Steroid-resistant mechanism in smoking asthma

• Project/Area Number: 22591097
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Wakayama Medical University
• Principal Investigator: MATSUNAGA Kazuto 和歌山県立医科大学, 医学部, 講師 (20347602)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 気管支喘息 / 喫煙 / 気道炎症 / 閉塞性障害 / 気道過敏性 / 酸化ストレス / 窒素化ストレス / ステロイド / 臨床免疫学 / 炎症関連物質 / 慢性閉塞性肺疾患 / 活性酸素種 / 活性窒素種 / アレルギー性鼻炎

Research Abstract

Smoking habit is an important contributor to difficult asthma. Oxidative/nitrative stress induced by smoking is assumed to be a cause of the airway remodeling. This research has demonstrated that the smoking history is an independent risk factor for persistent bronchial inflammation in steroid-treated asthma. Furthermore, our study suggested that peroxynitrite can influence tissue remodeling by promoting matrix metaloproteases release, while theophylline suppresses peroxynitrite-induced tissue remodeling via pathways involving NF-kB and/or HDAC in the fibroblasts.

Research Products

• [Journal Article] Natural history and risk factors of obstructive changes over a 10-year period in severe asthma (2013)
  • Author(s): Matsunaga K
  • Journal Title: Respir Med Volume: 107 Issue: 3 Pages: 355-360
  • DOI: 10.1016/j.rmed.2012.11.014
  • Peer Reviewed
• [Journal Article] Difference in time-course of improvement in asthma control measures between budesonide and budesonide/formoterol (2013)
  • Author(s): Matsunaga K
  • Journal Title: Pulm Pharmacol Ther Volume: 26 Issue: 2 Pages: 189-194
  • DOI: 10.1016/j.pupt.2012.10.006
  • Peer Reviewed
• [Journal Article] Predictors for identifying the efficacy of systemic steroids on sustained exhaled nitric oxide elevation in severe asthma (2013)
  • Author(s): Matsunaga K
  • Journal Title: Allergol Int Volume: in press
  • NAID: 130004477190
  • Peer Reviewed
• [Journal Article] 25-hydroxycholesterol enhances cytokine release and toll-like receptor 3 response in airway epithelial cells (2012)
  • Author(s): Koarai A, Yanagisawa S, Sugiura H, Ichikawa T, Kikuchi T, Furukawa K, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
  • Journal Title: Respir Res Volume: 13 Pages: 63-63
  • Peer Reviewed
• [Journal Article] Cigarette smoke augments the expression and responses of toll-like receptor 3 in human macrophages (2012)
  • Author(s): Koarai A, Yanagisawa S, Sugiura H, Ichikawa T, Akamatsu K, Hirano T, Nakanishi M, Matsunaga K, Minakata Y, Ichinose M
  • Journal Title: Respirology Volume: 17 Pages: 1018-1025
  • Peer Reviewed
• [Journal Article] Response to treatment in individuals with late-onset asthma (2012)
  • Author(s): Matsunaga K, Akamatsu K, Hirano T, Ichinose M
  • Journal Title: J Am Geriatric Soc Volume: 60 Pages: 1587-1588
  • Peer Reviewed
• [Journal Article] Associated demographics of persistent exhaled nitric oxide elevation in treated asthmatics (2012)
  • Author(s): Matsunaga K, Yanagisawa S, Hirano T, Ichikawa T, Koarai A, Akamatsu K, Sugiura H, Minakata Y, Matsunaga K, Kawayama T, Ichinose M
  • Journal Title: Clin Exp Allergy Volume: 42(5) Pages: 775-781
  • Peer Reviewed
• [Journal Article] Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease (2012)
  • Author(s): Sugiura H, Koarai A, Ichikawa T, Minakata Y, Matsunaga K, Hirano T, Akamatsu K, Yanagisawa S, Furusawa M, Uno Y, Yamasaki M, Satomi Y, Ichinose M
  • Journal Title: Respirology Volume: 17 Pages: 533-540
  • Peer Reviewed
• [Journal Article] Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts (2012)
