Analysis of myeloma stem cells

• Project/Area Number: 22591049
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Keio University
• Principal Investigator: MIYAKAWA Yoshitaka 慶應義塾大学, 医学部, 専任講師 (50250238)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 骨髄腫 / がん幹細胞 / 新規治療薬 / 化学療法 / 抗がん剤 / バイオテクノロジー

Research Abstract

Multiple myeloma is one of the intractable hematologicalmalignancies and its prognosis is poor. In this study, we analyzed the character of humanmyeloma cells in vivo using the congenitally immunodeficient mice. Transplanted myelomacells accumulated at th

Research Products

• [Journal Article] Neovascular niche forhuman myeloma cells in immunodeficientmouse bone. (2012)
  • Author(s): Iriuchishima H, Takubo K, Miyakawa Y,Nakamura-Ishizu A, Miyauchi Y, Fujita N,Miyamoto K, Miyamoto T, Ikeda E, KizakiM, Nojima Y, Suda T
  • Journal Title: PLoS One Volume: 7(2)
  • Peer Reviewed
• [Journal Article] In vivo behavior of multiple myeloma cells and their niche in immunodeficient mice (2012)
  • Author(s): Iriuchishima H, Kizaki M, et al
  • Journal Title: PLoS ONE Volume: 7(2) Issue: 2 Pages: e30557-e30557
  • DOI: 10.1371/journal.pone.0030557
  • Peer Reviewed
• [Presentation] Anti-tumor effects ofbendamustine on multiople myeloma cellsand myeloma niche in vivo. (2011)
  • Author(s): Iriuchishima H, Takubo K, Miyauchi Y,Fujita N, Miyamoto T, Miyakawa Y, NojimaY, Suda T
  • Organizer: 第73回 日本血液学会総会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2011-10-16
• [Presentation] Suppressor effect of novel antitumor drugs, bendamustine on multiple myeloma in humanized mouse model (2010)
  • Author(s): Takubo K., et al.
  • Organizer: 日本血液学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2010-09-25