Novel functions and Mechanisms of Coagulation Factor XIII/13 in the Platelet/Fibrin Clot Retraction Reaction
| Project/Area Number |
22591058
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Yamagata University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SOURI Masayoshi 山形大学, 医学部, 准教授 (20292419)
OSAKI Tukasa 山形大学, 医学部, 助教 (60380565)
KOHJI Kasahara (公財)東京都医学総合研究所, 細胞膜研究室, 副室長 (60250213)
YATOMI Yutaka 東京大学, 医学部附属病院, 教授 (60200523)
IWATA Hiroki 山形大学, 医学部, 助教 (70361251)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 第XIII因子 / 架橋結合 / 血小板 / フィブリン / 血餅退縮 / XIII因子 |
|---|
| Research Abstract |
The results of our 3-years studies strongly suggested that intracellular factor XIII (FXIII)A-subunit (FXIII-A) plays a role(s) in the proliferation and differentiation of monocytes/macrophages and megakaryocytes/platelets. It was clearly demonstrated thatextracellular FXIII-A activated the platelet signal transduction system(s) and inducedplatelet/fibrin clot retraction via biding to glycoprotein IIb/IIIa (Submitted). However, we could not conclude whether or not intracellular FXIII-A was essential in this reaction.
|
Report
(4 results)
Research Products
(114 results)
-
-
[Journal Article] Severe inhibitor-negative acquired factorXIII/13 deficiency with aggressivesubdural haemorrhage2013
Author(s)
Kawano H, Yamamoto D, Uchihashi Y, Wakahashi K, Kawano Y, Sada A, Minagawa K, Katayama Y, Kohmura E,Souri M, Ichinose A.
-
Journal Title
Blood Coagul Fibrinolysis
Volume: (印刷中)
Issue: 6
Pages: 638-41
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Translocation of Fibrin and myosin intoplatelet membrane rafts is an importantprocess for clot retraction via afunctional property of GPIIB/IIIA2011
Author(s)
Kasahara K, Kaneda M, Miki T, Iida K, Suzuki H, Hara Y, Shimonaka M, Arai M, Kobayashi T, Ichinose A, Yamamoto N
Organizer
XXIIICongress of the International Society onThrombosis and Haemostasis (ISTH2011) and 57th Annual SSC Meeting
Place of Presentation
KyotoInternational Conference Center (Kyoto,Japan)
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] フィブリンの血小板脂質ラフト移行と血餅退縮における働き2010
Author(s)
笠原浩二 ,兼田瑞穂 ,三木俊明 ,飯田和子,鈴木英紀 ,原裕太 ,下仲基之 ,小嶋聡一,新井盛大 ,惣宇利正善 ,一瀬白帝 ,山本正雅
Organizer
第48回東北止血・血栓研究会
Place of Presentation
山形テルサ(山形)
Year and Date
2010-09-04
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