  • Author(s): Sugiura H, Kawabata H, Ichikawa T, Koarai A, Yanagisawa S, Kikuchi T, Minakata Y, Matsunaga K, Nakanishi M, Hirano T, Akamatsu K, Furukawa K, Ichinose M
  • Journal Title: Am J Physiol Lung Cell Mol Physiol Volume: 302(8) Pages: 764-774
  • Peer Reviewed
• [Journal Article] Increase of 27-hydroxycholesterol in the airways of patients with chronic obstructive pulmonary disease: possible role of 27-hydroxycholesterol in tissue fibrosis (2012)
  • Author(s): Kikuchi T, Sugiura H, Koarai A, Ichikawa T, Minakata Y, Matsunaga K, Nakanishi M, Hirano T, Akamatsu K, Yanagisawa S, Furukawa K, Kawabata H, Ichinose M
  • Journal Title: Chest Volume: 142(2) Pages: 329-337
  • Peer Reviewed
• [Journal Article] Validation of the Triaxial Accelerometer for the Evaluation of Physical Activity in Japanese Patients with COPD (2012)
  • Author(s): Kanda M, Minakata Y, Matsunaga K, Sugiura H, Hirano T, Koarai A, Akamatsu K, Ichikawa T and Ichinose M
  • Journal Title: Intern Med Volume: 51 Pages: 369-375
  • NAID: 130002062007
  • Peer Reviewed
• [Journal Article] Validation of a Compact Motion Sensor for the Measurement of Physical Activity in Patients with Chronic Obstructive Pulmonary Disease (2012)
  • Author(s): Sugino A, Minakata Y, Kanda M, Akamatsu K, Koarai A, Hirano T, Sugiura H, Matsunaga K, Ichinose M
  • Journal Title: Respiration Volume: 83 Pages: 300-307
  • Peer Reviewed
• [Journal Article] 免疫・アレルギー-高齢者喘息と耳鼻咽喉科- (2012)
  • Author(s): 松永和人
  • Journal Title: JOHNS Volume: 28 Pages: 1429-1433
• [Journal Article] 呼吸器疾患と脳神経障害 (2012)
  • Author(s): 松永和人、一ノ瀬正和
  • Journal Title: 日本内科学会雑誌 Volume: 101 Pages: 2219-2225
  • NAID: 10031130602
  • Peer Reviewed
• [Journal Article] 典型的疾患から学ぶ呼吸機能(5)気管支喘息 (2012)
  • Author(s): 松永和人
  • Journal Title: 呼吸 Volume: 31(6) Pages: 532-537
• [Journal Article] 気道炎症モニタリングの現状と展望 (2012)
  • Author(s): 松永和人, 一ノ瀬正和
  • Journal Title: 最新 医学 Volume: 67 Pages: 1236-1242
• [Journal Article] 呼気凝縮液と気道炎症 (2012)
  • Author(s): 松永和人
  • Journal Title: 臨床免疫・アレルギー科 Volume: 57(3) Pages: 288-293
• [Journal Article] 喘息長期管理のための炎症モニタリング (2012)
  • Author(s): 松永和人、一ノ瀬正和
  • Journal Title: 臨牀と研究 Volume: 89(3) Pages: 63-68
• [Journal Article] 成人喘息:呼気ガス・呼気凝縮液による気道炎症評価 (2012)
  • Author(s): 松永和人
  • Journal Title: アレルギー Volume: 61(1) Pages: 1-9
  • Peer Reviewed
• [Journal Article] Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts. (2012)
  • Author(s): Sugiura H
  • Journal Title: Am J Physiol Lung Cell Mol Physiol Volume: 302 Issue: 8 Pages: 764-774
  • DOI: 10.1152/ajplung.00342.2011
  • Peer Reviewed
• [Journal Article] Associated demographics of persistent exhaled nitric oxide elevation in treated asthmatics. (2012)
  • Author(s): Matsunaga K
  • Journal Title: Clin Exp Allergy Volume: 42 Issue: 5 Pages: 775-781
  • DOI: 10.1111/j.1365-2222.2011.03945.x
  • Peer Reviewed
• [Journal Article] Cigarette smoke augments the expression and responses of toll-like receptor 3 in human macrophages. (2012)
  • Author(s): Koarai A
  • Journal Title: Respirology Volume: 17 Issue: 6 Pages: 1018-1025
  • DOI: 10.1111/j.1440-1843.2012.02198.x
  • Peer Reviewed
• [Journal Article] Improvement of airflow limitation by fluticasone propionate/salmeterol in chronic obstructive pulmonary disease: what is the specific marker? (2011)
  • Author(s): Akamatsu K, Matsunaga K, Sugiura H, Koarai A, Hirano T, Minakata Y and Ichinose M
  • Journal Title: Front Pharmacol Volume: 2 Pages: 36-36
  • Peer Reviewed
