| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We revealed that antigen-specific CD4 T cells were separated into CD27+and CD27-populations in the lymph node from OVA-immunized DO11.10/Rag-2-/-mice.The CD27+CD4 T cells produced a high level of IFN-・, representing Th1 cells. In contrast, CD27-CD4 T cells produced high levels of IL-4, IL-5, and IL-13, representing Th2 cells.Eosinophil infiltration and Th2 cytokine production in the lung and the population of CD27-Th2 cells was significantly reduced by the anti-CD70 mAb treatment. These results indicated an important role for CD27 in the development of pathogenic Th2 cells in a murine model of allergic lung inflammation.
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