Prediction and prophylaxis of graft-versus-host disease and late-onset non-infectious pulmonary complications after hematopoietic stem cell transplantation

• Project/Area Number: 22591068
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Osaka City University
• Principal Investigator: NAKAMAE Hirohisa 大阪市立大学, 大学院・医学研究科・血液腫瘍制御学, 准教授 (30364003)
• Co-Investigator(Kenkyū-buntansha): NAKANE Takahiko 大阪市立大学, 大学院・医学研究科, 講師 (10382136)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 同種幹細胞移植 / 移植片対宿主病(GVHD) / 遅発性非感染性肺合併症(LONIPCs) / Beclomethasone dipropionate (BDP) / 移植片対宿主病（GVHD） / 遅発性非感染性肺合併症（LONIPCs） / ベクロメタゾンプロピオン酸エステル製剤 / beclomethasone dipropionate(BDP) / Beclomethasone dipropionate(BDP)

Research Abstract

Since 2010, we have been performing a single center prospective observational study entitled “Establishment of convenient plasma biomarker for prediction of graft-versus-host disease following allogeneic hematopoietic cell transplantation”. Furthermore

Research Products

• [Journal Article] Serum Cytokine Profiles in Hemophagocytic Syndrome following Allogeneic Hematopoietic Stem Cell Transplantation (2012)
  • Author(s): Koh H, Nakane T, Sakamoto E, Katayama T, Nakamae H, Ohsawa M, Hino M
  • Journal Title: Acta Haematol Volume: 127 Issue: 3 Pages: 182-185
  • DOI: 10.1159/000335536
  • Peer Reviewed
• [Journal Article] Immunoglobulin prophylaxis against cytomegalovirus infection in patients at high risk of infection following allogeneic hemato poietic cell transplantation (2011)
  • Author(s): Ichihara H, Nakamae H, Hirose A, Nakane T, Koh H, Hayashi Y, Nishimoto M, Nakamae M, Yoshida M, Bingo M, Okamura H, Aimoto M, Manabe M, Hagihara K, Terada Y, Nakao Y, Hino M
  • Journal Title: Transplant Proc Volume: 43 Issue: 10 Pages: 3927-3932
  • DOI: 10.1016/j.transproceed.2011.08.104
  • Peer Reviewed
• [Journal Article] Factors that contribute to long-term survival in patients with leukemia not in remission at allogeneic hematopoietic cell transplantation (2011)
  • Author(s): Koh H, Nakamae H, Hagihara K, Nakane T, Manabe M, Hayashi Y, Nishimoto M, Umemoto Y, Nakamae M, Hirose A, Inoue E, Inoue A, Yoshida M, Bingo M, Okamura H, Aimoto R, Aimoto M, Terada Y, Koh KR, Yamane T, Ohsawa M, Hino M
  • Journal Title: J Exp Clin Cancer Res Volume: 30 Issue: 1 Pages: 30-36
  • DOI: 10.1186/1756-9966-30-36
  • Peer Reviewed
• [Journal Article] Reduced-intensity conditioning by fludarabine/busulfan without additional irradiation or T-cell depletion leads to low non-relapse mortality in unrelated bone marrow transplantation (2011)
  • Author(s): Nakane T, Nakamae H, Koh H, Nakamae M, Hayashi Y, Nishimoto M, Yoshimura T, Inoue E, Inoue A, Aimoto R, Aimoto M, Terada Y, Koh KR, Yamane T, Hino M
  • Journal Title: Int J Hematol Volume: 94 Issue: 4 Pages: 509-516
  • DOI: 10.1007/s12185-011-0805-z
  • NAID: 10029534640
  • Peer Reviewed
• [Journal Article] Reduced-intensity conditioning by fludarabine/busulfan without additional irradiation or T-cell depletion leads to low non-relapse mortality in unrelated bone marrow transplantation (2011)
