Role of galectin-9 and myeloid derived suppressor cells in patients with lung injury

• Project/Area Number: 22591095
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Kumamoto University
• Principal Investigator: ICHIYASU Hidenori 熊本大学, 医学部附属病院, 講師 (50419636)
• Co-Investigator(Renkei-kenkyūsha): OKAMOTO Shinichiro 熊本大学, 医学部附属病院, 特任助教 (20419633)
• Research Collaborator: MASUNAGA Aiko 熊本大学, 大学院・生命科学研究部, 大学院生 ; KOJIMA Keisuke 熊本大学, 医学部附属病院, 特任助教 (80467985) ; HORIO Yuko 熊本大学, 大学院・生命科学研究部, 大学院生
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 肺障害 / ガレクチン 9 / 骨髄由来免疫抑制性細胞 / 樹状細胞 / 免疫抑制性樹状細胞 / ガレクチン9 / 肺疾患 / 急性呼吸不全 / 血液浄化療法 / PBSCs / 間質性肺疾患 / TNF-α

Research Abstract

To examine immunomodulating activity of galectin-9, the inducibility of HLA-DRCD33+myeloid derived suppressor cells (MDSCs) and dendritic cells (DC) in peripheral bloodmononuclear cells (PBMC) by galectin-9 were compared between healthy volunteers group(HV group) and patients with lung diseases group (LD group). Culture of PBMC withgalectin-9 exhibited the induction of MDSCs, there was no difference between those groups.In the absence of galectin-9, percentage of cultured plasmacytoid DC (pDC) and myeloidDC (mDC) in patients with sarcoidosis were lower than those in HV group. In the presencewith galectin-9, suppression of pDC induction and enhancement of mDC induction wereobserved in both groups. These findings indicated that galectin-9 induced differentialresponses in subtypes of DC.

