| Project/Area Number |
22591067
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
NOJI Hideyoshi 福島県立医科大学, 医学部, 講師 (20347214)
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| Co-Investigator(Kenkyū-buntansha) |
SHICHISHIMA Tsutomu 福島県立医科大学, 医学部, 研究員 (10192105)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJITA Teizo 福島県立医科大学, 医学部, 教授 (20134223)
MANO Hiroyuki 自治医科大学, 医学部, 教授 (90240704)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 血液免疫学 / PNH / DNAマイクロアレイ / 免疫療法 / SCIDマウス / AC133^+細胞 / GPIアンカー膜蛋白 |
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| Research Abstract |
We planned this study in order to develop immunotherapy with peptide vaccine for paroxysmal nocturnal hemoglobinuria (PNH). 1) We investigated gene(s)associated with the expansion of PNH clones by microarray methods to clarify target for the therapy. 2) We tried to prepare a xenogeneic model of PNH resulting from the adoptive transfer of BM ACC133+cells from PNH patients into NOG mice. We have a next step such as assessment of effects for PNH clone and reactions of immune system in PNH patients by WT1 peptide vaccine.
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