• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Identification of myeloma stem cells and its clinical application

Research Project

Project/Area Number 22591047
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionJichi Medical University

Principal Investigator

FURUKAWA Yusuke  自治医科大学, 医学部, 教授 (00199431)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords癌 / 遺伝子 / 発現制御 / 移植再生医療 / 移植・再生医療
Research Abstract

Although myeloma tissues look homogenous,it has been demonstrated from the 70s that cells with clonogenic growth potential exist only 1 in 100 to 100,000 myeloma cells. Recent investigations indicate that myeloma stem cells express CD19 and CD27 but not C

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (61 results)

All 2013 2012 2011 2010 Other

All Journal Article (23 results) (of which Peer Reviewed: 8 results) Presentation (12 results) (of which Invited: 1 results) Book (22 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Homopiperazine Derivatives as a Novel Class of Proteasome Inhibitors with a Unique Mode of Proteasome Binding2013

    • Author(s)
      Kikuchi, J., Shibayama, N., Yamada, S., Wada, T., Nobuyoshi, M., Izumi, T., Akutsu, M., Kano, Y., Sugiyama, K., Ohki, M., Park, S.-Y. and Furukawa, Y.
    • Journal Title

      PLoS One

      Volume: 8

    • Related Report
      2012 Final Research Report
  • [Journal Article] BCR-ABL Regulates Death Receptor Expression for TNF-related Apoptosis-inducing Ligand (TRAIL) in Philadelphia Chromosome-positive Leukemia.2013

    • Author(s)
      Kuroda, I., Inukai, T., Zhang, X., Kikuchi, J., Furukawa, Y., Nemoto, A., Akahane, K., Hirose, K., Honna-Ooshiro, H., Goi, K., Kagami, K., Yagita, H., Tauchi, T., Maeda, Y. and Sugita, K.
    • Journal Title

      Oncogene

      Volume: 32 Pages: 1670-1681

    • Related Report
      2012 Final Research Report
  • [Journal Article] Homopiperazine Derivatives as a Novel Class of Proteasome Inhibitors with a Unique Mode of Proteasome Binding.2013

    • Author(s)
      Kikuchi J.
    • Journal Title

      PLoS One

      Volume: 8 Issue: 4 Pages: e60649-e60649

    • DOI

      10.1371/journal.pone.0060649

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone Deacetylase 1 Enhances microRNA Processing via Deacetylation of DGCR82012

    • Author(s)
      Wada, T., Kikuchi, J. and Furukawa, Y.
    • Journal Title

      EMBO Rep

      Volume: 13 Pages: 142-149

    • Related Report
      2012 Final Research Report
  • [Journal Article] Latexin Regulates the Abundance of Multiple Cellular Proteins in Hematopoietic Stem Cells.2012

    • Author(s)
      Mitsunaga, K., Kikuchi, J., Wada, T. and Furukawa, Y.
    • Journal Title

      J. Cell. Physiol

      Volume: 227 Pages: 1138-1147

    • Related Report
      2012 Final Research Report
  • [Journal Article] Promoter Methylation Confers Kidney-specific Expression of the Klotho Gene.2012

    • Author(s)
      Azuma, M., Koyama, D., Kikuchi, J., Yoshizawa, H., Thasinas, D., Shiizaki, K., Kuro-o, M., Furukawa, Y. and Kusano, E.
    • Journal Title

      FASEB J

      Volume: 26 Pages: 4264-4274

    • Related Report
      2012 Final Research Report
  • [Journal Article] Reduced Histone H3K9 Acetylation of Clock Genes and Abnormal Glucose Metabolism in ob/ob Mice2012

    • Author(s)
      Ishikawa-Kobayashi, E., Ushijima, K., Ando, H., Maekawa, T., Takuma, M., Furukawa, Y. and Fujimura, A.
    • Journal Title

      Chronobiol. Int

      Volume: 29 Pages: 982-993

    • Related Report
      2012 Final Research Report
  • [Journal Article] Promoter Methylation Confers Kidney-specific Expression of the Klotho Gene.2012