• [Journal Article] Exhaled nitric oxide cutoff values for asthma diagnosis according to rhinitis and smoking status in Japanese subjects (2011)
  • Author(s): Matsunaga K, Hirano T, Akamatsu K, Koarai A, Sugiura H, Minakata Y, Ichinose M
  • Journal Title: Allergol Int Volume: 60 Pages: 331-337
  • NAID: 130004723045
  • Peer Reviewed
• [Journal Article] Increase of nitrosative stress in patients with eosinophilic pneumonia (2011)
  • Author(s): Furukawa K, Sugiura H, Matsunaga K,Ichikawa T, Koarai A, Hirano T, Yanagisawa S, Minakata Y, Akamatsu K, Kanda M, Nishigai M and Ichinose M
  • Journal Title: Respir Res Volume: 12 Pages: 81-81
  • Peer Reviewed
• [Journal Article] 呼気 NO 濃度測定:喘息補助診断の新しいツール (2011)
  • Author(s): 松永和人、一ノ瀬正和
  • Journal Title: アレルギーの臨床 Volume: 31(4) Pages: 342-346
• [Journal Article] 成人喘息の早期診断における課題と展望 (2011)
  • Author(s): 松永和人、一ノ瀬正和
  • Journal Title: アレルギーの臨床 Volume: 31(11) Pages: 27-31
• [Journal Article] Exhaled Nitric Oxide Cutoff Values for Asthma Diagnosis According to Rhinitis and Smoking Status in Japanese Subjects (2011)
  • Author(s): Matsunaga K, Koarai A, et al.
  • Journal Title: Allergology International Volume: 60 Issue: 3 Pages: 331-337
  • DOI: 10.2332/allergolint.10-OA-0277
  • NAID: 130004723045
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Increase of nitrosative stress in patients with eosinophilic pneumonia (2011)
  • Author(s): Furukawa K, Koarai A, et al.
  • Journal Title: Respir Res Volume: 12 Issue: 1 Pages: 81-91
  • DOI: 10.1186/1465-9921-12-81
  • Peer Reviewed
• [Journal Article] Improvement of Airflow Limitation by Fluticasone Propionate/Salmeterol in Chronic Obstructive Pulmonary Disease : What is the Specific Marker? (2011)
  • Author(s): Akamatsu K, Koarai A, et al.
  • Journal Title: Front Pharmacol Volume: 2 Pages: 36-41
  • DOI: 10.3389/fphar.2011.00036
  • Peer Reviewed
• [Journal Article] Reference ranges for exhaled nitric oxide fraction in healthy Japanese adult population (2010)
  • Author(s): Matsunaga K, Hirano T, Kawayama T, Tsuburai T, Nagase H, Aizawa H, Akiyama K, Ohta K and Ichinose M
  • Journal Title: Allergol Int Volume: 59 Pages: 363-367
  • NAID: 10029671105
  • Peer Reviewed
• [Journal Article] High COPD prevalence in the patients with liver diseases (2010)
  • Author(s): Minakata Y , Ueda H, Akamatsu K, Kanda M, Yanagisawa S, Ichikawa T, Koarai A, Hirano T, Sugiura H, Matsunaga K, Ichinose M
  • Journal Title: Intern Med Volume: 49 Pages: 2687-2691
  • NAID: 130000413428
  • Peer Reviewed
• [Journal Article] Oxidative Stress Enhances Toll-like Receptor 3 Response to Double-stranded RNA in Airway Epithelial Cells. (2010)
  • Author(s): oarai A, Sugiura H, Yanagisawa S, Ichikawa T, Minakata Y, Matsunaga K, Hirano T, Akamatsu K, Ichinose M
  • Journal Title: Am J Respir Cell Mol Biol Volume: 42 Pages: 651-660
  • Peer Reviewed
• [Journal Article] 喘息発作の治療 高齢者喘息への対応 (2010)
  • Author(s): 松永和人
  • Journal Title: Mebio Volume: 27 Pages: 64-71
• [Journal Article] 呼気分析による気道炎症評価 (2010)
  • Author(s): 松永和人
  • Journal Title: 日本臨床生理学会雑誌 Volume: 40 Pages: 15-20
  • NAID: 10029429152
  • Peer Reviewed
• [Journal Article] One airway, one disease の治療戦略 ‐ロイコトリエン受容体拮抗薬‐ (2010)
  • Author(s): 松永和人, 一ノ瀬正和
  • Journal Title: 喘息 Volume: 23 Pages: 44-49
• [Journal Article] 抗コリン薬の位置付け (2010)
  • Author(s): 松永和人, 一ノ瀬正和
  • Journal Title: アレルギーの臨床 Volume: 29(14) Pages: 45-50
• [Journal Article] Reference ranges for exhaled nitric oxide fraction in healthy Japanese adult population (2010)
  • Author(s): Matsunaga K, et al.
