Clarification of RCAN1-mediated deregulation of cellular functionsin leukemia cells

• Project/Area Number: 22591048
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Jichi Medical University
• Principal Investigator: NAGAI Tadashi 自治医科大学, 医学部, 准教授 (40237483)
• Co-Investigator(Renkei-kenkyūsha): OHMINE Ken 自治医科大学, 医学部, 講師 (90316521) ; FUJIWARA Shin-ichiro 自治医科大学, 医学部, 講師 (20438667)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: RCAN1 / 急性骨髄性白血病 / HL60 / calcineurin / NFAT / 32D / NF-AT / 多発性骨髄腫 / U266

Research Abstract

RCAN1 is involved in the regulation of cell functions including inhibition ofcalcineurin. In this study, we found that RCAN1 is extraordinarily expressed in leukemia cells.Furthermore, we revealed that RCAN1 is important for cell growth, particularly unde

Research Products

• [Journal Article] Rituximab plus 70%cyclophosphamide, doxorubicin, vincristineand prednisone for Japanese patients withdiffuse large B-cell lymphoma aged 70 yearsand older. (2012)
  • Author(s): Meguro, A., Nagai, T., Ozawa, K.
  • Journal Title: Leuk Lymphoma. Volume: 53 Pages: 43-49
  • Peer Reviewed
• [Journal Article] Prediction of progression fromrefractory cytopenia with unilineagedysplasia by analysis of bone marrow blastcell composition. (2012)
  • Author(s): Oka, S., Nagai, T., Hanafusa, T.
  • Journal Title: J Clin. Exp. Hematop. Volume: 52 Pages: 63-66
  • Peer Reviewed
• [Journal Article] Rituximab-induced interstitial pneumonia dueto CD8-positive T-cell infiltration (2012)
  • Author(s): Sato, K., Nagai, T., Izumi, T., Ohmine, K.,Ozaki, K., Muroi, K., and Ozawa, K.
  • Journal Title: ActaHaematologica Volume: 128 Issue: 2 Pages: 107-109
  • DOI: 10.1159/000338259
  • Peer Reviewed
• [Journal Article] Autologous Hematopoietic Recovery with Aberrant Antigen Expression after Allogeneic Bone Marrow Transplantation (2012)
  • Author(s): Kobayashi, H., Nagai, T., Muroi, K.
  • Journal Title: Journal of Clinical and Experimental Hematopathology Volume: 52 Issue: 1 Pages: 81-83
  • DOI: 10.3960/jslrt.52.81
  • NAID: 10030615702
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed
• [Journal Article] Alteration of chromosome 13 abnormalitiesafter therapeutic heamatopoiesis recovery inmyelodysplastic syndrome (2012)
  • Author(s): Nagai, T., Suzuki, T., Komatsu, N.,Hosokawa, K., Nakao, S., and Ozawa, K.
  • Journal Title: Open J Hematol. Volume: 3 Issue: 1 Pages: 3-7
  • DOI: 10.13055/ojhmt_3_1_7.121227
  • Peer Reviewed
• [Journal Article] Alteration of chromosome 13 abnormalities after therapeutic heamatopoiesis recovery in myelodysplastic syndrome. (2012)
  • Author(s): Nagai, T.
  • Journal Title: Open J Hematol. Volume: 3 Pages: 3-7
  • Peer Reviewed
• [Journal Article] Autologous hematopoietic recovery with aberrant antigen expression after allogeneic bone marrow transplantation. (2012)
  • Author(s): Kobayashi H
  • Journal Title: J Clin Exp Hematop. Volume: 52 Issue: 4 Pages: 81-83
  • DOI: 10.3109/10428194.2012.725850
  • Peer Reviewed
• [Journal Article] Vincristine potentiates the anti-proliferativeeffect of an aurora kinase inhibitor, VE-465,in myeloid leukemia cells. (2011)
  • Author(s): Yoshida, K., Nagai, T., Ohmine, K., Uesawa,M., Sripayap, P., Ishida, Y., and Ozawa, K.
  • Journal Title: Biochem.Pharmcol. Volume: 82 Pages: 1884-1890
  • Peer Reviewed
• [Journal Article] Reciprocal upregulationof Notch signaling molecules inhematopoietic progenitor and mesenchymalstromal cells. (2011)
  • Author(s): Kikuchi, Y., Kume, A., Urabe, M.,Mizukami, H., Suzuki, T., Ozaki, K., Nagai,T., and Ozawa, K.
  • Journal Title: J Stem Cells Regenerative Med Volume: 7 Pages: 61-68
  • URL: http://www.pubstemcell.com/monthly/007020300010.htm
  • Peer Reviewed
• [Journal Article] Vincristine potentiates the anti-proliferative effect of an aurora kinase inhibitor, VE-465, in myeloid leukemia cells (2011)
  • Author(s): Yoshida, K.
  • Journal Title: Biochem.Pharmcol. Volume: 82 Pages: 1884-1890
  • Peer Reviewed
• [Journal Article] Combination of tipifarnib and rapamycinsynergistically inhibits the growth ofleukemia cells and overcomes resistance totipifarnib via alteration of cellular signalingpathways. (2010)
  • Author(s): Nagai, T., Ohmine, K., Fujiwara, S., Uesawa,M., Sakurai, C., and Ozawa, K.
  • Journal Title: Leukemia Res. Volume: 34 Pages: 1057-1063
  • Peer Reviewed
