Development of novel therapy for thrombotic microangiopathy after hematopoietic stem cell transplantation.

• Project/Area Number: 22591069
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Nara Medical University
• Principal Investigator: MATSUMOTO Masanori 奈良県立医科大学, 医学部, 准教授 (60316081)
• Co-Investigator(Kenkyū-buntansha): FUJIMURA Yoshihiro 奈良県立医科大学, 医学部, 教授 (80118033) ; 早川 正樹 奈良県立医科大学, 医学部附属病院, 研究員 (30516729)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 造血幹細胞移植学 / SCT / TMA / VWF / ADAMTS13

Research Abstract

The pathogenesis and optimal treatment of thrombotic microangiopathy (TMA) associated with stem cell transplantation (SCT) have not been established. We analyzed 3 patients with SCT-TMA from before SCT in detail and found increased plasma levels of von Willebrand factor (VWF) antigen without a deficiency of ADAMTS13 activity. VWF multimers analysis showed the existence of unusually large VWF multimers before TMA development and the defect of high molecular weight multimers during TMA bouts. Recombinant thrombomodulin might improve the efficacy of platelet transfusion in patients with SCT-TMA.

Research Products

• [Journal Article] Ticlopidine -associated ADAMTS13 activity deficient thrombotic thrombo- cytopenic purpura in 22 persons in Japan: A Report from the Southern Network on Adverse Reactions (SONAR) (2013)
  • Author(s): Bennett CL, Jacob S, Dunn BL, Georgantopoulos P, Zheng XL, Kwaan HC, McKoy JM, Magwood JS, Bandarenko N, Winters JL, Raife TJ, Carey PM, Sarode R, Kiss JE, Danielson C, Ortel TL, Clark WF, Ablin R, Rock G, Matsumoto M, Fujimura Y
  • Journal Title: Br J Haematol Volume: (in press)
• [Journal Article] ADAMTS13 unbound to larger von Willebrand factor multimers in cryosupernatant :Implications for selection of plasma preparations for TTP treatment (2013)
  • Author(s): Hori Y, Hayakawa M, Isonishi A, Soejima K, Matsumoto M, Fujimura Y
  • Journal Title: Transfusion Volume: (in press)
• [Journal Article] Limited renal prophylaxis in regular plasmatherapy for heritable ADAMTS13 deficiency (2013)
  • Author(s): Doi T, Ohga S, Ito N, Ishimura M, Suga N, Nomura A, Takada H, Matsumoto M, Fujimura Y, Hara T
  • Journal Title: Pediatr Blood Cancer Volume: (in press)
• [Journal Article] Analysis of genetic and predisposing factors in Japanese patients with atypical hemolytic uremic syndrome (2013)
  • Author(s): Fan X, Yoshida Y, Honda S, Matsumoto M, Sawada Y, Hattori M, Hisanaga S, Hiwa R, Nakamura F, Tomomori M, Miyagawa S, Fujimaru R, Yamada H, Sawai T, Ikeda Y, Iwata N, Uemura O, Matsukuma E, Aizawa Y, Harada H, Wada H, Ishikawa E, Ashida A, Nangaku M, Miyata T, Fujimura Y
  • Journal Title: Mol Immunol Volume: 54 Pages: 238-246
• [Journal Article] Drug-induced thrombotic thrombocytopenic purpura success- fully treated with recombinant human soluble thrombomodulin (2013)
  • Author(s): Nishijima Y, Hirata H, Himeno A, Kida H, Matsumoto M, Takahashi R, Otani Y, Inoue K, Nagatomo I, Takeda Y, Kijima T, Tachibana I, Fujimura Y, Kumanogoh A
  • Journal Title: Inter Med Volume: 52 Pages: 1111-1114
  • NAID: 130003365599
• [Journal Article] Ratio of von Willebrand factor propeptide to ADAMTS13 Is Associated With Severity of Sepsis (2013)
  • Author(s): Fukushima H, Nishio K, Asai H, Watanabe T, Seki T, Matsui H, Sugimoto M, Matsumoto M, Fujimura Y, Okuchi K
  • Journal Title: Shock Volume: 39 Pages: 409-414
• [Journal Article] ADAMTS13 activity and genetic mutations in Japanese subjects (2013)
  • Author(s): Miyata T, Kokame K, Matsumoto M, Fujimura Y
  • Journal Title: Hamostaseologie (review)
  • Peer Reviewed
• [Journal Article] 抗 ADAMTS13 自己抗体と血栓性血小板減少性紫斑病 (2013)
  • Author(s): 松本雅則
  • Journal Title: 日本臨床免疫学会会誌 Volume: 36 Pages: 95-103
  • NAID: 10031171399
• [Journal Article] Analysis of genetic and predisposing factors in Japanese patients with atypical hemolytic uremic syndrome. (2013)
  • Author(s): Fan X, Yoshida Y, Honda S, et al. (Matsumoto M ４番目)
  • Journal Title: Mol Immunol. Volume: 54 Issue: 2 Pages: 238-246
  • DOI: 10.1016/j.molimm.2012.12.006
  • Peer Reviewed
• [Journal Article] Drug-induced Thrombotic Thrombocytopenic Purpura Successfully Treated with Recombinant Human Soluble Thrombomodulin (2013)
  • Author(s): Nishijima Y, Hirata H, Himeno A, Kida H, Matsumoto M, Takahashi R, Otani Y, Inoue K, Nagatomo I, Takeda Y, Kijima T, Tachibana I, Fujimura Y, Kumanogoh A.
