Analysis of the tumor regulatory molecule, c-Cbl.
Project/Area Number |
22591046
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Jichi Medical University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 癌 / 細胞骨格 / 未分化造血幹細胞 / Cbl / c-Cb1 / シグナル伝達 / 骨髄系腫瘍 / 骨髄異形成症候群 |
Research Abstract |
c-Cbl is known as a ubiquitin E3 ligase and functions as a negative regulator for signals induced by various activated tyrosine kinases in hematopoietic cells by promoting ubiquitination and proteasomal degradation of these kinases. This negative regulati
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes.2012
Author(s)
Ueda Y, Mizutani C, Nannya Y, Kurokawa M, Kobayashi S, Takeuchi J, Tamura H, Ogata K, Dan K, Shibayama H, Kanakura Y, Niimi K, Sasaki K, Watanabe M, Emi N, Teramura M, Motoji T, Kida M, Usuki K, Takada S, Sakura T, Ito Y, Ohyashiki K, Ogawa H, Suzuki T, O
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Journal Title
Related Report
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[Journal Article] Flow Cytometric Analysis of Kappa and Lambda Light Chain Expression in Endoscopic Biopsy Specimens before the Diagnosis of B-Cell Lymphoma.2012
Author(s)
Oka S, Muroi K, Sato K, Fujiwara S, Oh I, Matsuyama T, Ohmine K, Suzuki T, Ozaki K, Mori M, Nagai T, Fukushima N, Fukushima N, Tanaka A, Ozawa K.
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Journal Title
J Clin Exp Hematop
Volume: 52(2)
Pages: 127-31
NAID
Related Report
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[Journal Article] Autologous hematopoietic recovery with aberrant antigen expression after allogeneic bone marrow transplantation2012
Author(s)
Kobayashi H, Matsuyama T, Oka S, Fujiwara S, Oh I, Suzuki T, Ozaki K, Mori M, Nagai T, Ozawa K, Muroi K.
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Journal Title
J Clin Exp Hematop
Volume: 52(1)
Pages: 81-3
NAID
Related Report
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[Journal Article] A pilot study of a novel therapy using mesenchymal stromal cells for steroid-resistant graft-versus-host disease2011
Author(s)
Sato K, Muroi K, Oka S, Sasazaki M, Hosonuma R, Ozaki K, Fujiwara S, Oh I, Matsuyama T, Ohmine K, Suzuki T, Mori M, Nagai T, Ozawa K
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Journal Title
Jichi Med. Univ.Journal
Volume: 34
Pages: 149-157
NAID
Related Report
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[Journal Article] Incidental carcinomas detected by PET/CT scans in patients with malignant lymphoma.2010
Author(s)
Sato K, Ozaki K, Fujiwara S, Oh I, Matsuyama T, Ohmine K, Suzuki T, Mori M, Nagai T, Muroi K, Ozawa K
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Journal Title
Int J Hematol
Volume: 92(4)
Pages: 647-50
NAID
Related Report
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[Journal Article]2010
Author(s)
Ogawa S, Sanada M, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP.
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Journal Title
Cell Cycle.
Volume: 9(6)
Pages: 1051-1056
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