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Analysis of the tumor regulatory molecule, c-Cbl.

Research Project

Project/Area Number 22591046
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionJichi Medical University

Principal Investigator

SUZUKI Takahiro  自治医科大学, 医学部, 講師 (40345210)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords癌 / 細胞骨格 / 未分化造血幹細胞 / Cbl / c-Cb1 / シグナル伝達 / 骨髄系腫瘍 / 骨髄異形成症候群
Research Abstract

c-Cbl is known as a ubiquitin E3 ligase and functions as a negative regulator for signals induced by various activated tyrosine kinases in hematopoietic cells by promoting ubiquitination and proteasomal degradation of these kinases. This negative regulati

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (46 results)

All 2013 2012 2011 2010 Other

All Journal Article (16 results) (of which Peer Reviewed: 3 results) Presentation (16 results) (of which Invited: 3 results) Book (14 results)

  • [Journal Article] Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes.2013

    • Author(s)
      Ueda Y
    • Journal Title

      Leuk Lymphoma

      Volume: 未定

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes.2012

    • Author(s)
      Ueda Y, Mizutani C, Nannya Y, Kurokawa M, Kobayashi S, Takeuchi J, Tamura H, Ogata K, Dan K, Shibayama H, Kanakura Y, Niimi K, Sasaki K, Watanabe M, Emi N, Teramura M, Motoji T, Kida M, Usuki K, Takada S, Sakura T, Ito Y, Ohyashiki K, Ogawa H, Suzuki T, O
    • Journal Title

      Leuk Lymphoma

    • Related Report
      2012 Final Research Report
  • [Journal Article] Flow Cytometric Analysis of Kappa and Lambda Light Chain Expression in Endoscopic Biopsy Specimens before the Diagnosis of B-Cell Lymphoma.2012

    • Author(s)
      Oka S, Muroi K, Sato K, Fujiwara S, Oh I, Matsuyama T, Ohmine K, Suzuki T, Ozaki K, Mori M, Nagai T, Fukushima N, Fukushima N, Tanaka A, Ozawa K.
    • Journal Title

      J Clin Exp Hematop

      Volume: 52(2) Pages: 127-31

    • NAID

      10031120437

    • Related Report
      2012 Final Research Report
  • [Journal Article] Autologous hematopoietic recovery with aberrant antigen expression after allogeneic bone marrow transplantation2012

    • Author(s)
      Kobayashi H, Matsuyama T, Oka S, Fujiwara S, Oh I, Suzuki T, Ozaki K, Mori M, Nagai T, Ozawa K, Muroi K.
    • Journal Title

      J Clin Exp Hematop

      Volume: 52(1) Pages: 81-3

    • NAID

      10030615702

    • Related Report
      2012 Final Research Report
  • [Journal Article] Flow Cytometric Analysis of Kappa and Lambda Light Chain Expression in Endoscopic Biopsy Specimens before the Diagnosis of B-Cell Lymphoma.2012

    • Author(s)
      Oka S
    • Journal Title

      J Clin Exp Hematop.

      Volume: 52 Pages: 127-131

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autologous hematopoietic recovery with aberrant antigen expression after allogeneic bone marrow transplantation.2012

    • Author(s)
      Kobayashi H
    • Journal Title

      J Clin Exp Hematop.

      Volume: 52 Issue: 4 Pages: 81-83

    • DOI

      10.3109/10428194.2012.725850

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 鉄過剰症と鉄キレート療法2012

    • Author(s)
      鈴木隆浩
    • Journal Title

      臨床血液

      Volume: 53 Pages: 25-35

    • NAID

      10030829699

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 輸血後鉄過剰症2012

    • Author(s)
      鈴木隆浩
    • Journal Title

      日本内科学会雑誌

      Volume: 101 Pages: 1986-1993

    • NAID

      10031123098

    • Related Report
      2012 Annual Research Report
  • [Journal Article] A pilot study of a novel therapy using mesenchymal stromal cells for steroid-resistant graft-versus-host disease2011

    • Author(s)
      Sato K, Muroi K, Oka S, Sasazaki M, Hosonuma R, Ozaki K, Fujiwara S, Oh I, Matsuyama T, Ohmine K, Suzuki T, Mori M, Nagai T, Ozawa K
    • Journal Title

      Jichi Med. Univ.Journal

      Volume: 34 Pages: 149-157

    • NAID

      110008922669

    • Related Report
      2012 Final Research Report
  • [Journal Article] 骨髄線維症の治療2011