  • Journal Title: Internal Medicine Volume: 52 Issue: 10 Pages: 1111-1114
  • DOI: 10.2169/internalmedicine.52.9180
  • NAID: 130003365599
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Ratio of von Willebrand Factor Propeptide to ADAMTS13 Is Associated With Severity of Sepsis. (2013)
  • Author(s): Fukushima H, Nishio K, Asai H, Watanabe T, Seki T, Matsui H, Sugimoto M, Matsumoto M, Fujimura Y, Okuchi K.
  • Journal Title: Shock. Volume: 39 Issue: 5 Pages: 409-414
  • DOI: 10.1097/shk.0b013e3182908ea7
  • Peer Reviewed
• [Journal Article] Acquired idiopathic ADAMTS13 activity deficient thrombotic thrombo- cytopenic purpura in a population from Japan (2012)
  • Author(s): Matsumoto M, Bennett CL, Isonishi A, Qureshi Z, Hori Y, Hayakawa M, Yoshida Y, Yagi H, Fujimura Y
  • Journal Title: PLoS One Volume: 7
• [Journal Article] The homozygous p.C1024R- ADAMTS13 gene mutation links to a late-onset phenotype of Upshaw-Schulman syndrome in Japan (2012)
  • Author(s): Taguchi F, Yagi H, Matsumoto M, Sadamura S, Isonishi A, Soejima K, Fujimura Y
  • Journal Title: Thromb Haemost Volume: 107 Pages: 1003-1005
• [Journal Article] ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis in comparison with the Child-Turcotte-Pugh score and the Model for End-Stage Liver Disease score (2012)
  • Author(s): Takaya H, Uemura M, Fujimura Y, Matsumoto M, Matsuyama T, Kato S, Morioka C, Ishizashi H, Hori Y, Fujimoto M, Tsujimoto T, Kawaratani H, Toyohara M, Kurumatani N, Fukui H
  • Journal Title: Hepatol Res Volume: 42 Pages: 459-72
  • NAID: 10031144260
• [Journal Article] Identification and Recombinant Analysis of Botrocetin-2, a Snake Venom Cofactor for von Willebrand Factor-Induced Platelet Agglutination (2012)
  • Author(s): Yamamoto-Suzuki Y, Sakurai Y, Fujimura Y, Matsumoto M, Hamako J, Kokubo T, Kitagawa H, Kawsar SM, Fujii Y, Ozeki Y, Matsushita F, Matsui T
  • Journal Title: Biochemistry Volume: 51 Pages: 5329-5338
• [Journal Article] Cilostazol down-regulates the height of mural platelet thrombi formed under a high-shear rate flow in the absence of ADAMTS13 activity (2012)
  • Author(s): Yagi H, Yamaguchi N, Shida Y, Hayakawa M, Matsumoto M, Sugimoto M, Wada H, Tsubaki K, Fujimura Y
  • Journal Title: Eur J Pharm Volume: 691 Pages: 151-155
• [Journal Article] Reduced larger VWF multimers at dawn in OSA plasmas reflect severity of apneic episodes (2012)
  • Author(s): Koyama N, Matsumoto M, Tamaki S, Yoshikawa M, Fujimura Y, Kimura H
