| Project/Area Number |
22591058
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SOURI Masayoshi 山形大学, 医学部, 准教授 (20292419)
OSAKI Tukasa 山形大学, 医学部, 助教 (60380565)
KOHJI Kasahara (公財)東京都医学総合研究所, 細胞膜研究室, 副室長 (60250213)
YATOMI Yutaka 東京大学, 医学部附属病院, 教授 (60200523)
IWATA Hiroki 山形大学, 医学部, 助教 (70361251)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 第XIII因子 / 架橋結合 / 血小板 / フィブリン / 血餅退縮 / XIII因子 |
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| Research Abstract |
The results of our 3-years studies strongly suggested that intracellular factor XIII (FXIII)A-subunit (FXIII-A) plays a role(s) in the proliferation and differentiation of monocytes/macrophages and megakaryocytes/platelets. It was clearly demonstrated thatextracellular FXIII-A activated the platelet signal transduction system(s) and inducedplatelet/fibrin clot retraction via biding to glycoprotein IIb/IIIa (Submitted). However, we could not conclude whether or not intracellular FXIII-A was essential in this reaction.
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