| Project/Area Number |
22591106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
|
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| Research Institution | National Institute of Infectious Diseases (2012)
Osaka University (2010-2011) |
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Principal Investigator |
OISHI Kazunori 国立感染症研究所, 感染症情報センター, センター長 (80160414)
|
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| Co-Investigator(Kenkyū-buntansha) |
KUROSU Takeshi 大阪大学, 微生物病研究所, 助教 (70432432)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
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| Keywords | デングウイルス / 血小板減少 / 血小板アポトーシス / 血小板 / 巨核球 / 骨髄系細胞 / インターフェロンレセプター欠損マウス / デング / 二次感染 / アポトーシス / アポトーシス血小板クリアランス / 血小板減少症 / フィリピン |
|---|
| Research Abstract |
Dengue illness has become a major public health concern particularly in tropical countries and the mechanism of thrombocytopenia remains uncertain. We previously reported from the clinical study in the Philippines a significant association between thrombocytopenia and an increased phagocytosis of platelets in an ex vivo setting during acute phase of secondary dengue virus infection (Honda S, et al. Am J Trop Med Hyg, 2009). We report here an increased phagocytosis of DV-induced apoptotic platelets by macrophages via a phosphatidylserine-recognizing pathway in secondary DV infection during the acute phase. Accelerated platelet clearance was overcome by thrombopietin-induced enhanced thrombopoiesis in these patients (Alonzo T, et al. J infect Dis, 2012).
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