The pathoetiology of destruction and regeneration in salivary gland of Sjogren's syndrome
| Project/Area Number |
22591096
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKASWA Shin 奈良県立医科大学, 医学部, 教授 (50187944)
KASAI Takahiko 奈良県立医科大学, 医学部, 助教 (50224374)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 免疫学 / シェーグレン症候群 / REG |
|---|
| Research Abstract |
Sjogren’s syndrome (SS) is a chronic autoimmune disease, characterized by inflammation of salivary and lacrimal glands, leading to dry mouth and dry eye. The regenerating gene (Reg) was originally isolated as a gene specifically overexpressed in regenerating pancreatic islets. In this study, we examined the expression of REG genes in the salivary glands (SG) and anti-REG autoantibodies in SS. These data strongly suggest that autoimmunity to REG may play a role in the degeneration of SG ductal epithelial cells in SS.
|
Report
(4 results)
Research Products
(57 results)
-
[Journal Article] Involvement of autoimmunity to REG, a regeneration factor, in patients with primary Sjogren's syndrome2013
Author(s)
Yoshimoto K, Fujimoto T, Itaya-HironakaA, Miyaoka T, Sakuramoto-Tsuchida S, Yamauchi A, Takeda M, Kasai T, Nakagawara K, Nonomura A, Takasawa S
-
Journal Title
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Involvement of autoimmunity to REG, a regeneration factor, in patients with primary Sjogren’s syndrome2013
Author(s)
Yoshimoto K, Fujimoto T, Itaya-HironakaA, Miyaoka T, Sakuramoto-Tsuchida S, Yamauchi A, Takeda M, Kasai T, Nakagawara K, Nonomura A, Takasawa S
-
Journal Title
Clin Exp Immunol
Volume: -
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] Deletion of platelet-derived growth factor receptor-β improves diabetic nephropathy in Ca^2+/calmodulin-dependent protein kinase Iiα (Thr286Asp) transgenic mice2011
Author(s)
Suzuki H, Usui I, Kato I, Oya T, Kanatani Y, Yamazaki Y, Fujisaka S, Senda S, Ishii Y, Urakaze M, Mahmood A, Takasawa S, Okamoto H, Kobayashi M, Tobe K, Sasahara M
-
Journal Title
Diabetologia.
Volume: 54
Pages: 2953-62
Related Report
Peer Reviewed
-
[Journal Article] Septic shock is associated with receptor for advanced glycation end products ligation of LPS2011
Author(s)
Yamamoto Y, Harashima A, Saito H, Tsuneyama K, Munesue S, Motoyoshi S, Han D, Watanabe T, Asano M, Takasawa S, Okamoto H, Shimura S, Karasawa T, Yonekura H, Yamamoto H
-
Journal Title
J Immunol.
Volume: 186
Pages: 3248-3257
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Journal Article] Regenerating gene I regulates interleukin-6 production in squamous esophageal cancer cells2010
Author(s)
Usami S, Motoyama S, Koyota S, Wang J, Hayashi-Shibuya K, Maruyama K, Takahashi N, Saito H, Minamiya Y, Takasawa S, Ogawa J I, Sugiyama T
-
Journal Title
Biochem Biophys Res Commun
Volume: 392
Pages: 4-8
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
[Presentation] INDUCTION OF REG IΑ, A NEW AUTO-ANTIGEN IN SJOGREN’S SYNDROME PATIENTS, IN SALIVARY DUCT EPITHELIAL CELLS BY INTERLEUKIN-6 AND -112013
Author(s)
Fujimura T, Itaya-Hironaka A, Miyaoka T, Yoshimoto K, Sakuramoto-Tsuchida S, Yamauchi A, Tsujinaka H, Takasawa S, Fujimoto T
Organizer
Annual European Congress of Rheumatology (EULAR) 2013
Place of Presentation
Madrid (Spain)
Related Report
-
-
-
-
-
-
[Presentation] The JAK/STAT signaling is essential for human REG Iα transcription in pancreatic β cells.2012
Author(s)
Yamauchi, A., Itaya-Hironaka, A., Sakuramoto-Tsuchida, S., Yoshimoto, K., Miyaoka, T., Fujimura, T., Tsujinaka, H., Tsuchida, C., Ota, H., Takasawa, S.
Organizer
The 9th IDF-WPR Congress/4th AASD Scientific Meeting
Place of Presentation
京都市（京都府）
Related Report
-
[Presentation] Intermittent hypoxia stimulates β cell proliferation via up-regulation of Reg family genes2012
Author(s)
Takasawa, S., Ota, H., Itaya-Hironaka, A., Yamauchi, A., Sakuramoto-Tsuchida, S., Miyaoka, T., Fujimura, T., Tsujinaka, H., Yoshimoto, K., Tsuchida, C., Tamaki, S., Kimura, H.
Organizer
The 9th IDF-WPR Congress/4th AASD Scientific Meeting
Place of Presentation
京都市（京都府）
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