  • Journal Title: Allergology International Volume: 59 Pages: 363-367
  • NAID: 10029671105
  • Peer Reviewed
• [Journal Article] Oxidative stress enhances Toll-like receptor 3 to double strand RNA in airway epithelial cells (2010)
  • Author(s): Koarai A, Matsunaga K, et al.
  • Journal Title: Am J Respir Cell Mol Biol Volume: 42 Pages: 651-660
  • Peer Reviewed
• [Journal Article] One airway;one diseaseの治療戦略 (2010)
  • Author(s): 松永和人、一ノ瀬正和
  • Journal Title: 喘息 Volume: 23 Pages: 44-49
• [Presentation] 鼻炎合併喘息: 鼻炎の状態からみた喘息に対する影響 (2012)
  • Author(s): 松永和人, 早田敦志, 南方良章, 一ノ瀬正和
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2012-12-01
• [Presentation] 高齢発症喘息におけるHFA-fluticasone/salmeterol 配合剤の治療反応性. (2012)
  • Author(s): 松永和人, 早田敦志, 南方良章, 一ノ瀬正和
  • Organizer: 第62回日本アレルギー学会秋季学術大会 (ミニシンポジウム)
  • Place of Presentation: 大阪
  • Year and Date: 2012-11-30
• [Presentation] Budesonide およびBudesonide/Formoterol による喘息指標の経時的な改善過程. (2012)
  • Author(s): 松永和人 , 川端宏樹 , 一ノ瀬正和
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2012-11-30
• [Presentation] 重症喘息における閉塞性換気障害の経年的進行パターン (2012)
  • Author(s): 松永和人, 赤松啓一郎, 宮武明彦, 藤田きみる, 一ノ瀬正和
  • Organizer: 第62回日本アレルギー学会秋季学術大会
  • Place of Presentation: 大阪
  • Year and Date: 2012-11-29
• [Presentation] Simultaneous analysis of clinical markers for predicting increased lung function fluctability in stable asthma (2012)
  • Author(s): K. Matsunaga, A. Hayata, T. Hirano, M. Ichinose
  • Organizer: 2012 ERS Annual Congress
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2012-09-03
• [Presentation] LATE-BREAKING ABSTRACT: Developing obstructive change over time is dominant in small airways in severe asthma (2012)
  • Author(s): K. Matsunaga, K. Akamatsu, M. Ichinose
  • Organizer: 2012 ERS Annual Congress
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2012-09-02
• [Presentation] Associated demographics of persistent exhaled nitric oxide elevation in treated asthmatics (2012)
  • Author(s): K. Matsunaga, S. Yanagisawa, T. Hirano, H. Sugiura, Y. Minakata, M. Ichinose
  • Organizer: The 22ndCongress of Interasma Japan/North Asia
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2012-07-06
• [Presentation] 気管支喘息における気道炎症評価の進歩 (2012)
  • Author(s): 松永和人
  • Organizer: 第79回日本呼吸器学会近畿地方会 (教育講演)
  • Place of Presentation: 京都市
  • Year and Date: 2012-06-30
• [Presentation] Thematic Poster Session: Evaluation Of Intensity-Based Physical Activity In Patients With COPD (2012)
  • Author(s): Y. Minakata, A. Sugino, Y. Honda, T. Ichikawa, K. Akamatsu, A. Koarai, T. Hirano, M. Nakanishi, H. Sugiura, K. Matsunaga, M Ichinose
  • Organizer: 2012 ATS International Conference
  • Place of Presentation: San Francisco, California, USA
  • Year and Date: 2012-05-23
• [Presentation] Thematic Poster Session: Persistent Exhaled Nitric Oxide Elevation And Augmentation Of Inhaled Corticosteroid Therapy In Asthma (2012)
  • Author(s): T. Hirano, K. Matsunaga, H. Sugiura, Y. Minakata, A. Koarai, K. Akamatsu, T. Ichikawa, K. Furukawa, M. Ichinose
  • Organizer: 2012 ATS International Conference
  • Place of Presentation: San Francisco, California,USA
  • Year and Date: 2012-05-23
• [Presentation] Thematic Poster Session:25-Hydroxycholesterol Enhances Interferon Release After Toll-Like Receptor 3 Stimulation In Human Airway Epithelial Cells (2012)