    • Author(s)
      Azuma M.
    • Journal Title

      FASEB Journal

      Volume: 26 Issue: 10 Pages: 4264-4274

    • DOI

      10.1096/fj.12-211631

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced Histone H3K9 Acetylation of Clock Genes and Abnormal GlucoseMetabolism in ob/ob Mice.2012

    • Author(s)
      Ishikawa-Kobayashi E.
    • Journal Title

      Chronobiology International

      Volume: 29 Issue: 8 Pages: 982-993

    • DOI

      10.3109/07420528.2012.706765

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR82012

    • Author(s)
      Wada T, Kikuchi J, Furukawa Y
    • Journal Title

      EMBO Reports

      Volume: 13 Issue: 2 Pages: 142-149

    • DOI

      10.1038/embor.2011.247

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Latexin regulates the abundance of multiple cellular proteins in hematopoietic stem cells2012

    • Author(s)
      Mitsunaga K, Kikuchi J, Wada T, Furukawa Y
    • Journal Title

      Journal of Cellular Physiology

      Volume: 227 Issue: 3 Pages: 1138-1147

    • DOI

      10.1002/jcp.22834

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seven-year Follow-up of Patients Receiving Imatinib for the Treatment of Newly Diagnosed Chronic Myelogenous Leukemia by the TARGET System2011

    • Author(s)
      Tauchi, T., Kizaki, M., Okamoto, S., Tanaka, H., Tanimoto, M., Inokuchi, K., Murayama, T., Saburi, Y., Hino, M., Tsudo, M., Shimomura, T., Isobe, Y., Oshimi, K., Dan, K., Ohyashiki, K, Ikeda, Y. and the TARGET Investigators (including Furukawa, Y.)
    • Journal Title

      Leuk. Res

      Volume: 35 Pages: 585-590

    • Related Report
      2012 Final Research Report
  • [Journal Article] Histone Deacetylases Are Critical Targets of Bortezomib-induced Cytotoxicity in Multiple Myeloma2010

    • Author(s)
      Kikuchi, J., Wada, T., Shimizu, R., Izumi, T., Akutsu, M., Mitsunaga, K., Noborio-Hatano, K., Nobuyoshi, M., Ozawa, K., Kano, Y. and Furukawa, Y.
    • Journal Title

      Blood

      Volume: 116 Pages: 406-417

    • Related Report
      2012 Final Research Report
  • [Journal Article] HDAC Inhibitors Augment Cytotoxic Activity of Rituximab by Upregulating CD20 Expression on Lymphoma Cells2010

    • Author(s)
      Shimizu, R., Kikuchi, J., Wada, T., Ozawa, K., Kano, Y. and Furukawa, Y.
    • Journal Title

      Leukemia

      Volume: 24 Pages: 1760-1768

    • Related Report
      2012 Final Research Report
  • [Journal Article] MSK1 Activation in Acute Myeloid Leukemia Cells with FLT3 Mutations2010

    • Author(s)
      Odgerel, T., Kikuchi, J., Wada, T., Shimizu, R., Kano, Y. and Furukawa, Y.
    • Journal Title

      Leukemia

      Volume: 24 Pages: 1087-1090

    • Related Report
      2012 Final Research Report
  • [Journal Article] Aberrant Induction of LMO2 by the E2A-HLF Chimeric Transcription Factor and Its Implication in Leukemogenesis of B-Precursor ALL with t(17;19)2010

    • Author(s)
      Hirose, K., Inukai,T., Kikuchi, J., Furukawa, Y., Ikawa, T., Kawamoto, H., Oram, S.H., Gottgens, B., Kiyokawa, N., Miyagawa, Y., Okita, H., Akahane, K., Zhang, X., Kuroda, I., Honna, H., Kagami, K., Goi, K., Kurosawa, H., Look, A.T., Matsui, H., Inaba, T.
    • Journal Title

