Study on the function of a novel inflammatorymarker protein(LRG) in the pathogenes I s of autoimmune d I sorders

• Project/Area Number: 22591101
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: 独立行政法人医薬基盤研究所
• Principal Investigator: NAKA Tetsuji 独立行政法人医薬基盤研究所, 創薬基盤研究部, 部長 (30303936)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 臨床免疫学 / LRG / 炎症

Research Abstract

The uncharacterized function of LRG, a novel biomarker for autoimmune disorders, was investigated in this study. By proteomics approach and two-hybrid screening, several candidates of LRG-interacting proteins including possible receptors have been identified. Generation and analysis of LRG knockout mice have revealed that LRG is dispensable for the survival of mice, but is involved in the progression of several immune diseases. The results suggest that LRG is a promising target of immune disorders. Further studies on LRG as a potential therapeutic target will be on the way in collaboration with a pharmaceutical company.

Research Products

• [Journal Article] Lectin-based immunoassay for aberrant IgG glycosylation as the biomarker for Crohn's disease (2013)
  • Author(s): Shinzaki S, Kuroki E, Iijima H, Tatsunaka N, Ishii M, Fujii H, Kamada Y, Kobayashi T, Shibukawa N, Inoue T, Tsujii M, Takeishi S, Mizushima T, Ogata A, Naka T, Plevy SE, Takehara T, Miyoshi E
  • Journal Title: Inflamm Bowel Dis Volume: 19(2) Pages: 321-31
  • Peer Reviewed
• [Journal Article] Plasma nlembrane proteonlics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer (2013)
  • Author(s): Yokoyama T, Enomoto T, Serada S, Morimoto A, Matsuzaki S, Ueda Y, Yoshino K, Fujita M, Kyo S, Iwahori K, Fujimoto M, Kimura T, Naka T
  • Journal Title: Int J Cancer Volume: 132(2) Issue: 2 Pages: 472-84
  • DOI: 10.1002/ijc.27679
  • Peer Reviewed
• [Journal Article] SOCS-1 gene delivery cooperates with cisplatin plus pemetrexed to exhibit preclinical antitUmor activity against malignant pleural mesothelioma (2013)
  • Author(s): Iwahori K, Serada S, Fujimoto M, Ripley B, Nomura S, Mizuguchi H, Shimada S, Takahashi T, Kawase I, Kishimoto T, Naka T
  • Journal Title: Int J Cancer Volume: 132(2) Issue: 2 Pages: 459-71
  • DOI: 10.1002/ijc.27611
  • Peer Reviewed
• [Journal Article] Lectin-based immunoassay for aberrant IgG glycosylation as the biomarker for Crohn's disease. (2013)
  • Author(s): Shinzaki S, 他13名, Naka T, Plevy S E, Takehara T, Miyoshi E.
  • Journal Title: Inflamm Bowel Dis. Volume: 19（2） Issue: 2 Pages: 321-31
  • DOI: 10.1097/mib.0b013e318280eade
  • Peer Reviewed
• [Journal Article] Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord lnJury (2012)
  • Author(s): Ishii H, Jin X, Ueno M, Tanabe S, Kubo, Serada S, Naka T. Yamashita T
  • Journal Title: Cell Death Dis Volume: 3 Issue: 8 Pages: e363-e363
  • DOI: 10.1038/cddis.2012.106
  • Peer Reviewed
• [Journal Article] Serum HE4 as a diagnostic and prognostic marker for lung cancer (2012)
  • Author(s): Iwahori K, Suzuki H, Kishi Y, Fujii Y, Uehara R, Okamoto N, Kobayashi M, Hirashima T, Kawase I, Naka T
  • Journal Title: Tumour Biol Volume: 33(4) Issue: 4 Pages: 1141-9
  • DOI: 10.1007/s13277-012-0356-9
  • Peer Reviewed
• [Journal Article] Suppressor of cytokine signaling 1 (SOCS1) DNA administration inhibits inflammatory and pathogenic responses in autoimmune myocarditis (2012)
  • Author(s): Tajiri K
  • Journal Title: Journal of Immunology Volume: 189 Issue: 4 Pages: 2043-2053
  • DOI: 10.4049/jimmunol.1103610
  • Peer Reviewed
• [Journal Article] Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice (2012)
  • Author(s): Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii E, Aozasa K, Kawamura T, Okumura M, Nakae J, et al.