  • Author(s): A. Koarai, S. Yanagisawa, H. Sugiura, T. Ichikawa, T. Kikuchi, K. Furukawa, K. Akamatsu, T. Hirano, M. Nakanishi, K. Matsunaga, Y. Minakata, M. Ichinose
  • Organizer: 2012 ATS International Conference
  • Place of Presentation: San Francisco, California,USA
  • Year and Date: 2012-05-22
• [Presentation] ndependent Predictors Of Persistent Exhaled Nitric Oxide Elevation In Treated Asthmatics (2012)
  • Author(s): K. Matsunaga, S. Yanagisawa, T. Hirano, K. Akamatsu, A. Koarai, H. Sugiura, Y. Minakata, M. Ichinose
  • Organizer: 2012 ATS International Conference
  • Place of Presentation: San Francisco, California,USA
  • Year and Date: 2012-05-22
• [Presentation] 安定期喘息において遷延する呼気 NO 濃度上昇と関連する背景因子 (2012)
  • Author(s): 松永和人
  • Organizer: 第24回日本アレルギー学会 (ミニシンポジウム)
  • Place of Presentation: 大阪
  • Year and Date: 2012-05-12
• [Presentation] ndependent Predictors of Persistent Exhaled Nitric Oxide Elevation in Treated Asthmatics. (2012)
  • Author(s): K. Matsunaga, T . Hirano, M. Ichinose
  • Organizer: The 52nd Annals of The Japanese Respiratory Society (English symposium)
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2012-04-20
• [Presentation] 高齢者喘息と COPD:オーバーラップ症候群 (2011)
  • Author(s): 松永和人
  • Organizer: 第61回日本アレルギー学会秋季学術大会 (教育セミナー)
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] 安定期喘息における PEF 変動率増大を予測する段階的アプローチの提唱 (2011)
  • Author(s): 松永和人, 早田敦司, 平野綱彦, 一ノ瀬正和
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] 高齢者喘息とCOPD(オーバーラップ症候群) (2011)
  • Author(s): 松永和人
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] 安定期喘息におけるPEF変動率増大を予測する段階的アプローチの提唱 (2011)
  • Author(s): 松永和人
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-11
• [Presentation] 呼気 NO 濃度測定の喘息補助診断における有用性と留意点 (2011)
  • Author(s): 松永和人
  • Organizer: 第48回日本小児アレルギー学会・第16回アジア太平洋小児アレルギー呼吸器免疫学会 (シンポジウム)
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-28
• [Presentation] 呼気NO濃度測定の喘息補助診断における有用性と留意点 (2011)
  • Author(s): 松永和人
  • Organizer: 第16回アジア太平洋小児アレルギー呼吸器免疫学会
  • Place of Presentation: 福岡(招待講演)
  • Year and Date: 2011-10-28
• [Presentation] Thematic Poster Session:Increase of 25-hydroxycholesterol in the lungs of chronic obstructive pulmonary disease (2011)
  • Author(s): H. Sugiura, A. Koarai, T . Ichikawa, Y. Minakata, K. Matsunaga, T. Hirano, K. Akamatsu, S. Yanagisawa, M. Furusawa, Y. Uno, M. Yamasaki, M.Ichinose
  • Organizer: 201 1 ERS Annual Congress
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 2011-09-27
• [Presentation] Thematic Poster Session:Validation of a compact accelerometer for the measurement of physical activity in patients with COPD (2011)
  • Author(s): Y. Minakata, A. Sugino, M. Nishigai, M.Kanda, K. Akamatsu, A. Koarai, T. Hirano, H. Sugiura, K. Matsunaga, M. Ichinose
  • Organizer: 2011ERS Annual Congress
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 2011-09-26
• [Presentation] Thematic Poster Session: Increase of nitrosative stress in patients with eosinophilic pneumonia (2011)
  • Author(s): K. Furukawa, H. Sugiura, K. Matsunaga, T. Ichikawa, A. Koarai, T. Hirano, M. Kanda, K. Akamatsu, Y. Minakata, M. Nishigai, M. Ichinose
  • Organizer: 2011 ERS Annual Congress
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 2011-09-25