      Blood

      Volume: 116 Pages: 962-970

    • Related Report
      2012 Final Research Report
  • [Journal Article] Up-regulation of Survivin by the E2A-HLF Chimera Is Indispensable for the Survival of t(17;19)-positive Leukemia Cells2010

    • Author(s)
      Okuya, M., Kurosawa, H., Kikuchi, J., Furukawa, Y., Matsui, H., Aki, D., Matsunaga, T., Inukai, T., Goto, H., Altura, R.A., Sugita, K., Arisaka, O., Look, A.T. and Inaba, T.
    • Journal Title

      J. Biol. Chem

      Volume: 285 Pages: 1850-1860

    • Related Report
      2012 Final Research Report
  • [Journal Article] Vinculin Is Indispensable for Repopulation by Hematopoietic Stem Cells, Independent of Integrin Function.2010

    • Author(s)
      Ohmori, T., Kashiwakura, Y., Ishiwata, A., Madoiwa, S., Mimuro, J., Furukawa, Y. and Sakata, Y.
    • Journal Title

      J. Biol. Chem

      Volume: 285 Pages: 31763-31773

    • Related Report
      2012 Final Research Report
  • [Journal Article] Inactivation of the Retinoblastoma Protein by Mutant B-Raf in Malignant Melanoma2010

    • Author(s)
      Kobayashi, Y., Kobayashi, T., Kikuchi, J., Futaki, K., Wada, T., Kusano, E., Murata, S., Ohtsuki, M. and Furukawa, Y.
    • Journal Title

      Nature Precedings

    • Related Report
      2012 Final Research Report
  • [Journal Article] Histone deacetylases are critical targets of bortezomib-induced…2010

    • Author(s)
      Kikuchi, J.Wada, T., et al.
    • Journal Title

      Blood

      Volume: 116 Pages: 406-417

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HDAC inhibitors augment cytotoxic activity of rituximab…2010

    • Author(s)
      Shimizu, R., Kikuchi, J., et al.
    • Journal Title

      Leukemia

      Volume: 24 Pages: 1760-1768

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MSK1 activation in acute myeloid leukemia cells with FLT3 mutations.2010

    • Author(s)
      Odgerel, T., Kikuchi, J., et al.
    • Journal Title

      Leukemia

      Volume: 24 Pages: 1087-1092

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Novel Orally Active Proteasome Inhibitor K-7174 Exerts Anti-myeloma Activity in vitro and in vivo by Down-regulating the Expression of Class I Histone Deacetylases.

    • Author(s)
      Kikuchi, J., Yamada, S., Koyama, D., Wada, T., Nobuyoshi, M., Izumi, T., Akutsu, M., Kano, Y. and Furukawa, Y.
    • Journal Title

      J. Biol. Chem

      Volume: (in press)

    • Related Report
      2012 Final Research Report
  • [Presentation] Bortezomib Overcomes the Cell Adhesion-mediated Drug Resistance by Down-regulating HDAC Expression in Multiple Myeloma.2013

    • Author(s)
      Furukawa, Y. and Kikuchi, J.
    • Organizer
      The 14th Intenational Myeloma Workshop
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2013-04-04
    • Related Report
      2012 Final Research Report
  • [Presentation] How to overcome the cell adhesion-mediated drug resistance in multiple myeloma2012

    • Author(s)
      古川雄祐
    • Organizer
      第74回日本血液学会学術総会、Symposium 6 "Multiple Myeloma: Topics in Basic Science Applicable to the Development of Novel Therapies"
    • Place of Presentation
      京都
    • Year and Date
      2012-10-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Multiple Myeloma Cells Acquire Anti-cancer Drug Resistnce via Interaction with Bone Marrow Microenvironment2012

    • Author(s)
      Furukawa, Y.
    • Organizer
      The 9th Nikko Intenational Symposium
    • Place of Presentation
      Shimotuke, Tochigi, Japan
    • Year and Date
      2012-10-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Low HDAC expression contributes to insufficient maturation of microRNAs in hematopoietic stem cells2011

    • Author(s)
      和田妙子、菊池次郎、古川雄祐
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Latexin regulates the abundance of multiple cellular proteins in hematopoietic stem cells2011

