Pathogen moleculoar pattern recognition mechanisms inside and outsied of the blood vessel
| Project/Area Number |
22591064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIMOTO Masao 佐賀大学, 医学部, 教授 (40153225)
TSUNEYOSHI Naoko 佐賀大学, 医学部, 客員研究員 (80336114)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 血液免疫学 / モノクローナル抗体 / 粗面小胞体 / ストレスシグナル / TLR4 / TLR / 血管内皮 / 敗血症 / アゴニスト / 抗体 |
|---|
| Research Abstract |
We demonstrated that sensitive LPS-recogition by macrophadese was due to the strong TLR4-signal transduction induced by raft-formation in the cells carring memebrane-associated CD14. The signal transduction was not so effective in CD14-negative cells such as B cells; however, it was significant to induce some responses. We discovered that LPS-tolerance was resulted by loss of antigen-presenting function in B cells differenciated by LPS-stimulation in the absence of antigen.
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Report
(4 results)
Research Products
(22 results)
