Antigen specificity and function of lymphocyte in persistent viral infection

• Project/Area Number: 22591060
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Nagoya University
• Principal Investigator: NISHIDA Tetsuya 名古屋大学, 医学部附属病院, 助教 (80508929)
• Co-Investigator(Kenkyū-buntansha): ITO Yoshinori 名古屋大学, 医学部附属病院, 講師 (20373491)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: サイトメガロウイルス / 抗原特異的 T 細胞 / Programmed cell death-1 / IL-6 / CD33陽性接着細胞 / 抗原特異的T細胞 / アデノウイルス / サイトメガロウイルス感染

Research Abstract

PD-1 was associated with exhaustion of CMV-specific CD8+T cells in persistent CMV infection after allogeneic hematopoietic stemcell transplantation. It was suggested that CD33+adherent cells produced IL-6 and regulated PD-1 expression and growth of CMV-specific CD8+T cells through cell-to-cell contact. Serum from patients with persistent CMV infection showed a significantly higher IL-6 level and IL-6 may be useful for a biomarker of persistent CMV infection.

Research Products

• [Journal Article] 同種造血幹細胞移植後ウイルス感染に対するドナーリンパ球を用いた養子免疫療法 (2012)
  • Author(s): 西田徹也
  • Journal Title: 日本アフェレーシス学会雑誌 Volume: 31(3) Pages: 223-228
• [Journal Article] Cytotoxic T-lymphocyte antigen 4 haplotype correlates with relapse and survival after allogeneic hematopoietic stem cell transplantation (2011)
  • Author(s): Murase M, NishidaT, OnizukaM, InamotoY, SugimotoK, ImahashiN, MurataM, MiyamuraK, KoderaY, InokoH, NaoeT
  • Journal Title: Bone Marrow Transplant Volume: 46(11) Pages: 1444-1449
  • Peer Reviewed
• [Journal Article] Cytotoxic T-lymphocyte antigen 4 haplotype correlates with relapse and survival after allogeneic hematopoietic stem cell transplantation (2011)
  • Author(s): Murase M
  • Journal Title: Bone Marrow Transplantation Volume: 印刷中
  • Peer Reviewed
• [Presentation] Identification of an HLA-A*24:02-restricted adenovirus serotype 11 epitope recognized by cytotoxic T-cells (2013)
  • Author(s): Imahashi N, Nishida T, Terakura S, Ito Y, Kawada J, Nakazawa Y, Kato T, Murata M,Naoe T
  • Organizer: 39th Annual Meeting of the European Group for Blood and Marrow Transplantation
  • Place of Presentation: ExCel London、ロンドン(英国)
  • Year and Date: 2013-04-09
• [Presentation] 同種造血幹細胞移植後サイトメガロウイルス感染症の後方視的検討-一元化データを用いた研究- (2013)
  • Author(s): 西田徹也、竹中克斗、森 有紀、大島久美、谷口修一、小川啓恭、大橋一輝、岩戸康治、坂巻 壽、森島泰雄、加藤剛二、鈴木律朗、福田隆浩
  • Organizer: 第35回日本造血細胞移植学会総会
  • Place of Presentation: ANA クラウンプラザ金沢、金沢
  • Year and Date: 2013-03-09
• [Presentation] Correlation of serum IL-6 with exhaustion of CMV-specific T cells after allogeneic stem cell transplantation (2012)
  • Author(s): 西田徹也, 加藤智則, 伊藤嘉規, 村田誠, 直江知樹
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2012-10-19
• [Presentation] Correlation of Serum IL-6 Level with Exhaustion of Cytomegalovirus-specific T Cells After Hematopoietic Stem Cell Transplantation (2011)
  • Author(s): Kato T, Nishida T, Murase M, Ito Y, Murata M, Naoe T
  • Organizer: The 53nd Annual Meeting of the American Society of Hematology
  • Place of Presentation: Marriott Hall、サンディエゴ(米国)
  • Year and Date: 2011-12-12
• [Presentation] Correlation of serum IL-6 level with exhaustion of cytomegalovirus-specific T cells after allogeneic hematopoietic stem cell transplantation (2011)
  • Author(s): NISHIDA Tetsuya
  • Organizer: 第53回American Society of Hematology Annual Meeting
  • Place of Presentation: Marriott Hall (San Diego, USA)
  • Year and Date: 2011-12-12
• [Presentation] Exhaustion ofCytomegalovirus specific T cells after allogeneic stem cell transplantation (2011)
  • Author(s): 加藤智則,西田徹也,村瀬未帆,村田誠,直江知樹
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場、名古屋
  • Year and Date: 2011-10-15
• [Presentation] Exhaustion of Cytomegalovirus specific T cells after allogeneic stem cell transplantation (2011)
  • Author(s): 西田徹也
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-15
• [Presentation] Exhaustion of CMV specific T cells with enhanced PD-1 expression in persistent cytomegalovirus infection after allogeneic stem cell transplantation (2010)
  • Author(s): Kato T, Nishida T, Murase M, Murata M, Naoe T
  • Organizer: The 52nd Annual Meeting of the American Society of Hematology
  • Place of Presentation: Orange County Convention Center、オー ランド(米国)
  • Year and Date: 2010-12-06
• [Presentation] Exhaustion of CMV specific T cells with enhanced PD-1 expression in persistent cytomegalovirus infection after allogeneic stem cell transplantation (2010)
  • Author(s): 西田徹也
  • Organizer: 第72回American Society of Hematology Annual Meeting
  • Place of Presentation: Orange County Convention Center(オーランド、米国)
  • Year and Date: 2010-12-06
• [Presentation] Generation of CMV antigen specific CTL using closed culture system (2010)
  • Author(s): 西田徹也、鈴木進、村田誠、高橋義行、小島勢二、直江知樹
  • Organizer: 第72回日本血液学会学 術集会
  • Place of Presentation: パシフィコ 横浜、横浜
  • Year and Date: 2010-09-24
• [Presentation] Generation of CMV antigen specific CTL using closed culture system (2010)
  • Author(s): 西田徹也
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2010-09-24
• [Presentation] Correlation of serum IL-6 with exhaustion of CMV-specific T cells after allogeneic stem cell transplantation
  • Author(s): Tetsuya Nishida, Tomonori Kato, Yoshinori Ito, Makoto Murata, Tomoki Naoe
  • Organizer: 第74回日本血液学会総会
  • Place of Presentation: 国立京都国際会館（京都）
• [Presentation] 同種造血幹細胞移植後サイトメガロウイルス感染症の後方視的検討―一元化データを用いた研究―
  • Author(s): 西田徹也、竹中克斗、森 有紀、大島久美、谷口修一、小川啓恭、大橋一輝、岩戸康治、坂巻 壽、森島泰雄、加藤剛二、鈴木律朗、福田隆浩
  • Organizer: 第35回日本造血細胞移植学会総会
  • Place of Presentation: ANAクラウンプラザ金沢（金沢）
• [Presentation] Identification of an HLA-A*24:02-restricted adenovirus serotype 11 epitope recognized by cytotoxic T-cells
  • Author(s): Nobuhiko Imahashi, Tetsuya Nishida, Seitaro Terakura, Yoshinori Ito, Junichi Kawada, Yozo Nakazawa, Tomonori Kato, Makoto Murata, Tomoki Naoe
  • Organizer: 39th Annual Meeting of the European Group for Blood and Marrow Transplantation
  • Place of Presentation: London（英国）