Mechanisms of Interleukin-13 and B1 cells upon prognosis of acute infectious diseases

• Project/Area Number: 22591103
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Fukushima Medical University
• Principal Investigator: YAMAMOTO Natsuo 福島県立医科大学, 感染制御医学講座, 講師 (50466562)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: IL-13 / 自然抗体 / IgM / M2 マクロファージ / インターロイキン(IL)-13 / 気道感染 / 初期抗体 / 貪食細胞 / B1細胞 / 血流感染 / 気道感染(急性肺炎) / イターロイキン(IL)-17 / B-1B細胞 / 経静脈感染 / 敗血症 / 早期獲得抗体 / 接触性過敏応答 / iNKT細胞 / 微生物(肺炎球菌、カンジダ)

Research Abstract

IL-13 is Th2 type cytokine as investigated in various physiological functions. Pathogen elimination was impaired in IL-13 deficient (KO) mice when we challenged low dose live S. pneumoniae, or C. albicans via airway route, compared to BALB/c wild type (WT). Serum natural IgM titer was lower in IL-13 KO compared to control WT. IL-13 may affect to amount and quality of natural IgM in the primary acute infection model.

Research Products

• [Journal Article] B-1B 細胞と呼吸器疾患 (2010)
  • Author(s): 山本夏男、金光敬二
  • Journal Title: 炎症と免疫
• [Journal Article] B-1B細胞と呼吸器疾患 (2010)
  • Author(s): 山本夏男、金光敬二
  • Journal Title: 炎症と免疫 Volume: 18
• [Journal Article] Activation of pulmonary invariant NKT cells leads to exacerbation of acute lung injury caused by LPS through local production of IFN-γ and TNF-α by Gr-1+ monocytes (2010)
  • Author(s): Aoyagi Tetsuji, Yamamoto Natsuo, Kawakami Kazuyoshi, et. al.
  • Journal Title: International Immunology Volume: 23(2) Pages: 97-108
  • Peer Reviewed
• [Journal Article] Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans (2010)
  • Author(s): Saijo Shinobu, Yamamoto Natsuo, Iwakura Yoichi, et. al.
  • Journal Title: Immunity Volume: 32(5) Pages: 681-91
  • Peer Reviewed
• [Presentation] カンジダ属の気道感染時における、IL-13 に依存した宿主応答の解析 (2013)
  • Author(s): 阿部良伸、山本夏男 他
  • Organizer: 第87回日本感染症学会学術講演会
  • Place of Presentation: 横浜
• [Presentation] カンジダ属の気道感染時における、IL-13に依存した宿主応答の解析 (2013)
  • Author(s): 阿部良伸、山本夏男 他
  • Organizer: 第87回日本感染症学会学術講演会
  • Place of Presentation: 横浜
• [Presentation] AID とMyD88 に依存した、腹腔内B1a 細胞移入による急性肺炎の改善効果 (2013)
  • Author(s): 山本夏男、阿部良伸、金光敬二 他
  • Organizer: 第86回日本感染症学会学術講演会
  • Place of Presentation: 長崎市
• [Presentation] AIDと MyD88 に依存した、腹腔内 B1a 細胞移入による急性肺炎の改善効果 (2012)
  • Author(s): 山本夏男、阿部良伸、金光敬二 他
  • Organizer: 第86回日本感染症学会学術講演会
  • Place of Presentation: 長崎
• [Presentation] Role of Dectin-2 in the host defense against S. Pneumoniaeinfection (2012)
  • Author(s): Ishii Keiko, Yamamoto Natsuo, Kawakami Kazuyoshi et al
  • Organizer: 99th Annual Meeting of American Association of Immunologists
  • Place of Presentation: Boston, USA
• [Presentation] Innate protective responses of B1-like cells dependent on activation-induced cytidine deaminase (AID) and interleukin-13 (2012)
  • Author(s): Yamamoto Natsuo, Abe Yoshinobu, Nakazawa Naomi, Kanemitsu Keiji
  • Organizer: 研究連携セミナー
  • Place of Presentation: 福島医科大学内 福島市
• [Presentation] Role of Dectin-2 in the host defense against S. pneumonia infection (2012)
