Investigation of integrin inside-out signaling using RIAM deficientplatelets.

• Project/Area Number: 22591070
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: Keio University
• Principal Investigator: WATANABE Naohide 慶應義塾大学, 医学部, 助教 (90338054)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 血栓止血 / 血小板 / インテグリン / RIAM / 細胞内刺激伝達機構 / 刺激伝達系 / 止血機能

Research Abstract

To investigate the molecular mechanism of platelet function, wegenerated platelet specific RIAM-deficient mice. However, the fibrinogen binding was notcompletely inhibited by RIAM deletion, the RIAM-deficient platelets showed impairedfibrinogen binding in

Research Products

• [Journal Article] RIAM-Rapとインテグリンをつなぐ架け橋- (2010)
  • Author(s): 渡邊直英
  • Journal Title: 臨床血液 Volume: 第51巻 Pages: 377-383
  • Peer Reviewed