The role of Notch on rheumatoid arthritis
Project/Area Number |
22591085
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
膠原病・アレルギー・感染症内科学
|
Research Institution | Juntendo University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | Notch / 関節リウマチ / 炎症 / 破骨細胞分化 / 血管新生 / リンパ管 / 破骨細胞 |
Research Abstract |
We revealed that Notch2/Delta-like 1 (Dll1) axis promotedosteoclastogenesis but Notch1/Jagged1 axis suppressed it. Actually, blockade of Dll1 suppressed osteoclastogenesis and bone loss in the affected joints of a mouse arthritis model as well as a mouse osteoporosis model while no effect was observed on normal mouse.Therefore, blockade of Dll1 could be a novel target for the treatment of RA.
|
Report
(4 results)
Research Products
(6 results)