• [Journal Article] Imatinib for Newly DiagnosedChronic-Phase Chronic Myeloid Leukemia:Results of a Prospective Study in Japan (2010)
  • Author(s): Nagai, T., Takeuchi, J., Usui, N.
  • Journal Title: Int Jhematol Volume: 92 Issue: 1 Pages: 111-117
  • DOI: 10.1007/s12185-010-0621-x
  • Peer Reviewed
• [Journal Article] AA amyloidosis associated withmacroglobulinemia (2010)
  • Author(s): Tatara, R., Nagai, T., Kobayashi, H., Hatano,K., Suzuki, T., Muroi, K., and Ozawa, K
  • Journal Title: (Letter) Int J Hematol Volume: 92 Issue: 4 Pages: 675-677
  • DOI: 10.1007/s12185-010-0700-z
  • NAID: 10027674199
  • Peer Reviewed
• [Journal Article] Incidental carcinomasdetected by PET/CT scans in patients withmalignant lymphoma. (2010)
  • Author(s): Sato, K., Ozaki, K., Matsuyama, T., Ohmine,K., Suzuki, T., Mori, M., Nagai, T., Muroi,K., and Ozawa, K.:
  • Journal Title: Int J Hematol Volume: 92 Issue: 4 Pages: 647-650
  • DOI: 10.1007/s12185-010-0702-x
  • Peer Reviewed
• [Journal Article] Combination of tipifarnib and rapamycin synergistically inhibits the growth of leukemia cells and overcomes resistance to tipifarnib via alteration of cellular signaling pathways. (2010)
  • Author(s): Nagai, T.
  • Journal Title: Leukemia Res. Volume: VOL.34 Pages: 1057-1063
  • Peer Reviewed
• [Journal Article] Imatinib for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia : Results of a Prospective Study in Japan. (2010)
  • Author(s): Nagai, T.
  • Journal Title: Int J Hematol. Volume: VOL.92 Pages: 111-117
  • NAID: 10026512176
  • Peer Reviewed
• [Journal Article] AA amyloidosis associated with macroglobulinemia. (2010)
  • Author(s): Tatara, R.
  • Journal Title: (Letter) Int J Hematol. Volume: VOL.92 Pages: 675-677
  • Peer Reviewed
• [Presentation] Histone deacetylase inhibitorromidepsin overcomes AZA-resistance inAZA-resistant cell lines. (2012)
  • Author(s): Sripayap, P.
  • Organizer: The 3rdJSHInternational Symposium
  • Place of Presentation: Kawagoe, Japan
• [Presentation] Overcoming resistance to5-azacytidine in acute myeloid leukemia (2012)
  • Author(s): Sripayap, P.
  • Organizer: The 54th Annual Meeting of AmericanSociety for Hematology
  • Place of Presentation: Atlanta, USA
• [Presentation] Analysis of primary smallintestinal lymphoma diagnosed withdouble-balloon endoscopy (2012)
  • Author(s): Kobayashi, H.
  • Organizer: 第74回日本血液学会学術集会
• [Presentation] Histone deacetylase inhibitorromidepsin overcomes 5-azacytidine (AZA)resistance. (2012)
  • Author(s): Sripayap, P.
  • Organizer: 第74回日本血液学会学術集会
• [Presentation] Histone deacetylase inhibitor romidepsin overcomes AZA-resistance in AZA-resistant cell lines. (2012)
  • Author(s): Sripayap, P.
  • Organizer: The 3rd JSH International Symposium
  • Place of Presentation: Kawagoe
• [Presentation] Histone deacetylase inhibitor romidepsin overcomes 5-azacytidine (AZA) resistance. (2012)
  • Author(s): Sripayap, P.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] Overcoming resistance to 5-azacytidine in acute myeloid leukemia. (2012)
  • Author(s): Sripayap, P.
  • Organizer: The 54th Annual Meeting of American Society for Hematology
  • Place of Presentation: Atlanta, USA
• [Presentation] Cloning of5-azacitidine-resistant acute myeloidleukemia cell lines, THP-1/AR andHL60/AR. (2011)
  • Author(s): Uesawa, M
  • Organizer: The 2ndJSH InternationalSymposium
  • Place of Presentation: Nagasaki
• [Presentation] Cloning and characterizationof 5-azacitidine-resistant human AML celllines, THP-1/AR and HL60/A. (2011)
  • Author(s): Sripayap, P
  • Organizer: 第73回日本血液学会学術集会
• [Presentation] Cloning and characterization of 5-azacitidine-resistant human AML cell lines, THP-1/AR and HL60/AR (2011)
  • Author(s): Sripayap, P.
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] Extraordinary expression ofRCAN1 - Crucial to leukemia progression. (2010)
  • Author(s): Fujiwara, S.
  • Organizer: 第72回日本血液学会学術集会
• [Presentation] Crucial role of RCAN1 inleukemia progression (2010)
  • Author(s): Fujiwara, S
  • Organizer: 第69回日本癌学会学術総会
• [Presentation] Crucial role of RCAN1 in leukemia progression (2010)
  • Author(s): 藤原慎一郎
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪市)
• [Presentation] Extraordinary expression of RCAN1-Crucial to leukemia progression (2010)
  • Author(s): 藤原慎一郎
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜(横浜市)