  • Journal Title: PLoS One Volume: 7 Issue: 5 Pages: e37803-e37803
  • DOI: 10.1371/journal.pone.0037803
  • Peer Reviewed
• [Journal Article] Periostin Facilitates Skin Sclerosis via PI3K/Akt Dependent Mechanism in a Mouse Model of Scleroderma (2012)
  • Author(s): Yang L, Serada S, Fujimoto M, Terao M, Kotobuki Y, Kitaba S, Matsui S, Kudo A, Naka T, Murota H, Katayama I
  • Journal Title: PLoS One Volume: 7(7) Issue: 7 Pages: e41994-e41994
  • DOI: 10.1371/journal.pone.0041994
  • Peer Reviewed
• [Journal Article] Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis (2012)
  • Author(s): Serada S, Fujimoto M, Terabe F, Iijima H, Shinzaki S, Matsuzaki S, Ohkawara T, Nezu R, Nakajima S, Kobayashi T, Plevy SE, Takehara T, Naka T
  • Journal Title: Inflamm Bowel Dis Volume: (in press) Issue: 11 Pages: 2169-79
  • DOI: 10.1002/ibd.22936
  • Peer Reviewed
• [Journal Article] Dysregulation of Melanocyte Function by Th17-related Cytokines: Significance of Th17 Cell Infiltration in Autoimmune Vitiligo Vulgaris (2012)
  • Author(s): Kotobuki Y, Tanemura A, Yang L, Itoi S, Kaneda M, Murota H, Fujimoto M, Serada S, Naka T Katayama I
  • Journal Title: Pigment Cell Melanonla Res Volume: 25(2) Pages: 219-30
  • Peer Reviewed
• [Journal Article] Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts (2012)
  • Author(s): Ontsuka K, Kotobuki Y, Shiraishi H, Serada S, Ohta S, Tanenlura A, Yang L, Fujimoto M, Arima K, Suzuki S, Murota H, Toda S, Kudo A, Conway S, Narisawa Y,Katayama I, Izuhara K, Naka T
  • Journal Title: Exp Dermatol Volume: 21(5) Pages: 331-336
  • Peer Reviewed
• [Journal Article] Blockade of interleukin-6 receptor alleviates disease in mouse model of scleroderma (2012)
  • Author(s): Kitaba S, Murota H, Terao M, Azukizawa H, Terabe F, Shima Y, Fujimoto M, Tanaka T, Naka T, Kishimoto T, Katayama I
  • Journal Title: Am J Pathol Volume: 180(1) Issue: 1 Pages: 165-176
  • DOI: 10.1016/j.ajpath.2011.09.013
  • Peer Reviewed
• [Journal Article] IL-6によるレギュラトリーT細胞の抑制:nTregとiTregの相違 (2012)
  • Author(s): 藤本 穣、寺部 文隆、仲 哲治
  • Journal Title: 臨床免疫・アレルギー科 Volume: 57(1) Pages: 79-86
  • NAID: 40019192523
• [Journal Article] Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts (2012)
  • Author(s): Ontsuka K, Kotobuki Y, Shiraishi H, Serada S, Ohta S, Tanemura A, Yang L, Fujimoto M, Arima K, Suzuki S, Murota H, Toda S, Kudo A, Conway S, Izuhara K, Katayama I, Naka T
  • Journal Title: Experimental Dermatology Volume: 21(5) Issue: 5 Pages: 331-336
  • DOI: 10.1111/j.1600-0625.2012.01454.x
  • Peer Reviewed
• [Journal Article] Antiproliferative effect of SOCS-1 through the suppression of STAT3 and p38 MAPK activation in gastric cancer cells (2011)
  • Author(s): Souma Y, Nishida T, Serada S, Iwahori K, Takahashi T, Fujimoto M, Ripley B, Nakajima K, Miyazaki Y, Mori M, Doki Y, Sawa Y, Naka T
  • Journal Title: Int J Cancer Volume: (in press) Issue: 6 Pages: 1287-96
  • DOI: 10.1002/ijc.27350
  • Peer Reviewed
• [Journal Article] IL-6-mediated Th17 differentiation through ROR{gamma} t is essential for the initiation of experimental autoimmune myocarditis (2011)