Research Products

• [Journal Article] Successful treatment of severeamiodarone pulmonary toxicity withpolymyxin B immobilized fiber columndirect hemoperfusion (PMX-DHP) (2013)
  • Author(s): Sato N, Kojima K, Horio Y, Goto E,Masunaga A, Ichiyasu H, Kohrogi H
  • Journal Title: Chest Volume: 143 Pages: 1146-50
  • Peer Reviewed
• [Journal Article] Favorable outcomewith hemoperfusion of polymyxinB-immobilized fiber column for rapidlyprogressive interstitial pneumoniaassociated with clinically amyopathicdermatomyositis: report of three cases (2013)
  • Author(s): Ichiyasu H, Horio Y, Tsumura S, HirosakoS, Sakamoto Y, Sakata S, Nakashima K,Komatsu T, Kojima K, Masunaga A, FujiiK, Saita N, Kohrogi H
  • Journal Title: Mod Rheumatol
  • Peer Reviewed
• [Journal Article] Lung miliarymicro-nodules in human T-cell leukemia virus type I carriers (2013)
  • Author(s): Fukuoka J, Tominaga M, Ichikado K,Tanaka T, Ichiyasu H, Kohrogi H,Ishizawa S, Suga M
  • Journal Title: Pathol Int Volume: 63 Pages: 108-112
  • Peer Reviewed
• [Journal Article] Favorable outcome with hemoperfusion of polymyxin B-immobilized fiber column for rapidly progressive interstitial pneumonia associated with clinically amyopathic dermatomyositis: report of three cases. (2013)
  • Author(s): Hidenori Ichiyasu
  • Journal Title: Modern Rheumatology Volume: in press
  • Peer Reviewed
• [Journal Article] Successful treatment of severe amiodarone pulmonary toxicity with polymyxin B immobilized fiber column direct hemoperfusion (PMX-DHP) (2013)
  • Author(s): Nahoko Sato, Hidenori Ichiyasu
  • Journal Title: Chest Volume: 143 Issue: 4 Pages: 1146-1150
  • DOI: 10.1378/chest.12-0994
  • Peer Reviewed
• [Journal Article] Fibroproliferative changes onhigh-resolution CT in the acuterespiratory distress syndrome predictmortality and ventilator dependency: aprospective observational cohort study (2012)
  • Author(s): Ichikado K, Muranaka H, Gushima Y,Kotani T, Nader HM, Fujimoto K, JohkohT, Iwamoto N, Kawamura K, Nagano J,Fukuda K, Hirata N, Yoshinaga T,Ichiyasu H, Tsumura S, Kohrogi H,Kawaguchi A, Yoshioka M, Sakuma T, SugaM
  • Journal Title: BMJ Open Volume: 2
  • Peer Reviewed
• [Journal Article] Pneumocyte biomarkers KL-6 andsurfactant protein D reflect thedistinct findings of high-resolutioncomputed tomography in nonspecificinterstitial pneumonia (2012)
  • Author(s): Ichiyasu H, Ichikado K, Yamashita A,Iyonaga K, Sakamoto O, Suga M, KohrogiH
  • Journal Title: Respiration Volume: 83 Pages: 190-197
  • Peer Reviewed
• [Journal Article] FDG-PET and chemotherapy for successfuldiagnosis and treatment of cardiacmetastasis from non-small cell lungcancer (2012)
  • Author(s): Sato R, Ichiyasu H, Saeki S, Sakata S,Sasaki J, Fujii K, Saita N, Kohrogi H
  • Journal Title: Intern Med Volume: 51(14) Pages: 1909-1912
  • Peer Reviewed
• [Journal Article] リンパ脈管筋腫症 7 例の臨床像と血清 VEGF-C, -Dおよび VEGF-R3 値の相関 (2012)
  • Author(s): 岡林比呂子, 増永愛子, 一安秀範, 津村真介, 小嶋圭介, 佐伯祥, 濱本淳二, 藤井一彦, 税田直樹, 興梠博次
  • Journal Title: 日呼吸誌 Volume: 1 Pages: 89-94
  • NAID: 10030269088
  • Peer Reviewed
• [Journal Article] 肺癌に伴う上大静脈症候群に対する血管内ステント留置15 症例の有効性と安全性 (2012)
  • Author(s): 佐藤奈穂子, 向笠洋介, 増永愛子, 佐伯祥,一安秀範,佐々木治一郎,藤井一彦,池田理,山下康行,興梠博次
  • Journal Title: 日呼吸誌 Volume: 1 Pages: 374-380
  • NAID: 10030794223
  • Peer Reviewed
• [Journal Article] 急性肺損傷モデルマウスにおけるガレクチン9誘導マクロファージによる炎症抑制効果 (2012)
  • Author(s): 小嶋圭介
  • Journal Title: International Review of Asthma & COPD Volume: 14 Pages: 167-171
• [Journal Article] Galectin-9と急性肺損傷 (2012)
  • Author(s): 小嶋圭介
  • Journal Title: 分子呼吸器病 Volume: 16 Pages: 12-15
• [Journal Article] Pneumocyte biomarkers KL-6 and surfactant protein D reflect the distinct findings of high-resolution computed tomography in nonspecific interstitial pneumonia (2012)
