Mechanisms of Interleukin-13 and B1 cells upon prognosis of acute infectious diseases
Project/Area Number |
22591103
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Infectious disease medicine
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Research Institution | Fukushima Medical University |
Principal Investigator |
YAMAMOTO Natsuo 福島県立医科大学, 感染制御医学講座, 講師 (50466562)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | IL-13 / 自然抗体 / IgM / M2 マクロファージ / インターロイキン(IL)-13 / 気道感染 / 初期抗体 / 貪食細胞 / B1細胞 / 血流感染 / 気道感染(急性肺炎) / イターロイキン(IL)-17 / B-1B細胞 / 経静脈感染 / 敗血症 / 早期獲得抗体 / 接触性過敏応答 / iNKT細胞 / 微生物(肺炎球菌、カンジダ) |
Research Abstract |
IL-13 is Th2 type cytokine as investigated in various physiological functions. Pathogen elimination was impaired in IL-13 deficient (KO) mice when we challenged low dose live S. pneumoniae, or C. albicans via airway route, compared to BALB/c wild type (WT). Serum natural IgM titer was lower in IL-13 KO compared to control WT. IL-13 may affect to amount and quality of natural IgM in the primary acute infection model.
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Report
(4 results)
Research Products
(37 results)
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[Presentation] Novel protective role of IL-13 in sepsis and respiratory infection against commensal microbes2011
Author(s)
Natsuo Yamamoto, Saori Miura, Minoru Takahashi, Teizo Fujita, Yuji Imafuku, Noboru Ohana, Steven M Kerfoot, Philip W.Askenase, Hiroyuki Hosokawa, Toshinori Nakayama, Kazuyoshi Kawakami, Mitsuo Kaku, Keiji Kanemitsu
Organizer
The Japanese Society for Interferon and Cytokine Research, The Japanese Society for Macrophage Molecular and Cell Biology (Joint International Meeting)
Place of Presentation
Osaka
Year and Date
2011-05-25
Related Report
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