Analysis of anti-tumor activity and anti-virus effect after allogeneic hematopoietic stem cell transplantation for patients with ATL

• Project/Area Number: 22591065
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: University of the Ryukyus (2012); Nagasaki University (2010-2011)
• Principal Investigator: FUKUSHIMA Takuya 琉球大学, 医学部, 教授 (40336160)
• Co-Investigator(Kenkyū-buntansha): TSUKASAKI Kunihiro 独立行政法人国立がん研究センター, その他部局等, その他 (40274659) ; 宮崎 泰司 長崎大学, 医歯(薬)学総合研究科, 教授 (40304943)
• Co-Investigator(Renkei-kenkyūsha): MIYAZAKI Yasushi 長崎大学, 医歯(薬)学総合研究科, 教授 (40304943)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 造血幹細胞移植学 / 成人T細胞白血病・リンパ腫 / 同種造血幹細胞移植 / graft-versus-ATL効果 / HTLV-1プロウイルス量 / ATL / HTLV-1プロウイルスDNA定量 / ATL細胞特異的クローン

Research Abstract

Among long-term survivors with ATL treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT) in Nagasaki prefecture, there was no patient with undetected level of HTLV-1 proviral DNA load except one patient of our previous report. However, we found an efficacy of all-HSCT for ATL patients with central nervous system involvement and feasibility of cord blood transplantation for patients with ATL, contributed by graft-versus-ATL (GvATL) effect of immunocompetent cells. And also we showed that donor lymphocyte infusion had effectiveness for some relapsed patients with ATL after allo-HSCT. In our analysis we find that GvATL effect work for anti-tumor activity in allo-HSCT for patients with ATL.

Research Products

• [Journal Article] Feasibility of cord blood transplantation in chemosensitive adult T-cell leukemia/lymphoma: a retrospective analysis of the Nagasaki Transplantation Network (2013)
  • Author(s): Fukushima T, Itonaga H, Moriuchi Y, Yoshida S, Taguchi J, Imaizumi Y, Imanishi D, Tsushima H, Sawayama Y, Matsuo E, Hata T, Miyazaki Y
  • Journal Title: Int J Hematol Volume: 97 Issue: 4 Pages: 485-490
  • DOI: 10.1007/s12185-013-1307-y
  • NAID: 10031168515
  • Peer Reviewed
• [Journal Article] Distinct clinical features of infectious complications in adult T-cell leukemia/lymphoma patients after allogeneic hematopoietic stem cell transplantation: a retrospective analysis in the Nagasaki transplant group (2013)
  • Author(s): Itonaga H, Taguchi J, Fukushima T, Tsushima H, Sato S, Ando K, Sawayama Y, Matsuo E, Yamasaki R, Onimaru Y, Imanishi D, Imaizumi Y, Yoshida S, Hata T, Moriuchi Y, Honda S, Miyasaki Y
  • Journal Title: Biol Blood Marrow Transplant Volume: 19 Issue: 4 Pages: 607-615
  • DOI: 10.1016/j.bbmt.2013.01.011
  • NAID: 120006985927
  • Peer Reviewed
• [Journal Article] Treatment of relapsed adult T-cell leukemia/lymphoma after allogeneic hematopoietic stem cell transplantation: the Nagasaki Transplant Group experience (2013)
  • Author(s): Itonaga H, Tsushima H, Taguchi J, Fukukshima T, Taniguchi H, Sato S, Ando K, Sawayama Y, Matsuo E, Yamasaki R, Onimaru Y, Imanishi D, Imaizumi YYoshida S, Hata T, Moriuchi Y, Uike N, Miyazaki Y
  • Journal Title: Blood Volume: 121 Issue: 1 Pages: 219-225
  • DOI: 10.1182/blood-2012-07-444372
  • Peer Reviewed
• [Journal Article] Radiat (2013)
