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The role of Notch on rheumatoid arthritis

Research Project

Project/Area Number 22591085
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionJuntendo University

Principal Investigator

SEKINE Chiyoko  順天堂大学, 医学部, 助教 (40392005)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsNotch / 関節リウマチ / 炎症 / 破骨細胞分化 / 血管新生 / リンパ管 / 破骨細胞
Research Abstract

We revealed that Notch2/Delta-like 1 (Dll1) axis promotedosteoclastogenesis but Notch1/Jagged1 axis suppressed it. Actually, blockade of Dll1 suppressed osteoclastogenesis and bone loss in the affected joints of a mouse arthritis model as well as a mouse osteoporosis model while no effect was observed on normal mouse.Therefore, blockade of Dll1 could be a novel target for the treatment of RA.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2012 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes2012

    • Author(s)
      Sekine C, Koyanagi A, Koyama N, Hozumi K, Chiba S, Yagita H
    • Journal Title

      Arthritis Research and Ttherapy

      Volume: Vol.14 Issue: 2

    • DOI

      10.1186/ar3758

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Notch receptors and ligands on immature and mature T cells2012

    • Author(s)
      Koyanagi A, Sekine C, Yagita H
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: Vol.418 Issue: 4 Pages: 799-805

    • DOI

      10.1016/j.bbrc.2012.01.106

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Blockade of Delta-like1 suppresses osteoclastogenesis and arthritis2011

    • Author(s)
      関根知世子
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Blockade of Delta-like1 suppresses osteoclastogenesis and arthritis2011

    • Author(s)
      関根知世子
    • Organizer
      アメリカリウマチ学会(ACR)
    • Place of Presentation
      マコーミックプレイスコンベンションセンター(シカゴ)
    • Year and Date
      2011-11-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Blockade of Delta-like 1 suppresses osteoclastogenesis and arthritis2010

    • Author(s)
      関根知世子
    • Organizer
      7^<th> International Conference on Autoimmunity
    • Place of Presentation
      GR Ljubljana Exhibition and Convention Centre(スロベニア)
    • Year and Date
      2010-05-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Notch signaling is not essential for the development of marginal zone B cells in autoimmune mice

    • Author(s)
      関根 知世子
    • Organizer
      8th International Congress on Autoimmunity
    • Place of Presentation
      グラナダ展示会議場 (スペイン)
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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