Hypogammaglobulinemia after rituximab administration and phenotypic change of B lymphocytes

• Project/Area Number: 22591057
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Hokkaido University
• Principal Investigator: NISHIO Mitsusumi 北海道大学, 大学院・医学研究科, 非常勤講師 (10322801)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: rituximab / 低免疫グロブリン血症 / リツキシマブ / 低免疫グロブリン / R-CHOP / メモリーB細胞 / 遺伝子多型 / リンパ腫 / Fc受容体

Research Abstract

We investigated the serum IgG levels in a total 16 of non-treated non-Hodgkin lymphoma before and after R-CHOP therapy. When hypogammaglobulinemia is defined as the levels lower than 800 mg/dl, 11 patients developed hypogammaglobulinemia after median 3 months of R-CHOP. However, the delayed recovery of surface CD20/CD27 positive and IgD negative cells were not seen in the patients who had hypogammglobulinemia. Hypogammaglobulinemia with abnormal B cell recovery is specific for the case underwent stem cell transplantation plus rituximab.

Research Products

• [Journal Article] Epidemiology and treatment outcome of invasive fungal infections in patients with hematologicalmalignancies (2012)
  • Author(s): Kurosawa M, Yonezumi M, Hashino S, Tanaka J, Nishio M, Kaneda M, Ota S, Koda K, Suzuki N, Yoshida M, Hirayama Y, Takimoto R, Torimoto Y,Mori A, Takahashi T, Iizuka S, Ishida T, Kobayashi R, Oda T, Sakai H, Yamamoto S, Takahashi F, Fukuhara T
  • Journal Title: Int J Hematol Volume: 96(6) Issue: 6 Pages: 748-57
  • DOI: 10.1007/s12185-012-1210-y
  • Peer Reviewed
• [Journal Article] A comparison of oral mucositis in allogeneic hematopoietic stem cell transplantation between conventional and reduced-intensity regimens (2012)
  • Author(s): Kashiwazaki H, Matsushita T, Sugita J, Shigematsu A, Kasashi K, Yamazaki Y, Kanehira T, Kondo T, Endo T, Tanaka J, Hashino S, Nishio M, Imamura M,Kitagawa Y, Inoue N.
  • Journal Title: Support Care Cancer Volume: 20(5) Issue: 5 Pages: 933-9
  • DOI: 10.1007/s00520-011-1164-2
  • NAID: 120005228676
  • Peer Reviewed
• [Journal Article] Efficacy of folinic acid in preventing oral mucositis in allogeneic hematopoietic stem cell transplant patients receiving MTX as prophylaxis forGVHD (2012)
  • Author(s): Sugita J, Matsushita T, Kashiwazaki H, Kosugi M, Takahashi S, Wakasa K, Shiratori S, Ibata M, Shono Y, Shigematsu A, Obara M, Fujimoto K, Endo T, Nishio M, Kondo T, Hashino S, Tanaka J, Asaka M,Imamura M
  • Journal Title: Bone Marrow Transplant Volume: 47(2) Issue: 2 Pages: 258-64
  • DOI: 10.1038/bmt.2011.53
  • NAID: 120004405533
  • Peer Reviewed
• [Journal Article] Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrowtransplantation (2012)
  • Author(s): Kashiwazaki H, Matsushita T, Sugita J, Shigematsu A, Kasashi K, Yamazaki Y, Kanehira T, Yamamoto S, Kondo T, Endo T,Tanaka J, Hashino S, Nishio M, Imamura M, Kitagawa Y, Inoue N
  • Journal Title: Support Care Cancer Volume: 20(2) Issue: 2 Pages: 367-73
  • DOI: 10.1007/s00520-011-1116-x
  • Peer Reviewed
• [Journal Article] Epidemiology and treatment outcome of invasive fungal infections in patients with hematological malignancies. (2012)
  • Author(s): Kurosawa M
  • Journal Title: Int J Hematol Volume: 96 Pages: 748-757
  • Peer Reviewed
• [Journal Article] A comparison of oral mucositis in allogeneic hematopoietic stem cell transplantation between conventional and reduced-intensity regimens. (2012)
  • Author(s): Kashiwazaki H
  • Journal Title: Support Care Cancer. Volume: 20 Pages: 233-239
  • Peer Reviewed
• [Journal Article] Efficacy of folinic acid in preventing oral mucositis in allogeneic hematopoietic stem cell transplant patients receiving MTX as prophylaxis for GVHD. (2012)
  • Author(s): Sugita J
  • Journal Title: Bone Marrow Transplantation Volume: 47 Pages: 258-264
  • Peer Reviewed
• [Journal Article] Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation. (2012)
  • Author(s): Kashiwazaki H
  • Journal Title: Support Care Cancer Volume: 20 Pages: 367-373
  • Peer Reviewed
• [Journal Article] Efficacy of folinic acid in preventing oral mucositis in allogeneic hematopoietic stem cell transplant patients receiving MTX as prophylaxis for GVHD (2012)
  • Author(s): Sugita J, Nishio M, et al.
  • Journal Title: Bone Marrow Transplantation Volume: 47 Pages: 258-264
  • NAID: 120004405533
  • Peer Reviewed
• [Journal Article] DOCK2 regulates cell proliferation through Rac and ERK activation in B cell lymphoma. (2010)
  • Author(s): Wang L, Nishio M, et al.
  • Journal Title: Biochem Biophys Res Commun Volume: 395 Pages: 111-115
  • NAID: 120002148671
  • Peer Reviewed
• [Journal Article] Reduced intensity conditioning regimen with fludarabine, busulfan, and low-dose TBI (Flu-BU2-TBI) : clinical efficacy in high-risk patients. (2010)
  • Author(s): Takahata M, Nishio M, et al.
  • Journal Title: American Journal of Hematology Volume: 85 Pages: 243-248
  • Peer Reviewed
• [Presentation] The absolute number of lymphocyte/monocyte do not predict survival of patients in DLBCL after PBSCT (2012)
  • Author(s): Nishio M
  • Organizer: 日本血液学会総会
  • Place of Presentation: 京都国際会議場(京都市)
• [Presentation] The absolute number of lymphocyte/monocyte do not predict survival of patients in DLBCL after PBSCT (2012)
  • Author(s): Nishio M
  • Organizer: 日本血液学会総会
  • Place of Presentation: 京都国際会議場(京都市）
• [Presentation] Both DOCK180 and DOCK2 participate in the CXCL12 and CCL19 dependent chemotaxis of human dendritic cells derived from monocytes through the activation of Rac (2011)
  • Author(s): Goto H, Nisho M, et al.
  • Organizer: アメリカ血液学会総会
  • Place of Presentation: SanDiego DonventionCenter (USA)
  • Year and Date: 2011-12-05
• [Presentation] Hematopoietic stem cell transplantation (HSCT) for patients with primary cutaneous lymphoma (PCL) (2010)
  • Author(s): 西尾充史, 他10名
  • Organizer: 第72回日本血液学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-25