  • Author(s): Hsu WL, Preston DL, Soda M, Sugiyama H, Funamoto S, Kodama K, Kimura A, Kamada N, Dohy H, Tomonaga M, Iwanaga M, Miyazaki Y, Cullings HM, Suyama A, Ozasa K, Shore RE, Mubuchi K
  • Journal Title: Res Volume: 179 Issue: 3 Pages: 361-382
  • DOI: 10.1667/rr2892.1
  • Peer Reviewed
• [Journal Article] Mutations in the nucleolar phosphoprotein, nucleophosmin, promote the expression of the oncogenic transcription factor MEF/ELF4 in leukemia cells and potentiates transformation. (2013)
  • Author(s): Ando K
  • Journal Title: Journal of Biological Chemistry Volume: 288 Issue: 13 Pages: 9457-9467
  • DOI: 10.1074/jbc.m112.415703
  • Peer Reviewed
• [Journal Article] Successful treatment of a chronic-phase T-315I-mutated chronic myelogenous leukemia patient with a combination of imatinib and interferon-alfa (2012)
  • Author(s): Itonaga H, Tsushima H, Hata T, Matsuo E, Imanishi D, Imaizumi Y, Kawaguchi Y, Fukushima T, Doi Y, Mori S, Kamihira S, Tomonaga M, Miyazaki Y
  • Journal Title: Int J Hematol Volume: 95 Issue: 2 Pages: 209-213
  • DOI: 10.1007/s12185-012-1005-1
  • NAID: 10030267492
  • Peer Reviewed
• [Journal Article] Clinical trials and treatment of ATL (2012)
  • Author(s): Tsukasaki K, Tobinai K
  • Journal Title: Leuk Res Volume: 2012 Pages: 1-12
  • DOI: 10.1155/2012/101754
  • Peer Reviewed
• [Journal Article] Duodenal involvement of mantle cell lymphoma observed by magnified endoscopy with narrow-band imaging. (2012)
  • Author(s): Norimura D, et al
  • Journal Title: Gastrointest Endosc. Volume: 76 Issue: 1 Pages: 188-189
  • DOI: 10.1016/j.gie.2012.02.047
  • Peer Reviewed
• [Journal Article] Heterogeneity in clonal nature in the smoldering subtype of adult T-cell leukemia: continuity from carrier status to smoldering ATL (2012)
  • Author(s): Kamihira S, Iwanaga M, Doi Y, Sasaki D, Mori S, Tsuruda K, Nagai K, Uno N, Hasagawa H, Yanagihara K, Morinaga Y, Tsukasaki K Taniguchi H
  • Journal Title: Int J Hematol Volume: 95 Issue: 4 Pages: 399-408
  • DOI: 10.1007/s12185-012-1020-2
  • NAID: 10030632587
  • Peer Reviewed
• [Journal Article] Gastric involvement by mantle cell lymphoma observed by magnified endoscopy with narrow-band imaging. (2012)
  • Author(s): Norimura D, et al
  • Journal Title: Gastrointest Endosc. Volume: 75 Issue: 2 Pages: 421-422
  • DOI: 10.1016/j.gie.2011.10.018
  • Peer Reviewed
• [Journal Article] Lymphoma study group of JCOG (2012)
  • Author(s): Tsukasaki K, Tobinai K, Hotta T, Shimoyama M
  • Journal Title: Jpn J Clin Oncol Volume: 42 Issue: 2 Pages: 85-95
  • DOI: 10.1093/jjco/hyr168
  • Peer Reviewed
• [Journal Article] Late effect of atomic bomb radiation on myeloid disorders: leukemia and myelodysplastic sydromes (2012)
  • Author(s): Tsushima H, Iwanaga M, Miyazaki Y
  • Journal Title: Int J Hematol Volume: 95 Issue: 3 Pages: 232-238
  • DOI: 10.1007/s12185-012-1002-4
  • Peer Reviewed
• [Journal Article] Current treatment strategy for adult T-cell leukemia/lymphoma (2012)
  • Author(s): Takuya Fukushima
  • Journal Title: Ryukyu Medical Journal Volume: 31 Pages: 1-6
  • NAID: 120005366456