  • Journal Title: Eur Resp J Volume: 40 Pages: 657-664
• [Journal Article] Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus (2012)
  • Author(s): Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y
  • Journal Title: Atherosclerosis Volume: 224 Pages: 511-514
• [Journal Article] Two newborn-onset patients of Upshaw-Schulman syndrome with distinct subsequent clinical courses (2012)
  • Author(s): Tanabe S, Yagi H, Kimura T, Isonishi A, Kato S, Yoshida Y, Hayakawa M, Matsumoto M, Ohtaki S, Takahashi Y, Fujimura Y
  • Journal Title: Int J Hematol Volume: 96 Pages: 789-797
  • NAID: 10031144620
• [Journal Article] Paradigm shift of childhood TTP with severe ADAMTS13 deficiency (2012)
  • Author(s): Yagi H, Matsumoto M, Fujimura Y
  • Journal Title: Presse Med Volume: 41 Pages: 137-155
• [Journal Article] 血液透析患者におけるヘパリン起因性血小板減少症(HIT) (2012)
  • Author(s): 小西康司、岩下裕一、萱島道徳、米田龍生、吉田克法、石西綾美、松本雅則、藤村吉博
  • Journal Title: 日本アフェレシス学会雑誌 Volume: 31 Pages: 53-57
• [Journal Article] 重症感染症における ADAMTS13 活性の低下 (2012)
  • Author(s): 加藤隆之、川嶋隆久、石井昇、 松本雅則、藤村吉博、安藤維洋、吉田剛
  • Journal Title: 日本救急医学会雑誌 Volume: 23 Pages: 285-294
  • NAID: 130004840934
• [Journal Article] 難治性血栓性血小板減少性紫斑病に対して血漿交換とリツキシマブの併用療法で救命し得た症例 (2012)
  • Author(s): 萱島道徳、岩下祐一、小西康司、浅井英樹、西尾健治、奥地一夫。石西綾美、松本雅則、藤村吉博
  • Journal Title: 日本急性血液浄化学会雑誌 Volume: 3 Pages: 78-81
• [Journal Article] ADAMTS13 と TTP (2012)
  • Author(s): 松本雅則
  • Journal Title: Thromb Med Volume: 2 Pages: 63-66
• [Journal Article] 血栓性血小板減少性紫斑病/溶血性尿毒症症候群 (2012)
  • Author(s): 松本雅則
  • Journal Title: 内科 Volume: 109 Pages: 1115-1117
• [Journal Article] 血栓性血小板減少性紫斑病(TTP)の最近の話題 (2012)
  • Author(s): 松本雅則
  • Journal Title: Pharma Medica Volume: 30 Pages: 43-47
• [Journal Article] von Willebrand因子と ADAMTS13 (2012)
  • Author(s): 宮田敏行、松本雅則
  • Journal Title: 内科 Volume: 110 Pages: 87-90
• [Journal Article] 血栓性血小板減少性紫斑病と抗 ADAMTS13 抗体 (2012)
  • Author(s): 松本雅則
  • Journal Title: 医学のあゆみ Volume: 242 Pages: 590-595
• [Journal Article] 血栓性血小板減少性紫斑病(TTP) (2012)
  • Author(s): 石西綾美、早川正樹、松本雅則、八木秀男、藤村吉博
  • Journal Title: 日本アフェレシス学会雑誌 Volume: 31 Pages: 7-13
• [Journal Article] A typical HUS (2012)
  • Author(s): 吉田瑶子、松本雅則、早川正樹、藤村吉博
  • Journal Title: 日本アフェレシス学会雑誌 Volume: 31 Pages: 27-32
• [Journal Article] Pediatric idiopathic TTP diagnosed with decreased ADAMTS13 activity. (2012)
  • Author(s): Morishima T, Nomura A, Saida S, Watanabe K, Yagi H, Matsumoto M, Fujimura Y, Heike T, Nakahata T, Adachi S.