• [Presentation] OralPresentation Session: Cigarette smoking augments toll-like receptor 3expression and responses in macrophages (2011)
  • Author(s): A. Koarai, S. Yanagisawa, H. Sugiura, T. Ichikawa, K. Akamatsu, T. Hirano, M. Nakanishi, K. Matsunaga, Y. Minakata, and M. Ichinose
  • Organizer: ERS Annual Congress
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 2011-09-25
• [Presentation] Optimization of diagnosis and long-term management in elderly asthmatics (2011)
  • Author(s): K. Matsunaga
  • Organizer: The 21st Congress of Interasma Japan/North Asia
  • Place of Presentation: Gifu, Japan
  • Year and Date: 2011-07-01
• [Presentation] hematic Poster Session: 25-hydroxycholesterol enhances cytokines release and toll-like receptor 3 responses in human airway epithelial cells (2011)
  • Author(s): A. Koarai, S. Yanagisawa, H. Sugiura, T. Ichikawa, H. Kawabata, T. Kikuchi, M. Kanda, K. Furukawa, K. Akamatsu, T. Hirano, K. Matsunaga, Y. Minakata and M.Ichinose
  • Organizer: 2011 ATS International Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-17
• [Presentation] Differences In Cutoff Values Of Exhaled Nitric Oxide For Asthma Diagnosis According To Rhinitis And Smoking Status (2011)
  • Author(s): K. Matsunaga, T. Hirano, A. Koarai, K. Akamatsu, H. Sugiura, Y. Minakata and M. Ichinose
  • Organizer: 2011 ATS International Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-17
• [Presentation] Thematic poster session: Increased27-hydroxycholesterol Production In The Airways Of Chronic ObstructivePulmonary Disease (2011)
  • Author(s): T. Kikuchi, H. Sugiura, A. Koarai, T. Ichikawa, Y. Minakata, K. Matsunaga, M. Nakanishi, T. Hirano, K. Akamatsu, S. Yanagisawa, K. Furukawa, M. Kanda, H. Kawabata, M. Ichinose
  • Organizer: 2011 ATS International Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-16
• [Presentation] Thematic Poster Session: Increase of25-hydroxycholesterol in the lungs of chronic obstructive pulmonary disease (2011)
  • Author(s): H. Sugiura, A. Koarai, T. Ichikawa, Y. Minakata, K. Matsunaga, T. Hirano, K. Akamatsu, S. Yanagisawa, M. Furusawa, Y. Uno, M. Yamasaki, Y.Satomi, M. Ichinose
  • Organizer: 2011 ATS International Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-16
• [Presentation] Relationship Between Inflammatory Markers In Exhaled Air And Small Airway Function In Chronic Obstructive Pulmonary Disease(COPD) (2011)
  • Author(s): T. Hirano, K. Matsunaga, Y. Minakata, H. Sugiura, M. Nakanishi, A. Koarai, K. Akamatsu, T. Ichikawa, S. Yanagisawa, M. Furusawa, M. Kanda, T. Kikuchi, H. Kawabata, M. Ichinose
  • Organizer: 2011 ATSInternational Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-15
• [Presentation] 松永和人 (2011)
  • Author(s): 松永和人
  • Organizer: 第23回日本アレルギー学会春季臨床大会 (シンポジウム)
  • Place of Presentation: 千葉
  • Year and Date: 2011-05-14
• [Presentation] Difference in cutoff values of exhaled nitric oxide for asthma diagnosis according to rhinitis and smoking status (2011)
  • Author(s): Matsunaga K
  • Organizer: 2011 American Thoracic Society International Conference
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-14
• [Presentation] 呼気凝縮液と気道炎症 (2011)
  • Author(s): 松永和人
  • Organizer: 第23回日本アレルギー学会春季臨床大会
  • Place of Presentation: 千葉(招待講演)
  • Year and Date: 2011-05-14
• [Presentation] 喘息診断に用いる呼気 NO濃度カットオフ値の提唱 (2010)