  • Author(s): Ishii Keiko, Natsuo Yamamoto, Kawakami Kazuyoshi et al.
  • Organizer: 99th Annual Meeting of American Association of Immunologists
  • Place of Presentation: Boston, Massachussets, USA
• [Presentation] Signaling via an adapter molecule CARD9 is essential for the host defense to infection with C. neoformans (2012)
  • Author(s): Yamamoto Hideki, Yamamoto Natsuo, Kawakami Kazuyoshi et al.
  • Organizer: 99th Annual Meeting of American Association of Immunologists
  • Place of Presentation: Boston, Massachussets, USA
• [Presentation] Innate protective responses of B1-like cells dependent on activation-induced cytidine deaminase (AID) and interleukin-13 (2012)
  • Author(s): Yamamoto Natsuo, Abe Yoshinobu, Nakazawa Naomi, Kanemitsu Keiji et al.
  • Organizer: 研究連携セミナー
  • Place of Presentation: 福島医科大学、福島市
• [Presentation] Protective role of IL-13 in sepsis and respiratory infection against S.pneumoniae (2011)
  • Author(s): YAMAMOTO Natsuo, et al.
  • Organizer: 2011 The Japanese Society for Immunology
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2011-11-29
• [Presentation] Indispensable role of CAED9 in the host defense against infection with Cryptococcus neoformans (2011)
  • Author(s): YAMAMOTO Hideki, YAMAMOTO Natsuo, et al
  • Organizer: 2011 The Japanese Society for Immunology
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2011-11-28
• [Presentation] Involvement of TLR9 signaling in mouse model of Candida albicans systemic infection (2011)
  • Author(s): MIYAZATO Akiko, YAMAMOTO Natsuo, et al
  • Organizer: 2011 The Japanese Society for Immunology
  • Place of Presentation: 幕張メッセ(千葉市)
  • Year and Date: 2011-11-28
• [Presentation] 血流感染時に宿主保護に関わるIL-13の役割 (2011)
  • Author(s): 山本夏男、金光敬二, 他
  • Organizer: 第60回東日本感染症学会、第58回日本化学療法学会合同学会
  • Place of Presentation: 山形市
  • Year and Date: 2011-10-28
• [Presentation] 常在微生物による肺炎及び血流感染に対するIL-13の宿主保護的な役割 (2011)
  • Author(s): 山本夏男、三浦里織、高橋実、藤田禎三、大花昇、今福裕司、細川裕之、中山俊憲、山本秀輝、川上和義、賀来満夫、金光敬二
  • Organizer: 第22回日本生体防御学会学術総会
  • Place of Presentation: 那覇市(沖縄県)
  • Year and Date: 2011-06-29
• [Presentation] Novel protective role of IL-13 in sepsis and respiratory infection against commensal microbes (2011)
  • Author(s): Natsuo Yamamoto, Saori Miura, Minoru Takahashi, Teizo Fujita, Yuji Imafuku, Noboru Ohana, Steven M Kerfoot, Philip W.Askenase, Hiroyuki Hosokawa, Toshinori Nakayama, Kazuyoshi Kawakami, Mitsuo Kaku, Keiji Kanemitsu
  • Organizer: The Japanese Society for Interferon and Cytokine Research, The Japanese Society for Macrophage Molecular and Cell Biology (Joint International Meeting)
  • Place of Presentation: Osaka
  • Year and Date: 2011-05-25
• [Presentation] Novel protective role of IL-13 in sepsis and respiratory infection against commensal microbes (2011)
  • Author(s): Natsuo Yamamoto, SM Kerfoot, PW Askenase, Toshinori Nakayama et al.
  • Organizer: The Japanese Society for Interferon and Cytokine Researc
  • Place of Presentation: Osaka