  • Journal Title: Pediatr Int. Volume: 54 Issue: 3 Pages: 422-423
  • DOI: 10.1111/j.1442-200x.2011.03467.x
  • Peer Reviewed
• [Journal Article] Identification and recombinant analysis of botrocetin-2, a snake venom cofactor for von Willebrand factor-induced platelet agglutination (2012)
  • Author(s): Yamamoto-Suzuki Y, Sakurai Y, Fujimura Y, Matsumoto M, Hamako J, Kokubo T, Kitagawa H, Kawsar SMA, Fujii Y, Ozeki Y, Matsushita F, Matsui T
  • Journal Title: Biochemistry Volume: 51 Issue: 26 Pages: 5329-5338
  • DOI: 10.1021/bi300442c
  • Peer Reviewed
• [Journal Article] Identification of epitopes on ADAMTS13 recognized by a panel of monoclonal antibodies with functional or non-functional effects on catalytic activity. (2012)
  • Author(s): Igari A, Nakagawa T, Moriki T, Yamaguchi Y, Matsumoto M, Fujimura Y, Soejima K, Murata M.
  • Journal Title: Thromb Res. Volume: 130 Issue: 3 Pages: e79-e83
  • DOI: 10.1016/j.thromres.2012.06.006
  • Peer Reviewed
• [Journal Article] Cilostazol down-regulates the height of mural platelet thrombi formed under a high-shear rate flow in the absence of ADAMTS13 activity. (2012)
  • Author(s): Yagi H, Yamaguchi N, Shida Y, Hayakawa M, Matsumoto M, Sugimoto M, Wada H, Tsubaki K, Fujimura Y.
  • Journal Title: Eur J Pharmacol. Volume: 691 Issue: 1-3 Pages: 151-155
  • DOI: 10.1016/j.ejphar.2012.07.001
  • Peer Reviewed
• [Journal Article] Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus. (2012)
  • Author(s): Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y.
  • Journal Title: Atherosclerosis. Volume: 224 Issue: 2 Pages: 511-514
  • DOI: 10.1016/j.atherosclerosis.2012.07.027
  • Peer Reviewed
• [Journal Article] Ticlopidine-, clopidogrel-, and prasugrel-associated thrombotic thrombocytopenic purpura: a 20- year review from the Southern Network on Adverse Reactions (SONAR). (2012)
  • Author(s): Jacob S, Dunn BL, Qureshi ZP, et al. （Mastumoto M 20番目）
  • Journal Title: Semin Thromb Hemost. Volume: 38 Issue: 08 Pages: 845-853
  • DOI: 10.1055/s-0032-1328894
• [Journal Article] A novel Wiskott-Aldrich syndrome protein mutation in an infant with thrombotic thrombocytopenic purpura. (2012)
  • Author(s): Kawasaki Y, Toyoda H, Otsuki S, Iwasa T, Iwamoto S, Azuma E, Itoh-Habe N, Wada H, Fujimura Y, Morio T, Imai K, Mitsuiki N, Ohara O, Komada Y.
  • Journal Title: Eur J Haematol. Volume: 90 Issue: 2 Pages: 164-168
  • DOI: 10.1111/ejh.12057
  • Peer Reviewed
• [Journal Article] The ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis-in comparison with the Child-Turcotte-Pugh score and the MELD score (2012)
  • Author(s): Takaya H, Uemura M, Fujimura Y, Matsumoto M, Matsuyama T, Kato S, Morioka C, Ishizashi H, Hori Y, Fujimoto M, Tsujimoto T, Kawaratani H, Kurumatani N, FukuiH
  • Journal Title: Hepatology research Volume: 42 Issue: 5 Pages: 459-459
  • DOI: 10.1111/j.1872-034x.2011.00950.x
  • Peer Reviewed
• [Journal Article] Reduced larger VWF multimers at dawn in OSA plasmas reflect severity of apneic episodes (2012)
  • Author(s): Koyama N, Matsumoto M, Tamaki S, Yoshikawa M, Fujimura Y, Kimura H
  • Journal Title: Eur Resp J Volume: (印刷中) Issue: 3 Pages: 657-664
  • DOI: 10.1183/09031936.00186210
  • Peer Reviewed