  • Author(s): Yamashita T, Iwakura T, Matsui K, Kawaguchi H, Obana M, Hayama A, Maeda M, Izumi Y, Komuro I, Ohsugi Y, Fujimoto M, Naka T, Kishimoto T, Nakayama H, Fujio Y
  • Journal Title: Cardiovasc Res Volume: 91(4) Issue: 4 Pages: 640-648
  • DOI: 10.1093/cvr/cvr148
  • Peer Reviewed
• [Journal Article] Blockade of interleukin-6 signaling suppresses not only th17 but also interphotoreceptor retinoid binding protein-specific Th1 by promoting regulatory T cells in experimental autoimmune uveoretinitis (2011)
  • Author(s): Haruta H, Ohguro N, Fujimoto M, Hohki S, Terabe F, Serada S, Nomura S, Nishida K, Kishimoto T, Naka T
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52(6) Issue: 6 Pages: 3264-3271
  • DOI: 10.1167/iovs.10-6272
  • Peer Reviewed
• [Journal Article] The influence of excessive IL-6 production in vivo on the development and function of Foxp3+regulatory T cells (2011)
  • Author(s): Fujimoto M, Nakano M, Terabe F, Kawahata H, Ohkawara T, Han Y, Ripley B, Serada S, Nishikawa T, Kimura A, Nomura S, Kishimoto T, Naka T
  • Journal Title: J Immunol Volume: 186(1) Issue: 1 Pages: 32-40
  • DOI: 10.4049/jimmunol.0903314
  • Peer Reviewed
• [Journal Article] Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma (2011)
  • Author(s): Iwahori K, Serada S, Fujimoto M, Nomura S, Osaki T, Lee CM, Mizuguchi H, Takahashi T, Ripley B, Okumura M, Kawase I, Kishimoto T, Naka T
  • Journal Title: Int J Cancer Volume: 129(4) Issue: 4 Pages: 993-1005
  • DOI: 10.1002/ijc.25716
  • Peer Reviewed
• [Journal Article] Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+T-cell responses in murine colitis (2011)
  • Author(s): Terabe F, Fujimoto M, Serada S, Shinzaki S, Iijima H, Tsujii M, Hayashi N, Nomura S, Kawahata H, Jang MH, Miyasaka M, Mihara M, Ohsugi Y, Kishimoto T, Naka T
  • Journal Title: Inflamm Bowel Dis Volume: 17(2) Issue: 2 Pages: 491-502
  • DOI: 10.1002/ibd.21384
  • Peer Reviewed
• [Journal Article] Dysregulation of Melanocyte Function by Th17-related Cytokines : Significance of Th17 Cell Infiltration in Autoimmune Vitiligo Vulgaris (2011)
  • Author(s): Kotobuki Y, Tanemura A, Yang L, Itoi S, Wataya-Kaneda M, Murota H, Fujimoto M, Serada S, Naka T, Katayama I
  • Journal Title: Pigment Cell & Melanoma Research Volume: 25(2) Pages: 219-30
  • Peer Reviewed
• [Journal Article] IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis (2011)
  • Author(s): Yamashita T, Iwakura T, Matsui K, Kawaguchi H, Obana M, Hayama A, Maeda M, Izumi Y, Komuro I, Ohsugi Y, Fujimoto M, Naka T, Kishimoto T, Nakayama H, Fujio
  • Journal Title: Cardiovasc Res Volume: 91(4) Pages: 640-8
  • Peer Reviewed
• [Journal Article] Blockade of Interleukin-6 Signaling Suppresses Not Only Thl7 But Also Interphotoreceptor Retinoid Binding Protein-Specific Thl By Promoting Regulatory T cells In Experimental Autoimmune Uveoretinitis. (2011)
  • Author(s): Haruta H, Ohguro N, Fujimoto M, Hohki S, Terabe F, Serada S, Nomura S, Nishida K, Kishimoto T, Naka T.
