Contribution of integrin in the pathogenesis ofrheumatoid arthritis
| Project/Area Number |
22591076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kobe University |
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Principal Investigator |
KAWANO Seiji 神戸大学, 医学部附属病院, 特命准教授 (20351512)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMACHI Yuji 神戸大学, 医学部附属病院, 臨床検査技師 (80379429)
KASAGI Shimpei 神戸大学, 医学部附属病院, 特命助教 (80457051)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | マイクロ RNA / 関節リウマチ / インテグリン / マイクロRNA |
|---|
| Research Abstract |
We investigated the roles of miRNA with regard to the regulation of beta1 integrin in the pathogenesis of rheumatoid arthiritis. We found that (1) Overexpression of miR-124 caused lower expression of beta1 integrin in RA synoviocyte cell line, (2) Injection of miR-124 ameliorated the arthritis and reduced beta-1 integrin expression in histological section of joints in rat adjuvant-induced arthritis model.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Mycophenolate mofetil versus intravenous cyclophosphamide for induction treatment of proliferative lupus nephritis in a Japanese population: a retrospective study2012
Author(s)
Onishi A, Sugiyama D, Tsuji G, Nakazawa T, Kogata Y, Tsuda K, Naka I, Nishimura K, Misaki K, Kurimoto C, Hayashi H, Kageyama G, Saegusa J, Sugimoto T, Kawano S, Kumagai S, and Morinobu A
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Journal Title
NAID
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[Journal Article] SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production2012
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Jauharoh SA, Saegusa J, Sugimoto T, Ardianto B, Kasagi S, Sugiyama D, Kurimoto C, Tokuno O, Nakamachi Y, Kumagai S, and Kawano S.
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Journal Title
Biochem Biophys Res Comm
Volume: 417(1)
Pages: 582-7
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[Journal Article] Diagnostic Accuracy of Serum 1,3-β-D-Glucan Aspergillosis: Systematic Review and Meta-Analysis. for Pneumocystis Jiroveci Pneumonia, Invasive Candidiasis and Invasive aspergillosis: systematic review and meta-analysis2011
Author(s)
Onishi A, Sugiyama D, Kogata Y, Saegusa J, Sugimoto T, Kawano S,Morinobu A, Nishimura K, and Kumagai S
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Journal Title
J Clin Microbiol
Volume: 50(1)
Pages: 7-15
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[Journal Article] Assembly defect due Q:1 to a PSMB8 mutation ; 2 reduces proteasome activity and causes the autoinflammatory disorder, Nakajo-Nishimura syndrome2011
Author(s)
Arima K, Kinoshita A, Mishima H,Kanazawa N, Kaneko T, Mizushima T, Ichinose K, Nakamura H, Tsujino A,Kawakami A, Matsunaka M, Kasagi S, Kawano S, Kumagai S, Ohmura K, MimoriT, Hirano M, Ueno S, Tanaka K, Tanaka M, Toyoshima I, Sugino H, Yamakawa A,Tanaka K, Niikawa N, Furukawa F, Murata S, Eguchi K, Ida H, and Yoshiura K.
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Journal Title
PNAS U S A
Volume: 108(36)
Pages: 14914-9
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Peer Reviewed
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[Journal Article] Role of imaging studies in the diagnosis and evaluation of giant cell arteritis in Japanese: report of eight cases2011
Author(s)
Morinobu A, Tsuji G, Kasagi S, Saegusa J, Hayashi H, Nakazawa T, Kogata Y, Misaki K, Nishimura K, Sendo S, Miura N, Kawano S,and Kumagai S.
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Journal Title
Mod Rheumatol
Volume: 21(4)
Pages: 391-6
NAID
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Peer Reviewed
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