  • Peer Reviewed
• [Journal Article] Allogeneic hematopoietic stem cell transplantation for ATL with central nervous system involvement: the Nagasaki transplant group experience (2011)
  • Author(s): Fukushima T, Taguchi J, Moriuchi Y, Yoshida S, Itonaga H, Ando K, Sawayama Y, Imaizumi Y, Imanishi D, Hata T, Miyazaki Y
  • Journal Title: Int J Hematol Volume: 94 Issue: 4 Pages: 390-394
  • DOI: 10.1007/s12185-011-0935-3
  • NAID: 10030265432
  • Peer Reviewed
• [Journal Article] Expression of myeloperoxidase and gene mutations in AML patients with normal karyotype: double CEBPA mutations are associated with high percentage of MPO positivity in leukemic blasts (2011)
  • Author(s): Tominaga-Sato S, Tsushima H, Ando K, Itonaga H, Imaizumi Y, Imanishi D, Iwanaga M, Taguchi J, Fukushima T, Yoshida S, Hata T, Moriuchi Y, Kuriyama K, Mono H, Tomonaga M, Miyazaki Y
  • Journal Title: Int J Hematol Volume: 94 Issue: 1 Pages: 81-89
  • DOI: 10.1007/s12185-011-0883-y
  • NAID: 10029536517
  • Peer Reviewed
• [Journal Article] High expression of 67-kDa laminin receptor relates to the proliferation of leukemia cells and increases expression of GM-CSF receptor (2011)
  • Author(s): Ando K, Miyazaki Y, Sawayama Y, Tominaga S, Matuso E, Yamasaki R, Inoue Y, Iwanaga M, Imanishi D, Tsushima H, Fukushima T, Imaizumi Y, Taguchi J, Yoshida S, Hata T, Tomonaga M
  • Journal Title: Exp Hematol Volume: 39 Pages: 179-186
  • Peer Reviewed
• [Journal Article] Aberrant overexpression of membrane-associatedmucin contributes to tumor progression in adult T-cell leukemia/lymphoma cells (2011)
  • Author(s): Hasegawa H, Komoda M, Yamada Y, Yonezawa S, Tsutsumida H, Nagai K, Atogami S, Tsuruda K, Osaka A, Sasaki D, Yanagihara K, Imaizumi Y, Tsukasaki K, Miyazaki Y, Kamihira S
  • Journal Title: Leuk Lymphoma Volume: 52 Issue: 6 Pages: 1108-1117
  • DOI: 10.3109/10428194.2011.559671
  • Peer Reviewed
• [Journal Article] LBH589, a deacetylase inhibitor, induces apoptosis in adult T-cell leukemia/lymphoma cells via activation of a novel RAIDD-caspase-2 pathway (2011)
  • Author(s): Hasegawa H, Yamada Y, Tsukasaki K, Mori N, Tsuruda K, Sasaki D, Usui T, Osaka A, Atogami S, Ishikawa C, Machijima Y, Sawada S, Hayashi T, Miyazaki Y, Kamihira S
  • Journal Title: Leukemia Volume: 25 Issue: 4 Pages: 575-587
  • DOI: 10.1038/leu.2010.315
  • NAID: 120006984803
  • Peer Reviewed
• [Journal Article] Overexpression of enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy (2011)
  • Author(s): Sasaki F, Imaizumi Y, Hasegawa H, Osaka A, Tsukasaki K, ChoiYL, Mano H, Marquez VE, Hayashi T, Yanagihara K, Moriwaki Y, Miyazaki Y, Kamihira S, Yamada Y
  • Journal Title: Haematologica Volume: 96 Pages: 712-719
  • Peer Reviewed
• [Journal Article] Case series of duodenal follicular lymphoma observed by magnified endoscopy with narrow-band imaging (2011)
  • Author(s): Norimura D, Isomoto H, Imaizumi Y, Akazawa Y, Matsushima K, Inoue N, Yamaguchi N, Ohnita K, Shikuwa S, Arima T, Hayashi T, Takeshima F, Miyazaki Y, Nakao K
  • Journal Title: Gastrointest Endosc Volume: 74 Issue: 2 Pages: 428-434