  • Journal Title: Investigative Ophthalmology and Visual Science Volume: (In press, In press)
  • Peer Reviewed
• [Journal Article] The Influence of Excessive IL-6 Production In Vivo on the Development and Function of Foxp3+ Regulatory T Cells. (2011)
  • Author(s): Fujimoto M, Nakano M, Terabe F, Kawahata H, Ohkawara T, Han Y, Ripley B, Serada S, Nishikawa T, Kimura A, Nomura S, Kishimoto T, Naka T.
  • Journal Title: The Journal of Immunology Volume: 186 Pages: 32-40
  • Peer Reviewed
• [Journal Article] Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma (2011)
  • Author(s): Iwahori K, Serada S, Fujimoto M, Nomura S, Osaki T, Chun Man Lee, Mizuguchi H, Takahashi T, Ripley B, Okumura M, Kawase I, Kishimoto T, Naka T
  • Journal Title: International Journal of Cancer Volume: (In press, In press)
  • Peer Reviewed
• [Journal Article] Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4+ T-cell responses in murine colitis (2011)
  • Author(s): Terabe F, Fujimoto M, Serada S, Shinzaki S, Iijima H, Tsujii M, Hayashi N, Nomura S, Kawahata H, Myoung Ho Jang, Miyasaka M, Mihara M, Ohsugi Y, Kishimoto T, Naka T
  • Journal Title: Inflammatory Bowel Diseases Volume: 17 Pages: 491-502
  • Peer Reviewed
• [Journal Article] SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases (2010)
  • Author(s): Fujimoto M, Naka T
  • Journal Title: Gastroenterol Res Pract Volume: 2010 Pages: 470468-470468
  • DOI: 10.1155/2010/470468
  • Peer Reviewed
• [Journal Article] Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses (2010)
  • Author(s): Hohki S, Ohguro N, Haruta H, Nakai K, Terabe F, Serada S, Fujimoto M, Nomura S, Kawahata H, Kishimoto T, Naka T
  • Journal Title: Exp Eye Res Volume: 91(2) Issue: 2 Pages: 162-170
  • DOI: 10.1016/j.exer.2010.04.009
  • Peer Reviewed
• [Journal Article] Green tea polyphenol epigallocatechin gallate inhibits cell signaling by inducing SOCS1 gene expression (2010)
  • Author(s): Ripley BJ, Fujimoto M, Serada S, Ohkawara T, Nishikawa T, Terabe F, Matsukawa Y, Stephanou A, Knight RA, Isenberg DA, Latchman DS, Kishimoto T, Naka T
  • Journal Title: Int Immunol Volume: 22(5) Issue: 5 Pages: 359-366
  • DOI: 10.1093/intimm/dxq015
  • NAID: 10027579870
  • Peer Reviewed
• [Journal Article] iTRAQ-based proteomic identification of leucine rich alpha 2 glycoprotein (LRG) as a novel inflammatory biomarker in autoimmune diseases (2010)
  • Author(s): Serada S, Fujimoto M, Ogata A, Terabe F, Hirano T, Iijima H, Shinzaki S, Nishikawa T, Ohkawara T, wahori K, Ohguro N, Kishimoto T, Naka T
  • Journal Title: Ann Rheum Dis Volume: 69 Pages: 770-774
  • Peer Reviewed
• [Journal Article] SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases. (2010)
  • Author(s): Fujimoto M, Naka T.
  • Journal Title: Gastroenterology Research Practice Volume: On line
  • Peer Reviewed
• [Journal Article] Blockade of Interleukin-6 Signaling Suppresses Experimental Autoimmune Uveoretinitis by the Inhibition of Inflammatory Thl7 Responses. (2010)
  • Author(s): Hohki S, Ohguro N, Haruta H, Nakai K, Terabe F, Serada S, Fujimoto M, Nomura S, Kawahata H, Kishimoto T, Naka T.