  • Author(s): Nakane T, Nakamae H, Koh H, Nakamae M, Hayashi Y, Nishimoto M, Yoshimura T, Inoue E, Inoue A, Aimoto R, Aimoto M, Terada Y, Koh KR, Yamane T, Hino M.
  • Journal Title: Int J Hematol(Epub,Mar,2011) Volume: 93 Pages: 509-516
  • NAID: 10029534640
  • Peer Reviewed
• [Journal Article] Prognostic factors and outcomes of adult patients with acute myeloid leukemia after first relapse. (2010)
  • Author(s): Kurosawa S, Yamaguchi T, Miyawaki S, Uchida N, Sakura T, Kanamori H, Usuki K, Yamashita T, Okoshi Y, Shibayama H, Nakamae H, Mawatari M, Hatanaka K, Sunami K, Shimoyama M, Fujishima N, Maeda Y, Miura I, Takaue Y, Fukuda T
  • Journal Title: Haematologica Volume: 95 Pages: 1857-1864
  • Peer Reviewed
• [Presentation] 非血縁者間同種造血幹細胞移植後、自律神経障害を呈したHHV6脳炎・脊髄炎の1例 (2011)
  • Author(s): 西本光孝、中前博久、林良樹、間部賢寛、康秀男、中根孝彦、廣瀬朝生、中前美佳、寺田芳樹、日野雅之
  • Organizer: 第95回近畿血液学地方会、6月1日
  • Place of Presentation: 尼崎
  • Year and Date: 2011-06-01
• [Presentation] 非寛解期に同種造血幹細胞移植(HCT)を施行された白血病患者の長期生存に寄与する因子の検討 (2011)
  • Author(s): 康秀男、中前博久、中根孝彦、林良樹、西本光孝、相本瑞樹、井上敦司、間部賢寛、備後真登、吉田全宏、岡村浩史、梅本由香里、井上恵里、相本蘭、廣瀬朝生、中前美佳、寺田芳樹、高起良、山根孝久、日野雅之
  • Organizer: 第33回日本造血細胞移植学会総会
  • Place of Presentation: 愛媛県県民文化会館、松山市、愛媛県
  • Year and Date: 2011-03-09
• [Presentation] 当科におけるPh陽性ALLの同種造血幹細胞移植成績及び予後因子の検討 (2011)
  • Author(s): 吉村卓朗、中根孝彦、廣瀬朝生、康秀男、中前美佳、相本蘭、井上恵里、相本瑞樹、井上敦司、西本光孝、林良樹、寺田芳樹、中尾吉孝、中前博久、高起良、山根孝久、日野雅之
  • Organizer: 第33回日本造血細胞移植学会総会
  • Place of Presentation: 愛媛県県民文化会館、松山市、愛媛県
  • Year and Date: 2011-03-09
• [Presentation] Serum cytokine profile in hemmophagocyte syndrome after allogeneic hematopoietic transplant (2011)
  • Author(s): Koh H, Koh KR, Nakane T, Sakamoto E, Katayama T, Nakamae M, Terada Y, Nakamae H, Yamane T, Hino M
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] Cold-AIHA in a case of MDS relapsed after allogenic bone marrow transplantation (2011)
  • Author(s): Okamura H, Nakane T, Yoshida M, Bingo M, Aimoto M, Nishimoto M, Hayashi Y, Manabe M, Koh H, Nakamae M, Terada Y, Nakamae H, Hino M
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] Risk factors affecting cardiac left ventricular systolic and diastolic function and hypertrophy in the chronic phase post-allogeneic hematopietic cell transplantation (2011)
  • Author(s): Nishimoto M, Nakamae H, Nakane T, Koh H, Hayashi Y, Nakamae M, Yoshida M, Bingo M, Okamura H, Aimoto M, Manabe M, Yoshimura T, Inaba A, Nanno S, Hirose A, Hagihara K, Nakao Y, Terada Y, Hino M
  • Organizer: 53rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: San Diego, USA
• [Presentation] Factors That Contribute to Long-Term Survival in Patients with Leukemia Not In Remission at Allogeneic Hematopoietic Cell Transplantation (2010)
  • Author(s): Koh H, Nakamae H, Nakane T, Manabe M, Hayashi Y, Nishimoto M, Umemoto K, Nakamae M, Hirose A, Inoue E, Inoue A, Yoshida M, Bingo M, Okamura H, Aimoto R, Aimoto M, Terada Y, Koh KR, Yamane T, Hino M
  • Organizer: 52th Annual Meeting of the American Society of Hematology
  • Place of Presentation: Orlando, USA
  • Year and Date: 2010-12-06
• [Remarks]
  • URL: http://medwebsv.med.osaka-cu.ac.jp/labmed/index.html
• [Remarks]
  • URL: http://medwebsv.med.osaka-cu.ac.jp/labmed/index.html