Antigen specificity and function of lymphocyte in persistent viral infection
| Project/Area Number |
22591060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ITO Yoshinori 名古屋大学, 医学部附属病院, 講師 (20373491)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | サイトメガロウイルス / 抗原特異的 T 細胞 / Programmed cell death-1 / IL-6 / CD33陽性接着細胞 / 抗原特異的T細胞 / アデノウイルス / サイトメガロウイルス感染 |
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| Research Abstract |
PD-1 was associated with exhaustion of CMV-specific CD8+T cells in persistent CMV infection after allogeneic hematopoietic stemcell transplantation. It was suggested that CD33+adherent cells produced IL-6 and regulated PD-1 expression and growth of CMV-specific CD8+T cells through cell-to-cell contact. Serum from patients with persistent CMV infection showed a significantly higher IL-6 level and IL-6 may be useful for a biomarker of persistent CMV infection.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Cytotoxic T-lymphocyte antigen 4 haplotype correlates with relapse and survival after allogeneic hematopoietic stem cell transplantation2011
Author(s)
Murase M, NishidaT, OnizukaM, InamotoY, SugimotoK, ImahashiN, MurataM, MiyamuraK, KoderaY, InokoH, NaoeT
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Journal Title
Bone Marrow Transplant
Volume: 46(11)
Pages: 1444-1449
Related Report
Peer Reviewed
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