Mechanism and therapy of neutrophilic allergic airway inflammation in severe asthma
| Project/Area Number |
22591092
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Okayama University |
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Principal Investigator |
KANEHIRO ARIHIKO 岡山大学, 医歯(薬)学総合研究科, 准教授 (20243503)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAHARA Nobuaki 岡山大学, 大学病院, 講師 (70335610)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 重症喘息 / アレルギー / 好中球性炎症 / 気道炎症 / 好中球エラスターゼ / 好中球エラスターゼ阻害薬 / ロイコトリエン受容体拮抗薬 / IL-17 / 難治性喘息 / 気管支喘息 / 好中球性気道炎症 / アレルギー性気道炎症 / 気道過敏性 / マウス喘息モデル / 気道過敏症 |
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| Research Abstract |
Severe asthma is often associated with neutrophilic allergic inflammation in the airways. Neutrophils contain elastase, a potent secretagogue in the airways, nonetheless the role for neutrophil elastase as well as neutrophilic inflammation in allergen-induced airway responses is not well defined. We have investigated the impact of neutrophil elastase inhibition on the development of allergic airway inflammation and airway hyperresponsiveness (AHR) in previously sensitized and challenged mice. We indicate that neutrophil elastase plays an important role in the development of the neutrophilic and eosinophilic airway inflammation and hyperresponsiveness.
Furthermore, we demonstrate that treatment with cysteinyl leukotriene receptor antagonist significantly suppressed the AHR, static compliance, and eosinophilic and neutrophilic airway inflammation in OVA sensitization and challenge asthma model with porcine pancreatic elastase (PPE) instillation.
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Report
(5 results)
Research Products
(58 results)
