| Project/Area Number |
22591088
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
|
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
FUJII Ryoji 聖マリアンナ医科大学, 医学(系)研究科(研究院), 講師 (10333535)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Tomoo 聖マリアンナ医科大学, 医学(系)研究科(研究院), 講師 (30387063)
|
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| Co-Investigator(Renkei-kenkyūsha) |
YAMANO Yoshihisa 聖マリアンナ医科大学, 医学(系)研究科(研究院), 准教授 (80445882)
SATO Tomoo 聖マリアンナ医科大学, 医学(系)研究科(研究院), 講師 (30387063)
|
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| Research Collaborator |
KOMATSU Rie 聖マリアンナ医科大学, 医学(系)研究科(研究院), 研究技術員 (80517475)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | リウマチ学 / 細胞分子生物学 / 滑膜炎 / 細胞増殖 / 炎症 / SPACIA1 / 関節リウマチ / 滑膜細胞 |
|---|
| Research Abstract |
Recently we identified a novel factor SPACIA1 associated with synovitis. In this study we identified a core promoter of SPACIA1 gene. We have been trying purification and identification of transcriptional factor that bound the core promoter. We also discovered that SPACIA1 related a G1 phase-cell cycle factor (CDK6) gene expression. Using SPACIA1 transgenic mouse, we showed SPACIA1 is a disease-modifying, but not causal, factor.
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