  • Author(s): Hidenori Ichiyasu
  • Journal Title: Respiration Volume: 83(3) Issue: 3 Pages: 190-197
  • DOI: 10.1159/000326924
  • Peer Reviewed
• [Presentation] サルコイドーシス患者における末梢血マクロファージの機能特異性と Galectin-9 刺激による反応性の検討 (2013)
  • Author(s): 増永愛子, 税田直樹, 小嶋圭介, 堀尾雄甲, 津村真介, 一安秀範, 興梠博次
  • Organizer: 第53回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム(東京)
• [Presentation] Rebamipidereduces risk of hospital-acquiredpneumonia (HAP) in patients receivingproton pump inhibitor (2012)
  • Author(s): Okamoto S, Hirosako S, Ichiyasu H, FujiiK, Saita N, Kohrogi H
  • Organizer: 17th Congress ofthe Asian Pacific Society of Respirology
  • Place of Presentation: Hong Kong
• [Presentation] 人工呼吸管理を行った間質性肺疾患患者に対する PMX-DHP 療法の検討 (2012)
  • Author(s): 坂本安見子, 小嶋圭介, 一安秀範, 増永愛子, 堀尾雄甲, 津村真介, 廣佐古進,興梠博次
  • Organizer: 第34回日本呼吸療法医学会学術集会
  • Place of Presentation: 沖縄コンベンションセンター(宜野湾市)
• [Presentation] Effect Of DirectHemoperfusion Using PolymixinB-Immobilized Fiber Column For PatientsWith Rapidly Progressive InterstitialPneumonias (2012)
  • Author(s): Horio Y, Ichiyasu H, Masunaga A,Sakamoto Y, Sakata S, Tsumura S, KojimaK, Saeki S, Hirosako S, Okamoto S, FujiiK, Saita N, Kohrogi H
  • Organizer: American Thoracic SocietyInternational conference
  • Place of Presentation: San Francisco, California, USA
• [Presentation] High Prevalenceof Sleep Disordered Breathing In ChronicRespiratory Diseases: Usefullness ofNocturnal Oximetry Screening (2012)
  • Author(s): Tsumura S, Fujii K, Horio Y, Hirosako S,Sakamoto Y, Sakata S, Sato R, MasunagaA, Saeki S, Kojima K, Okamoto S, IchiyasuH, Saita N, Kohrogi H
  • Organizer: AmericanThoracic Society Internationalconference
  • Place of Presentation: SanFrancisco, California, USA
• [Presentation] LPS 誘起性肺損傷マウスにおけるGalectin-9 誘導plasmacytoid dendritic cell-likemacrophage による炎症抑制効果 (2012)
  • Author(s): 小嶋圭介, 税田直樹, 増永愛子, 津村真介, 一安秀範, 興梠博次
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸国際会議場(神戸)
• [Presentation] 急性呼吸不全を呈する間質性肺疾患に対する PMX-DHP 療法施行症例の臨床的検討 (2012)
  • Author(s): 一安秀範, 増永愛子, 小嶋圭介, 堀尾雄甲, 坂本安見子, 坂田晋也, 津村真介,廣佐古進, 岡本真一郎, 藤井一彦, 税田直樹, 興梠博次
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸国際会議場(神戸)
• [Presentation] 多発性筋炎・皮膚筋炎に伴う間質性肺炎急性増悪症例の臨床的検討 (2012)
  • Author(s): 堀尾雄甲, 一安秀範, 津村真介, 小嶋圭介,坂本安見子, 廣佐古進, 岡本真一郎, 藤井一彦,税田直樹,興梠博次
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸国際会議場(神戸)
• [Presentation] Effect Of Direct Hemoperfusion Using Polymixin B-Immobilized Fiber Column For Patients With Rapidly Progressive Interstitial Pneumonias. (2012)
  • Author(s): Yuko Horio, Hidenori Ichiyasu
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: San Francisco, California, USA.
• [Presentation] High Prevalence of Sleep Disordered Breathing In Chronic Respiratory Diseases: Usefullness of Nocturnal Oximetry Screening. (2012)
  • Author(s): Shunsuke Tsumura, Hidenori Ichiyasu
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: San Francisco, California, USA.
• [Presentation] 急性呼吸不全を呈する間質性肺疾患に対するPMX-DHP療法施行症例の臨床的検討. (2012)
  • Author(s): 一安秀範
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸国際会議場、神戸市
• [Presentation] LPS誘起性肺損傷マウスにおけるGalectin-9誘導plasmacytoid dendritic cell-like macrophageによる炎症抑制効果 (2012)
  • Author(s): 小嶋圭介
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸国際会議場、神戸市
• [Presentation] 人工呼吸管理を行った間質性肺疾患患者に対するPMX-DHP療法の検討. (2012)
  • Author(s): 坂本安見子
  • Organizer: 第34回日本呼吸療法医学会学術集会
  • Place of Presentation: 沖縄コンベンションセンター、宜野湾市
• [Presentation] 当科における間質性肺疾患に対するPMX-DHP治療23症例の検討 (2011)
  • Author(s): 増永愛子、一安秀範, 他
  • Organizer: 第51回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2011-04-23
• [Remarks]
  • URL: http://www.respir-med-kumamoto-u.com/