• [Presentation] Protective role of IL-13 in sepsis and respiratory infection against S. pneumoniae (2011)
  • Author(s): Yamamoto Natsuo et al
  • Organizer: 2011 The Japanese Society for Immunology
  • Place of Presentation: Chiba
• [Presentation] Involvement of TLR9 signaling in mouse model of Candida albicans systemic infection. (2011)
  • Author(s): Miyazato Akiko, Yamamoto Natsuo, Kawakami Kazuyoshi et al
  • Organizer: 2011 The Japanese Society for Immunology
  • Place of Presentation: Chiba
• [Presentation] 常在微生物による肺炎及び血流感染に対する IL-13 の宿主保護的な役割 (2011)
  • Author(s): 山本夏男、中山俊憲、川上和義、賀来満夫、金光敬二
  • Organizer: 第22回日本生体防御学会学術総会
  • Place of Presentation: 那覇市(沖縄)
• [Presentation] 血流感染時に宿主保護的に関わる IL-13 の役割 (2011)
  • Author(s): 山本夏男、金光敬二 他
  • Organizer: 第60回東日本感染症学会
  • Place of Presentation: 山形市
• [Presentation] Protective roles of IL-13 in sepsis and acute airway infection with B-1a cell function (2010)
  • Author(s): Yamamoto Natsuo, et. al.
  • Organizer: 48th Infectious Disease Society of America (1DSA) annual meeting
  • Place of Presentation: Vancouver Convention Centre, Vancouver, Canada
  • Year and Date: 2010-10-23
• [Presentation] Protective roles of B-1a cells and IL-13 in sepsis and acute airway infection with S. pneumoniae (2010)
  • Author(s): Miura Saori, Yamamoto Natsuo, Kanemitsu Keiji, et al.
  • Organizer: 第36回生体防御学会
  • Place of Presentation: 戦災復興会館、仙台
  • Year and Date: 2010-07-22
• [Presentation] IL-13に依存したB-1細胞機能と液性因子による急性感染症感受性制御機構 (2010)
  • Author(s): 山本夏男, 今福裕司, 金光敬二, 他.
  • Organizer: 第84回日本感染症学会総会・学術集会
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2010-04-05
• [Presentation] Protective roles of IL-13 in sepsis and acute airway infection with B-1a cell function (2010)
  • Author(s): Yamamoto Natsuo et al
  • Organizer: 48th Infectious Disease Society of America (IDSA) annual meeting
  • Place of Presentation: Vancouver, Canada
• [Presentation] Kanemitsu Keiji et al. Protective roles of B-1a cellsand IL-13 in sepsis and acute airway infection with S. pneumoniae. (2010)
  • Author(s): Miura Saori, Yamamoto Natsuo
  • Organizer: 36回生体防御学会
  • Place of Presentation: 仙台
• [Presentation] IL-13に依存した B-1 細胞機能と液性因子による急性感染症感受性制御機構 (2010)
  • Author(s): 山本夏男、今福裕司、金光敬二 他
  • Organizer: 第84回日本感染症学会総会
  • Place of Presentation: 京都
• [Remarks] Allergy and Clinical Immunology, YaleUniversity
  • URL: http://medicine.yale.edu/intmed/allergy/people/philip_askenase.profile
• [Remarks] 医学部医学科 感染制御医学講座、福島医科大学研究者データベース
  • URL: http://www.fmu.ac.jp/kenkyu/Profiles/39/0003823/profile.html
• [Remarks] Allergy and Clinical Immunology, Yale University
  • URL: http://medicine.yale.edu/intmed/allergy/people/philip_askenase.profile
• [Remarks] 医学部医学科 感染制御医学講座、福島医科大学研究者データベース
  • URL: http://www.fmu.ac.jp/kenkyu/Profiles/39/0003823/profile.html
• [Remarks]
  • URL: http://www.fmu.ac.jp/kenkyu/Profiles/39/0003823/profile.html
• [Remarks]
  • URL: http://medicine.yale.edu/intmed/allergy/people/philip_askenase.profile
• [Remarks]
  • URL: http://www.fmu.ac.jp/kenkyu/Profiles/39/0003823/profile.html