  • Journal Title: Experimental Eye Research. Volume: 91 Pages: 162-170
  • Peer Reviewed
• [Journal Article] Green tea polyphenol epigallocatechin gallate inhibits cell signaling by inducing SOCS1 gene expression. (2010)
  • Author(s): Ripley BJ, Fujimoto M, Serada S, Ohkawara T, Nishikawa T, Terabe F, Matsukawa Y, Stephanou A, Knight RA, Isenberg DA, Latchman DS, Kishimoto T, Naka T
  • Journal Title: International Immunology Volume: 22 Pages: 359-366
  • NAID: 10027579870
  • Peer Reviewed
• [Journal Article] iTRAQ-based proteomic identification of leucine rich alpha 2 glycoprotein (LRG) as a novel inflammatory biomarker in autoimmune diseases (2010)
  • Author(s): Serada S, Fujimoto M, Ogata A, Terabe F, Hirano T, Iijima H, Shinzaki S, Nishikawa T, Ohkawara T, Iwahori K, Ohguro N, Kishimoto T, Naka T
  • Journal Title: Annals of the Rheumatic Diseases Volume: 69 Pages: 770-774
  • Peer Reviewed
• [Presentation] Heterogeneous Nuclear RNP-K Is a Novel Cold-Related Autoantigen in Patients with Raynaud' s Phenomenon (2012)
  • Author(s): Serada S, Fujimoto M, Naka T
  • Organizer: ACR2012第78回米国リウマチ学会議
  • Place of Presentation: 米国(ワシントン)
• [Presentation] Heterogeneous Nuclear RNP-K Is a Novel Cold-Related Autoantigen in Patients with Raynaud’s Phenomenon. (2012)
  • Author(s): Serada S, Fujimoto M, Naka T.
  • Organizer: ACR2012 第78回米国リウマチ学会議
  • Place of Presentation: 米国（ワシントン）
• [Presentation] INTERLEUKIN (IL)-6 DEFICIENCY DOES NOT AFFECT MOTOR NEURON DISEASE CAUSED BY SUPEROXIDE DISMUTASE 1 MUTATIONS (2012)
  • Author(s): YONG MEI, Fujimoto M, Ohkawara T, Yang L, Serada S, Tsunoda S, Naka T.
  • Organizer: International Cytokine Society 2012
  • Place of Presentation: スイス（ジュネーブ）
• [Presentation] UP-REGULATION OF INTERLEUKIN 8 AND CXC CHEMOKINE LIGAND 1 BY COLD STIMULATION IN HUMAN DERMAL MICROVASCULAR ENDOTHELIAL CELLS: A ROLE IN WINTER ULCERATION AND COLD URTICARIA (2012)
  • Author(s): Yang L, Murota H, Fujimoto M, Serada S, Yong M, Ohkawara T, Naka T, Katayama I.
  • Organizer: International Cytokine Society 2012
  • Place of Presentation: スイス（ジュネーブ）
• [Presentation] PERIOSTIN, A NOVEL MATRICELLULAR PROTEIN, IS REQUIRED FOR CUTANEOUS SCLEROSIS IN A MOUSE MODEL OF SCLERODERMA (2012)
  • Author(s): Yang L, Serada S, Fujimoto M, Murota H, Kotobuki Y, Kitaba S, Naka T, Katayama I.