    • Author(s)
      鈴木隆浩
    • Journal Title

      血液フロンティア

      Volume: 21 Pages: 703-709

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Incidental carcinomas detected by PET/CT scans in patients with malignant lymphoma.2010

    • Author(s)
      Sato K, Ozaki K, Fujiwara S, Oh I, Matsuyama T, Ohmine K, Suzuki T, Mori M, Nagai T, Muroi K, Ozawa K
    • Journal Title

      Int J Hematol

      Volume: 92(4) Pages: 647-50

    • NAID

      10027674104

    • Related Report
      2012 Final Research Report
  • [Journal Article] AA amyloidosis associated with macroglobulinemia.2010

    • Author(s)
      Tatara R, Nagai T, Kobayashi H, Hatano K, Suzuki T, Muroi K, Ozawa K.
    • Journal Title

      Int J Hematol

      Volume: 92(4) Pages: 675-7

    • NAID

      10027674199

    • Related Report
      2012 Final Research Report
  • [Journal Article] Deregulated Intracellular Signaling by Mutated c-CBL in Myeloid Neoplasms2010

    • Author(s)
      Ogawa S, Shih LY, Suzuki T, Otsu M, Naikauch H, Koeffler HP, Sanada M
    • Journal Title

      Clin Cancer Res.

      Volume: 16(15) Pages: 3825-3831

    • Related Report
      2012 Final Research Report
  • [Journal Article]2010

    • Author(s)
      Ogawa S, Sanada M, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP.
    • Journal Title

      Cell Cycle.

      Volume: 9(6) Pages: 1051-1056

    • Related Report
      2012 Final Research Report
  • [Journal Article] Deregulated Intracellular Signaling by Mutated c-CBL in Myeloid Neoplasms.2010

    • Author(s)
      Ogawa S
    • Journal Title

      Clin Cancer Res.

      Volume: 16 Pages: 3825-3831

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.2010

    • Author(s)
      Ogawa S
    • Journal Title

      Cell Cycle.

      Volume: 23 Pages: 1051-1056

    • Related Report
      2010 Annual Research Report
  • [Presentation] 鉄過剰症と鉄キレート療法-その病態と診療-2013

    • Author(s)
      鈴木隆浩
    • Organizer
      第60回 日本輸血・細胞治療学会東海支部例会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-02-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Impacts of Blood Transfusion and Iron Overload on MDS Patients and Hematopoiesis2012

    • Author(s)
      鈴木隆浩
    • Organizer
      The 2nd JSH International Symposium 2011 in Nagasaki
    • Place of Presentation
      長崎
    • Year and Date
      2012-04-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨髄異形成症候群の現状と将来2012

    • Author(s)
      鈴木隆浩
    • Organizer
      第50回日本癌治療学会学術集会 シンポジウム
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] エクリズマブ治療で溶血改善後に患者事情で治療を中止した PNH の一症例2012

    • Author(s)
      鈴木隆浩、上原英輔、岡部 寛、上田真寿、佐藤一也、尾崎勝俊、永井 正、室井一男、小澤敬也
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] エクリズマブ治療で溶血改善後に患者事情で治療を中止したPNHの一症例2012

    • Author(s)
      鈴木隆浩
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都市
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Bone Marrow Hematopoietic Microenvironment is Functionally Impaired in Iron-overloaded Mice2011

    • Author(s)
      Okabe H, Suzuki T, Uehara E, Ueda M, Nagai T, Ozawa K
    • Organizer
      53rdASH Annual Meeting and Exposition
    • Place of Presentation
      SanDiego
    • Related Report
      2012 Final Research Report
  • [Presentation] Impacts of Blood Transfusion and Iron Overload on MDS Patients and Hematopoiesis2011

    • Author(s)
      Suzuki T
    • Organizer
      The 2nd JSH International Symposium 2011 in Nagasaki
    • Place of Presentation
      Nagasaki
    • Related Report
      2012 Final Research Report
  • [Presentation] Racを介する細胞骨格シグナルによってc-Cb1は骨髄細胞の骨髄ホーミングを制御する2010

    • Author(s)
      上原英輔
    • Organizer
      第72回日本血液学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] c-Cbl REGULATES INTERACTION OF IMMATURE HEMATOPOIETIC CELLS WITH THE BONE MARROW MICROENVIRONMENT BY Rac GTPase-MEDIATED CYTOSKELETAL SIGNALS.2010