• [Journal Article] The homozygous p.C1024R-ADAMTS13 gene mutation links to a late-on set phenotype of Upshaw-Schulman syndrome in Japan (2012)
  • Author(s): Taguchi F, Yagi H, Matsumoto M, Sadamura S, Isonishi A, Soejima K, Fujimura Y
  • Journal Title: Thromb Haemost Volume: (印刷中) Issue: 05 Pages: 1003-1005
  • DOI: 10.1160/th11-11-0799
  • Peer Reviewed
• [Journal Article] Acquired idiopathic ADAMTS13 activity deficient thrombotic thrombocyt openic purpura in a population from Japan (2012)
  • Author(s): Matsumoto M, Bennett CL, Isonishi A, Qureshi Z, Hori Y, Hayakawa M, Yoshida Y, Yagi H, Fujimura Y
  • Journal Title: PLoS ONE Volume: 7 Issue: 3 Pages: e33029-e33029
  • DOI: 10.1371/journal.pone.0033029
  • Peer Reviewed
• [Journal Article] H1N1 influenza (swine flu)-associated thrombotic microangiopathy with a gigantically high plasma ratio of von Willebrand factor to ADAMTS13 (2011)
  • Author(s): Akiyama R, Komori I, Hiramoto R, Isonishi A, Matsumoto M, Fujimura Y
  • Journal Title: Intern Med Volume: 50 Pages: 643-647
• [Journal Article] Epitope analysis of autoantibodies to ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura (2011)
  • Author(s): Yamaguchi Y, Moriki T, Igari A, Nakagawa T, Wada H, Matsumoto M, Fujimura Y, Murata M
  • Journal Title: Thromb Res Volume: 128 Pages: 169-73
• [Journal Article] Determination of ADAMTS13 and Its Clinical Significance for ADAMTS13 Supplementation Therapy to Improve the Survival of Patients with Decompensated Liver Cirrhosis (2011)
  • Author(s): Uemura M, Fujimura Y, Ko S, Matsumoto M, Nakajima Y, Fukui H
  • Journal Title: Int J Hepatol Volume: 759047
• [Journal Article] Natural history of Upshaw-Schulman syndrome based on ADAMTS13 gene analysis in Japan (2011)
  • Author(s): Fujimura Y, Matsumoto M, Isonishi A, Yagi H, Kokame K, Soejima K, Murata M, Miyata T
  • Journal Title: J Thromb Haemost Volume: 9 Supp l 1 Pages: 283-301
  • NAID: 120006669559
• [Journal Article] ADAMTS13 (2011)
  • Author(s): 松本雅則, 藤村吉博
  • Journal Title: 分子脳血管病 Volume: 10 Pages: 74-77
  • NAID: 10029767493
• [Journal Article] TMAとHUSの違いは何でしょうか (2011)
  • Author(s): 松本雅則
  • Journal Title: 血栓と循環 Volume: 19 Pages: 24-26
• [Journal Article] 症急性膵炎における ADAMTS13 活性の動態とその臨床的意義 (2011)
  • Author(s): 森岡千恵,植村正人、高谷正章、松本雅則、藤村吉博、福井博
  • Journal Title: 消化器内科 Volume: 52 Pages: 200-208
• [Journal Article] TTPの検査と治療-ADAMTS13検査の意義 - (2011)
  • Author(s): 松本雅則
  • Journal Title: 機器と試薬 Volume: 34 Pages: 251-256
• [Journal Article] 血栓性微小血管障害症(TMA)-TTP, HUS,移植後TMAを中心に (2011)
  • Author(s): 松本雅則
  • Journal Title: 医学のあゆみ Volume: 238 Pages: 136-140
• [Journal Article] 溶血性尿毒症症候群、血栓性血小板減少性紫斑病 (2011)
  • Author(s): 藤村吉博、松本雅則、八木秀男
  • Journal Title: 日本内科学会雑誌 Volume: 5 Pages: 1296-1307
  • NAID: 10029097169
• [Journal Article] 血栓性微小血管障害症(TMA)と妊娠 -その診断と治療- (2011)
  • Author(s): 藤村吉博、八木秀男、石西綾美、山口直子、早川正樹、松本雅則、佐道俊幸
  • Journal Title: 日本産婦人科・新生児血液学雑誌 Volume: 20 Pages: 83-92
  • NAID: 10029377850
• [Journal Article] 血栓性微小血管障害性(TMA)の診断と治療戦略 (2011)
  • Author(s): 藤村吉博、吉田瑶子、石西綾美、堀勇二、早川正樹、八木秀男、松本雅則
  • Journal Title: 血液フロンティア Volume: 21 Pages: 43-59
• [Journal Article] Registry of 919 patients with thrombotic microangiopathies across Japan: Database of Nara Medical University during 1998-2008 (2010)
  • Author(s): Fujimura Y, Matsumoto M.