  • DOI: 10.1016/j.gie.2011.03.1237
  • Peer Reviewed
• [Journal Article] Expression of myeloperoxidase and gene mutations in AML patients with normal karyotype : double CEBPA mutations are associated with high percentage of MPO positivity in leukemic blasts (2011)
  • Author(s): 佐藤信也、福島卓也、宮崎泰司, ほか
  • Journal Title: Int J Hematol Volume: 94 Pages: 81-89
  • NAID: 10029536517
  • Peer Reviewed
• [Journal Article] Allogeneic hematopoietic stem cell transplantation for ATL with central nervous system involvement : The Nagasaki Transplant Group experience (2011)
  • Author(s): 福島卓也、宮崎泰司, ほか
  • Journal Title: Int J Hematol Volume: 94 Pages: 390-394
  • NAID: 10030265432
  • Peer Reviewed
• [Journal Article] High expression of 67-kDa laminin receptor relates to the proliferation of leukemia cells and increases expression of GM-CSF receptor. (2011)
  • Author(s): 安東恒史、福島卓也, ほか
  • Journal Title: Experimental Hematology Volume: 39 Pages: 179-186
  • Peer Reviewed
• [Journal Article] Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan (2010)
  • Author(s): Iwanaga M, Watanabe T, Utsunomiya A, Okayama A, Uchimaru K, Koh KR, Ogata M, Kikuchi H, Sagara Y, Uozumi K, Mochizuki M, Tsukasaki K, Saburi Y, Yamamura M, Tanaka J, Moriuchi Y, Hino S, Kamihira S, Yamaguchi K
  • Journal Title: Blood Volume: 116 Issue: 8 Pages: 1211-1219
  • DOI: 10.1182/blood-2009-12-257410
  • Peer Reviewed
• [Journal Article] Is Zidovudine and Interferon-alfa the gold standard for adult T-cell leukemia-lymphoma? (2010)
  • Author(s): 石塚賢治、福島卓也, ほか
  • Journal Title: Journal of Clinical Oncology Volume: 28 Pages: 765-765
  • Peer Reviewed
• [Presentation] Characterization of long-term survivors and a predictive model for aggressive adult T-cell leukemia-lymphoma (ATL): an ancillary study by the Japan Clinical Oncology Group, JCOG0902A (2012)
  • Author(s): Fukushima T, Nomura S, Shimoyama M, Utsunomiya A, Shibata T, Ishitsuka K, Moriuchi Y, Yoshida S, Uike N, Hata H, Kawano F, Sueoka E, Uozumi K, Mosuda M, Yamada Y, Kaba H, Watanabe Y, Fukuda H, Hotta T, Tobinai K, Tsukasaki K
  • Organizer: 53th American Society of Hematology Annual Meeting and Exposition
  • Place of Presentation: San Diego, US
  • Year and Date: 2012-12-12
• [Presentation] Prospective nationwide observational study of hepatitis B virus (HBV) DNA monitoring and preemptive antiviral therapy for HBV reactivation in patients with B-cell non-Hodgkin lymphoma following rituximab containing chemotherapy: results of interim analysis (2012)
  • Author(s): Kusumoto S, Tanaka Y, Suzuki R, Watanabe T, Nakata M, Takasaki H, Fukushima N, Fukushima T, Moriuchi Y, Itoh K, Nosaka K, Choi I, Sawa M, Okamoto R, Tsujimura H, Uchida T, Suzuki S, Okamoto M, Takahashi T, Sugiura I, Onishi Y, Kohri Myoshida S, Sakai R, Kojima M, Takahashi H, Tomita A, Maruyama D, Atsuta Y, Tanaka E, Suzuki T, Kinoshita T, Ogura M, Mizokami M, Ueda R
  • Organizer: 54th American Society of Hematology Annual Meeting and Exposition
  • Place of Presentation: Atlanta, US
  • Year and Date: 2012-12-09
