| Project/Area Number |
22591095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Shinichiro 熊本大学, 医学部附属病院, 特任助教 (20419633)
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| Research Collaborator |
MASUNAGA Aiko 熊本大学, 大学院・生命科学研究部, 大学院生
KOJIMA Keisuke 熊本大学, 医学部附属病院, 特任助教 (80467985)
HORIO Yuko 熊本大学, 大学院・生命科学研究部, 大学院生
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 肺障害 / ガレクチン 9 / 骨髄由来免疫抑制性細胞 / 樹状細胞 / 免疫抑制性樹状細胞 / ガレクチン9 / 肺疾患 / 急性呼吸不全 / 血液浄化療法 / PBSCs / 間質性肺疾患 / TNF-α |
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| Research Abstract |
To examine immunomodulating activity of galectin-9, the inducibility of HLA-DRCD33+myeloid derived suppressor cells (MDSCs) and dendritic cells (DC) in peripheral bloodmononuclear cells (PBMC) by galectin-9 were compared between healthy volunteers group(HV group) and patients with lung diseases group (LD group). Culture of PBMC withgalectin-9 exhibited the induction of MDSCs, there was no difference between those groups.In the absence of galectin-9, percentage of cultured plasmacytoid DC (pDC) and myeloidDC (mDC) in patients with sarcoidosis were lower than those in HV group. In the presencewith galectin-9, suppression of pDC induction and enhancement of mDC induction wereobserved in both groups. These findings indicated that galectin-9 induced differentialresponses in subtypes of DC.
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