  • Journal Title: Inter Med Volume: 49 Pages: 7-15
  • NAID: 130000142252
• [Journal Article] Influenza A infection triggers thrombotic thrombocytopenic purpura by producing the anti-ADAMTS13 IgG inhibitor (2010)
  • Author(s): Kosugi N, Tsurutani Y, Isonishi A, Hori Y, Matsumoto M, Fujimura Y.
  • Journal Title: Inter Med Volume: 49 Pages: 689-693
  • NAID: 130000251788
• [Journal Article] A second national questionnaire survey of TMA (2010)
  • Author(s): Ito-Habe N, Wada H, Matsumoto M, Fujimura Y, Murata M, Izuno T, Sugita M, Ikeda Y
  • Journal Title: Int J Hematol Volume: 92 Pages: 68-75
  • NAID: 10026512028
• [Journal Article] Proteolytic fragmentation and sugar chains of plasma ADAMTS13 purified by a conformation-dependent monoclonal antibody (2010)
  • Author(s): Hiura H, Matsui T, Matsumoto M, Hori Y, Isonishi A, Kato S, Iwamoto T, Mori T, Fujimura Y
  • Journal Title: J Biochem Volume: 148 Pages: 403-411
  • NAID: 10027878689
• [Journal Article] Pivotal role of ADAMTS13 function in liver diseases (2010)
  • Author(s): Uemura M, Fujimura Y, Ko S, Matsumoto M, Nakajima Y, Fukui H
  • Journal Title: Int J Hematol Volume: 91 Pages: 20-29
  • NAID: 10026110380
• [Journal Article] 胎児治療を行った重症 RhE 不適合妊娠による新生児溶血性疾患の 1例 (2010)
  • Author(s): 武山雅博,藤田百合,内田賀子,柴田真里,釜本智之,新居育世,井崎和史,西久保敏也,佐道俊幸,赤坂珠理晃,小林浩,西田幸世,松本雅則,藤村吉博,高橋幸博
  • Journal Title: 日本産婦人科・新生児血液学会誌 Volume: 19 Pages: 51-55
  • NAID: 10026710419
• [Journal Article] 奈良県立医科大学透析部におけるヘパリン起因性血小板減少症(HIT)症例の検討 (2010)
  • Author(s): 小西康司,吉田克法,多山幸,切畑屋智史,岩下裕一,横田基次,萱島道徳,米田龍生,石西綾美, 松本雅則, 藤村吉博
  • Journal Title: 奈透析会誌 Volume: 15 Pages: 59-63
• [Journal Article] ADAMTS13活性測定用 ELISA キットの開発 (2010)
  • Author(s): 伊藤晋,山本茂一,林司,加藤誠司,日裏久英, 松本雅則, 藤村吉博
  • Journal Title: 日輸細治会誌 Volume: 56 Pages: 27-35
  • NAID: 10027584258
• [Journal Article] 新鮮凍結血漿の適応基準 (2010)
  • Author(s): 松本雅則
  • Journal Title: 医学のあゆみ Volume: 235 Pages: 83-88
• [Journal Article] 血栓性微小血管障害症(TMA) (2010)
  • Author(s): 松本雅則
  • Journal Title: 最新医学 Volume: 65 Pages: 1175-1181
  • NAID: 40021627342
• [Journal Article] 難治性血栓性血小板減少性紫斑病の治療 (2010)
  • Author(s): 松本雅則
  • Journal Title: 日集中医誌 Volume: 17 Pages: 457-459
  • NAID: 10027854041
• [Journal Article] Registry of 919 patients with thrombotic microangiopathies across Japan : Database of Nara Medical University during 1998-2008. (2010)
  • Author(s): Fujimura Y, Matsumoto M.
  • Journal Title: Inter Med Volume: 49 Pages: 7-15
  • NAID: 130000142252
  • Peer Reviewed
• [Journal Article] Influenza A infection triggers thrombotic thrombocytopenic purpura by producing the anti-ADAMTS13 IgG inhibitor. (2010)
  • Author(s): Kosugi N, Tsurutani Y, Isonishi A, Hori Y, Matsumoto M, Fujimura Y.
