骨髄性白血病(AML)症例におけるCD59陰性白血病細胞の出現2010

    • Author(s)
      野地秀義, 七島勉, 他
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 後天性骨髄不全症候群(BMFS)症例におけるFLAERによるGPIアンカー発現の検討2010

    • Author(s)
      高橋裕志, 七島勉, 他
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of long term eculizumab treatment on chronic kidney disease in Japanese patients with PNH2010

    • Author(s)
      七島勉, 他
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Safety, feasibility and efficacy of MCVC therapy followed by auto-PBSCT for malignant lymphoma2010

    • Author(s)
      亀岡弥生, 七島勉, 他
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Impaired c-fos induction by emetin in granulocytes from myelodysplastic syndrome patients2010

    • Author(s)
      Feng X, 七島勉, 他
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血液学的およびクローン性寛解に至った発作性夜間ヘモグロビン尿症の2症例2010

    • Author(s)
      古川未希, 七島勉, 他
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Clinical and biological features of T-Cell prolymphocytic leukemia in Japan2010

    • Author(s)
      亀岡淳一, 七島勉, 他
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of autologous PBSCT in four patients with cardiac amyloidosis2010

    • Author(s)
      小川一英, 七島勉, 他
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 急性骨髄性白血病へ移行した骨髄異形成症候群を合併した発作性夜間ヘモグロビン尿症の一例2010

    • Author(s)
      木村哲, 七島勉, 他
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] PNHにおける補体溶血と関連した病態2010

    • Author(s)
      七島勉
    • Organizer
      第47回補体シンポジウム
    • Place of Presentation
      福島(講演)
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 講演:PNHと生きる2010

    • Author(s)
      七島 勉
    • Organizer
      ソリリス 発売記念講演会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-28
    • Related Report
      2012 Final Research Report
  • [Presentation] PNHと生きる2010

    • Author(s)
      七島勉
    • Organizer
      ソリリス^[○!R]発売記念講演会
    • Place of Presentation
      東京(講演)
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発作性夜間ヘモグロビン尿症(PNH)4症例におけるEculizumabの効果および安全性2010

    • Author(s)
      七島勉
    • Organizer
      第2回造血器腫瘍免疫療法研究会学術集会
    • Place of Presentation
      松山
    • Year and Date
      2010-08-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Expression of HMGA2 in blood cells from patients with paroxysmal nocturnal hemoglobinuria2010

    • Author(s)
      Murakami Y, Inoue N, Shichishima T, Noji H, Nishimura J, Kanakura Y, Kinoshita T
    • Organizer
      52nd American Society of Hematology (ASH) Annual Meeting and Exposition
    • Place of Presentation
      Orlando, FL, USA
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] Appearance of CD59-negative leukemic cells in patients with acute myeloid leukemia.2010

    • Author(s)
      高橋裕志, 七島 勉, 野地秀義, 古川未希, 七島晶子, 竹石恭知
    • Organizer
      第72回 日本血液学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Studies on GPI-anchor expressions by flow cytometry using FLAER in patients with acquired BMFS2010

    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Effect of long term eculizumab treatment on chronic kidney disease in Japanese patients with PNH2010

    • Author(s)
      Shichishima T, Kanakura Y, Ohyashiki K, Okamoto S, Ando K, Ninomiya H, Kawaguchi T, Nakao S, Nakakuma H, Nishimura J, Kinoshita T, Ozawa K, Omine M
    • Organizer
      第72回 日本血液学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Safety, feasibility and efficacy of MCVC therapy followed by auto-PBSCT for malignant lymphoma.2010

    • Author(s)
      Kameoka Y, Takahashi N, Hirokawa M, Aoki Y, Yamamoto J, Kato Y, Hiroshima Y, Ito J, Noji H, Ishizawa K, Shichishima T, Ishida Y, Harigae H, Sawada K
    • Organizer
      第72回 日本血液学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Impaired c-fos induction by emetin in granulocytes from myelodysplastic syndrome patients.2010

    • Author(s)
      Feng X, Shikama Y, Shichishima T, Noji H, Ogawa K, Takeishi Y
    • Organizer
      第72回 日本血液学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Two paroxysmal nocturnal hemoglobinuria patients reached hematological and clonal remission.2010

    • Organizer
      第72回 日本血液学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Clinical and biological features of T-cell prolymphocytic leukemia in Japan2010

    • Author(s)
      Kameoka J, Takahashi N, Noji H, Murai K, Tajima K, Kameoka Y, Shichishima T, Ishida Y, Harigae H, Sawada K
    • Organizer
      第72回 日本血液学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of autologous PBSCT in four patients with cardiac amyloidosis.2010

    • Author(s)
      Ogawa K, Kimura S, Furukawa M, Harada K, Mashimo Y, Takahashi H, Matsumoto H, Shichishima-Nakamura A, Ohkawara H, Noji H, Shichishima T, Ohto H, Takeishi Y
    • Organizer
      第72回 日本血液学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] A PNH patient complained of MDS and developed AML2010

    • Organizer
      第72回 日本血液学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] 講演:PNHにおける補体溶血と関連した病態(ランチョンセミナー).2010