  • Author(s): 松永和人, 平野綱彦, 川端宏樹, 神田匡兄, 柳澤 悟, 市川朋宏 , 小荒井晃, 赤松啓一郎, 中西正典, 杉浦久敏, 南方良章, 一ノ瀬正和
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-26
• [Presentation] 難治性喘息～治療標的としての呼気NOの有用性 (2010)
  • Author(s): 平野綱彦、松永和人, ら
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-26
• [Presentation] 喘息診断に用いる呼気NO濃度のカットオフ値の提唱 (2010)
  • Author(s): 松永和人
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-26
• [Presentation] 気管支喘息における気道炎症評価 (2010)
  • Author(s): 松永和人
  • Organizer: Respiratory Executive Meeting
  • Place of Presentation: 岡山
  • Year and Date: 2010-11-19
• [Presentation] Expression of TLR-3 in alveolar macrophages from patients with COPD (2010)
  • Author(s): Koarai A, Matsunaga K, et al
  • Organizer: 2010 ERS annual congress
  • Place of Presentation: Barcelona
  • Year and Date: 2010-09-18
• [Presentation] 呼気NO濃度測定の一般臨床応用に向けて (2010)
  • Author(s): 松永和人
  • Organizer: 第17回西日本喘息治療研究会
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-21
• [Presentation] Oxidative stress enhances TLR3 response to double-stranded RNA in airway epithelial cells (2010)
  • Author(s): A. Koarai, H. Sugiura, S. Yanagisawa, T. Ichikawa, Y. Minakata, K. Matsunaga, T. Hirano, K. Akamatsu and M. Ichinose
  • Organizer: Tokyo Asia COPD symposium 2010 Tokyo
  • Place of Presentation: Tokyo
  • Year and Date: 2010-07-31
• [Presentation] Peroxynitorite augments fibroblast-mediated tissue remodeling through NF-Kβ activation (2010)
  • Author(s): T. Ichikawa, H. Sugiura, A. Koarai, S. Yanagisawa, M. Kanda, K. Akamatsu, T. Hirano, K. Matsunaga, Y. Minakata, M. Ichinose
  • Organizer: The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Kyoto
  • Year and Date: 2010-06-18
• [Presentation] Oxidative stress enhances TLR3 response to double-stranded RNA in airway epithelial cells (2010)
  • Author(s): A. Koarai, H. Sugiura, S. Yanagisawa, T. Ichikawa, Y. Minakata, K. Matsunaga, T. Hirano, K. Akamatsu and M. Ichinose
  • Organizer: The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Kyoto
  • Year and Date: 2010-06-16
• [Presentation] Oxydative Stress Augments Toll-Like Receptor 8 Mediated Neutrophilic Responses (2010)
  • Author(s): S. Yanagisawa, A. Koarai, H. Sugiura, T. Ichikawa, M. Kanda, K. Akamatsu, T. Hirano, K. Matsunaga, Y. Minakata, M. Ichinose
  • Organizer: The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Kyoto
  • Year and Date: 2010-06-16
• [Presentation] Oxidative stress enhances TLR3 response to dsRNA in airway epithelial cells (2010)
  • Author(s): Koarai A, Matsunaga K, et al
  • Organizer: 第6回国際NO学会
  • Place of Presentation: Kyoto
  • Year and Date: 2010-06-16
• [Presentation] 喫煙喘息における呼気 NO 濃度 (2010)
  • Author(s): 松永和人, 神田匡兄,柳澤悟,市川朋宏,小荒井晃,赤松啓一郎, 平野綱彦,杉浦久敏,南方良章,一ノ瀬正和
  • Organizer: 第22回日本アレルギー学会春季臨床大会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-08
• [Presentation] 喘息診断における呼気 NO 濃度のカットオフ値 (2010)
  • Author(s): 松永和人, 神田匡兄, 柳澤 悟, 市川朋宏, 小荒井晃, 赤松啓一郎, 平野綱彦, 杉浦久敏, 南方良章, 一ノ瀬正和
  • Organizer: 第22回日本アレルギー学会春季臨床大会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-08
• [Presentation] 喫煙喘息における呼気NO濃度 (2010)
  • Author(s): 松永和人
  • Organizer: 第22回日本アレルギー学会春季臨床大会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-08
• [Presentation] 喫煙喘息における呼気 NO 濃度 (2010)
  • Author(s): 松永和人, 神田匡兄,柳澤 悟,市川朋宏,小荒井晃,赤松啓一郎, 平野綱彦,杉浦久敏,南方良章,一ノ瀬正和