    • Author(s)
      Uehara E, Suzuki T, Okabe H, Ueda M, Nagai T, Sanada M, Ogawa S, Ozawa K
    • Organizer
      16thAnnual Meeting of JSGT
    • Place of Presentation
      Utsunomiya
    • Related Report
      2012 Final Research Report
  • [Presentation] Hematopoietic Disturbance in Iron-Overload2010

    • Author(s)
      Okabe H, Suzuki T, Uehara E, Omori T, Ueda M, Nagai T, Sakata Y, Ozawa K
    • Organizer
      The 1st JSH International Symposium 2010 in Akita
    • Place of Presentation
      Akita
    • Related Report
      2012 Final Research Report
  • [Presentation] 骨髄異形成症候群(MDS)の治療選択2010

    • Author(s)
      鈴木隆浩
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] c-Cbl regulates interaction of hematopoietic cells with the bone marrow microenvironment by Rac-mediated signals

    • Author(s)
      Uehara E, Suzuki T, Sasazaki M, Okabe H, Hatano K, Ueda M, Nagai T, Sanada M, Ogawa S, Ozawa K
    • Organizer
      72th Annual Meeting of JSH
    • Place of Presentation
      Yokohama
    • Related Report
      2012 Final Research Report
  • [Presentation] Hematopoietic Disturbance in Iron-Overload

    • Author(s)
      Okabe H, Suzuki T, Uehara E, Ueda M, Nagai T, Ozawa K
    • Organizer
      72th Annual Meeting of JSH
    • Place of Presentation
      Yokohama
    • Related Report
      2012 Final Research Report
  • [Presentation] 鉄過剰症と鉄キレート療法-その病態と診療-

    • Author(s)
      鈴木隆浩
    • Organizer
      第60回 日本輸血・細胞治療学会東海支部例会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 骨髄異形成症候群の現状と将来

    • Author(s)
      鈴木隆浩
    • Organizer
      第50回日本癌治療学会学術集会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] MDSの病態と治療-ゲノム医学と新薬の時代を迎えて-

    • Author(s)
      鈴木隆浩
    • Organizer
      第98回近畿血液学地方会
    • Place of Presentation
      京都市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 骨髄形成症候群. 今日の治療と看護(第3版)2013

    • Author(s)
      鈴木隆浩
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Book] 遺伝性球状赤血球症. 別冊日本臨床 血液症候群 I(第2版)2013

    • Author(s)
      鈴木隆浩
    • Publisher
      日本臨牀社
    • Related Report
      2012 Final Research Report
  • [Book] 骨髄異形成症候群. 今日の治療指針2013

    • Author(s)
      鈴木隆浩
    • Publisher
      医学書院
    • Related Report
      2012 Final Research Report
  • [Book] 低リスク MDS の治療方針. EBM血液疾患の治療2012

    • Author(s)
      鈴木隆浩.
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] 輸血後鉄過剰症に対する鉄キレート療法:予後と造血能の改善効果. Annual Review 2012 血液2012

    • Author(s)
      鈴木隆浩
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] 自己免疫性溶血性貧血. 今日の治療指針 20122012

    • Author(s)
      鈴木隆浩
    • Publisher
      医学書院
    • Related Report
      2012 Final Research Report
  • [Book] 鉄過剰症と鉄キレート療法. 最新医学別冊 再生不良性貧血2011

    • Author(s)
      鈴木隆浩
    • Publisher
      最新医学社
    • Related Report
      2012 Final Research Report
  • [Book] 低リスク MDS の治療. 白血病・リンパ腫・骨髄腫-今日の診断と治療-第4版2011

    • Author(s)
      鈴木隆浩
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] MDS の化学療法. 骨髄異形成症候群(MDS)診療 up-to-date2011

    • Author(s)
      鈴木隆浩
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] 自己免疫性溶血性貧血:温式、冷式. 血液専門医テキスト2011

    • Author(s)
      鈴木隆浩
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Book] 鉄キレート療法. 血液専門医テキスト2011

    • Author(s)
      鈴木隆浩
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Book] 輸血後鉄過剰症に対する鉄キレート療法. 難治性貧血の診療ガイド(2011

    • Author(s)
      鈴木隆浩
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Book] 鉄キレート療法. 骨髄異形成症候群(MDS)のマネジメント2011

    • Author(s)
      鈴木隆浩
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Final Research Report
  • [Book] 輸血後鉄過剰症の治療. 血液診療エキスパート「貧血」2010

    • Author(s)
      鈴木隆浩
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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