    • Author(s)
      七島 勉
    • Organizer
      第47回 補体シンポジウム
    • Place of Presentation
      福島
    • Related Report
      2012 Final Research Report
  • [Presentation] 発作性夜間ヘモグロビン尿症4症例におけるヒト化モノクローナル抗C5抗体 (Eculizumab) の効果および安全性の検討2010

    • Author(s)
      野地秀義, 七島 勉, 高橋裕志, 小川一英, 竹石恭知
    • Organizer
      第47回 補体シンポジウム
    • Place of Presentation
      福島
    • Related Report
      2012 Final Research Report
  • [Presentation] 発作性夜間ヘモグロビン尿症(PNH)4 症例におけるEculizumabの効果および安全性2010

    • Author(s)
      野地秀義, 七島 勉, 高橋裕志, 小川一英, 竹石恭知
    • Organizer
      第2回造血器腫瘍免疫療法研究会学術集会
    • Place of Presentation
      松山
    • Related Report
      2012 Final Research Report
  • [Presentation] 急性骨髄性白血病(AML)症例におけるCD59陰性白血病細胞の出現

    • Author(s)
      野地秀義, 七島 勉, 岡本正俊, 池田和彦, 七島晶子, 阿久津和子, 竹石恭知
    • Related Report
      2012 Final Research Report
  • [Presentation] 後天性骨髄不全症候群(BMFS)症例におけるFLAERによるGPIアンカー発現の検討

    • Author(s)
      高橋裕志, 七島 勉, 野地秀義, 古川未希, 七島晶子, 竹石恭知
    • Related Report
      2012 Final Research Report
  • [Presentation] 血液学的およびクローン性寛解に至った発作性夜間ヘモグロビン尿症の2症例

    • Author(s)
      古川未希, 野地秀義, 七島 勉, 原田佳代, 眞下由美子, 高橋裕志, 松本勇人, 木村 哲, 七島晶子, 大河原浩, 小川一英, 竹石恭知
    • Related Report
      2012 Final Research Report
  • [Presentation] 急性骨髄性白血病へ移行した骨髄異形成症候群を合併した発作性夜間ヘモグロビン尿症の一例

    • Author(s)
      木村 哲, 野地秀義, 七島 勉, 大河原浩, 古川未希, 原田佳代, 眞下由美子, 高橋裕志, 松本勇人, 七島晶子, 小川一英, 竹石恭知
    • Related Report
      2012 Final Research Report
  • [Presentation] T-PIG研究の中間報告

    • Author(s)
      野地秀義, 七島 勉
    • Organizer
      第3回 東北PNH研究会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] OPTIMA試験:高精度フローサイトメトリー法によるGPIアンカー型蛋白欠損血球の検出

    • Author(s)
      山本正樹, 西村純一, 細川晃平, 杉盛千春, 米村雄士, 小原 直, 野地秀義, 中村嘉彦, 安藤 潔, 七島 勉, 二宮治彦, 千葉 滋, 川口辰哉, 中尾眞二, 金倉 譲
    • Organizer
      第22回 サイトメトリー学会
    • Place of Presentation
      豊中
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨髄低形成を伴うPNH症例に対するEculizmab使用経験

    • Author(s)
      野地秀義, 七島 勉, 竹石恭知
    • Organizer
      2012 Japan PNH Masters
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Paroxysmal nocturnal hemoglobinuria (PNH)症例におけるEculizumab治療の赤血球結合IgGおよびC3に対する影響

    • Author(s)
      野地秀義, 亀崎豊実, 濱中純子, 山口公平, 神林裕行, 竹石恭知, 七島 勉
    • Organizer
      第4回 造血器腫瘍免疫療法研究会
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report
  • [Presentation] OPTIMA試験:高精度フローサイトメトリー法によるGPIアンカー膜蛋白欠損血球の検出

    • Author(s)
      山本正樹, 西村純一, 細川晃平, 杉盛千春, 米村雄士, 小原 直, 中村嘉彦, 野地秀義, 七島 勉, 安藤 潔, 二宮治彦, 千葉 滋, 川口辰哉, 中尾眞二, 金倉 譲
    • Organizer
      第49回 補体シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] PNH治療の最新治験

    • Author(s)
      七島 勉
    • Organizer
      秋田PNH講演会
    • Place of Presentation
      秋田
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 最新のPNH治療

    • Author(s)
      七島 勉
    • Organizer
      山形PNH講演会
    • Place of Presentation
      山形
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] PNHの治療戦略とエクリズマブ

    • Author(s)
      七島 勉
    • Organizer
      NPO法人 PNH倶楽部設立1周年記念 医療講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 病気と薬パーフェクトブック2011,発作性夜間ヘモグロビン尿症2011

    • Author(s)
      七島勉
    • Publisher
      南山堂,東京
    • Related Report
      2012 Final Research Report
  • [Book] 病気と薬パーフェクトブック20112011

    • Author(s)
      七島勉
    • Publisher
      南山堂(分担)
    • Related Report
      2011 Annual Research Report
  • [Book] 病気と薬パーフェクトブック2010,発作性夜間ヘモグロビン尿症2010

    • Author(s)
      七島勉
    • Publisher
      南山堂,東京
    • Related Report
      2012 Final Research Report
  • [Book] 病気と薬パーフェクトブック2010(発作性夜間ヘモグロビン尿症)2010

    • Author(s)
      七島勉
    • Publisher
      南山堂
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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