  • Organizer: 31th EULAR 2012
  • Place of Presentation: ドイツ（ベルリン）
• [Presentation] Periostin, a matricellular protein, accelerates wound repair by activating dermal fibroblasts (2011)
  • Author(s): Yorihisa Kotobuki, Kanako Ontsuka, Satoshi Serada, Hiroshi Shiraishi, Atsushi Tanemura, Shoichiro Ohta, Lingli Yang, Tetsuji Naka, Kenji Izuhara, Ichiro Katayama
  • Organizer: 第36回日本研究皮膚科学会学術大会・総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-12-09
• [Presentation] Leucine rich alpha 2 glycoprotein (LRG) is a novel biomarker for monitoring disease activity in patients with Ulcerative Colitis (2011)
  • Author(s): Serada S, Fujimoto M, Terabe F, Naka T
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] Leucine rich alpha 2 glycoprotein (LRG) is a novel biomarker for monitoring disease activity in patients with Ulcerative Colitis (2011)
  • Author(s): Satoshi Serada, Minoru Fujimoto, Fumitaka Terabe, Tetsuji Naka
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2011-11-28
• [Presentation] TGFbeta1 promotes bleomycin-induced murine dermal sclerosis via its downstream molecule of periostin (2011)
  • Author(s): Yan L, Fujimoto M, Serada S, Murota H, Kotobuki Y, Kitaba S, Katayama I, Naka T
  • Organizer: 9th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research
  • Place of Presentation: イタリア(フィレンツェ)
  • Year and Date: 2011-10-11
• [Presentation] Nuclear receptor PPAR-gamma interacts with IRF7 to negatively regulate TLR7/9-mediated type I interferon production and the development of murine lupus (2011)
  • Author(s): Ripley B, Fujimoto M, Han A, Millrine D, Lee S, Kawai T, Akira S, Naka T, Kishimoto T
  • Organizer: 9th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research
  • Place of Presentation: イタリア(フィレンツェ)
  • Year and Date: 2011-10-10
• [Presentation] Tregの分化、機能におけるIL-6の作用 (2011)
  • Author(s): 藤本穣、仲哲治
  • Organizer: 第31回日本臨床免疫学会総会
  • Place of Presentation: 京王プラザ(東京)(招待講演)
  • Year and Date: 2011-09-17
• [Presentation] 定量的プロテオーム解析による子宮内膜癌抗原蛋白質の探索 (2011)
  • Author(s): Satoshi Serada, Takuhei Yokoyama, Takayuki Enomoto, Shinya Matsuzaki, Akiko Morimoto, Ayako Kim, Minoru Fujimoto, Tadashi Kimura, Tetsuji Naka
  • Organizer: 第9回日本プロテオーム学会
  • Place of Presentation: 新潟市朱鷺メッセ
  • Year and Date: 2011-07-29
• [Presentation] MYD88 GENE KNOCKOUT INHIBITS THE DEVELOPMENT OF LUPUS-LIKE DISEASE IN NZB/W F1 MICE (2011)
  • Author(s): T.Ohkawara, B.Ripley, M.Fujimoto, T.Naka
  • Organizer: EULAR
  • Place of Presentation: イギリス(ロンドン)
  • Year and Date: 2011-05-28
• [Presentation] NUCLEAR RECEPTOR PPAR-GAMMA NEGATIVELY REGULATES TYPE I INTERFERON PRODUCTION VIA INTERACTION WITH IRF7 (2011)
  • Author(s): B.Ripley, M.Fujimoto, S.Serada, L.-L.Yang, F.Terabe, Y.-M.Han, T.Ohkawara, T.Nishikawa, T.Naka
  • Organizer: EULAR
  • Place of Presentation: イギリス(ロンドン)
  • Year and Date: 2011-05-27
• [Presentation] PERIOSTIN GENE KNOCKOUT IS PROTECTIVE AGAINST THE DEVELOPMENT OF BLEOMYCIN-INDUCED MURINE SKIN SCLERODERMA (2011)
  • Author(s): L.Yang, M.Fujimoto, S.Serada, H.Murota, B.Ripley, S.Kitaba, Y.Kotobuki, T.Naka, I.Katayama
  • Organizer: EULAR
  • Place of Presentation: イギリス(ロンドン)
  • Year and Date: 2011-05-27
