Analysis of in vivo effects of possible immune regulatory moleculesfor artificial management of immune systems
| Project/Area Number |
22591062
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
ORITANI Kenji 大阪大学, 医学系研究科, 准教授 (70324762)
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| Co-Investigator(Kenkyū-buntansha) |
KANAKURA Yuzuru 大阪大学, 医学系研究科, 教授 (20177489)
EZOE Sachiko 大阪大学, 医学部附属病院, 特任講師(常勤) (90379173)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 免疫 / 炎症 / リンパ球 / 分化 / 増殖 / 遺伝子改変マウス / マクロファージ / OSF-5 / STAP-2 / 腸炎モデル / キメラマウス / サイトカイン / OSF-5(Pleiotrophin) |
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| Research Abstract |
We analyzed in vivo effects of signal-transducing adaptor protein-2 (STAP-2) as well as proliferin, pleiotrophin, and osteoblast stimulating factor (OSF)-5. We established knock-in chimera mice to produce proliferin, pleiotrophin, or OSF-5, respectively. Only OSF-5-KI chimera mice showed lymphocytopenia in peripheral blood, spleen, and bone marrow. The mice had few B lymphocytes after pre-B cell differentiation. In addition, OSF-5 was produced by stromal cells. We also evaluated DSS-induced colitis in signal-transducing adaptor protein-2 (STAP-2)-knockout mice. STAP-2 deficiency resulted in less body weight loss and colon shortening. Colon cells had responsibility to less phenotypes of colitis, and production of chemokines was impaired in STAP-2-knockout mice.
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Report
(4 results)
Research Products
(76 results)
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[Journal Article] The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal2012
Author(s)
Sudo T, Yokota T, Oritani K, Satoh Y, Sugiyama T, Ishida T, Shibayama H, Ezoe S, Fujita N, Tanaka H, Maeda T, Nagasawa T, Kanakura Y
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Journal Title
J Immunol
Volume: 189
Pages: 200-210
Related Report
Peer Reviewed
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[Journal Article] NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells2012
Author(s)
Matsui K, Ezoe S, Oritani K, Shibata M, Tokunaga M, Fujita N, Tanimura A, Sudo T, Tanaka H, McBurney MW, Matsumura I, Kanakura Y
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Journal Title
Biochem Biophys Res Commun
Volume: 418
Pages: 811-817
Related Report
Peer Reviewed
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[Journal Article] Efficacy and safety of nilotinib in Japanese patients with imatinib-resistant or -intolerant Ph+ CML or relapsed/refractory Ph+ ALL: a 36-month analysis of a phase I and II study2012
Author(s)
Usuki K, Tojo A, Maeda Y, Kobayashi Y, Matsuda A, Ohyashiki K, Nakaseko C, Kawaguchi T, Tanaka H, Miyamura K, Miyazaki Y, Okamoto S, Oritani K, Okada M, Usui N, Nagai T, Amagasaki T, Wanajo A, Naoe T.
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Journal Title
Int J Hematol
Volume: 95
Pages: 409-419
NAID
Related Report
Peer Reviewed
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[Journal Article] Predictability of the response to tyrosine kinase inhibitors via in vitro analysis of Bcr-Abl phosphorylation2011
Author(s)
Shibata M, Ezoe S, Oritani K, Matsui K, Tokunaga M, Fujita N, Saito Y, Takahashi T, Hino M, Matsumura I, Kanakura Y
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Journal Title
Leuk Res
Volume: 35
Pages: 1205-1211
Related Report
Peer Reviewed
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[Journal Article] Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4)2011
Author(s)
Togi S, Ikeda O, Kamitani S, Nakasuji M, Sekine Y, Muromoto R, Nanbo A, Oritani K, Kawai T, Akira S, Matsuda T
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Journal Title
J Biol Chem
Volume: 286
Pages: 19170-19177
Related Report
Peer Reviewed
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[Journal Article] Kruppel-associated box-associated protein 1 negatively regulates TNF-α -induced NF- κ B transcriptional activity by influencing the interactions among STAT3, p300, and NF-κB/p652011
Author(s)
Kamitani S, Togi S, Ikeda O, Nakasuji M, Sakauchi A, Sekine Y, Muromoto R, Oritani K, Matsuda T
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Journal Title
J Immunol
Volume: 187
Pages: 2476-2483
Related Report
Peer Reviewed
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[Journal Article] The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal2010
Author(s)
Ikeda O, Sekine Y, Mizushima A, Nakasuji M, Miyasaka Y, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T
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Journal Title
J Biol Chem
Volume: 285
Pages: 38093-38103
Related Report
Peer Reviewed
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[Journal Article] BS69 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation2010
Author(s)
Ikeda O, Miyasaka Y, Yoshida R, Mizushima A, Oritani K, Sekine Y, Kuroda M, Yasui T, Fujimuro M, Muromoto R, Nanbo A, Matsuda T
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Journal Title
FEBS Lett
Volume: 584
Pages: 865-872
Related Report
Peer Reviewed
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