• [Presentation] An ancillary study for aggressive ATL by the Japan Clinical Oncology Group (2012)
  • Author(s): Moriuchi Y, Fukushima T, Nomura S, Shimoyama M, Utsunomiya A, Shibata T, Tamura K, Ishitsuka K, Yoshida S, Uike N, Hata H, Kawano F, Fukushima N, Uozumi K, Masuda M, Yamada Y, Kaba H, Watanabe Y, Fukuda H, Hotta T, Tobinai K, Tsukasaki K
  • Organizer: JCOG0902A. 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-21
• [Presentation] Proliferation of donor-derived HTLV-1-infected cells in an ATL patient after allogeneic PBSCT (2012)
  • Author(s): Taguchi M, Taguchi J, Sasaki D, Kato T, Hourai M, Itonaga H, Imaizumi Y, Imanishi D, Tsushima H, Hata T, Fukushima T, Tsukasaki K, Kamihira S, Miyazaki Y
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-19
• [Presentation] An ancillary study for aggressive ATL by the Japan Clinical Oncology Group, JCOG0902A (2012)
  • Author(s): Yukiyoshi Moriuchi
  • Organizer: the 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Kyoto, Japan
• [Presentation] Proliferation of donor-derived HTLV-1 infected cells in an ATL patient after allogeneic PBSCT (2012)
  • Author(s): Masataka Taguchi
  • Organizer: the 74th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Kyoto, Japan
• [Presentation] Prospective Nationwide Observational Study of Hepatitis B Virus (HBV) DNA Monitoring and Preemptive Antiviral Therapy for HBV Reactivation in Patients with B-Cell Non-Hodgkin Lymphoma Following Rituximab Containing Chemotherapy: Results of Interim Analysis (2012)
  • Author(s): Shigeru Kusumoto
  • Organizer: 54th ASH Annual Meeting and Exposion
  • Place of Presentation: Atlant, GA, US
• [Presentation] A prospective feasibility trial of unrelated bonemarrow transplantation with reduced intensity conditioning regimen for elderly patients with adult T-cell leukemia/lymphoma (2011)
  • Author(s): Eto T, Choi I, Tanosaki R, Takatsuka Y, Takemoto S, Taguchi J, Fukushima T, Kato K, Teshima T, Suehiro Y, Yamanaka T, Okamura J, Uike N
  • Organizer: 53th American Society of Hematology Annual Meeting and Exposition
  • Place of Presentation: San Diego, US
  • Year and Date: 2011-12-12
• [Presentation] Characterization of Long Term Survivors and a Predictive Model for Aggressive Adult T-Cell Leukemia-Lymphoma (ATL) : An Ancillary Study by the Japan Clinical Oncology Group, JCOG0902A (2011)
  • Author(s): 福島卓也、塚崎邦弘, ほか
  • Organizer: 53回米国血液学会(53^<rd> ASH Annual Meeting and Exposition)
  • Place of Presentation: サンディエゴ、アメリカ
  • Year and Date: 2011-12-12
• [Presentation] ワークショップ7「ATL」長崎県における成人T細胞白血病・リンパ腫(ATL)に対する臍帯血移植(CBT)の治療成績 (2011)
  • Author(s): 福島卓也 森内幸美 吉田真一郎 糸永英弘 田口潤 宮崎泰司
  • Organizer: 第33回日本造血細胞移植学会総会
  • Place of Presentation: 松山(愛媛)
  • Year and Date: 2011-03-09
• [Presentation] 長崎県における成人T細胞白血病・リンパ腫(ATL)に対する濟帯血移植(CBT)の治療成績 (2011)
  • Author(s): 福島卓也
  • Organizer: 第33回日本造血細胞移植学会総会
  • Place of Presentation: 松山市
  • Year and Date: 2011-03-09
• [Book] 現場で役立つ血液腫瘍プロトコール集改訂版 (2011)
  • Author(s): 福島卓也、塚崎邦弘
  • Total Pages: 7
  • Publisher: 医薬ジャーナル社
• [Book] 血液・腫瘍科(化学療法時の感染症の予防対策) (2010)
  • Author(s): 福島卓也
  • Total Pages: 7
  • Publisher: 科学評論社