Involvement of HTLV-I for Sjogren's syndrome

• Project/Area Number: 22591078
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Nagasaki University
• Principal Investigator: NAKAMURA Hideki 長崎大学, 大学病院, 講師 (10437832)
• Co-Investigator(Kenkyū-buntansha): KAWAKAMI Atsushi 長崎大学, 医歯薬学総合研究科, 教授 (90325639) ; 中村 龍文 長崎大学, 医歯(薬)学総合研究科, 准教授 (00198219)
• Research Collaborator: NAKAMURA Tatsufumi 長崎大学, 医歯薬学総合研究科, 准教授 (00198219)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 膠原病学 / HTLV-I / シェーグレン症候群 / ケモカイン

Research Abstract

In labial salivary glands from HTLV-I-seronegative SS with germinal center, follicular dendritic cells with CXCL13 were observed. Co-culture of SGEC with HCT-5 showed variation of some molecules.

Research Products

• [Journal Article] TLR3-mediated apoptosis and activation of phosphorylated Akt in the salivary gland epithelial cells of primary Sjogren's syndromepatients (2013)
  • Author(s): Nakamura H, Horai Y, Suzuki T, Okada A, Ichinose K, Yamasaki S, Koji T, Kawakami A
  • Journal Title: Rheumatol Int. Volume: 33(2) Pages: 441-50
• [Journal Article] HTLV-I virological and histopathological analysis in two cases of anti-centromere-antibody-seropositive Sjogren's syndrome (2013)
  • Author(s): Nakamura H, Horai Y, Tokuyama A, Yoshimura S, Nakajima H, Ichinose K, Yamasaki S, Nakamura T, Hayashi T, Kawakami A
  • Journal Title: Mod Rheumatol Volume: 23(1) Pages: 133-9
  • NAID: 10031167676
• [Journal Article] TLR3-mediated apoptosis and activation of phosphorylated Akt in the salivary gland epithelial cells of primary Sjögren’s syndrome patients. (2013)
  • Author(s): Hideki Nakamura
  • Journal Title: Rheumatology International Volume: 33 Issue: 2 Pages: 441-450
  • DOI: 10.1007/s00296-012-2381-9
  • NAID: 120006985741
  • Peer Reviewed
• [Journal Article] HTLV-I virological and histopathological analysis in two cases of anti-centromere-antibody-seropositive Sjögren's syndrome. (2013)
  • Author(s): Hideki Nakamura
  • Journal Title: Modern Rheumatology Volume: 23 Issue: 1 Pages: 133-139
  • DOI: 10.1007/s10165-012-0641-x
  • Peer Reviewed
• [Journal Article] TLR3-mediated apoptosis and activation of phosphorylated Akt in the salivary gland epithelial cells of primary Sjogren's syndrome patients (2012)
  • Author(s): Hideki Nakamura, et al
  • Journal Title: Rheumatology International Volume: (in press)
  • Peer Reviewed
• [Presentation] シェーグレン症候群唾液腺におけるToll-like receptor 3による細胞死調節機序について (2011)
  • Author(s): 中村英樹他
  • Organizer: 第55回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-07-20
• [Presentation] 抗HTLV-I抗体およびセントロメア抗体陽性シェーグレン症候群２症例の検討：HAMとHTLV-Iキャリアの比較から
  • Author(s): 中村英樹
  • Organizer: 第21回日本シェーグレン症候群学会学術集会
  • Place of Presentation: 京都