  • Journal Title: Inter Med Volume: 49 Pages: 689-693
  • NAID: 130000251788
  • Peer Reviewed
• [Journal Article] A 9-month-old infant with acquired idiopathic thrombotic thrombo- cyto penic purpura caused by inhibitory IgG-autoantibody to ADAMTS13. (2010)
  • Author(s): Sato A, Hoshi Y, Onuma M, Sato R Tsunematsu Y, Isonishi A, Mats umoto M, Fujimura Y, Imaizumi M.
  • Journal Title: Pediatr Hematol Oncol. Volume: 27 Pages: 53-58
  • Peer Reviewed
• [Journal Article] ADAMTS13 activity decreases after hepatectomy, reflecting a postoperative liver function. (2010)
  • Author(s): Okano E, Ko S, Matsumoto M, Fujimura Y, Nakajima Y.
  • Journal Title: Hepato-Gastroenterology Volume: 57 Pages: 316-320
  • Peer Reviewed
• [Journal Article] A 42-day-old boy with acute idiopathic thrombocytopenic purpura. (2010)
  • Author(s): Kato K, Matsumoto M, 他11名
  • Journal Title: Pediatr Int Volume: 52 Pages: 485-487
  • Peer Reviewed
• [Journal Article] A second national questionnaire survey of TMA. (2010)
  • Author(s): Ito-Habe N, Wada H, Matsumoto M, 他5名
  • Journal Title: Int J Hematol Volume: 92 Pages: 68-75
  • NAID: 10026512028
  • Peer Reviewed
• [Journal Article] Potential Role of Enhanced Cytokinemia and Plasma Inhibitor on the Decreased Activity of Plasma ADAMTS13 in Patients With Alcoholic Hepatitis : Relationship to Endotoxemia. (2010)
  • Author(s): Ishikawa M, Matsumoto M, 他12名
  • Journal Title: Alcohol Clin Exp Res Volume: 34
  • Peer Reviewed
• [Journal Article] Proteolytic fragmentation and sugar chains of plasma ADAMTS13 purified by a conformation-dependent monoclonal antibody. (2010)
  • Author(s): Hiura H, Matsui T, Matsumoto M, 他6名
  • Journal Title: J Biochem Volume: 148 Pages: 403-411
  • NAID: 10027878689
  • Peer Reviewed
• [Journal Article] H1N1 influenza (swine flu)- associated thrombotic micro- angiopathy with a gigantically high plasma ratio of von Willebrand factor to ADAMTS 13. (2010)
  • Author(s): Akiyama R, Komori I, Hiramoto R, Isonishi A, Matsumoto M, Fujimura Y.
  • Journal Title: Intern Med Volume: 50 Pages: 643-647
  • Peer Reviewed
• [Presentation] A large-pore gel electrophoresis separates the complex in both of ADAMTS13 bound to VWF and to the IgG autoantibodies from the unbound in plasma milieu (2011)
  • Author(s): M.Matsumoto, A.Isonishi, Y.Hori, M.Hayakawa, K. Soejima, Y. Fujimura
  • Organizer: The 54th American Society of Hematology annual meeting and exposition
  • Place of Presentation: San Diego
  • Year and Date: 2011-12-08
• [Presentation] A large-pore gel electrophorosis separates the complex in both of ADAM TS13 bound to VWF and to the IgG autoantibodies from unbound in plasma milieu (2011)
  • Author(s): 松本雅則
  • Organizer: The 54^<th> American Society of Hematology annual meeting and exposition
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2011-12-08
• [Presentation] 造血幹細胞移植後致死的合併症に対する新鮮凍結血漿の新たな適応 (2011)
  • Author(s): 松本雅則
  • Organizer: 第55回日本輸血・細胞治療学会近畿支部総会
  • Place of Presentation: 兵庫医大(兵庫県)
  • Year and Date: 2011-11-26
• [Presentation] Acquired idiopathic thrombotic thrombocytopenic purpura in a population from Japan (2011)
  • Author(s): M.Matsumoto, C.Bennett, A. Isonishi, Z. Qureshi, Y.Hori, M. Hayakawa, Y.Yoshida, H.Yagi, Y. Fujimura
