Study of novel factor, SPACIA1 which is expressed in synovial tissue in rheumatoid arthritis.
| Project/Area Number |
22591088
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
FUJII Ryoji 聖マリアンナ医科大学, 医学(系)研究科(研究院), 講師 (10333535)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Tomoo 聖マリアンナ医科大学, 医学(系)研究科(研究院), 講師 (30387063)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMANO Yoshihisa 聖マリアンナ医科大学, 医学(系)研究科(研究院), 准教授 (80445882)
SATO Tomoo 聖マリアンナ医科大学, 医学(系)研究科(研究院), 講師 (30387063)
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| Research Collaborator |
KOMATSU Rie 聖マリアンナ医科大学, 医学(系)研究科(研究院), 研究技術員 (80517475)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | リウマチ学 / 細胞分子生物学 / 滑膜炎 / 細胞増殖 / 炎症 / SPACIA1 / 関節リウマチ / 滑膜細胞 |
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| Research Abstract |
Recently we identified a novel factor SPACIA1 associated with synovitis. In this study we identified a core promoter of SPACIA1 gene. We have been trying purification and identification of transcriptional factor that bound the core promoter. We also discovered that SPACIA1 related a G1 phase-cell cycle factor (CDK6) gene expression. Using SPACIA1 transgenic mouse, we showed SPACIA1 is a disease-modifying, but not causal, factor.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Analysis of a Core Promoter Context of Synoviocyte Proliferation- Associated in Collagen Induced Arthritis 1 (SPACIA1) Gene Associated with Synovitis.2012
Author(s)
Fujii R, Komatsu R, Sato T, Yagishita N, Aratani S, Araya N, Nishikawa H, Yamano Y, Yudoh K,Beppu M, Nishioka K, Nakajima T
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Journal Title
J St. Marianna Univ.
Volume: 40(2)
Pages: 51-56
Related Report
Peer Reviewed
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