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 京 都
  • Year and Date: 2010-04-23
• [Presentation] 喫煙喘息における呼気NO濃度 (2010)
  • Author(s): 松永和人
  • Organizer: 第50回日本呼吸器学会学術講演会
  • Place of Presentation: 京都
  • Year and Date: 2010-04-23
• [Presentation] Thematic Poster Session: Expression of toll-like receptor 3 in alveolar macrophages from patients with COPD (2010)
  • Author(s): A. Koarai, S. Yanagisawa, H. Sugiura,T . Ichikawa, M. Kanda, K. Furukawa, K. Akamatsu, T . Hirano, K. Matsunaga, Y . Minakata, M. Ichinose
  • Organizer: 2010 ERS Annual Congress 2010.09.18-22
  • Place of Presentation: Barcelona, Spain
• [Presentation] 喫煙喘息における呼気NO濃度
  • Author(s): Matsunaga K
  • Organizer: 2013 ATS International Conference
  • Place of Presentation: Philadelphia, USA
• [Presentation] 鼻炎合併喘息における喘息コントロール不良の独立した規定因子
  • Author(s): 松永和人
  • Organizer: 第24回日本アレルギー学会春季臨床大会
  • Place of Presentation: 横浜
• [Presentation] 呼気NO濃度高値が遷延する難治性喘息に対する全身性ステロイド薬の反応性
  • Author(s): 松永和人
  • Organizer: 第24回日本アレルギー学会春季臨床大会
  • Place of Presentation: 横浜
• [Presentation] Difference in time-course of improvement in asthma control measures between budesonide and budesonide/formoterol
  • Author(s): Matsunaga K
  • Organizer: The 53rd annual meeting of the Japanese Respiratory Society
  • Place of Presentation: Tokyo
• [Presentation] Independent Predictors Of Persistent Exhaled Nitric Oxide Elevation In Treated Asthmatics
  • Author(s): Matsunaga K
  • Organizer: 2012 ATS International Conference
  • Place of Presentation: San Francisco, USA
• [Presentation] Associated demographics of persistent exhaled nitric oxide elevation in treated asthmatics
  • Author(s): Matsunaga K
  • Organizer: The 22nd Congress of Interasma Japan/North Asia
  • Place of Presentation: Fukuoka
  • Invited
• [Presentation] Developing obstructive change over time is dominant in small airways in severe asthma
  • Author(s): Matsunaga K
  • Organizer: 2012 ERS Annual Congress
  • Place of Presentation: Vienna, Austria
• [Presentation] 安定期喘息において遷延する呼気NO濃度上昇と関連する背景因子
  • Author(s): 松永和人
  • Organizer: 第24回日本アレルギー学会
  • Place of Presentation: 大阪
• [Book] 気管支喘息(成人喘息とは), 一般社団法人 日本アレルギー学会 編集 臨床医のためのアレルギー診療ガイドブック (2012)
  • Author(s): 松永和人, 一ノ瀬正和:
  • Publisher: 診断と治療社
• [Book] 検査・鑑別・重症度(判定), 一般社団法人 日本アレルギー学会 編集 臨床医のためのアレルギー診療ガイドブック (2012)
  • Author(s): 松永和人, 一ノ瀬正和
  • Publisher: 診断と治療社
• [Book] 難治性喘息. アレルギー・リウマチ膠原病診療 最新ガイドライン. (2012)
  • Author(s): 松永和人, 一ノ瀬正和
  • Publisher: 総合医学社
• [Book] 気管支喘息. 新呼吸療法テキスト (2012)
  • Author(s): 松永和人, 一ノ瀬正和
  • Publisher: アトムス
• [Book] 日本アレルギー学会 アレルギー診療ガイドブック (2012)
  • Author(s): 松永和人
  • Total Pages: 564
  • Publisher: 診断と治療社
• [Book] 日本アレルギー学会 アレルギー・リウマチ膠原病診療最新ガイドライン (2012)
  • Author(s): 松永和人
  • Total Pages: 317
  • Publisher: 総合医学社
• [Book] 日本呼吸器学会 新呼吸療法テキスト (2012)
  • Author(s): 松永和人
  • Total Pages: 426
  • Publisher: アトムス
• [Book] 日本アレルギー学会 喘息予防・管理ガイドライン2012 (2012)
  • Author(s): 松永和人
  • Total Pages: 288
  • Publisher: 協和企画
• [Book] 成人喘息の早期診断における課題と展望 (2011)
  • Author(s): 松永和人
  • Total Pages: 5
  • Publisher: 北隆館
• [Book] 呼気NO濃度測定:喘息補助診断の新しいツール (2011)
  • Author(s): 松永和人
  • Total Pages: 5
  • Publisher: 北隆館
• [Book] 喘息治療管理のモニタリング法の今後の見通しは?EBM アレルギー疾患の治療2010-2011 (2009)
  • Author(s): 松永和人、一ノ瀬正和
  • Publisher: 中外医学社