    • Author(s)
      光永佳奈枝、菊池次郎、和田妙子、古川雄祐
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Latexin Regulates the Abundance of Multiple Cellular Proteins in Hematopoietic Stem Cells.2011

    • Author(s)
      Mitsunaga, K., Kikuchi, J., Wada, T. and Furukawa, Y.
    • Organizer
      The XXV Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
    • Place of Presentation
      Hongo, Tokyo
    • Year and Date
      2011-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Multiple myeloma: Introduction of novel drugs with unique mechanisms of action to overcome drug resistance2011

    • Author(s)
      古川雄祐
    • Organizer
      第9回日本臨床腫瘍学会学術総会、日本臨床腫瘍学会/日本血液学会合同シンポジウム"分子標的治療薬導入から10年を迎えて"
    • Place of Presentation
      横浜
    • Year and Date
      2011-07-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Multiple myeloma : Introduction of novel drugs with unique mechanisms of action to overcome drug resistance2011

    • Author(s)
      古川雄祐
    • Organizer
      第9回日本臨床腫瘍学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-07-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Latexin Regulates the Abundance of Multiple Cellular Proteins in Hematopoietic Stem Cells.2011

    • Author(s)
      Mitsunaga, K., Kikuchi, J., Wada, T. and Furukawa, Y.
    • Organizer
      The 9th Stem Cell Research Symposium
    • Place of Presentation
      Roppongi、Tokyo, Japan
    • Year and Date
      2011-05-14
    • Related Report
      2012 Final Research Report
  • [Presentation] ボルテゾミブの抗骨髄腫作用はヒストン脱アセチル化酵素の発現抑制を介する2010

    • Author(s)
      菊池次郎、和田妙子、清水瑠美、和泉透、光永佳奈枝、畑野かおる、信吉正治、小澤敬也、加納康彦、古川雄祐
    • Organizer
      第35回日本骨髄腫研究会総会
    • Place of Presentation
      富山
    • Year and Date
      2010-11-20
    • Related Report
      2012 Final Research Report
  • [Presentation] ボルテゾミブによる接着耐性の解除と骨髄腫治療戦略への組み込み2010

    • Author(s)
      古川雄祐
    • Organizer
      厚生労働省がん研究助成金木崎班班会議特別講演
    • Place of Presentation
      東京
    • Year and Date
      2010-01-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] How to overcome the cell adhesion-mediated drug resistance in multiple myeloma.

    • Author(s)
      古川雄祐
    • Organizer
      第74回日本血液学会学術総会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Klotho遺伝子の発現調節機構。Annual Review 腎臓2012

    • Author(s)
      古川雄祐、東昌広、草野英二
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] Klotho遺伝子の発現調節機構。腎と透析 722012

    • Author(s)
      東昌広、古川雄祐、草野英二
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] 多発性骨髄腫の薬剤耐性化とボルテゾミブの抗がん剤併用による抗腫瘍効果増強、血液フロンティア222012

    • Author(s)
      菊池次郎、古川雄祐
    • Related Report
      2012 Final Research Report
  • [Book] ボルテゾミブの新たな作用機序と他剤との併用の理論的妥当性。血液内科 642012

    • Author(s)
      古川雄祐、菊池次郎
    • Related Report
      2012 Final Research Report
  • [Book] 造血器腫瘍の治療標的としてのDNA 修復機構。血液内科 642012

    • Author(s)
      小山大輔、古川雄祐
    • Related Report
      2012 Final Research Report
  • [Book] ヒストン脱アセチル化酵素阻害剤による多発性骨髄腫の治療。医学のあゆみ 2422012

    • Author(s)
      菊池次郎、古川雄祐
    • Related Report
      2012 Final Research Report
  • [Book] ボルテゾミブの新たな作用機序:エピジェネティック制御を介する骨髄腫細胞の制御。, 造血器腫瘍とエピジェネティクス-治療への応用と新たな展開2012

