Establishment of targeting therapy for autoreactive B cells in systemic lupus erythematosus
| Project/Area Number |
22591077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | SLE / B cells / RP105 / BCMA / BAFF / APRIL / CD40L / B細胞 / 形質細胞 |
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| Research Abstract |
Systemic lupus erythematosus (SLE) is on of the systemic autoimmune diseases that is characterized by production of various autoantibodies including anti-double strand (ds)-DNA antibodies from B cells. In the pathogenesis of SLE, autoantibody-producing B cells may play a pivotal role in developing autoimmunity. Therefore, understanding of human autoantibody-producing B cell is an essential issue. We investigated phenotype of RP105-negative B cell subsets that produce anti-dsDNA antibodies and are increased in patients with SLE. Phenotyping RP105-negaive B cell subsets was performed using a flow cytometer. RP105-negative B cells consist of at least 5 subsets of late B cells, including CD19(+)RP105(int), CD19(+)RP105(-), CD19(low)RP105(-)CD138(-), CD19(low)RP105(-)CD138(int), and CD19(low)RP105(-)CD138(++) B cells. CD19(+)RP105(int) and CD19(low)RP105(-)CD138(int) B cells are larger population than other RP105(-) B cell subsets in SLE. The phenotypic analysis of RP105(-) B cell subsets suggests dysregulation of later B cell subsets in SLE and may provide new insights into understanding regulation of late B cells in human.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Therapeutic response of patients with adult Still's disease to biologic agents: multicenter results in Japan2012
Author(s)
Suematsu R, Ohta A, Matsuura E, Takahashi H, Fujii T, Horiuchi T, Minota S, Ishigatsubo Y, Ota T, Takei S, Soejima S, Inoue H, Koarada S, Tada Y, Nagasawa K
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Journal Title
Mod Rheumatol
Volume: 22
Pages: 712-9
NAID
Related Report
Peer Reviewed
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[Journal Article] Therapeutic response of patients with adult Still's disease to biologic agents : multicenter results in Japan2012
Author(s)
Suematsu R, Ohta A, Matsuura E, Takahashi H, Fujii T, Horiuchi T, Minota S, Ishigatsubo Y, Ota T, Takei S, Soejima S, Inoue H, Koarada S, Tada Y, Nagasawa K
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Journal Title
Mod Rheumatol
Volume: 22(In press)
Issue: 5
Pages: 712-9
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Autoantibody-producing RP105(-) B cells, from patients with systemic lupus erythematosus, showed more preferential expression of BCMA compared with BAFF-R than normal subjects2010
Author(s)
Koarada S, Tada Y, Sohma Y, Haruta Y, Suematsu R, Mitamura M, Inoue H, Ehara H, Tokoro Y, Ohta A, Nagasawa K
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Journal Title
Rheumatology (Oxford)
Volume: 49
Pages: 662-70
Related Report
Peer Reviewed
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[Journal Article] Autoantibody-producing RP105-negative B cells.from patients with systemic lupus erythematosus, showed more preferential expression of BCMA compared with BAFF-R than normal subjects2010
Author(s)
Koarada S, Tada Y, Sohma Y, Haruta Y, Suematsu R, Mitamura M, Inoue H, Ehara H, Tokoro Y, Ohta A, Nagasawa K
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Journal Title
Rheumatology
Volume: 49
Pages: 662-670
Related Report
Peer Reviewed
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