• [Presentation] Quantitative proteomic analysis of cell-surface membrane proteins : Biomarker discovery in endometrial cancer (2011)
  • Author(s): Takuhei Yokoyama, Takayuki Enomoto, Satoshi Serada, Shinya Matsuzaki, Toshihiro Kimura, Yutaka Ueda, Masami Fujita, Kiyoshi Yoshino, Ayako Kim, Minoru Fujimoto, Tadashi Kimura, Tetsuji Naka
  • Organizer: AACR
  • Place of Presentation: アメリカ(オーランド)
  • Year and Date: 2011-04-06
• [Presentation] SOCS-1, -3 gene delivery in gastric cancer cells induces a potent anti-proliferative effect via the suppression of TAK/STAT and P38 MAPK signaling pathways (2011)
  • Author(s): Maiko Urase, Satoshi Serada, Yoshihito Souma, Kouta Iwahori, Kazuki Shimada, Toshirou Nishida, Minoru Fujimoto, Tetsuji Naka
  • Organizer: AACR
  • Place of Presentation: アメリカ(オーランド)
  • Year and Date: 2011-04-04
• [Presentation] SOCS-1,-3 GENE DELIVERY IN GASTRIC CANCER CELLS INDUCES A POTENT ANTI-PROLIFERATIVE EFFECT VIA THE SUPPRESSION OF JAK/STAT AND P38 MAPK SIGNALING PATHWAYS (2010)
  • Author(s): Serada S, Souma Y, Nishida T, Fujimoto M, Naka T
  • Organizer: 35th ESMO Congress
  • Place of Presentation: イタリア(ミラノ)
  • Year and Date: 2010-10-09
• [Presentation] The deficiency of thymus fails to improve lethal inflammation in SOCS-1 knock-out mice (2010)
  • Author(s): Ukita T, Fujimoto M, Yong mei, Kawabata H, Kishimoto T, Naka T
  • Organizer: Cytokines in Infectious Diseases, Autoimmune Disorders and Cancer (Cytokines 2010)
  • Place of Presentation: Chicago
  • Year and Date: 2010-10-05
• [Presentation] Blockade of IL-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Thl7 responses (2010)
  • Author(s): Hohki S, Ohguro N, Haruta H, Terabe F, Serada S, Fujimoto M, Kishimoto T, Naka T
  • Organizer: Cytokines in Infectious Diseases, Autoimmune Disorders and Cancer (Cytokines 2010)
  • Place of Presentation: Chicago
  • Year and Date: 2010-10-05
• [Presentation] The effect of IL-6 overproduction in vivo on wound healing. Cytokines in Infectious Diseases (2010)
  • Author(s): Fujimoto M, Kotobuki Y, Ktaba S, Ukita T, Terabe F, Haruta H, Kishimoto T, Naka T
  • Organizer: Autoimmune Disorders and Cancer (Cytokines 2010)
  • Place of Presentation: アメリカ(シカゴ)
  • Year and Date: 2010-10-04
• [Presentation] The effect of IL-6 overproduction in vivo on wound healing (2010)
  • Author(s): Fujimoto M, Kotobuki Y, Kitaba S, Ukita T, Terabe F, Haruta H, Kishimoto T, Naka T
  • Organizer: Cytokines in Infectious Diseases, Autoimmune Disorders and Cancer (Cytokines 2010)
  • Place of Presentation: Chicago
  • Year and Date: 2010-10-04
• [Presentation] Interleukin-6 blockade in CD4 T cells inhibits the development of experimental autoimmune uveitis (2010)
  • Author(s): Haruta H, Ohguro N, Hohki S, Nishida K, Fujimoto M, Naka T
  • Organizer: Cytokines in Infectious Diseases, Autoimmune Disorders and Cancer (Cytokines 2010)
  • Place of Presentation: Chicago
  • Year and Date: 2010-10-04
• [Presentation] The effect of IL-6 0verproduction on helper cell differentiation in vivo (2010)
  • Author(s): Fujimoto M, Terabe F, Ukita T, Mei Y, Serada S, Nishikawa T, Ripley B, Kishinloto T, Naka T
