| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Research Abstract |
The uncharacterized function of LRG, a novel biomarker for autoimmune disorders, was investigated in this study. By proteomics approach and two-hybrid screening, several candidates of LRG-interacting proteins including possible receptors have been identified. Generation and analysis of LRG knockout mice have revealed that LRG is dispensable for the survival of mice, but is involved in the progression of several immune diseases. The results suggest that LRG is a promising target of immune disorders. Further studies on LRG as a potential therapeutic target will be on the way in collaboration with a pharmaceutical company.
|