  • Organizer: The 73rd Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: Nagoya
  • Year and Date: 2011-10-16
• [Presentation] Acquired idiopathic thrombotic thrombocytopenic purpura in a population from Japan (2011)
  • Author(s): 松本雅則
  • Organizer: 第73回日本血液学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-16
• [Presentation] Size of vWF multimers, modulated by therapeutic regimens in hematopoietic stem cell transprantation, determine an adverse reaction to bleeding or thrombotic microangiopathy (2011)
  • Author(s): M.Matsumoto, K.Yamada, K. Nakayama, A.Isonishi, M. Hayakawa, M.Inoue, K.Kawa, Y. Fujimura
  • Organizer: XXIII Congress of the International Society on Thrombosis and Haemostasis
  • Place of Presentation: Kyoto
  • Year and Date: 2011-07-27
• [Presentation] Size of VWF multimers, modulated by therapeutic stem cell transplantation, determine an adverse reaction to bleeding or thrombotic microangiopathy (2011)
  • Author(s): 松本雅則
  • Organizer: XIII congress of ISTH
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2011-07-27
• [Presentation] Pathogenesis of thrombotic microangiopthy: analy- sis of 919 patients with TMA in Japan (2010)
  • Author(s): M Matsumoto
  • Organizer: The 6th Congress of Asia Pacific Society on Thrombosis and Haemostasis
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2010-10-16
• [Presentation] Pathogenesis of thrombotic microangiopthy : analy- sis of 919 patients with TMA in Japan. (2010)
  • Author(s): M Matsumoto.
  • Organizer: The 6^<th> Congress of Asia Pacific Society on Throm bosis and Haemostasis.
  • Place of Presentation: インドネシア
  • Year and Date: 2010-10-16
• [Presentation] 血栓性血小板減少性紫斑病(TTP)の診断と治療(血漿交換の適応と効果) (2010)
  • Author(s): 松本雅則
  • Organizer: 第58回日本輸血・細胞治療学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-05-28
• [Presentation] 後天性・特発性TTPでADAMTS13活性著減を示す195例と古典的pentadで診断された89例の比較検討 (2010)
  • Author(s): 松本雅則、石西綾美、加藤誠司、堀勇二、八木秀男、藤村吉博
  • Organizer: 第33回日本血栓止血学会学術集会
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-04-22
• [Presentation] 均一な集団と考えられるADAMTS13 活性著減（＜0.5%）後天性特発性TTP 150 例の解析.
  • Author(s): 松本雅則，Bennett Charles，石西綾美，Qureshi Zenia，堀勇二，早川正樹，吉田瑶子，八木秀男， 藤村吉博.
  • Organizer: 第34回日本血栓止血学会学術集会.
  • Place of Presentation: 東京
• [Presentation] TTPの診断と治療におけるADAMTS13
  • Author(s): 松本雅則
  • Organizer: 第13回日本検査血液学会学術総会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 抗ADAMTS13抗体と血栓性血小板減少性紫斑病
  • Author(s): 松本雅則
  • Organizer: 第40回日本臨床免疫学会総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 血小板減少症におけるHIT抗体検査の重要性-奈良医大での経験
  • Author(s): 松本雅則、藤村吉博
  • Organizer: 2010年度第31回日本アフェレシス学会学術大会
  • Place of Presentation: 千葉
• [Book] 「後天性 TTP に対するリツキシマブ療法」 Annual Review 血液 (2013)
  • Author(s): 松本雅則,藤村吉博
  • Publisher: 中外医学社
• [Book] Annual Review 2013 血液 (2013)
  • Author(s): 松本雅則、藤村吉博
  • Total Pages: 8
  • Publisher: 中外医学社
• [Book] 今日の治療指針 2012血栓性血小板減少性紫斑病 (2012)
  • Author(s): 松本雅則
• [Book] わかりやすい血栓と止血の臨床、造血幹細胞移植後血栓性微小血管障害症の診断と治療 (2011)
  • Author(s): 松本雅則
  • Publisher: 南江堂
• [Book] 非定型尿毒症症候群 (2011)
  • Author(s): 松本雅則
  • Publisher: Annual review 2011 血液
• [Remarks] ホームページ
  • URL: http://www.naramed-u.ac.jp/~trans/
• [Remarks]
  • URL: http://www.naramed-u.ac.jp/~trans/