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-25
• [Presentation] The effect of IL-6 overproduction on T helper cell differentiation in vivo (2010)
  • Author(s): Fujimoto M, Terabe F, Ukita T, Mei Y, Serada S, Nishikawa T, Ripley B, Kishimoto T, Naka T
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-25
• [Presentation] 自己免疫疾患の新規活動性マーカーとしての leucine rich alpha 2 glycoprotein Proteomics-based identification of leucine rich alpha 2 glycoprotein (LRG) as anovel biomarker associated with disease activity of inflammatory autoimmune disorders (2010)
  • Author(s): 世良田聡、藤本穣、寺部文隆、西川哲平、仲哲治
  • Organizer: 第8回日本プロテオーム学会
  • Place of Presentation: 千葉
  • Year and Date: 2010-07-26
• [Presentation] 自己免疫疾患の新規活動性マーカーとしてのleucine rich alpha 2 glycoprotein Proteomics-based identification of leucine rich alpha 2 glycoprotein (LRG) as a novel biomarker associated with disease activity of inflammatory autoimmune disorders (2010)
  • Author(s): 世良田聡、藤本穣、寺部文隆、西川哲平、仲哲治
  • Organizer: 第8回日本プロテオーム学会
  • Place of Presentation: 千葉
  • Year and Date: 2010-07-26
• [Book] Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis. 潰瘍性大腸炎の疾患活動性マーカーとしての血清ロイシンリッチアルファ2グリコプロテインINTESTINE (2013)
  • Author(s): 工藤進英, 世良田聡, 藤本穣, 仲哲治, 他
  • Total Pages: 112
  • Publisher: 日本メディカルセンター
• [Book] INTESTINE (2013)
  • Author(s): 工藤進英 世良田聡 藤本穣 仲哲治 他
  • Total Pages: 112
  • Publisher: 日本メディカルセンター
• [Book] 先端医療シリーズ43循環器疾患の最新医療 (2012)
  • Author(s): 永井良三, 許俊鋭, 鄭忠和, 澤芳樹, 堀正二, 小川聡田, 林胱一, 佐野俊二, 天野篤, 筒井裕之, 小川久雄, 寺田弘司, 世良田聡, 仲哲治
  • Total Pages: 506
  • Publisher: 先端医療技術研究所
• [Book] 先端医療シリーズ43 循環器疾患の最新医療 (2012)
  • Author(s): 永井良三 許俊鋭 鄭忠和 澤芳樹 堀正二 小川聡 田林晄一 佐野俊二 天野篤 筒井裕之 小川久雄 寺田弘司 世良田聡 仲哲治
  • Total Pages: 506
  • Publisher: 先端医療技術研究所
• [Book] 医学のあゆみサイトカインシグナル伝達抑制分子(SOCS)の新規抗癌剤としての応用 (2010)
  • Author(s): 世良田聡,仲哲治
  • Publisher: 医歯薬出版株式会社
• [Patent(Industrial Property Rights)] 膠原病に伴うレイノー症状を診断する方法及び診断用キット (2012)
  • Inventor(s): 仲哲治、藤本穣、世良田聡
  • Industrial Property Rights Holder: 独立行政法人医薬基盤研究所
  • Industrial Property Number: 2012-141434
  • Filing Date: 2012-06-22
• [Patent(Industrial Property Rights)] 結核検査用バイオマーカー (2012)
  • Inventor(s): 仲哲治、藤本穣、世良田聡、松本智成
  • Industrial Property Rights Holder: 独立行政法人医薬基盤研究所
  • Industrial Property Number: 2012-084996
  • Filing Date: 2012-04-03
• [Patent(Industrial Property Rights)] 膠原病に伴うレイノー症状を診断する方法及び診断用キット (2012)
  • Inventor(s): 仲哲治 藤本穣 世良田聡
  • Industrial Property Rights Holder: 独立行政法人医薬基盤研究所
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-141434
  • Filing Date: 2012-06-22
• [Patent(Industrial Property Rights)] 結核検査用バイオマーカー (2012)
  • Inventor(s): 仲哲治 藤本穣 世良田聡
  • Industrial Property Rights Holder: 独立行政法人医薬基盤研究所
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-084996
  • Filing Date: 2012-04-03
• [Patent(Industrial Property Rights)] 創傷治癒剤 (2010)
  • Inventor(s): 寿 順久、世良田 聡、仲 哲治
  • Industrial Property Rights Holder: 財団法人ヒューマンサイエンス振興財団
  • Industrial Property Number: 2010-151139
  • Filing Date: 2010-07-01
• [Patent(Industrial Property Rights)] 創傷治癒剤 (2010)
  • Inventor(s): 寿順久、世良田聡、仲哲治
  • Industrial Property Rights Holder: 財団法人ヒューマンサイエンス振興財団
  • Industrial Property Number: 2010-151139
  • Filing Date: 2010-07-01