| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
Smoking habit is an important contributor to difficult asthma. Oxidative/nitrative stress induced by smoking is assumed to be a cause of the airway remodeling. This research has demonstrated that the smoking history is an independent risk factor for persistent bronchial inflammation in steroid-treated asthma. Furthermore, our study suggested that peroxynitrite can influence tissue remodeling by promoting matrix metaloproteases release, while theophylline suppresses peroxynitrite-induced tissue remodeling via pathways involving NF-kB and/or HDAC in the fibroblasts.
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