    • Author(s)
      菊池次郎、古川雄祐, 木崎昌弘編
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Final Research Report
  • [Book] アルキル化剤の作用機序、適応、副作用。血液内科 652012

    • Author(s)
      平岡信弥、古川雄祐
    • Related Report
      2012 Final Research Report
  • [Book] 骨髄腫細胞と間質細胞の相互作用:薬剤耐性とその対策。BIO Clinica272012

    • Author(s)
      菊池次郎、古川雄祐
    • Related Report
      2012 Final Research Report
  • [Book] B白血病/リンパ芽球性リンパ腫。押味和夫編、悪性リンパ腫の基礎と臨床 改訂版2011

    • Author(s)
      古川雄祐、加納康彦
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Final Research Report
  • [Book] 新規抗腫瘍薬ベンダムスチンの作用機序と臨床効果。日薬理誌(新規抗腫瘍薬ベンダムスチンの作用機序と臨床効果。日薬理誌(Folia Pharmacol. Jpn) 13822011

    • Author(s)
      古川雄祐、平岡信弥、和田妙子、菊池次郎、加納康彦
    • Related Report
      2012 Final Research Report
  • [Book] 多発性骨髄腫における細胞死の抑制。血液内科622011

    • Author(s)
      古川雄祐、菊池次郎
    • Related Report
      2012 Final Research Report
  • [Book] 骨髄腫幹細胞を標的とする薬剤。最新医学662011

    • Author(s)
      古川雄祐、菊池次郎
    • Related Report
      2012 Final Research Report
  • [Book] ヒストン脱アセチル化酵素阻害剤によるリツキシマブ耐性の克服。血液内科622011

    • Author(s)
      古川雄祐、清水瑠美、和田妙子、菊池次郎
    • Related Report
      2012 Final Research Report
  • [Book] 血漿蛋白とその働き。 図説臨床看護医学(エディターシップ) 5: [1. 1]2011

    • Author(s)
      古川雄祐、小澤敬也監修
    • Total Pages
      3
    • Related Report
      2012 Final Research Report
  • [Book] 血清蛋白の検査, 小澤敬也監修、図説臨床看護医学(エディターシップ) 5:[3]2011

    • Author(s)
      古川雄祐, 小澤敬也監修
    • Total Pages
      7
    • Related Report
      2012 Final Research Report
  • [Book] 染色体分析とFISH,図説臨床看護医学(エディターシップ) 5:[3]2011

    • Author(s)
      古川雄祐, 小澤敬也監修
    • Total Pages
      10
    • Related Report
      2012 Final Research Report
  • [Book] 白血球減少症と無顆粒球症, 図説臨床看護医学(エディターシップ) 5:[4.2]2011

    • Author(s)
      古川雄祐, 小澤敬也監修
    • Total Pages
      1
    • Related Report
      2012 Final Research Report
  • [Book] 好中球機能異常症, 図説臨床看護医学(エディターシップ) 5:[4.2]2011

    • Author(s)
      古川雄祐, 小澤敬也監修
    • Total Pages
      15
    • Related Report
      2012 Final Research Report
  • [Book] ボルテゾミブによる未治療多発性骨髄腫の治療戦略。血液フロンティア 212011

    • Author(s)
      木崎昌弘、Meletios A.Demopoulos、安部正博、石田禎夫、古川雄祐
    • Related Report
      2012 Final Research Report
  • [Book] 多発性骨髄腫における薬剤耐性機序。Annual Review血液2010

    • Author(s)
      古川雄祐、菊池次郎
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] 骨髄腫幹細胞研究の進展。血液・腫瘍科、612010

    • Author(s)
      菊池次郎、古川雄祐
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.jichi.ac.jp/stem/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.jichi.ac.jp/stem/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.jichi.ac.jp/stem/index.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] ホモピペラジン化合物を主成分とするプロテアソーム阻害剤

    • Inventor(s)
      菊池次郎・古川雄祐
    • Industrial Property Rights Holder
      菊池次郎・古川雄祐
    • Industrial Property Number
      2011-013923
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi